Page last updated: 2024-11-06

sorbitol and Ischemia

sorbitol has been researched along with Ischemia in 15 studies

D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"To describe a case of extensive intestinal necrosis with oral intake of calcium polystyrene sulfonate without sorbitol."7.77Intestinal Necrosis Associated with Orally Administered Calcium Polystyrene Sulfonate Without Sorbitol. ( Bordes, J; Goutorbe, P; Lacroix, G; Meaudre, E; Montcriol, A; Souraud, JB, 2011)
"Intestinal ischemia is a recognized risk of SPS in sorbitol."7.75Intestinal necrosis due to sodium polystyrene sulfonate (Kayexalate) in sorbitol. ( Chu, G; McGowan, CE; Moss, SF; Resnick, MB; Saha, S, 2009)
"To describe a case of extensive intestinal necrosis with oral intake of calcium polystyrene sulfonate without sorbitol."3.77Intestinal Necrosis Associated with Orally Administered Calcium Polystyrene Sulfonate Without Sorbitol. ( Bordes, J; Goutorbe, P; Lacroix, G; Meaudre, E; Montcriol, A; Souraud, JB, 2011)
"Intestinal ischemia is a recognized risk of SPS in sorbitol."3.75Intestinal necrosis due to sodium polystyrene sulfonate (Kayexalate) in sorbitol. ( Chu, G; McGowan, CE; Moss, SF; Resnick, MB; Saha, S, 2009)
"Cardioplegic myocardial protection with magnesium asparaginate procaine (Cardioplegin) is assessed in normothermic ischemia by left ventricular function curves."3.66[Animal experiment evaluation of myocardial protection with a magnesium-asparaginate-procaine solution]. ( Fornaro, M; Turina, M; von Gossler, W; Walpoth, B, 1978)
"Mononeuritis (or mononeuritis multiplex) seems to be the result of ischaemia due to intrinsic or extrinsic (altered coagulability) vascular disease."2.37[Pathogenesis of diabetic neuropathies]. ( Arlot, S; Lalau, JD; Quichaud, J, 1985)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199010 (66.67)18.7374
1990's1 (6.67)18.2507
2000's2 (13.33)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Usta, Y1
Ramirez, C1
Dennert, B1
McGowan, CE1
Saha, S1
Chu, G1
Resnick, MB1
Moss, SF1
Goutorbe, P1
Montcriol, A1
Lacroix, G1
Bordes, J1
Meaudre, E1
Souraud, JB1
Kelsey, PB1
Chen, S1
Lauwers, GY1
Gilbert, RE1
Cooper, ME1
Isselhard, W1
Schorn, B1
Uekermann, U1
Hügel, W1
Ekeland, A1
Uflacker, R1
Walpoth, B1
Fornaro, M1
von Gossler, W1
Turina, M1
Price, DE1
Airey, CM1
Alani, SM1
Wales, JK1
Lalau, JD1
Arlot, S1
Quichaud, J1
MacGregor, LC1
Rosecan, LR1
Laties, AM1
Matschinsky, FM1
Hetzer, R1
Balten, U1
Nevermann, L1
Vycoupil, KF1
Walter, P1
Borst, HG1
Kalmar, P1
Bleese, N1
Kirsch, U1
Lutz, G1
Pokar, H1
Rodewald, G1
Heiss, WD1
Prosenz, P1
Herles, HJ1
Trim, CM1
Mason, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 DiabetesL a Open-label Trial[NCT02502071]Phase 445 participants (Actual)Interventional2017-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Number of Participants With Urine Uric Acid Precipitation by Polarized Microscopy

Urine uric acid crystals were identified by polarized microscopy (Polarized light imaging Zeiss Axiovert 135; 0.3NA objective), and pictures were captured from each urine sample. UA crystals were defined dichotomously as being present or absent. (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)

Interventionparticipants (Number)
Day 1 (pre-therapy)Day 2 (post-therapy)
Sodium Bicarbonate143

Change in Urine Uric Acid Concentration (Increased Solubility) by Assay

Urine uric acid were evaluated using a QuantiChrom UA kit assay (DIUA-250) with quantitative colorimetric UA determination at 590 nm (BioAssay System, California, USA). (NCT02502071)
Timeframe: Day 1 (pre-therapy) and Day 2 (post-therapy)

Interventionmg/dl (Geometric Mean)
Day 1 (pre-therapy)Day 2 (post-therapy)
Sodium Bicarbonate23.8122.30

Reviews

2 reviews available for sorbitol and Ischemia

ArticleYear
The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?
    Kidney international, 1999, Volume: 56, Issue:5

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetic Nephropathies; Glucose; Humans; Ischemia

1999
[Pathogenesis of diabetic neuropathies].
    Annales de medecine interne, 1985, Volume: 136, Issue:6

    Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Energy Metabolism; Humans;

1985

Other Studies

13 other studies available for sorbitol and Ischemia

ArticleYear
Image of the Month: Emphysematous Gastritis and Necrosis as a Result of Orally Ingested Sodium Polystyrene Sulfonate (Kayexalate) in Sorbitol.
    The American journal of gastroenterology, 2016, Volume: 111, Issue:3

    Topics: Acute Kidney Injury; Aged; Cathartics; Chelating Agents; Gastritis; Gastroscopy; Humans; Hyperkalemi

2016
Intestinal necrosis due to sodium polystyrene sulfonate (Kayexalate) in sorbitol.
    Southern medical journal, 2009, Volume: 102, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Cathartics; Cation Exchange Resins; Cohort Studies; Female; Humans;

2009
Intestinal Necrosis Associated with Orally Administered Calcium Polystyrene Sulfonate Without Sorbitol.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:2

    Topics: Aged; Cecum; Colonic Pseudo-Obstruction; Fatal Outcome; Female; Humans; Hyperkalemia; Intestinal Muc

2011
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2003. A 79-year-old man with coronary artery disease, peripheral vascular disease, end-stage renal disease, and abdominal pain and distention.
    The New England journal of medicine, 2003, Nov-27, Volume: 349, Issue:22

    Topics: Abdominal Pain; Aged; Aortography; Cation Exchange Resins; Colon; Coronary Artery Disease; Diagnosis

2003
[Myocardial metabolic status in various methods of inducing a reversible heart arrest].
    Chirurgisches Forum fur experimentelle und klinische Forschung, 1979

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspartic Acid; Dogs; Drug Combinations; Glycog

1979
Effect of meglumine metrizoate and metrizamide on the microcirculation. Animal experiments.
    Acta radiologica: diagnosis, 1978, Volume: 19, Issue:6

    Topics: Animals; Cineradiography; Depression, Chemical; Ear, External; Iodobenzoates; Ischemia; Meglumine; M

1978
[Animal experiment evaluation of myocardial protection with a magnesium-asparaginate-procaine solution].
    Chirurgisches Forum fur experimentelle und klinische Forschung, 1978, Issue:1978

    Topics: Animals; Asparagine; Dogs; Drug Combinations; Heart; Heart Arrest, Induced; Ischemia; Procaine; Sorb

1978
Effect of aldose reductase inhibition on nerve conduction velocity and resistance to ischemic conduction block in experimental diabetes.
    Diabetes, 1988, Volume: 37, Issue:7

    Topics: Action Potentials; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Inositol; Insulin;

1988
Altered retinal metabolism in diabetes. I. Microanalysis of lipid, glucose, sorbitol, and myo-inositol in the choroid and in the individual layers of the rabbit retina.
    The Journal of biological chemistry, 1986, Mar-25, Volume: 261, Issue:9

    Topics: Animals; Choroid Plexus; Diabetes Mellitus, Experimental; Glucose; Inositol; Ischemia; Lipids; Male;

1986
[Histochemical studies of the extension of necrosis following temporary regional myocardial ischemis in pigs (author's transl)].
    Thoraxchirurgie, vaskulare Chirurgie, 1974, Volume: 22, Issue:4

    Topics: Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Cineradiography; Coronary Disease; He

1974
[Combination of cardioplegia and coronary perfusion in heart surgery under normothermia].
    Thoraxchirurgie, vaskulare Chirurgie, 1972, Volume: 20, Issue:6

    Topics: Aortic Valve; Arrhythmias, Cardiac; Cardiac Surgical Procedures; Cardiomegaly; Coronary Vessels; Hea

1972
[Effect of hemodilution and dehydration on regional cerebral circulation].
    Der Nervenarzt, 1973, Volume: 44, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Brain; Brain Damage, Chronic; Brain Neoplasms; Cerebrovascular Circul

1973
Post-anaesthetic forelimb lameness in horses.
    Equine veterinary journal, 1973, Volume: 5, Issue:2

    Topics: Acepromazine; Alcohol Oxidoreductases; Anesthesia, Inhalation; Animals; Aspartate Aminotransferases;

1973