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cimetidine and Ischemia

cimetidine has been researched along with Ischemia in 16 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"Microdialysis was used to study how ischemia-evoked gastric mucosal injury affects rat stomach histamine, which resides in enterochromaffin-like (ECL) cells and mast cells."7.73Ischemia of rat stomach mobilizes ECL cell histamine. ( Bernsand, M; Haenuki, Y; Håkanson, R; Hasegawa, J; Kishimoto, Y; Kitano, M; Kudo, M; Norlén, P, 2005)
"This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine."7.70Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000)
"We previously demonstrated that both histamine synthesis (histidine decarboxylase activity) and polyamine synthesis (ornithine decarboxylase activity) increased in the rat intestinal mucosa after ischemia-reperfusion, whereas the relationship between these two factors remains unclear."7.69Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Gotoh, Y; Iwakiri, R; Koyama, T; Matsunaga, C; Morita, H; Ogata, S; Sakata, Y; Tsunada, S, 1995)
"This study was performed to determine the relationship between net ion fluxes across the rat gastric mucosa and gastric mucosal damage after gastric ischemia and after intravenous administration of acetylsalicylic acid, and to determine the effect of cimetidine on these parameters."7.67Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid. ( Parsons, ME; Pipkin, G; Price, CA, 1984)
"Microdialysis was used to study how ischemia-evoked gastric mucosal injury affects rat stomach histamine, which resides in enterochromaffin-like (ECL) cells and mast cells."3.73Ischemia of rat stomach mobilizes ECL cell histamine. ( Bernsand, M; Haenuki, Y; Håkanson, R; Hasegawa, J; Kishimoto, Y; Kitano, M; Kudo, M; Norlén, P, 2005)
"This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine."3.70Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000)
"We previously demonstrated that both histamine synthesis (histidine decarboxylase activity) and polyamine synthesis (ornithine decarboxylase activity) increased in the rat intestinal mucosa after ischemia-reperfusion, whereas the relationship between these two factors remains unclear."3.69Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Gotoh, Y; Iwakiri, R; Koyama, T; Matsunaga, C; Morita, H; Ogata, S; Sakata, Y; Tsunada, S, 1995)
" Rats were pretreated with alpha-fluoromethylhistidine (a suicide inhibitor of histidine decarboxylase, a synthesizing enzyme of histamine), H1-receptor antagonist (chlorpheniramine maleate), H2-antagonist (cimetidine), or H3-antagonist (thioperamide) before ischemia-reperfusion (I/R)."3.69Histaminergic control of mucosal repair in the small intestine. ( Fujimoto, K; Gotoh, Y; Ogata, S; Ohyama, T; Okamoto, K; Ootani, A; Sakata, T; Tsunada, S, 1995)
"This study was performed to determine the relationship between net ion fluxes across the rat gastric mucosa and gastric mucosal damage after gastric ischemia and after intravenous administration of acetylsalicylic acid, and to determine the effect of cimetidine on these parameters."3.67Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid. ( Parsons, ME; Pipkin, G; Price, CA, 1984)
" The osmotic reflection coefficient for total plasma proteins and isogravimetric capillary pressure were estimated in canine gracilis muscle for the following conditions: control, ischemia, and ischemia plus pretreatment with allopurinol (a xanthine oxidase inhibitor), catalase (a peroxidase that reduces hydrogen peroxide to water and molecular oxygen), superoxide dismutase (a superoxide anion scavenger), dimethyl sulfoxide (a hydroxyl radical scavenger), diphenhydramine (a histamine H1-receptor blocker), or cimetidine (a histamine H2-receptor blocker)."3.67The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability. ( Granger, DN; Korthuis, RJ; Taylor, AE; Townsley, MI, 1985)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19907 (43.75)18.7374
1990's7 (43.75)18.2507
2000's2 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kitano, M2
Bernsand, M1
Kishimoto, Y2
Norlén, P1
Håkanson, R1
Haenuki, Y1
Kudo, M1
Hasegawa, J1
Granger, DN2
Rutili, G1
McCord, JM1
Pipkin, G1
Price, CA1
Parsons, ME2
Maher, JF1
Menguy, R1
Fujimoto, K3
Sakata, Y1
Tsunada, S2
Koyama, T1
Morita, H1
Ogata, S2
Matsunaga, C1
Gotoh, Y2
Iwakiri, R2
Kaszaki, J1
Boros, M1
Szabó, A1
Nagy, S1
Moses, FM1
Ohyama, T1
Ootani, A1
Okamoto, K2
Sakata, T1
Nakamoto, K1
Wada, K1
Ashida, K1
Kamisaki, Y1
Kawasaki, H1
Itoh, T1
Umeda, M1
Fujita, A1
Nishiwaki, H1
Takeuchi, K1
Yoshida, T1
Noda, T1
Kojima, M1
Fukuyama, K1
Owen, DA1
Farrington, HE1
Blakemore, R1
Bysani, GK1
Kennedy, TP1
Ky, N1
Rao, NV1
Blaze, CA1
Hoidal, JR1
Gottlieb, JE1
Menashe, PI1
Cruz, E1
Korthuis, RJ1
Townsley, MI1
Taylor, AE1

Reviews

2 reviews available for cimetidine and Ischemia

ArticleYear
Clinicopathologic spectrum of drug nephrotoxicity.
    Advances in internal medicine, 1984, Volume: 30

    Topics: Aminoglycosides; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents;

1984
Gastrointestinal bleeding and the athlete.
    The American journal of gastroenterology, 1993, Volume: 88, Issue:8

    Topics: Cimetidine; Colitis; Exercise; Female; Gastritis; Gastrointestinal Hemorrhage; Humans; Ischemia; Mal

1993

Other Studies

14 other studies available for cimetidine and Ischemia

ArticleYear
Ischemia of rat stomach mobilizes ECL cell histamine.
    American journal of physiology. Gastrointestinal and liver physiology, 2005, Volume: 288, Issue:5

    Topics: Animals; Cimetidine; Enterochromaffin-like Cells; Gastric Mucosa; Histamine; Histamine H2 Antagonist

2005
Superoxide radicals in feline intestinal ischemia.
    Gastroenterology, 1981, Volume: 81, Issue:1

    Topics: Animals; Blood Pressure; Blood Proteins; Capillary Permeability; Cats; Cimetidine; Endotoxins; Femal

1981
Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid.
    Gastroenterology, 1984, Volume: 87, Issue:6

    Topics: Animals; Aspirin; Biological Transport; Chromium Radioisotopes; Cimetidine; Drug Interactions; Elect

1984
The prophylaxis of stress ulceration.
    The New England journal of medicine, 1980, Feb-21, Volume: 302, Issue:8

    Topics: Animals; Antacids; Burns; Cimetidine; Gastric Mucosa; Guanidines; Humans; Intestinal Mucosa; Ischemi

1980
Newly synthesized histamine accelerates ornithine decarboxylase activity in rat intestinal mucosa after ischemia-reperfusion.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:4

    Topics: Animals; Chlorpheniramine; Cimetidine; Histamine; Histamine Antagonists; Histidine Decarboxylase; In

1995
Role of histamine in the intestinal flow response following mesenteric ischemia.
    Shock (Augusta, Ga.), 1994, Volume: 2, Issue:6

    Topics: Animals; Blood Flow Velocity; Cimetidine; Cromolyn Sodium; Dogs; Female; Guanidines; Histamine; Ileu

1994
Histaminergic control of mucosal repair in the small intestine.
    Obesity research, 1995, Volume: 3 Suppl 5

    Topics: Animals; Biological Transport; Chlorpheniramine; Cimetidine; Enzyme Inhibitors; Histamine; Histamine

1995
The role of endogenous acid in the development of acute gastric ulcer induced by ischemia-reperfusion in the rat.
    Life sciences, 1998, Volume: 62, Issue:4

    Topics: Acute Disease; Animals; Anti-Ulcer Agents; Cimetidine; Gastric Acid; Gastric Mucosa; Ischemia; Male;

1998
Effect of lafutidine, a novel histamine H2-receptor antagonist, on monochloramine-induced gastric lesions in rats: role of capsaicin-sensitive sensory neurons.
    Journal of gastroenterology and hepatology, 1999, Volume: 14, Issue:9

    Topics: Acetamides; Animals; Anti-Ulcer Agents; Capsaicin; Chloramines; Cimetidine; Gastric Mucosa; Histamin

1999
Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:6

    Topics: Animals; Apoptosis; Chlorpheniramine; Cimetidine; Guanidines; Histamine; Histamine Antagonists; Inte

2000
Reduction by cimetidine of acute gastric hemorrhage caused by reinfusion of blood after exposure to exogenous acid during gastric ischemia in rats.
    Gastroenterology, 1979, Volume: 77, Issue:5

    Topics: Acute Disease; Animals; Blood Transfusion, Autologous; Cimetidine; Female; Gastrointestinal Hemorrha

1979
Role of cytochrome P-450 in reperfusion injury of the rabbit lung.
    The Journal of clinical investigation, 1990, Volume: 86, Issue:5

    Topics: Animals; Capillary Permeability; Cimetidine; Cytochrome P-450 Enzyme System; Iron; Ischemia; Lung; M

1990
Gastrointestinal complications in critically ill patients: the intensivists' overview.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:4

    Topics: Animals; Antacids; Cholecystitis; Cimetidine; Critical Care; Gastric Acid; Gastrointestinal Diseases

1986
The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability.
    Circulation research, 1985, Volume: 57, Issue:4

    Topics: Allopurinol; Animals; Blood Flow Velocity; Blood Pressure; Capillaries; Capillary Permeability; Cata

1985