Page last updated: 2024-10-15

acetylpuerarin

Description

acetylpuerarin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID156963230
MeSH IDM0511365

Synonyms (1)

Synonym
acetylpuerarin

Research Excerpts

Overview

Acetylpuerarin is a newly modified isoflavone based on puerarin. It has neuroprotective and antioxidant effects.

ExcerptReference
"Acetylpuerarin is a newly modified isoflavone based on puerarin that has neuroprotective and antioxidant effects."( Anti-inflammatory effect of acetylpuerarin on eicosanoid signaling pathway in primary rat astrocytes.
Chen, L; Liu, H; Liu, X; Wang, T; Wei, X; Xiang, Y; Zhang, X, 2014
)
"Acetylpuerarin (AP) is an acetylated derivative of puerarin (PUE). "( Polysorbate 80-coated PLGA nanoparticles improve the permeability of acetylpuerarin and enhance its brain-protective effects in rats.
Lou, H; Shi, H; Sun, D; Xue, A; Zhang, B; Zhang, X, 2015
)

Actions

ExcerptReference
"Acetylpuerarin (AP), because of its lower water solubility, shows poor absorption that hinders its therapeutic application. "( Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions.
Fang, Z; Lou, H; Ren, M; Sun, D; Wei, X; Xue, X; Zhang, X, 2014
)

Treatment

ExcerptReference
"Acetylpuerarin treatment mitigated Aβ25-35-induced morphological changes associated with microglia activation."( Anti-neuroinflammation activity of acetylpuerarin mediated by a PKC-δ-dependent caspase signaling pathway:
Cai, QY; Li, M; Liu, XL; Liu, YX; Meng, QH; Zhang, XM; Zhang, XQ; Zhao, CZ, 2016
)

Pharmacokinetics

ExcerptReference
" The validated LC-MS/MS method was further successfully applied to a pharmacokinetic study of AP and PUE in rats following intravenous and oral administration."( Simultaneous determination of acetylpuerarin and puerarin in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study following intravenous and oral administration.
Li, Q; Sun, C; Sun, D; Wu, J; Xue, A; Yu, J; Zhang, B, 2015
)

Compound-Compound Interactions

ExcerptReference
" The NPs were prepared using a solvent diffusion method optimized via uniform design (UD) combined with response surface methodology (RSM) and characterized by their morphology, particle size, zeta (ζ)-potential, encapsulation efficiency (EE), drug loading (DL), and in vitro drug release."( Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology.
Liu, W; Sun, D; Xue, A; Xue, X; Zhang, B; Zhang, J, 2016
)

Bioavailability

ExcerptReference
"Enhanced oral bioavailability in nanoemulsions was achieved via the mechanism of the maintenance of drug solubilization in the gastrointestinal tract and the enhancement of lymphatic transport, which resulted in therapeutic improvement of cerebral ischemic reperfusion injury."( Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions.
Fang, Z; Lou, H; Ren, M; Sun, D; Wei, X; Xue, X; Zhang, X, 2014
)
" However, AP has low oral bioavailability because of its poor water solubility."( Enhanced oral bioavailability of acetylpuerarin by poly(lactide-co-glycolide) nanoparticles optimized using uniform design combined with response surface methodology.
Liu, W; Sun, D; Xue, A; Xue, X; Zhang, B; Zhang, J, 2016
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's9 (90.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]