antipyrine has been researched along with Ischemia in 27 studies
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A novel free radical scavenger, edaravone, has been demonstrated to exert a neuroprotective effect and improve outcomes in acute ischemic stroke, but there have been few clinical studies." | 7.79 | Investigation of effect of edaravone on ischemic stroke. ( Adachi, H; Ishibashi, A; Yoshitake, Y, 2013) |
| "The protective effect of edaravone, an inhibitor of reactive oxygen species (ROS), against the development of ischemia-induced facial palsy was investigated." | 7.74 | Protective effects of edaravone against ischemia-induced facial palsy. ( Hamada, M; Kakigi, A; Nakatani, H; Okada, T; Takeda, S; Takeda, T; Takumida, M; Yamakawa, K, 2008) |
| "Iodoantipyrine was used to record relative blood flow in the retina, choroid, optic nerve head, lamina cribrosa, and postlaminar optic nerve of cats at different levels of intraocular pressure." | 7.66 | Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with iodoantipyrine I 125. ( Anderson, DR; Sossi, N, 1983) |
| "Edaravone treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, and the expression of proinflammatory cytokine interleukin-6 mRNA in the lungs after intestinal I/R compared to the I/R-treated rat lungs without edaravone treatment." | 5.33 | Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005) |
| "A novel free radical scavenger, edaravone, has been demonstrated to exert a neuroprotective effect and improve outcomes in acute ischemic stroke, but there have been few clinical studies." | 3.79 | Investigation of effect of edaravone on ischemic stroke. ( Adachi, H; Ishibashi, A; Yoshitake, Y, 2013) |
| "The protective effect of edaravone, an inhibitor of reactive oxygen species (ROS), against the development of ischemia-induced facial palsy was investigated." | 3.74 | Protective effects of edaravone against ischemia-induced facial palsy. ( Hamada, M; Kakigi, A; Nakatani, H; Okada, T; Takeda, S; Takeda, T; Takumida, M; Yamakawa, K, 2008) |
| "Iodoantipyrine was used to record relative blood flow in the retina, choroid, optic nerve head, lamina cribrosa, and postlaminar optic nerve of cats at different levels of intraocular pressure." | 3.66 | Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with iodoantipyrine I 125. ( Anderson, DR; Sossi, N, 1983) |
| " The effect of ischemia on vascular resistance was investigated in cutaneous tissue of hand and foot by means of the 131I-Antipyrine initial slope technique." | 3.65 | Vascular resistance in peripheral blood vessels at normotension and at local orthostatic hypertension in healty humans. ( Henriksen, O; Paaske, WP, 1975) |
| "Edaravone treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, and the expression of proinflammatory cytokine interleukin-6 mRNA in the lungs after intestinal I/R compared to the I/R-treated rat lungs without edaravone treatment." | 1.33 | Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. ( Horikawa, S; Ito, K; Ozasa, H, 2005) |
| "Cochlear ischemia was induced in the animals by occluding the vertebral arteries bilaterally for 15 min." | 1.32 | Free radical scavenger protects against inner hair cell loss after cochlear ischemia. ( Gyo, K; Hakuba, N; Hyodo, J; Maetani, T; Shimizu, Y; Taniguchi, M, 2003) |
| "Paraplegia is a serious complication of operations on the thoracic and thoracoabdominal aorta." | 1.32 | MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia. ( Abe, K; Itoyama, Y; Sakurai, M; Tabayashi, K; Takahashi, G, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (48.15) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ishibashi, A | 1 |
| Yoshitake, Y | 1 |
| Adachi, H | 1 |
| Chiazza, F | 1 |
| Chegaev, K | 1 |
| Rogazzo, M | 1 |
| Cutrin, JC | 1 |
| Benetti, E | 1 |
| Lazzarato, L | 1 |
| Fruttero, R | 1 |
| Collino, M | 1 |
| Ninomiya, M | 1 |
| Shimada, M | 1 |
| Harada, N | 1 |
| Shiotani, S | 1 |
| Hiroshige, S | 1 |
| Soejima, Y | 1 |
| Suehiro, T | 1 |
| Sugimachi, K | 1 |
| Maetani, T | 1 |
| Hakuba, N | 1 |
| Taniguchi, M | 1 |
| Hyodo, J | 1 |
| Shimizu, Y | 1 |
| Gyo, K | 1 |
| Takahashi, G | 2 |
| Sakurai, M | 2 |
| Abe, K | 2 |
| Itoyama, Y | 2 |
| Tabayashi, K | 2 |
| Qi, X | 1 |
| Okuma, Y | 1 |
| Hosoi, T | 1 |
| Nomura, Y | 1 |
| Ito, K | 1 |
| Ozasa, H | 1 |
| Horikawa, S | 1 |
| Hashizume, K | 1 |
| Ueda, T | 1 |
| Shimizu, H | 1 |
| Mori, A | 1 |
| Yozu, R | 1 |
| Song, Y | 1 |
| Li, M | 1 |
| Li, JC | 1 |
| Wei, EQ | 1 |
| Satoh, S | 1 |
| Toshima, Y | 1 |
| Ikegaki, I | 1 |
| Iwasaki, M | 1 |
| Asano, T | 1 |
| Takeda, T | 1 |
| Takeda, S | 1 |
| Takumida, M | 1 |
| Okada, T | 1 |
| Kakigi, A | 1 |
| Nakatani, H | 1 |
| Hamada, M | 1 |
| Yamakawa, K | 1 |
| Kövamees, A | 2 |
| Zetterquist, S | 1 |
| Sossi, N | 1 |
| Anderson, DR | 1 |
| Bjerre-Jepsen, K | 1 |
| Faris, I | 1 |
| Henriksen, O | 2 |
| Tønnesen, KH | 1 |
| Dolan, EJ | 1 |
| Transfeldt, EE | 1 |
| Tator, CH | 1 |
| Simmons, EH | 1 |
| Hughes, KF | 1 |
| Dellian, M | 1 |
| Walenta, S | 1 |
| Gamarra, F | 1 |
| Kuhnle, GE | 1 |
| Mueller-Klieser, W | 1 |
| Goetz, AE | 1 |
| Carroll, JE | 1 |
| Kaiser, KK | 1 |
| Bondy, SC | 1 |
| Purdy, JL | 1 |
| Bingham, WG | 1 |
| Goldman, H | 1 |
| Friedman, SJ | 1 |
| Murphy, S | 1 |
| Yashon, D | 1 |
| Hunt, WE | 1 |
| Bradley, WG | 1 |
| O'Brien, MD | 1 |
| Walder, DN | 1 |
| Murchison, D | 1 |
| Johnson, M | 1 |
| Newell, DJ | 1 |
| Marshall, LF | 1 |
| Durity, F | 1 |
| Lounsbury, R | 1 |
| Graham, DI | 1 |
| Welsh, F | 1 |
| Langfitt, TW | 1 |
| Paaske, WP | 1 |
| Minard, G | 1 |
| Bynoe, R | 1 |
| Wood, GC | 1 |
| Fabian, TC | 1 |
| Croce, M | 1 |
| Kudsk, KA | 1 |
| Lassen, NA | 1 |
| Holstein, P | 1 |
| Fieschi, C | 1 |
27 other studies available for antipyrine and Ischemia
| Article | Year |
|---|---|
Investigation of effect of edaravone on ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Antipyrine; Arginine; Edaravone; Female; Free Radical Scavengers; Hu | 2013 |
A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion.
Topics: Acetylglucosamine; Acute-Phase Proteins; Animals; Antipyrine; Creatinine; Disease Models, Animal; Ed | 2015 |
Beneficial effect of MCI-186 on hepatic warm ischemia-reperfusion in the rat.
Topics: Animals; Antipyrine; Apoptosis; Edaravone; Free Radical Scavengers; In Situ Nick-End Labeling; Ische | 2002 |
Free radical scavenger protects against inner hair cell loss after cochlear ischemia.
Topics: Analysis of Variance; Animals; Antipyrine; Auditory Threshold; Cell Death; Cochlear Diseases; Edarav | 2003 |
MCI-186 prevents spinal cord damage and affects enzyme levels of nitric oxide synthase and Cu/Zn superoxide dismutase after transient ischemia in rabbits.
Topics: Animals; Antipyrine; Biopsy, Needle; Disease Models, Animal; Edaravone; Immunohistochemistry; Inject | 2003 |
Edaravone protects against hypoxia/ischemia-induced endoplasmic reticulum dysfunction.
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cells, Cultured; Edaravone; Endoplasmic Reticulum; F | 2004 |
MCI-186 reduces oxidative cellular damage and increases DNA repair function in the rabbit spinal cord after transient ischemia.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antipyrine; Apoptosis; Ataxia; Biomarkers; Cell Count; Cell Nu | 2004 |
Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat.
Topics: Animals; Antipyrine; Disease Progression; Edaravone; Interleukin-6; Intestines; Ischemia; Lung; Male | 2005 |
Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit.
Topics: Animals; Antipyrine; Cell Death; Dose-Response Relationship, Drug; Edaravone; Free Radical Scavenger | 2005 |
Edaravone protects PC12 cells from ischemic-like injury via attenuating the damage to mitochondria.
Topics: Animals; Antipyrine; Apoptosis; bcl-2-Associated X Protein; Edaravone; Flow Cytometry; Ischemia; Mic | 2006 |
Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antipyrine; Cell Death; Dose-Response Relati | 2007 |
Protective effects of edaravone against ischemia-induced facial palsy.
Topics: Animals; Antipyrine; Axons; Blinking; Edaravone; Facial Nerve; Facial Paralysis; Free Radical Scaven | 2008 |
Pre- and postoperative skin clearance in severe ischaemia of the foot.
Topics: Aged; Antipyrine; Foot; Gangrene; Humans; Iodine Radioisotopes; Ischemia; Male; Muscles; Radioisotop | 1967 |
The elimination of labelled antipyrine from muscle and skin of ischemic limbs during exercises before and after parenteral administration of vasodilating substances.
Topics: Antipyrine; Arteriosclerosis Obliterans; Humans; Iodine Radioisotopes; Ischemia; Leg; Muscles; Physi | 1967 |
Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with iodoantipyrine I 125.
Topics: Animals; Antipyrine; Blood Flow Velocity; Cats; Female; Glaucoma; Intraocular Pressure; Ischemia; Ma | 1983 |
Determination of the subcutaneous tissue to blood partition coefficient in patients with severe leg ischaemia by a double isotope washout technique.
Topics: Aged; Antipyrine; Arterial Occlusive Diseases; Female; Humans; Iodine Radioisotopes; Ischemia; Leg; | 1982 |
The effect of spinal distraction on regional spinal cord blood flow in cats.
Topics: Animals; Antipyrine; Autoradiography; Cats; Electrophysiology; Evoked Potentials; Female; Ischemia; | 1980 |
Ischemia and loss of ATP in tumours following treatment with focused high energy shock waves.
Topics: Adenosine Triphosphate; Animals; Antipyrine; Carbon Radioisotopes; Cricetinae; Electric Stimulation | 1993 |
Blood flow and uptake of glucose and amino acids in ischemic muscle.
Topics: Absorption; Aminoisobutyric Acids; Animals; Antipyrine; Deoxy Sugars; Deoxyglucose; Hypertrophy; Isc | 1977 |
Blood flow in normal and injured monkey spinal cord.
Topics: Animals; Antipyrine; Autoradiography; Carbon Dioxide; Carbon Radioisotopes; Cardiac Output; Cats; Ch | 1975 |
Failure to confirm a vascular cause of muscular dystrophy.
Topics: Adult; Animals; Antipyrine; Autoradiography; Blood Circulation; Child; Humans; Iodine Radioisotopes; | 1975 |
Experimental cerebral oligemia and ischemia produced by intracranial hypertension. Part 1: Pathophysiology, electroencephalography, cerebral blood flow, blood-brain barrier, and neurological function.
Topics: Animals; Antipyrine; Autoradiography; Blood Pressure; Blood-Brain Barrier; Brain; Carbon Radioisotop | 1975 |
Vascular resistance in peripheral blood vessels at normotension and at local orthostatic hypertension in healty humans.
Topics: Adipose Tissue; Antipyrine; Blood Pressure; Body Temperature Regulation; Foot; Forearm; Hand; Humans | 1975 |
Effect of isolated hepatic ischemia on organic anion clearance and oxidative metabolism.
Topics: Animals; Antipyrine; Hemodynamics; Indocyanine Green; Ischemia; Liver; Metabolic Clearance Rate; Oxi | 1992 |
Use of radioisotopes in assessment of distal blood flow and distal blood pressure in arterial insufficiency.
Topics: Aged; Amputation, Surgical; Antipyrine; Arterial Occlusive Diseases; Blood Flow Velocity; Blood Pres | 1974 |
Skin blood flow in obliterative arterial disease of the leg. Effect of vascular reconstruction examined with xenon and iodine antipyrine clearance and skin temperature measurements.
Topics: Adult; Aged; Alcoholic Beverages; Antipyrine; Blood Flow Velocity; Body Temperature; Collateral Circ | 1968 |
Regional cerebral blood flow in acute apoplexy, including pharmacodynamic studies.
Topics: Acute Disease; Animals; Antipyrine; Autoradiography; Blood Pressure; Carbon Dioxide; Carbon Isotopes | 1968 |