celastrol has been researched along with Insulin Resistance in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (65.00) | 24.3611 |
| 2020's | 7 (35.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afrin, S; Cao, J; Chau, D; Cheng, B; Dong, Y; Gao, Y; He, Z; Hu, L; Huang, Y; Hwang, ES; Kabahizi, A; Lieu, L; Okolo, J; Wallace, B; Williams, KW; Yao, T | 1 |
| Abu Bakar, MH; Karunakaran, T; Mohamad Khalid, MSF; Nor Shahril, NS; Shariff, KA | 1 |
| Fan, N; Huang, M; Li, D; Luo, D; Ngo, FY; Rong, J; Wang, Y; Zhang, X; Zhao, J; Zhao, W | 1 |
| Abu Bakar, MH; Karunakaran, T; Mohamad Khalid, MSF; Mohamad Rosdi, MN; Mohammad, S; Mohd Salleh, R; Nor Shahril, NS; Shariff, KA | 1 |
| Fan, N; Luo, D; Nie, H; Rong, J; Wang, Y; Zhang, Z; Zhao, J | 1 |
| Abu Bakar, MH; Lee, LK; Shariff, KA; Tan, JS | 1 |
| Chen, G; Fang, K; Li, J; Li, L; Lu, F; Luo, J; Lynch, EC; Wu, F; Xie, L; Xu, L; Yang, X; Zhao, Y; Zou, X | 1 |
| Feng, Y; He, W; Li, X; Xu, S; Xu, W; Yang, H | 1 |
| Abu Bakar, MH; Tan, JS | 1 |
| Cao, FF; Ge, HY; Gu, YJ; Peng, B; Uzan, G; Wang, Y; Yang, CX; Zhang, DH; Zhang, X | 1 |
| Cao, FF; Peng, B; Uzan, G; Wang, Y; Xue, XC; You, J; Zhang, DH; Zhang, X | 1 |
| Chen, Q; Chen, Y; Deng, L; Qiu, P; Wei, X; Xiao, J; Yan, C; Yang, Y; Zhan, X | 1 |
| Bishayee, A; Deshmukh, RR; Kumar, P; Kumar, S; Sharma, H | 1 |
| Cha, DR; Cha, JJ; Han, JY; Han, KH; Han, SY; Hyun, YY; Kang, YS; Kim, HW; Kim, JE; Lee, JE; Lee, MH; Nam, DH; Song, HK | 1 |
| Bakar, MH; Huri, HZ; Kai, CK; Sarmidi, MR; Yaakob, H | 1 |
| Abu Bakar, MH; Cheng, KK; Huri, HZ; Sarmidi, MR; Yaakob, H | 1 |
| Leibel, R; Tortoriello, DV; Weisberg, S | 1 |
| Chang, Y; Fang, F; Gao, M; Geng, C; Li, M; Liu, X; Zhang, Y | 1 |
| Abu Bakar, MH; Mohamad Rosdi, MN; Sarmidi, MR; Tan, JS | 1 |
| Kang, SW; Kang, YH; Kim, HS; Kim, MS; Kim, Y; Park, JH; Shin, D | 1 |
2 review(s) available for celastrol and Insulin Resistance
| Article | Year |
|---|---|
Celastrol in metabolic diseases: Progress and application prospects.
Topics: Animals; Diabetes Mellitus, Type 2; Energy Metabolism; Humans; Inflammation; Insulin Resistance; Lipid Metabolism; Metabolic Diseases; Obesity; Pentacyclic Triterpenes; Tripterygium | 2021 |
Pentacyclic triterpenes: New tools to fight metabolic syndrome.
Topics: Animals; Heart; Humans; Insulin Resistance; Liver; Metabolic Syndrome; Muscle, Skeletal; Oleanolic Acid; Oxidative Stress; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid | 2018 |
18 other study(ies) available for celastrol and Insulin Resistance
| Article | Year |
|---|---|
PERK in POMC neurons connects celastrol with metabolism.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Diet, High-Fat; Eating; eIF-2 Kinase; Endoplasmic Reticulum Stress; Energy Metabolism; Glucose; Insulin Resistance; Leptin; Male; Mice; Mice, Knockout; Neurons; Obesity; Pentacyclic Triterpenes; Pro-Opiomelanocortin | 2021 |
Celastrol attenuates high-fructose diet-induced inflammation and insulin resistance via inhibition of 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose tissues.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Diet; Fructose; Inflammation; Insulin Resistance; Pentacyclic Triterpenes; Rats | 2022 |
Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice.
Topics: Adipose Tissue; Animals; Diet, High-Fat; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Inflammation; Insulin Resistance; Lipid Metabolism; Liver; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Pentacyclic Triterpenes; RAW 264.7 Cells | 2022 |
Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex.
Topics: Animals; Diet, High-Fat; Glucose; Insulin Resistance; Male; Mice; Muscle, Skeletal; Obesity; Oxidative Stress; Pentacyclic Triterpenes; Pyruvate Dehydrogenase Complex; Up-Regulation | 2022 |
Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Ethylene Glycols; Gastrointestinal Tract; Inflammation; Insulin Resistance; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Obesity; Particle Size; Pentacyclic Triterpenes; Polyesters; Triterpenes | 2019 |
Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Blood Glucose; Diet, High-Fat; Disease Models, Animal; Inflammation Mediators; Insulin Resistance; Macrophage Activation; Macrophages; Male; Mitochondria, Muscle; Muscle, Skeletal; Obesity; Organelle Biogenesis; Panniculitis; Pentacyclic Triterpenes; Rats, Sprague-Dawley; Signal Transduction; Sirtuin 1 | 2020 |
Celastrol alleviates metabolic disturbance in high-fat diet-induced obese mice through increasing energy expenditure by ameliorating metabolic inflammation.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Cytokines; Diet, High-Fat; Dyslipidemias; Energy Metabolism; Glucose Intolerance; Inflammasomes; Inflammation; Insulin Resistance; Liver; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Pentacyclic Triterpenes; Thermogenesis; Triterpenes; Weight Gain | 2021 |
Improvement of mitochondrial function by celastrol in palmitate-treated C2C12 myotubes via activation of PI3K-Akt signaling pathway.
Topics: Animals; Cell Line; Cell Survival; Insulin Resistance; Mitochondria; Muscle Fibers, Skeletal; Palmitates; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Tripterygium; Triterpenes | 2017 |
Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA.
Topics: Animals; Diet, High-Fat; Gene Expression Regulation; Humans; Inflammation; Insulin Resistance; Mice, Inbred C57BL; Palmitic Acid; Pentacyclic Triterpenes; Signal Transduction; Toll-Like Receptor 4; Triterpenes | 2018 |
Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway.
Topics: Animals; Down-Regulation; Gene Expression Regulation; Glucose Transporter Type 4; Hep G2 Cells; Humans; Insulin Resistance; MicroRNAs; Palmitic Acid; Pentacyclic Triterpenes; Phosphorylation; Signal Transduction; Triterpenes | 2019 |
Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway.
Topics: Animals; Autophagy; Cytokines; Diabetic Nephropathies; Gene Expression Regulation, Enzymologic; Glucose; Heme Oxygenase-1; Inflammation; Insulin Resistance; Membrane Proteins; Mice; Pentacyclic Triterpenes; Podocytes; Signal Transduction; Triterpenes | 2018 |
Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice.
Topics: Adipose Tissue; Albuminuria; Animals; Cells, Cultured; Cytokines; Diabetes Mellitus, Experimental; Fatty Acids; Glycated Hemoglobin; Inflammation Mediators; Insulin Resistance; Kidney; Kidney Function Tests; Kidney Glomerulus; Lipid Peroxidation; Lipids; Liver; Male; Mice; NF-kappa B; Oxidative Stress; Pentacyclic Triterpenes; Podocytes; Triterpenes | 2013 |
Amelioration of mitochondrial dysfunction-induced insulin resistance in differentiated 3T3-L1 adipocytes via inhibition of NF-κB pathways.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Cell Survival; Electron Transport; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Humans; Insulin; Insulin Resistance; Interleukin-1beta; Intracellular Space; Lipolysis; Mice; Mitochondria; NF-kappa B; Oligomycins; Oxidative Stress; Pentacyclic Triterpenes; Signal Transduction; Triterpenes; Tumor Necrosis Factor-alpha | 2014 |
Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells.
Topics: Antimycin A; Cell Line; Glucose; Glucose Transporter Type 4; Humans; Inflammation; Insulin; Insulin Resistance; Mitochondria; Muscle Cells; Muscle, Skeletal; NF-kappa B; Pentacyclic Triterpenes; Phosphatidylinositol 3-Kinases; Phosphorylation; Protective Agents; Protein Kinase C; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes | 2015 |
Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice.
Topics: 3T3-L1 Cells; Animals; Body Composition; Cell Survival; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Supplements; Glycated Hemoglobin; Homeostasis; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Obesity; Oligopeptides; Pentacyclic Triterpenes; Polyphenols; Proteasome Inhibitors; Receptors, Leptin; Triterpenes | 2016 |
Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1.
Topics: AMP-Activated Protein Kinases; Animals; Diet, High-Fat; Hepatocytes; Insulin Resistance; Lipogenesis; Liver; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Non-alcoholic Fatty Liver Disease; Obesity; Oxidative Stress; Pentacyclic Triterpenes; Sirtuin 1; Triterpenes | 2017 |
Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes.
Topics: Biological Transport; Cell Survival; Cytokines; Cytoprotection; Fatty Acids; Glucose; Hepatocytes; Humans; Inflammation; Insulin; Insulin Resistance; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Mitochondria; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Palmitates; Pentacyclic Triterpenes; Signal Transduction; Triterpenes | 2017 |
Celastrol attenuates adipokine resistin-associated matrix interaction and migration of vascular smooth muscle cells.
Topics: Aorta; Atherosclerosis; Cell Movement; Cell Proliferation; Cells, Cultured; Collagen Type IV; Gene Expression; Humans; Insulin Resistance; Macrophages; Muscle, Smooth, Vascular; Pentacyclic Triterpenes; Resistin; Toll-Like Receptor 4; Tripterygium; Triterpenes | 2013 |