theobromine has been researched along with Ischemia in 17 studies
Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients with ischemic rest pain were treated with intravenous pentoxifylline, 1,200 mg daily, for up to three weeks." | 7.67 | Intravenous pentoxifylline in the treatment of rest pain: a preliminary report. ( Carey, D; Kent, P; McCollum, PT; Moore, DJ; O'Driscoll, K; Shanik, DG; Stanley, ST; Weil von der Ahe, CA, 1989) |
| "This study examined the cytoprotective mechanisms of a combination of ischemic preconditioning (IPC) and allopurinol against liver injury caused by ischemia/reperfusion (I/R)." | 3.78 | A combination of ischemic preconditioning and allopurinol protects against ischemic injury through a nitric oxide-dependent mechanism. ( Koh, EJ; Lee, SM; Lee, WY, 2012) |
| "Twenty patients with ischemic rest pain were treated with intravenous pentoxifylline, 1,200 mg daily, for up to three weeks." | 3.67 | Intravenous pentoxifylline in the treatment of rest pain: a preliminary report. ( Carey, D; Kent, P; McCollum, PT; Moore, DJ; O'Driscoll, K; Shanik, DG; Stanley, ST; Weil von der Ahe, CA, 1989) |
| "The effect of pentoxifylline on the recovery of renal energy metabolism after ischemia and reperfusion was studied by 31P nuclear magnetic resonance spectroscopy in vivo." | 3.67 | Effect of pentoxifylline on the ischemic rat kidney monitored by 31P NMR spectroscopy in vivo. ( Ellermann, J; Gründer, W; Keller, T, 1988) |
| " Consequently, when a dialysis patient required this drug, we started at a low dose and gradually increased the dosage while monitoring the patient for signs or symptoms of toxicity and following plasma concentrations of parent drug and its metabolites." | 1.27 | Pentoxifylline in end-stage renal disease. ( Kroboth, PD; Silver, MR, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, WY | 1 |
| Koh, EJ | 1 |
| Lee, SM | 1 |
| Kaz'min, AI | 1 |
| Pavlova, GA | 1 |
| Travkin, AA | 1 |
| Mitskevich, VA | 1 |
| Davis, JM | 1 |
| Gute, DC | 1 |
| Jones, S | 1 |
| Krsmanovic, A | 1 |
| Korthuis, RJ | 1 |
| Sugino, H | 1 |
| Shimada, H | 1 |
| Tsuchimoto, K | 1 |
| Hartmann, JF | 1 |
| Becker, RA | 1 |
| Cohen, MM | 1 |
| Gerzić, Z | 1 |
| Dukić, V | 1 |
| Milicević, M | 1 |
| Huismans, H | 1 |
| Dinn, RF | 1 |
| Yang, HT | 1 |
| Terjung, RL | 1 |
| Okyayuz-Baklouti, I | 1 |
| Beykirch, H | 1 |
| Reuter, W | 1 |
| Voigt, H | 1 |
| Herrmann, W | 1 |
| Tikhonov, VP | 1 |
| Statsenko, ME | 1 |
| McCollum, PT | 1 |
| Kent, P | 1 |
| O'Driscoll, K | 1 |
| Carey, D | 1 |
| Stanley, ST | 1 |
| Weil von der Ahe, CA | 1 |
| Moore, DJ | 1 |
| Shanik, DG | 1 |
| Ellermann, J | 1 |
| Gründer, W | 1 |
| Keller, T | 1 |
| Barker, JH | 1 |
| Menger, MD | 1 |
| Sack, FU | 1 |
| Messmer, K | 1 |
| Silver, MR | 1 |
| Kroboth, PD | 1 |
| Mavrelis, PG | 1 |
| Doumanian, H | 1 |
| Lee, BY | 1 |
| Berkowitz, P | 1 |
| Savitsky, JP | 1 |
| May, GS | 1 |
| Brobst, J | 1 |
| McCann, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062] | 21 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for theobromine and Ischemia
| Article | Year |
|---|---|
A combination of ischemic preconditioning and allopurinol protects against ischemic injury through a nitric oxide-dependent mechanism.
Topics: Adenosine Deaminase; Alanine Transaminase; Allopurinol; Animals; Arginine; Cyclic GMP; Glutathione; | 2012 |
[Trental treatment of spinal and radicular ischemic syndromes in spinal diseases].
Topics: Adolescent; Adult; Aged; Drug Evaluation; Female; Humans; Ischemia; Kyphosis; Male; Microcirculation | 1981 |
Ischemic preconditioning prevents postischemic P-selectin expression in the rat small intestine.
Topics: Adenosine; Adenosine Deaminase; Animals; Antibodies, Monoclonal; Ischemia; Ischemic Preconditioning; | 1999 |
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats.
Topics: Adenosine; Animals; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Ischemia; Ischemic Preco | 2001 |
Effects of pentoxifylline on cerebral ultrastructure of normal and ischemic gerbils.
Topics: Animals; Brain; Cerebral Cortex; Female; Gerbillinae; Hippocampus; Ischemia; Male; Mitochondria; Pen | 1977 |
[Drug therapy of chronic tissue ischemia with improvement of microcirculation].
Topics: Adult; Blood Vessel Prosthesis; Chronic Disease; Extremities; Humans; Ischemia; Ischemic Attack, Tra | 1978 |
[Acute ischemia of the optic nerve (with a color plate)].
Topics: Acute Disease; Female; Humans; Ischemia; Middle Aged; Nicotinic Acids; Optic Nerve; Optic Nerve Dise | 1978 |
The influence of pentoxifylline and torbafylline on muscle blood flow in animals with peripheral arterial insufficiency.
Topics: Animals; Drug Evaluation, Preclinical; Hindlimb; Ischemia; Male; Pentoxifylline; Physical Exertion; | 1990 |
The effects of torbafylline on blood flow, pO2 and function of rat ischaemic skeletal muscle.
Topics: Acute Disease; Animals; Blood Pressure; Erythrocytes; Hindlimb; Ischemia; Lactates; Male; Microspher | 1989 |
[Lipid metabolism and peripheral hemodynamics in arteriosclerosis obliterans treated with nifedipine--a comparison with pentoxifylline].
Topics: Arteriosclerosis Obliterans; Hemodynamics; Humans; Ischemia; Leg; Lipids; Male; Middle Aged; Nifedip | 1989 |
[Pharmacologic correction of the adverse effects of beta-adrenoblockaders on the kidneys in patients with hypertension].
Topics: Adult; Aged; Female; Humans; Hypertension; Ischemia; Kidney; Male; Middle Aged; Pentoxifylline; Prop | 1989 |
Intravenous pentoxifylline in the treatment of rest pain: a preliminary report.
Topics: Aged; Female; Humans; Injections, Intravenous; Ischemia; Leg; Male; Pain; Pentoxifylline; Pilot Proj | 1989 |
Effect of pentoxifylline on the ischemic rat kidney monitored by 31P NMR spectroscopy in vivo.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Ischemia; Kidney; Magnetic Resonance Spectroscopy; | 1988 |
[Nutritive skin circulation in partial ischemia: effect of various vasoactive substances].
Topics: Animals; Furans; Ischemia; Mice; Mice, Hairless; Nafronyl; Pentoxifylline; Pyrrolidines; Regional Bl | 1988 |
Pentoxifylline in end-stage renal disease.
Topics: Adult; Dose-Response Relationship, Drug; Female; Hand; Humans; Ischemia; Kidney Failure, Chronic; Pe | 1987 |
Pentoxifylline for mesenteric ischemia.
Topics: Humans; Ischemia; Mesenteric Arteries; Mesenteric Vascular Occlusion; Pentoxifylline; Theobromine | 1987 |
Pentoxifylline treatment of moderate to severe chronic occlusive arterial disease.
Topics: Aged; Arterial Occlusive Diseases; Exercise Test; Humans; Intermittent Claudication; Ischemia; Leg; | 1985 |