inosine-diphosphate and Ischemia

Experiments on Wistar rats showed the development of endotoxicosis 12 h after severe compression injury. Endotoxicosis manifested in disorders in bromosulfaleine excretion from the blood, increase of blood urea, uric acid, creatinine, and potassium levels and aminotransferase activities. Injection of succinate-containing antihypoxants (reamberine, cytoflavin, metaprot plus, succinamic acid 2-amino-4-acetylthiasolo[5,4-b]indole) directly after decompression promoted recovery of liver function, prevented the development of hyperfermentemia and renal failure as a result of reduced blood levels of potassium and non-protein nitrogen. The protective effect of the drugs in traumatic toxicosisdecreased in the following order: metaprot plus>cytoflavin>2-amino-4-acetylthiasolo[5,4-b]indole succinaminic acid>reamberine.

Topics: Animals; Antioxidants; Drug Combinations; Endotoxemia; Flavin Mononucleotide; Inosine Diphosphate; Ischemia; Male; Meglumine; Niacinamide; Nitrogen; Potassium; Rats; Rats, Wistar; Succinates

Method of complex surgical treatment of inguinal hernia in children, basing on the early conduction of surgical correction of pathology, application of microsurgical technique of the operation conduction, using of pharmacologic defense of hematotesticular barrier and medicinal therapy of the man sexual gland ischemia, was elaborated and substantiated.

Topics: Age Factors; Antioxidants; Ascorbic Acid; Aspirin; Blood-Testis Barrier; Child; Dipyridamole; Hernia, Inguinal; Humans; Hyperbaric Oxygenation; Infant; Infant, Newborn; Inosine Diphosphate; Ischemia; Male; Microcirculation; Platelet Aggregation Inhibitors; Postoperative Care; Testis; Vasodilator Agents