| Assay ID | Title | Year | Journal | Article |
|---|
| AID189939 | Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID32166 | Binding affinity carried out with [3H]cyclohexyladenosine in guinea pig forebrain membranes against adenosine A1 receptor | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID189937 | Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID33587 | Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID170592 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 5 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID108715 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.02 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID118937 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID188278 | Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID194317 | Compound administered at a dose of 6.25 mg/25 mL/kg orally to rats, urine collected for 6 hr and measured for urine volume. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID229793 | Ratio of Ki for A2 and A1 adenosine receptors | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID33740 | Binding affinity at Adenosine A2 receptor from rat striatal membranes by N-[3H] ethyladenosin-5'- uronamide displacement. | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID108719 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after p.o. administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID228357 | Ratio of Ki at A2 receptor to that of A1 receptor | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID188280 | Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID191204 | Oral diuretic activity was measured after oral administration of 25 mg/kg to rats(control volume is 0.85+/-0.06) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID33563 | Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes. | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. |
| AID33752 | Ratio of A2 to A1. | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
| AID230247 | Ratio of Na+ to K+ excretion | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID32294 | Binding affinity against Adenosine A1 receptor from guinea pig forebrain membranes by N6-[3H]- cyclohexyladenosine displacement. | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID194315 | Compound administered at a dose of 6.25 mg/25 mL/kg orally to rats, urine collected for 6 hr and measured for K+ excretion. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID108851 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 5 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID32193 | Binding affinity towards adenosine A1 receptor in rat forebrain membranes using N6-[3H]cyclohexyladenosine | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID108716 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.08 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID188282 | Ratio of sodium ion/potassium ion concentration in treated rats to that in control rats, at a peroral dose of 25 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID115113 | Tested for locomotor activity after oral administration of 2.5 mg/kg for 120 min | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID190351 | Urea nitrogen concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 182.5+/-3.4) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID33746 | Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
| AID115112 | Tested for locomotor activity after oral administration of 10 mg/kg for 120 min | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID170577 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 0.08 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID115115 | Tested for locomotor activity after oral administration of 5 mg/kg for 120 min | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID192859 | Compound was evaluated for Urea Nitrogen concentration in glycerol injected rats treated with 1 mg/kg administered intraperitoneally | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID32291 | Binding affinity for adenosine A1 receptor using [3H]- CHA | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
| AID33754 | Selectivity is defined as the ratio of Ki(A2 adenosine receptor) / Ki(A1 adenosine receptor) | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. |
| AID118920 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.08 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID170585 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID228330 | Ki ratio evaluated as the Ki of A2 to that A1 receptor values. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID188246 | Effect on urinary excretion potassium and sodium after oral administration of 6.25 mg/kg to rats(potassium and sodium excretion in control rat is 0.138+/-0.011) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID189923 | Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID189925 | Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 25 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID118928 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID191560 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID191545 | Retention time in Scopolamine induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID191552 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 0.02 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID108722 | Acquisition time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 1.25 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID192806 | Percent inhibition of serum creatinine by the compound given as ratio of Cr value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 5.43+/-0.11) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID187935 | Effect on urinary excretion potassium and sodium after oral administration of 0.4 mg/kg to rats(potassium and sodium excretion in control rat is 0.175+/-0.014) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID191559 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.08 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID191360 | Oral diuretic activity was measured after oral administration of 6.25 mg/kg to rats(control volume is 1.00+/-0.12) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID191573 | Retention time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 5 mg/kg (n=15) | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID118924 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID21763 | Solubility was measured in saline | 1992 | Journal of medicinal chemistry, Sep-18, Volume: 35, Issue:19
| 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist. |
| AID194316 | Compound administered at a dose of 6.25 mg/25 mL/kg orally to rats, urine collected for 6 hr and measured for Na+ excretion. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID32292 | Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID188407 | Ratio of sodium ion/potassium ion concentration in urine of rats following 6.25 mg/kg p.o. | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID191184 | Oral diuretic activity was measured after oral administration of 1.6 mg/kg to rats(control volume is 0.83+/-0.07) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID189927 | Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 6.25 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID174549 | Serum creatinine concentration measured after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 5.43+/-0.11) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID21767 | Solubility of the compound(10 mg) was measured in water(2.5 mL) at 20 degree celsius for 1 hr | 1992 | Journal of medicinal chemistry, Sep-18, Volume: 35, Issue:19
| 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist. |
| AID192857 | Compound was evaluated for Serum creatinine concentration in glycerol injected rats treated with 1 mg/kg administered intraperitoneally | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID118918 | Retention time in (R)-PIA) induced avoidance test (performed in mice) for antagonistic activity after peroral administration of 0.02 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID32289 | Binding affinity towards adenosine A1 receptor using N6-[3H]cyclohexyladenosine in guinea pig forebrain membranes | 1992 | Journal of medicinal chemistry, Sep-18, Volume: 35, Issue:19
| 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist. |
| AID187949 | Effect on urinary excretion potassium and sodium after oral administration of 1.6 mg/kg to rats(potassium and sodium excretion in control rat is 0.122+/-0.008) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID170573 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after peroral administration of 0.02 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID33906 | Binding affinity carried out with [3H]5'-(N-ethylcarbamoyl)-adenosine in the presence of 50 nM cyclopentyladenosine in rat striatal membranes against adenosine A2 receptor. | 1991 | Journal of medicinal chemistry, Jan, Volume: 34, Issue:1
| 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities. |
| AID189935 | Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID189933 | Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID189921 | Ratio of urinary excretion value (Na+ concentration) in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID188109 | Effect on urinary excretion potassium and sodium after oral administration of 25 mg/kg to rats(potassium and sodium excretion in control rat is 0.162+/-0.018) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID30502 | Binding affinity for adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide in guinea pig forebrain membranes | 1992 | Journal of medicinal chemistry, Sep-18, Volume: 35, Issue:19
| 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist. |
| AID229795 | Ratio of Ki against rat forebrain membrane A1 and rat striatal membrane A2 adenosine receptors | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID32508 | Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID30503 | Ratio of binding to adenosine A2 and A1 receptors | 1992 | Journal of medicinal chemistry, Sep-18, Volume: 35, Issue:19
| 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist. |
| AID191171 | Oral diuretic activity was measured after oral administration of 0.4 mg/kg to rats(control volume is 0.94+/-0.03) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID32163 | Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. |
| AID194958 | Percent inhibition of Urea nitrogen by the compound given as ratio of UN value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 182.5+/-3.4) | 1992 | Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
| Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
| AID170581 | Acquisition time in Scopolamine induced avoidance test (performed in rat) for antagonistic activity after p.o. administration of 0.31 mg/kg | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| AID493017 | Wombat Data for BeliefDocking | 1993 | Journal of medicinal chemistry, Aug-20, Volume: 36, Issue:17
| Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |