Bis(5'-adenosyl)-triphosphatase

A bis(5-adenosyl)-triphosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49789]

EC 3.6.1.29;
AP3A hydrolase;
AP3Aase;
Diadenosine 5',5'''-P1,P3-triphosphate hydrolase;
Dinucleosidetriphosphatase;
Fragile histidine triad protein

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
4,9-dimethyl-3-(2H-tetrazol-5-ylmethoxy)-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-6-one	Homo sapiens (human)	IC50	4.6600	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
diadenosine triphosphate	Homo sapiens (human)	Km	1.9000	1	1

This protein enables 8 target(s):

Target	Category	Definition
nucleotide binding	molecular function	Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. [GOC:mah, ISBN:0198547684]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
adenosine 5'-monophosphoramidase activity	molecular function	Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester. [PMID:11805111, RHEA:67916]
adenylylsulfate-ammonia adenylyltransferase activity	molecular function	Catalysis of the reaction: 5'-adenylyl sulfate + NH4 = adenosine 5'-phosphoramidate + 2 H+ + sulfate. [EC:2.7.7.51, RHEA:19197]
adenylylsulfatase activity	molecular function	Catalysis of the reaction: 5'-adenylyl sulfate + H2O = AMP + 2 H+ + sulfate. [EC:3.6.2.1, RHEA:17041]
bis(5'-adenosyl)-triphosphatase activity	molecular function	Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP + 2 H+. [EC:3.6.1.29, RHEA:13893]

This protein is located in 5 target(s):

Target	Category	Definition
fibrillar center	cellular component	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. [PMID:10754561]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 3 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 4 target(s):

Target	Category	Definition
purine nucleotide metabolic process	biological process	The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. [GOC:go_curators, ISBN:0198506732]
diadenosine triphosphate catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached. [GOC:ai]
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. [GOC:mah]
intrinsic apoptotic signaling pathway by p53 class mediator	biological process	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. [GOC:mah, GOC:mtg_apoptosis]