cimetidine has been researched along with Ischemia in 16 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Microdialysis was used to study how ischemia-evoked gastric mucosal injury affects rat stomach histamine, which resides in enterochromaffin-like (ECL) cells and mast cells." | 7.73 | Ischemia of rat stomach mobilizes ECL cell histamine. ( Bernsand, M; Haenuki, Y; Håkanson, R; Hasegawa, J; Kishimoto, Y; Kitano, M; Kudo, M; Norlén, P, 2005) |
| "This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine." | 7.70 | Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000) |
| "We previously demonstrated that both histamine synthesis (histidine decarboxylase activity) and polyamine synthesis (ornithine decarboxylase activity) increased in the rat intestinal mucosa after ischemia-reperfusion, whereas the relationship between these two factors remains unclear." | 7.69 | Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Gotoh, Y; Iwakiri, R; Koyama, T; Matsunaga, C; Morita, H; Ogata, S; Sakata, Y; Tsunada, S, 1995) |
| "This study was performed to determine the relationship between net ion fluxes across the rat gastric mucosa and gastric mucosal damage after gastric ischemia and after intravenous administration of acetylsalicylic acid, and to determine the effect of cimetidine on these parameters." | 7.67 | Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid. ( Parsons, ME; Pipkin, G; Price, CA, 1984) |
| "Microdialysis was used to study how ischemia-evoked gastric mucosal injury affects rat stomach histamine, which resides in enterochromaffin-like (ECL) cells and mast cells." | 3.73 | Ischemia of rat stomach mobilizes ECL cell histamine. ( Bernsand, M; Haenuki, Y; Håkanson, R; Hasegawa, J; Kishimoto, Y; Kitano, M; Kudo, M; Norlén, P, 2005) |
| "This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine." | 3.70 | Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000) |
| "We previously demonstrated that both histamine synthesis (histidine decarboxylase activity) and polyamine synthesis (ornithine decarboxylase activity) increased in the rat intestinal mucosa after ischemia-reperfusion, whereas the relationship between these two factors remains unclear." | 3.69 | Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Gotoh, Y; Iwakiri, R; Koyama, T; Matsunaga, C; Morita, H; Ogata, S; Sakata, Y; Tsunada, S, 1995) |
| " Rats were pretreated with alpha-fluoromethylhistidine (a suicide inhibitor of histidine decarboxylase, a synthesizing enzyme of histamine), H1-receptor antagonist (chlorpheniramine maleate), H2-antagonist (cimetidine), or H3-antagonist (thioperamide) before ischemia-reperfusion (I/R)." | 3.69 | Histaminergic control of mucosal repair in the small intestine. ( Fujimoto, K; Gotoh, Y; Ogata, S; Ohyama, T; Okamoto, K; Ootani, A; Sakata, T; Tsunada, S, 1995) |
| "This study was performed to determine the relationship between net ion fluxes across the rat gastric mucosa and gastric mucosal damage after gastric ischemia and after intravenous administration of acetylsalicylic acid, and to determine the effect of cimetidine on these parameters." | 3.67 | Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid. ( Parsons, ME; Pipkin, G; Price, CA, 1984) |
| " The osmotic reflection coefficient for total plasma proteins and isogravimetric capillary pressure were estimated in canine gracilis muscle for the following conditions: control, ischemia, and ischemia plus pretreatment with allopurinol (a xanthine oxidase inhibitor), catalase (a peroxidase that reduces hydrogen peroxide to water and molecular oxygen), superoxide dismutase (a superoxide anion scavenger), dimethyl sulfoxide (a hydroxyl radical scavenger), diphenhydramine (a histamine H1-receptor blocker), or cimetidine (a histamine H2-receptor blocker)." | 3.67 | The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability. ( Granger, DN; Korthuis, RJ; Taylor, AE; Townsley, MI, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kitano, M | 2 |
| Bernsand, M | 1 |
| Kishimoto, Y | 2 |
| Norlén, P | 1 |
| Håkanson, R | 1 |
| Haenuki, Y | 1 |
| Kudo, M | 1 |
| Hasegawa, J | 1 |
| Granger, DN | 2 |
| Rutili, G | 1 |
| McCord, JM | 1 |
| Pipkin, G | 1 |
| Price, CA | 1 |
| Parsons, ME | 2 |
| Maher, JF | 1 |
| Menguy, R | 1 |
| Fujimoto, K | 3 |
| Sakata, Y | 1 |
| Tsunada, S | 2 |
| Koyama, T | 1 |
| Morita, H | 1 |
| Ogata, S | 2 |
| Matsunaga, C | 1 |
| Gotoh, Y | 2 |
| Iwakiri, R | 2 |
| Kaszaki, J | 1 |
| Boros, M | 1 |
| Szabó, A | 1 |
| Nagy, S | 1 |
| Moses, FM | 1 |
| Ohyama, T | 1 |
| Ootani, A | 1 |
| Okamoto, K | 2 |
| Sakata, T | 1 |
| Nakamoto, K | 1 |
| Wada, K | 1 |
| Ashida, K | 1 |
| Kamisaki, Y | 1 |
| Kawasaki, H | 1 |
| Itoh, T | 1 |
| Umeda, M | 1 |
| Fujita, A | 1 |
| Nishiwaki, H | 1 |
| Takeuchi, K | 1 |
| Yoshida, T | 1 |
| Noda, T | 1 |
| Kojima, M | 1 |
| Fukuyama, K | 1 |
| Owen, DA | 1 |
| Farrington, HE | 1 |
| Blakemore, R | 1 |
| Bysani, GK | 1 |
| Kennedy, TP | 1 |
| Ky, N | 1 |
| Rao, NV | 1 |
| Blaze, CA | 1 |
| Hoidal, JR | 1 |
| Gottlieb, JE | 1 |
| Menashe, PI | 1 |
| Cruz, E | 1 |
| Korthuis, RJ | 1 |
| Townsley, MI | 1 |
| Taylor, AE | 1 |
2 reviews available for cimetidine and Ischemia
| Article | Year |
|---|---|
Clinicopathologic spectrum of drug nephrotoxicity.
Topics: Aminoglycosides; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents; | 1984 |
Gastrointestinal bleeding and the athlete.
Topics: Cimetidine; Colitis; Exercise; Female; Gastritis; Gastrointestinal Hemorrhage; Humans; Ischemia; Mal | 1993 |
14 other studies available for cimetidine and Ischemia
| Article | Year |
|---|---|
Ischemia of rat stomach mobilizes ECL cell histamine.
Topics: Animals; Cimetidine; Enterochromaffin-like Cells; Gastric Mucosa; Histamine; Histamine H2 Antagonist | 2005 |
Superoxide radicals in feline intestinal ischemia.
Topics: Animals; Blood Pressure; Blood Proteins; Capillary Permeability; Cats; Cimetidine; Endotoxins; Femal | 1981 |
Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid.
Topics: Animals; Aspirin; Biological Transport; Chromium Radioisotopes; Cimetidine; Drug Interactions; Elect | 1984 |
The prophylaxis of stress ulceration.
Topics: Animals; Antacids; Burns; Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Mucosa; Ischemi | 1980 |
Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion.
Topics: Animals; Chlorpheniramine; Cimetidine; Histamine; Histamine Antagonists; Histidine Decarboxylase; In | 1995 |
Role of histamine in the intestinal flow response following mesenteric ischemia.
Topics: Animals; Blood Flow Velocity; Cimetidine; Cromolyn Sodium; Dogs; Female; Guanidines; Histamine; Ileu | 1994 |
Histaminergic control of mucosal repair in the small intestine.
Topics: Animals; Biological Transport; Chlorpheniramine; Cimetidine; Enzyme Inhibitors; Histamine; Histamine | 1995 |
The role of endogenous acid in the development of acute gastric ulcer induced by ischemia-reperfusion in the rat.
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Cimetidine; Gastric Acid; Gastric Mucosa; Ischemia; Male; | 1998 |
Effect of lafutidine, a novel histamine H2-receptor antagonist, on monochloramine-induced gastric lesions in rats: role of capsaicin-sensitive sensory neurons.
Topics: Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Chloramines; Cimetidine; Gastric Mucosa; Histamin | 1999 |
Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion.
Topics: Animals; Apoptosis; Chlorpheniramine; Cimetidine; Guanidines; Histamine; Histamine Antagonists; Inte | 2000 |
Reduction by cimetidine of acute gastric hemorrhage caused by reinfusion of blood after exposure to exogenous acid during gastric ischemia in rats.
Topics: Acute Disease; Animals; Blood Transfusion, Autologous; Cimetidine; Female; Gastrointestinal Hemorrha | 1979 |
Role of cytochrome P-450 in reperfusion injury of the rabbit lung.
Topics: Animals; Capillary Permeability; Cimetidine; Cytochrome P-450 Enzyme System; Iron; Ischemia; Lung; M | 1990 |
Gastrointestinal complications in critically ill patients: the intensivists' overview.
Topics: Animals; Antacids; Cholecystitis; Cimetidine; Critical Care; Gastric Acid; Gastrointestinal Diseases | 1986 |
The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability.
Topics: Allopurinol; Animals; Blood Flow Velocity; Blood Pressure; Capillaries; Capillary Permeability; Cata | 1985 |