Page last updated: 2024-10-27

flumazenil and Ischemia

flumazenil has been researched along with Ischemia in 7 studies

Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model."7.83Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016)
"The effect of flumazenil, a benzodiazepine antagonist, on hepatic encephalopathy was studied in rabbits with acute hepatic failure induced by a two-stage liver devascularization procedure."7.68Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit. ( de Knegt, RJ; Mechelse, K; Schalm, SW; Terpstra, OT; van der Rijt, CC, 1990)
"Multitracer micro-PET of ET1 focal ischemia in rats was performed using [11C]-flumazenil ([11C]FMZ) as a flow- and viability tracer and [18F]-fluoromisonidazole ([18F]FMISO) as hypoxia marker in order to characterize the physiological time-course of this model."3.83Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1. ( Bedell, B; Dancause, N; Dea, M; Funck, T; Heiss, WD; Kostikov, A; Quessy, S; Schirrmacher, R; Thiel, A, 2016)
"The effect of flumazenil, a benzodiazepine antagonist, on hepatic encephalopathy was studied in rabbits with acute hepatic failure induced by a two-stage liver devascularization procedure."3.68Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit. ( de Knegt, RJ; Mechelse, K; Schalm, SW; Terpstra, OT; van der Rijt, CC, 1990)
"Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49 degrees C water, after the release of the tourniquet."1.29Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines. ( Cartmell, SM; Mitchell, D, 1993)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's0 (0.00)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Cappelli, A1
Anzini, M1
Castriconi, F1
Grisci, G1
Paolino, M1
Braile, C1
Valenti, S1
Giuliani, G1
Vomero, S1
Di Capua, A1
Betti, L1
Giannaccini, G1
Lucacchini, A1
Ghelardini, C1
Di Cesare Mannelli, L1
Frosini, M1
Ricci, L1
Giorgi, G1
Mascia, MP1
Biggio, G1
Yasuda, S1
Katakura, Y1
Kubo, Y1
Dobashi, K1
Kimura, K1
Fujiwara, S1
Chida, K2
Akamatsu, Y1
Kobayashi, M2
Yoshida, K2
Terasaki, K2
Ogasawara, K2
Schirrmacher, R1
Dea, M1
Heiss, WD1
Kostikov, A1
Funck, T1
Quessy, S1
Bedell, B1
Dancause, N1
Thiel, A1
Aso, K1
Suga, Y1
Tsushina, E1
Ogawa, A1
Cartmell, SM2
Mitchell, D2
van der Rijt, CC1
de Knegt, RJ1
Schalm, SW1
Terpstra, OT1
Mechelse, K1

Other Studies

7 other studies available for flumazenil and Ischemia

ArticleYear
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Catt

2016
Recovery of Cortical Neurotransmitter Receptor Function and Its Impact on Cognitive Improvement after Indirect Revascularization Surgery Alone for Adult Patients with Ischemic Moyamoya Disease:
    World neurosurgery, 2022, Volume: 164

    Topics: Adult; Cerebral Cortex; Cerebral Revascularization; Cerebrovascular Circulation; Cognition; Flumazen

2022
Which Aspects of Stroke Do Animal Models Capture? A Multitracer Micro-PET Study of Focal Ischemia with Endothelin-1.
    Cerebrovascular diseases (Basel, Switzerland), 2016, Volume: 41, Issue:3-4

    Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Endothelin-1; Flumazenil; Infarction, M

2016
Postcarotid endarterectomy improvement in cognition is associated with resolution of crossed cerebellar hypoperfusion and increase in 123I-iomazenil uptake in the cerebral cortex: a SPECT study.
    Cerebrovascular diseases (Basel, Switzerland), 2010, Volume: 29, Issue:4

    Topics: Adult; Afferent Pathways; Aged; Carotid Artery, Internal; Carotid Stenosis; Cerebellum; Cerebral Cor

2010
Diazepam attenuates hyperexcitability and mechanical hypersensitivity of dorsal horn convergent neurones during reperfusion of the rat's tail following ischaemia.
    Brain research, 1994, Oct-03, Volume: 659, Issue:1-2

    Topics: Animals; Diazepam; Electrophysiology; Flumazenil; Ischemia; Male; Naloxone; Neurons; Physical Stimul

1994
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-R

1993
Flumazenil does not improve hepatic encephalopathy associated with acute ischemic liver failure in the rabbit.
    Metabolic brain disease, 1990, Volume: 5, Issue:3

    Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Electroencephalography; Flumazenil; Hepati

1990