| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
cytosine
[no description available] | 2.07 | 1 | 0 | aminopyrimidine;
pyrimidine nucleobase;
pyrimidone | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
niacinamide
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. | 3.58 | 2 | 0 | pyridine alkaloid;
pyridinecarboxamide;
vitamin B3 | anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor |
1,5-dihydroxyisoquinoline
1,5-dihydroxyisoquinoline: structure in first source. isoquinoline-1,5-diol : An isoquinolinol that is isoquinoline in which the hydrogens at positions 1 and 5 are replaced by hydroxy groups. | 2 | 1 | 0 | isoquinolinol | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
3-aminobenzamide
[no description available] | 3.8 | 3 | 0 | benzamides;
substituted aniline | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
4-amino-1,8-naphthalimide
4-amino-1,8-naphthalimide: inhibits ADP-ribosylation; sometimes abreviated as 4-AN; | 2 | 1 | 0 | benzoisoquinoline;
dicarboximide | |
phenanthridone
phenanthridone: coal tar derivative; structure given in first source. phenanthridone : A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity. | 3.53 | 2 | 0 | lactam;
phenanthridines | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
immunosuppressive agent;
mutagen |
benzamide
benzamide : An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides. | 2.44 | 2 | 0 | benzamides | |
benzamidine
benzamidine: RN given refers to parent cpd. benzamidine : A carboxamidine that is benzene carrying an amidino group. | 2.11 | 1 | 0 | benzenes;
carboxamidine | serine protease inhibitor |
pj-34
PJ34 : A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. | 3.15 | 1 | 0 | phenanthridines;
secondary carboxamide;
tertiary amino compound | angiogenesis inhibitor;
anti-inflammatory agent;
antiatherosclerotic agent;
antineoplastic agent;
apoptosis inducer;
cardioprotective agent;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
neuroprotective agent |
urethane
[no description available] | 1.94 | 1 | 0 | carbamate ester | fungal metabolite;
mutagen |
thymidine
[no description available] | 7.44 | 2 | 0 | pyrimidine 2'-deoxyribonucleoside | Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite |
1-hydroxyphthalazine
1-hydroxyphthalazine: RN given refers to cpd with unspecified locants; do not confuse with cpd phthalazinol RN: 56611-65-5 | 2 | 1 | 0 | phthalazines | |
chlorthenoxazin
chlorthenoxazin: RN given refers to parent cpd; structure | 2 | 1 | 0 | benzoxazine | |
4-phenylpyridine
[no description available] | 2.13 | 1 | 0 | phenylpyridine | |
dichlorobenzyl alcohol
2,4-dichlorobenzyl alcohol : A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines. | 2.11 | 1 | 0 | benzyl alcohols;
dichlorobenzene | antiseptic drug |
2'-deoxyadenosine triphosphate
2'-deoxyadenosine triphosphate: RN given refers to unlabeled parent cpd | 2 | 1 | 0 | 2'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-triphosphate | Escherichia coli metabolite;
mouse metabolite |
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures. | 2.03 | 1 | 0 | titanium group element atom | |
methanesulfonyl chloride
[no description available] | 2.03 | 1 | 0 | | |
tricyclazole
tricyclazole: RN given refers to parent cpd. tricyclazole : A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union. | 2.13 | 1 | 0 | triazolobenzothiazole | antifungal agrochemical;
melanin synthesis inhibitor |
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | 2.07 | 1 | 0 | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent |
2,4(1h,3h)-quinazolinedione
2,4(1H,3H)-quinazolinedione: structure given in first source | 2 | 1 | 0 | | |
thymidine 5'-triphosphate
thymidine 5'-triphosphate: RN given refers to parent cpd. dTTP : A thymidine phosphate having a triphosphate group at the 5'-position. | 2 | 1 | 0 | pyrimidine 2'-deoxyribonucleoside 5'-triphosphate;
thymidine phosphate | Escherichia coli metabolite;
mouse metabolite |
4-hydroxybenzamide
[no description available] | 2 | 1 | 0 | | |
2'-deoxycytidine 5'-triphosphate
2'-deoxycytidine 5'-triphosphate: RN given refers to unlabeled parent cpd | 2 | 1 | 0 | 2'-deoxycytidine phosphate;
pyrimidine 2'-deoxyribonucleoside 5'-triphosphate | Escherichia coli metabolite;
human metabolite;
mouse metabolite |
naphthalimides
Naphthalimides: Compounds with three fused rings that appear like a naphthalene fused to piperidone or like a benz(de)isoquinoline-1,3-dione (not to be confused with BENZYLISOQUINOLINES which have a methyl separating the naphthyl from the benzyl rings). Members are CYTOTOXINS. | 2 | 1 | 0 | | |
4-fluorobenzamide
4-fluorobenzamide: structure in first source | 2 | 1 | 0 | | |
4-aminobenzamide
[no description available] | 2 | 1 | 0 | benzamides | |
5-(3-methyl-1-triazeno)imidazole-4-carboxamide
5-(3-methyl-1-triazeno)imidazole-4-carboxamide: structure; RN given refers to parent cpd. MTIC : A monocarboxylic acid amide that is dacarbazine in which one of the methyl groups is replaced by a hydrogen. It is the active metabolite of dacarbazine, and is also produced by spontaneous hydrolysis of temozolomide in the body. | 1.99 | 1 | 0 | imidazoles;
monocarboxylic acid amide;
triazene derivative | alkylating agent;
antineoplastic agent |
5-chloroindole-2-carboxylate
5-chloroindole-2-carboxylate: N-methyl-D-aspartate glycine site antagonist | 2.11 | 1 | 0 | indolyl carboxylic acid | |
5-chloroindole
5-chloroindole: a positive allosteric modulator of the 5-HT3 receptor | 2.11 | 1 | 0 | | |
3-methoxybenzamide
[no description available] | 2 | 1 | 0 | | |
3,4-dihydro-5-methyl-1(2h)-isoquinolinone
3,4-dihydro-5-methyl-1(2H)-isoquinolinone: structure given in first source | 2.4 | 2 | 0 | isoquinolines | |
2,8-dimercapto-6-hydroxypurine
[no description available] | 2.13 | 1 | 0 | | |
iniparib
[no description available] | 3.15 | 1 | 0 | carbonyl compound;
organohalogen compound | |
ag 14361
[no description available] | 3.15 | 1 | 0 | benzimidazoles | |
rucaparib
AG14447: Poly(ADP-ribose) polymerase inhibitor; structure in first source | 3.15 | 1 | 0 | azepinoindole;
caprolactams;
organofluorine compound;
secondary amino compound | antineoplastic agent;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinone
[no description available] | 2 | 1 | 0 | | |
oligonucleotides
[no description available] | 2 | 1 | 0 | | |
nu 1025
NU 1064: structure in first source | 3.8 | 3 | 0 | phenols;
quinazolines | EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor |
guanosine
ribonucleoside : Any nucleoside where the sugar component is D-ribose. | 2.07 | 1 | 0 | guanosines;
purines D-ribonucleoside | fundamental metabolite |
inosine
[no description available] | 3.15 | 1 | 0 | inosines;
purines D-ribonucleoside | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite |
2-methyl-4(3h)-quinazolinone
2-methyl-4(3H)-quinazolinone: from Bacillus cereus; structure given in first source | 2 | 1 | 0 | | |
4-hydroxyquinazoline
4-oxo-3,4-dihydroquinazoline: structure in first source | 3.53 | 2 | 0 | quinazolines | |