flumazenil has been researched along with Ischemia in 7 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 7.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "The effect of flumazenil, a benzodiazepine antagonist, on hepatic encephalopathy was studied in rabbits with acute hepatic failure induced by a two-stage liver devascularization procedure." | 7.68 | Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit. ( de Knegt, RJ; Mechelse, K; Schalm, SW; Terpstra, OT; van der Rijt, CC, 1990) |
| "Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model." | 3.83 | Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016) |
| "The effect of flumazenil, a benzodiazepine antagonist, on hepatic encephalopathy was studied in rabbits with acute hepatic failure induced by a two-stage liver devascularization procedure." | 3.68 | Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit. ( de Knegt, RJ; Mechelse, K; Schalm, SW; Terpstra, OT; van der Rijt, CC, 1990) |
| "Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49 degrees C water, after the release of the tourniquet." | 1.29 | Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines. ( Cartmell, SM; Mitchell, D, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Cappelli, A | 1 |
| Anzini, M | 1 |
| Castriconi, F | 1 |
| Grisci, G | 1 |
| Paolino, M | 1 |
| Braile, C | 1 |
| Valenti, S | 1 |
| Giuliani, G | 1 |
| Vomero, S | 1 |
| Di Capua, A | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Lucacchini, A | 1 |
| Ghelardini, C | 1 |
| Di Cesare Mannelli, L | 1 |
| Frosini, M | 1 |
| Ricci, L | 1 |
| Giorgi, G | 1 |
| Mascia, MP | 1 |
| Biggio, G | 1 |
| Yasuda, S | 1 |
| Katakura, Y | 1 |
| Kubo, Y | 1 |
| Dobashi, K | 1 |
| Kimura, K | 1 |
| Fujiwara, S | 1 |
| Chida, K | 2 |
| Akamatsu, Y | 1 |
| Kobayashi, M | 2 |
| Yoshida, K | 2 |
| Terasaki, K | 2 |
| Ogasawara, K | 2 |
| Schirrmacher, R | 1 |
| Dea, M | 1 |
| Heiss, WD | 1 |
| Kostikov, A | 1 |
| Funck, T | 1 |
| Quessy, S | 1 |
| Bedell, B | 1 |
| Dancause, N | 1 |
| Thiel, A | 1 |
| Aso, K | 1 |
| Suga, Y | 1 |
| Tsushina, E | 1 |
| Ogawa, A | 1 |
| Cartmell, SM | 2 |
| Mitchell, D | 2 |
| van der Rijt, CC | 1 |
| de Knegt, RJ | 1 |
| Schalm, SW | 1 |
| Terpstra, OT | 1 |
| Mechelse, K | 1 |
7 other studies available for flumazenil and Ischemia
| Article | Year |
|---|---|
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Catt | 2016 |
Recovery of Cortical Neurotransmitter Receptor Function and Its Impact on Cognitive Improvement after Indirect Revascularization Surgery Alone for Adult Patients with Ischemic Moyamoya Disease:
Topics: Adult; Cerebral Cortex; Cerebral Revascularization; Cerebrovascular Circulation; Cognition; Flumazen | 2022 |
Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Endothelin-1; Flumazenil; Infarction, M | 2016 |
Postcarotid endarterectomy improvement in cognition is associated with resolution of crossed cerebellar hypoperfusion and increase in 123I-iomazenil uptake in the cerebral cortex: a SPECT study.
Topics: Adult; Afferent Pathways; Aged; Carotid Artery, Internal; Carotid Stenosis; Cerebellum; Cerebral Cor | 2010 |
Diazepam attenuates hyperexcitability and mechanical hypersensitivity of dorsal horn convergent neurones during reperfusion of the rat's tail following ischaemia.
Topics: Animals; Diazepam; Electrophysiology; Flumazenil; Ischemia; Male; Naloxone; Neurons; Physical Stimul | 1994 |
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-R | 1993 |
Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit.
Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Hepati | 1990 |