nitroglycerin has been researched along with Insulin Resistance in 24 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin improves both endothelial function and insulin resistance in patients with MS." | 9.11 | Metformin improves endothelial function in patients with metabolic syndrome. ( Cornoldi, A; Fini, M; Mercuro, G; Rosano, GM; Vitale, C; Volterrani, M, 2005) |
| "To determine the effects of pioglitazone (30 mg once daily for 16 weeks) on insulin sensitivity, insulin-mediated vasodilation, vascular inflammatory markers, fat distribution and lipids in Asian Indians and Caucasians of European ancestry." | 7.73 | Effect of pioglitazone on insulin sensitivity, vascular function and cardiovascular inflammatory markers in insulin-resistant non-diabetic Asian Indians. ( Gerhard-Herman, MD; O'connor, ME; Raji, A; Simonson, DC; Williams, JS, 2006) |
| "Insulin resistance is related to the atherosclerotic process." | 5.34 | Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone. ( Harano, Y; Suzuki, M; Takamisawa, I; Yoshimasa, Y, 2007) |
| "We tested the effect of rosiglitazone on FFA-induced endothelial dysfunction of the forearm resistance vessels, insulin sensitivity, asymmetric dimethylarginine (ADMA), and high-sensitivity C-reactive protein concentrations in humans." | 5.12 | Rosiglitazone prevents free fatty acid-induced vascular endothelial dysfunction. ( Kapiotis, S; Krzyzanowska, K; Mittermayer, F; Pleiner, J; Roden, M; Schaller, G; Wolzt, M, 2007) |
| " FMD was significantly correlated with fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), malondialdehyde-modified low density lipoprotein (MDA-LDL), LDL particle size, and HMW adiponectin (r = 0." | 5.12 | Impact of the high-molecular-weight form of adiponectin on endothelial function in healthy young men. ( Cheng, XW; Matsui, H; Murakami, H; Murakami, R; Murohara, T; Numaguchi, Y; Ogawa, Y; Okumura, K; Torigoe, M, 2007) |
| "Metformin improves both endothelial function and insulin resistance in patients with MS." | 5.11 | Metformin improves endothelial function in patients with metabolic syndrome. ( Cornoldi, A; Fini, M; Mercuro, G; Rosano, GM; Vitale, C; Volterrani, M, 2005) |
| "07 mg of nitroglycerin per hour yielded nitrate tolerance and a state of insulin resistance and no increase in insulin sensitivity in response to food." | 3.77 | Block by nitrate tolerance of meal-induced insulin sensitization in conscious rabbits. ( Bajza, A; Németh, J; Peitl, B; Szilvássy, Z, 2011) |
| "To determine the effects of pioglitazone (30 mg once daily for 16 weeks) on insulin sensitivity, insulin-mediated vasodilation, vascular inflammatory markers, fat distribution and lipids in Asian Indians and Caucasians of European ancestry." | 3.73 | Effect of pioglitazone on insulin sensitivity, vascular function and cardiovascular inflammatory markers in insulin-resistant non-diabetic Asian Indians. ( Gerhard-Herman, MD; O'connor, ME; Raji, A; Simonson, DC; Williams, JS, 2006) |
| " In all patients, insulin resistance, residual pancreatic C-peptide secretion, endothelial function and oxidative stress were investigated using the homoeostasis model assessment (HOMA) index, glucagon bolus test, brachial reactivity, Trolox equivalent antioxidant capacity (TEAC) and thiobarbituric acid-reacting substances (TBARS)." | 3.72 | Residual C-peptide secretion and endothelial function in patients with Type II diabetes. ( Abbatecola, AM; Grella, R; Manzella, D; Paolisso, G; Ragno, E, 2003) |
| "A subset of individuals with type 1 or type 2 diabetes (n = 108) was re-evaluated after 5 years." | 1.72 | Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes. ( Antoniou, S; Bódis, K; Burkart, V; Karusheva, Y; Löffler, L; Möser, C; Roden, M; Schön, M; Strassburger, K; Szendroedi, J; Yurchenko, I; Zaharia, OP, 2022) |
| " Future studies should pay attention to the delicate balance between sufficient dosing and timely normalization of plasma haem levels." | 1.43 | Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study. ( Bilos, A; Dekker, D; Dorresteijn, MJ; Pennings, SW; Peters, WH; Smits, P; Wagener, FA, 2016) |
| "The insulin resistance was estimated by the insulin sensitivity index (ISI)." | 1.37 | Kidney transplantation improves arterial function measured by pulse wave analysis and endothelium-independent dilatation in uraemic patients despite deterioration of glucose metabolism. ( Clausen, P; Feldt-Rasmussen, B; Hansen, JM; Hornum, M; Idorn, T; Mathiesen, ER, 2011) |
| "Insulin resistance is related to the atherosclerotic process." | 1.34 | Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone. ( Harano, Y; Suzuki, M; Takamisawa, I; Yoshimasa, Y, 2007) |
| "Insulin sensitivity was measured according to the steady-state plasma glucose (SSPG) method." | 1.32 | Close association of endothelial dysfunction with insulin resistance and carotid wall thickening in hypertension. ( Harano, Y; Hiuge, A; Horio, T; Suzuki, K; Suzuki, M; Takamisawa, I; Yoshimasa, Y, 2004) |
| "Nitroglycerin treatment of 7 days produced a lack of hypotensive response to a single intravenous bolus of 30 microg/kg nitroglycerin, which caused a significant decrease in mean arterial blood pressure in control rabbits." | 1.32 | Development of insulin resistance by nitrate tolerance in conscious rabbits. ( Bajza, A; Literati-Nagy, P; Nemeth, J; Peitl, B; Porszasz, R; Rabloczky, G; Szilvassy, J; Szilvassy, Z, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 16 (66.67) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Zaharia, OP | 1 |
| Schön, M | 1 |
| Löffler, L | 1 |
| Strassburger, K | 1 |
| Möser, C | 1 |
| Yurchenko, I | 1 |
| Bódis, K | 1 |
| Antoniou, S | 1 |
| Karusheva, Y | 1 |
| Szendroedi, J | 1 |
| Burkart, V | 1 |
| Roden, M | 2 |
| Dekker, D | 1 |
| Dorresteijn, MJ | 1 |
| Peters, WH | 1 |
| Bilos, A | 1 |
| Pennings, SW | 1 |
| Wagener, FA | 1 |
| Smits, P | 1 |
| Schaller, G | 2 |
| Kretschmer, S | 1 |
| Gouya, G | 1 |
| Haider, DG | 1 |
| Mittermayer, F | 2 |
| Riedl, M | 1 |
| Wagner, O | 1 |
| Pacini, G | 1 |
| Wolzt, M | 2 |
| Ludvik, B | 1 |
| Hornum, M | 1 |
| Clausen, P | 1 |
| Idorn, T | 1 |
| Hansen, JM | 1 |
| Mathiesen, ER | 1 |
| Feldt-Rasmussen, B | 1 |
| Bajza, A | 2 |
| Németh, J | 2 |
| Peitl, B | 2 |
| Szilvássy, Z | 2 |
| Jedrzkiewicz, S | 1 |
| Parker, JD | 1 |
| Manzella, D | 1 |
| Ragno, E | 1 |
| Abbatecola, AM | 1 |
| Grella, R | 1 |
| Paolisso, G | 1 |
| Anfossi, G | 2 |
| Russo, I | 1 |
| Massucco, P | 2 |
| Mattiello, L | 2 |
| Trovati, M | 2 |
| Suzuki, M | 2 |
| Takamisawa, I | 2 |
| Suzuki, K | 1 |
| Hiuge, A | 1 |
| Horio, T | 1 |
| Yoshimasa, Y | 2 |
| Harano, Y | 2 |
| Porszasz, R | 1 |
| Rabloczky, G | 1 |
| Literati-Nagy, P | 1 |
| Szilvassy, J | 1 |
| Kelly, AS | 1 |
| Wetzsteon, RJ | 1 |
| Kaiser, DR | 1 |
| Steinberger, J | 1 |
| Bank, AJ | 1 |
| Dengel, DR | 1 |
| Vitale, C | 1 |
| Mercuro, G | 1 |
| Cornoldi, A | 1 |
| Fini, M | 1 |
| Volterrani, M | 1 |
| Rosano, GM | 1 |
| Paradisi, G | 1 |
| Biaggi, A | 1 |
| Savone, R | 1 |
| Ianniello, F | 1 |
| Tomei, C | 1 |
| Caforio, L | 1 |
| Caruso, A | 1 |
| Raji, A | 1 |
| Gerhard-Herman, MD | 1 |
| Williams, JS | 1 |
| O'connor, ME | 1 |
| Simonson, DC | 1 |
| Fernández-Real, JM | 2 |
| López-Bermejo, A | 1 |
| Castro, A | 2 |
| Casamitjana, R | 1 |
| Ricart, W | 2 |
| Dogra, G | 1 |
| Irish, A | 1 |
| Chan, D | 1 |
| Watts, G | 1 |
| Pleiner, J | 1 |
| Krzyzanowska, K | 1 |
| Kapiotis, S | 1 |
| Torigoe, M | 1 |
| Matsui, H | 1 |
| Ogawa, Y | 1 |
| Murakami, H | 1 |
| Murakami, R | 1 |
| Cheng, XW | 1 |
| Numaguchi, Y | 1 |
| Murohara, T | 1 |
| Okumura, K | 1 |
| Brillante, DG | 1 |
| O'Sullivan, AJ | 1 |
| Johnstone, MT | 1 |
| Howes, LG | 1 |
| Aggoun, Y | 1 |
| Farpour-Lambert, NJ | 1 |
| Marchand, LM | 1 |
| Golay, E | 1 |
| Maggio, AB | 1 |
| Beghetti, M | 1 |
| Mularoni, EM | 1 |
| Burzacca, S | 1 |
| Ponziani, MC | 1 |
| Cavalot, F | 1 |
| Arcaro, G | 1 |
| Zamboni, M | 1 |
| Rossi, L | 1 |
| Turcato, E | 1 |
| Covi, G | 1 |
| Armellini, F | 1 |
| Bosello, O | 1 |
| Lechi, A | 1 |
| Lainez, B | 1 |
| Vendrell, J | 1 |
| Rigla, M | 1 |
| Peñarroja, G | 1 |
| Broch, M | 1 |
| Pérez, A | 1 |
| Richart, C | 1 |
| Engel, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients[NCT01055093] | 2,000 participants (Anticipated) | Observational | 2005-09-30 | Recruiting | |||
| Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity[NCT01821313] | 43 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome[NCT03355469] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2017-08-07 | Recruiting | ||
| Self-management of Postnatal Anti-hypertensive Treatment: a Trial Development Pilot Study[NCT02333240] | 101 participants (Actual) | Interventional | 2015-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for nitroglycerin and Insulin Resistance
| Article | Year |
|---|---|
Alcohol acutely increases vascular reactivity together with insulin sensitivity in type 2 diabetic men.
Topics: Aged; Alcohol Drinking; Body Mass Index; Brachial Artery; Diabetes Mellitus, Type 2; Endothelium, Va | 2010 |
Acute and chronic effects of glyceryl trinitrate therapy on insulin and glucose regulation in humans.
Topics: Adolescent; Adult; Blood Glucose; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Re | 2013 |
Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise.
Topics: Adolescent; Blood Glucose; Body Mass Index; C-Reactive Protein; Child; Cholesterol; Endothelium, Vas | 2004 |
Metformin improves endothelial function in patients with metabolic syndrome.
Topics: Brachial Artery; Endothelium, Vascular; Female; Homeostasis; Humans; Hypoglycemic Agents; Image Proc | 2005 |
Rosiglitazone prevents free fatty acid-induced vascular endothelial dysfunction.
Topics: Acetylcholine; Adult; Anticoagulants; Arginine; C-Reactive Protein; Endothelium, Vascular; Fatty Aci | 2007 |
Impact of the high-molecular-weight form of adiponectin on endothelial function in healthy young men.
Topics: Adiponectin; Adult; Brachial Artery; Cross-Sectional Studies; Endothelium, Vascular; Humans; Hyperem | 2007 |
18 other studies available for nitroglycerin and Insulin Resistance
| Article | Year |
|---|---|
Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes.
Topics: Brachial Artery; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glucose; Glycated Hemoglobin; Hum | 2022 |
Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study.
Topics: Acetylcholine; Adult; Aged; Arginine; Bilirubin; Cross-Over Studies; Endothelium, Vascular; Female; | 2016 |
Kidney transplantation improves arterial function measured by pulse wave analysis and endothelium-independent dilatation in uraemic patients despite deterioration of glucose metabolism.
Topics: Adult; Arteries; Blood Flow Velocity; Blood Pressure; Case-Control Studies; Dilatation; Endothelium, | 2011 |
Block by nitrate tolerance of meal-induced insulin sensitization in conscious rabbits.
Topics: Animals; Blood Glucose; Blood Pressure; Cyclic GMP; Drug Tolerance; Eating; Fasting; Glucose Clamp T | 2011 |
Residual C-peptide secretion and endothelial function in patients with Type II diabetes.
Topics: Aged; Analysis of Variance; Area Under Curve; Brachial Artery; C-Peptide; Diabetes Mellitus, Type 2; | 2003 |
Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects.
Topics: Acetylcysteine; Adenosine Diphosphate; Adult; Amifostine; Antioxidants; Collagen; Cyclic GMP; Drug R | 2003 |
Close association of endothelial dysfunction with insulin resistance and carotid wall thickening in hypertension.
Topics: Aged; Biomarkers; Blood Glucose; Blood Pressure; Brachial Artery; Carotid Artery Diseases; Carotid A | 2004 |
Development of insulin resistance by nitrate tolerance in conscious rabbits.
Topics: Animals; Blood Pressure; Drug Tolerance; Glucose; Glucose Clamp Technique; Heart Rate; Insulin Resis | 2004 |
Cardiovascular risk factors in healthy women with previous gestational hypertension.
Topics: Adult; Blood Glucose; Body Composition; Brachial Artery; Carbohydrate Metabolism; Cardiovascular Dis | 2006 |
Effect of pioglitazone on insulin sensitivity, vascular function and cardiovascular inflammatory markers in insulin-resistant non-diabetic Asian Indians.
Topics: Adipose Tissue; Administration, Sublingual; Adult; Aged; Biomarkers; Blood Glucose; Brachial Artery; | 2006 |
Thyroid function is intrinsically linked to insulin sensitivity and endothelium-dependent vasodilation in healthy euthyroid subjects.
Topics: Brachial Artery; Cholesterol, HDL; Cohort Studies; Cross-Sectional Studies; Endothelium-Dependent Re | 2006 |
Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Hypogl | 2007 |
Insulin resistance, inflammation, and blood pressure determine vascular dysfunction in CKD.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arteries; Blood Pressure; Brachial Artery; Cardiovascula | 2006 |
Arterial stiffness and haemodynamic response to vasoactive medication in subjects with insulin-resistance syndrome.
Topics: Adult; Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Arteries; Dose-Response Relationship | 2008 |
Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure.
Topics: Atherosclerosis; Blood Pressure; Brachial Artery; Carotid Artery Diseases; Carotid Artery, Common; C | 2008 |
Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Blood Glucose; Blood Platelets; Blood Pressure; | 1998 |
Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity.
Topics: Adipose Tissue; Adult; Arteriosclerosis; Biomarkers; Blood Flow Velocity; Body Composition; Endothel | 1999 |
Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus.
Topics: Adult; Aged; Antigens, CD; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 1; Diabetes Mell | 2002 |