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antipyrine and Ischemia

antipyrine has been researched along with Ischemia in 27 studies

Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"A novel free radical scavenger, edaravone, has been demonstrated to exert a neuroprotective effect and improve outcomes in acute ischemic stroke, but there have been few clinical studies."7.79Investigation of effect of edaravone on ischemic stroke. ( Adachi, H; Ishibashi, A; Yoshitake, Y, 2013)
"The protective effect of edaravone, an inhibitor of reactive oxygen species (ROS), against the development of ischemia-induced facial palsy was investigated."7.74Protective effects of edaravone against ischemia-induced facial palsy. ( Hamada, M; Kakigi, A; Nakatani, H; Okada, T; Takeda, S; Takeda, T; Takumida, M; Yamakawa, K, 2008)
"Iodoantipyrine was used to record relative blood flow in the retina, choroid, optic nerve head, lamina cribrosa, and postlaminar optic nerve of cats at different levels of intraocular pressure."7.66Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with iodoantipyrine I 125. ( Anderson, DR; Sossi, N, 1983)
"Edaravone treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, and the expression of proinflammatory cytokine interleukin-6 mRNA in the lungs after intestinal I/R compared to the I/R-treated rat lungs without edaravone treatment."5.33Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005)
"A novel free radical scavenger, edaravone, has been demonstrated to exert a neuroprotective effect and improve outcomes in acute ischemic stroke, but there have been few clinical studies."3.79Investigation of effect of edaravone on ischemic stroke. ( Adachi, H; Ishibashi, A; Yoshitake, Y, 2013)
"The protective effect of edaravone, an inhibitor of reactive oxygen species (ROS), against the development of ischemia-induced facial palsy was investigated."3.74Protective effects of edaravone against ischemia-induced facial palsy. ( Hamada, M; Kakigi, A; Nakatani, H; Okada, T; Takeda, S; Takeda, T; Takumida, M; Yamakawa, K, 2008)
"Iodoantipyrine was used to record relative blood flow in the retina, choroid, optic nerve head, lamina cribrosa, and postlaminar optic nerve of cats at different levels of intraocular pressure."3.66Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with iodoantipyrine I 125. ( Anderson, DR; Sossi, N, 1983)
" The effect of ischemia on vascular resistance was investigated in cutaneous tissue of hand and foot by means of the 131I-Antipyrine initial slope technique."3.65Vascular resistance in peripheral blood vessels at normotension and at local orthostatic hypertension in healty humans. ( Henriksen, O; Paaske, WP, 1975)
"Edaravone treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, and the expression of proinflammatory cytokine interleukin-6 mRNA in the lungs after intestinal I/R compared to the I/R-treated rat lungs without edaravone treatment."1.33Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005)
"Cochlear ischemia was induced in the animals by occluding the vertebral arteries bilaterally for 15 min."1.32Free radical scavenger protects against inner hair cell loss after cochlear ischemia. ( Gyo, K; Hakuba, N; Hyodo, J; Maetani, T; Shimizu, Y; Taniguchi, M, 2003)
"Paraplegia is a serious complication of operations on the thoracic and thoracoabdominal aorta."1.32MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia. ( Abe, K; Itoyama, Y; Sakurai, M; Tabayashi, K; Takahashi, G, 2004)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199013 (48.15)18.7374
1990's2 (7.41)18.2507
2000's10 (37.04)29.6817
2010's2 (7.41)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ishibashi, A1
Yoshitake, Y1
Adachi, H1
Chiazza, F1
Chegaev, K1
Rogazzo, M1
Cutrin, JC1
Benetti, E1
Lazzarato, L1
Fruttero, R1
Collino, M1
Ninomiya, M1
Shimada, M1
Harada, N1
Shiotani, S1
Hiroshige, S1
Soejima, Y1
Suehiro, T1
Sugimachi, K1
Maetani, T1
Hakuba, N1
Taniguchi, M1
Hyodo, J1
Shimizu, Y1
Gyo, K1
Takahashi, G2
Sakurai, M2
Abe, K2
Itoyama, Y2
Tabayashi, K2
Qi, X1
Okuma, Y1
Hosoi, T1
Nomura, Y1
Ito, K1
Ozasa, H1
Horikawa, S1
Hashizume, K1
Ueda, T1
Shimizu, H1
Mori, A1
Yozu, R1
Song, Y1
Li, M1
Li, JC1
Wei, EQ1
Satoh, S1
Toshima, Y1
Ikegaki, I1
Iwasaki, M1
Asano, T1
Takeda, T1
Takeda, S1
Takumida, M1
Okada, T1
Kakigi, A1
Nakatani, H1
Hamada, M1
Yamakawa, K1
Kövamees, A2
Zetterquist, S1
Sossi, N1
Anderson, DR1
Bjerre-Jepsen, K1
Faris, I1
Henriksen, O2
Tønnesen, KH1
Dolan, EJ1
Transfeldt, EE1
Tator, CH1
Simmons, EH1
Hughes, KF1
Dellian, M1
Walenta, S1
Gamarra, F1
Kuhnle, GE1
Mueller-Klieser, W1
Goetz, AE1
Carroll, JE1
Kaiser, KK1
Bondy, SC1
Purdy, JL1
Bingham, WG1
Goldman, H1
Friedman, SJ1
Murphy, S1
Yashon, D1
Hunt, WE1
Bradley, WG1
O'Brien, MD1
Walder, DN1
Murchison, D1
Johnson, M1
Newell, DJ1
Marshall, LF1
Durity, F1
Lounsbury, R1
Graham, DI1
Welsh, F1
Langfitt, TW1
Paaske, WP1
Minard, G1
Bynoe, R1
Wood, GC1
Fabian, TC1
Croce, M1
Kudsk, KA1
Lassen, NA1
Holstein, P1
Fieschi, C1

Other Studies

27 other studies available for antipyrine and Ischemia

ArticleYear
Investigation of effect of edaravone on ischemic stroke.
    The Kurume medical journal, 2013, Volume: 60, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Arginine; Edaravone; Female; Free Radical Scavengers; Hu

2013
A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Acetylglucosamine; Acute-Phase Proteins; Animals; Antipyrine; Creatinine; Disease Models, Animal; Ed

2015
Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.
    Transplantation, 2002, Nov-27, Volume: 74, Issue:10

    Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; In Situ Nick-End Labeling; Ische

2002
Free radical scavenger protects against inner hair cell loss after cochlear ischemia.
    Neuroreport, 2003, Oct-06, Volume: 14, Issue:14

    Topics: Analysis of Variance; Animals; Antipyrine; Auditory Threshold; Cell Death; Cochlear Diseases; Edarav

2003
MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits.
    The Journal of thoracic and cardiovascular surgery, 2003, Volume: 126, Issue:5

    Topics: Animals; Antipyrine; Biopsy, Needle; Disease Models, Animal; Edaravone; Immunohistochemistry; Inject

2003
Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1

    Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cells, Cultured; Edaravone; Endoplasmic Reticulum; F

2004
MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia.
    The Annals of thoracic surgery, 2004, Volume: 78, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Apoptosis; Ataxia; Biomarkers; Cell Count; Cell Nu

2004
Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.
    Free radical biology & medicine, 2005, Feb-01, Volume: 38, Issue:3

    Topics: Animals; Antipyrine; Disease Progression; Edaravone; Interleukin-6; Intestines; Ischemia; Lung; Male

2005
Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit.
    The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi, 2005, Volume: 53, Issue:8

    Topics: Animals; Antipyrine; Cell Death; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavenger

2005
Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria.
    Journal of Zhejiang University. Science. B, 2006, Volume: 7, Issue:9

    Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Edaravone; Flow Cytometry; Ischemia; Mic

2006
Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
    Brain research, 2007, Jan-12, Volume: 1128, Issue:1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipyrine; Cell Death; Dose-Response Relati

2007
Protective effects of edaravone against ischemia-induced facial palsy.
    Auris, nasus, larynx, 2008, Volume: 35, Issue:3

    Topics: Animals; Antipyrine; Axons; Blinking; Edaravone; Facial Nerve; Facial Paralysis; Free Radical Scaven

2008
Pre- and postoperative skin clearance in severe ischaemia of the foot.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1967, Volume: 99

    Topics: Aged; Antipyrine; Foot; Gangrene; Humans; Iodine Radioisotopes; Ischemia; Male; Muscles; Radioisotop

1967
The elimination of labelled antipyrine from muscle and skin of ischemic limbs during exercises before and after parenteral administration of vasodilating substances.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1967, Volume: 99

    Topics: Antipyrine; Arteriosclerosis Obliterans; Humans; Iodine Radioisotopes; Ischemia; Leg; Muscles; Physi

1967
Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with iodoantipyrine I 125.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1983, Volume: 101, Issue:1

    Topics: Animals; Antipyrine; Blood Flow Velocity; Cats; Female; Glaucoma; Intraocular Pressure; Ischemia; Ma

1983
Determination of the subcutaneous tissue to blood partition coefficient in patients with severe leg ischaemia by a double isotope washout technique.
    Clinical physiology (Oxford, England), 1982, Volume: 2, Issue:6

    Topics: Aged; Antipyrine; Arterial Occlusive Diseases; Female; Humans; Iodine Radioisotopes; Ischemia; Leg;

1982
The effect of spinal distraction on regional spinal cord blood flow in cats.
    Journal of neurosurgery, 1980, Volume: 53, Issue:6

    Topics: Animals; Antipyrine; Autoradiography; Cats; Electrophysiology; Evoked Potentials; Female; Ischemia;

1980
Ischemia and loss of ATP in tumours following treatment with focused high energy shock waves.
    British journal of cancer, 1993, Volume: 68, Issue:1

    Topics: Adenosine Triphosphate; Animals; Antipyrine; Carbon Radioisotopes; Cricetinae; Electric Stimulation

1993
Blood flow and uptake of glucose and amino acids in ischemic muscle.
    Journal of the neurological sciences, 1977, Volume: 33, Issue:1-2

    Topics: Absorption; Aminoisobutyric Acids; Animals; Antipyrine; Deoxy Sugars; Deoxyglucose; Hypertrophy; Isc

1977
Blood flow in normal and injured monkey spinal cord.
    Journal of neurosurgery, 1975, Volume: 43, Issue:2

    Topics: Animals; Antipyrine; Autoradiography; Carbon Dioxide; Carbon Radioisotopes; Cardiac Output; Cats; Ch

1975
Failure to confirm a vascular cause of muscular dystrophy.
    Archives of neurology, 1975, Volume: 32, Issue:7

    Topics: Adult; Animals; Antipyrine; Autoradiography; Blood Circulation; Child; Humans; Iodine Radioisotopes;

1975
Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 1: Pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier, and neurological function.
    Journal of neurosurgery, 1975, Volume: 43, Issue:3

    Topics: Animals; Antipyrine; Autoradiography; Blood Pressure; Blood-Brain Barrier; Brain; Carbon Radioisotop

1975
Vascular resistance in peripheral blood vessels at normotension and at local orthostatic hypertension in healty humans.
    Acta physiologica Scandinavica, 1975, Volume: 95, Issue:4

    Topics: Adipose Tissue; Antipyrine; Blood Pressure; Body Temperature Regulation; Foot; Forearm; Hand; Humans

1975
Effect of isolated hepatic ischemia on organic anion clearance and oxidative metabolism.
    The Journal of trauma, 1992, Volume: 32, Issue:4

    Topics: Animals; Antipyrine; Hemodynamics; Indocyanine Green; Ischemia; Liver; Metabolic Clearance Rate; Oxi

1992
Use of radioisotopes in assessment of distal blood flow and distal blood pressure in arterial insufficiency.
    The Surgical clinics of North America, 1974, Volume: 54, Issue:1

    Topics: Aged; Amputation, Surgical; Antipyrine; Arterial Occlusive Diseases; Blood Flow Velocity; Blood Pres

1974
Skin blood flow in obliterative arterial disease of the leg. Effect of vascular reconstruction examined with xenon and iodine antipyrine clearance and skin temperature measurements.
    Acta chirurgica Scandinavica. Supplementum, 1968, Volume: 397

    Topics: Adult; Aged; Alcoholic Beverages; Antipyrine; Blood Flow Velocity; Body Temperature; Collateral Circ

1968
Regional cerebral blood flow in acute apoplexy, including pharmacodynamic studies.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1968, Volume: 102

    Topics: Acute Disease; Animals; Antipyrine; Autoradiography; Blood Pressure; Carbon Dioxide; Carbon Isotopes

1968