Page last updated: 2024-11-05

theobromine and Ischemia

theobromine has been researched along with Ischemia in 17 studies

Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"Twenty patients with ischemic rest pain were treated with intravenous pentoxifylline, 1,200 mg daily, for up to three weeks."7.67Intravenous pentoxifylline in the treatment of rest pain: a preliminary report. ( Carey, D; Kent, P; McCollum, PT; Moore, DJ; O'Driscoll, K; Shanik, DG; Stanley, ST; Weil von der Ahe, CA, 1989)
"This study examined the cytoprotective mechanisms of a combination of ischemic preconditioning (IPC) and allopurinol against liver injury caused by ischemia/reperfusion (I/R)."3.78A combination of ischemic preconditioning and allopurinol protects against ischemic injury through a nitric oxide-dependent mechanism. ( Koh, EJ; Lee, SM; Lee, WY, 2012)
"Twenty patients with ischemic rest pain were treated with intravenous pentoxifylline, 1,200 mg daily, for up to three weeks."3.67Intravenous pentoxifylline in the treatment of rest pain: a preliminary report. ( Carey, D; Kent, P; McCollum, PT; Moore, DJ; O'Driscoll, K; Shanik, DG; Stanley, ST; Weil von der Ahe, CA, 1989)
"The effect of pentoxifylline on the recovery of renal energy metabolism after ischemia and reperfusion was studied by 31P nuclear magnetic resonance spectroscopy in vivo."3.67Effect of pentoxifylline on the ischemic rat kidney monitored by 31P NMR spectroscopy in vivo. ( Ellermann, J; Gründer, W; Keller, T, 1988)
" Consequently, when a dialysis patient required this drug, we started at a low dose and gradually increased the dosage while monitoring the patient for signs or symptoms of toxicity and following plasma concentrations of parent drug and its metabolites."1.27Pentoxifylline in end-stage renal disease. ( Kroboth, PD; Silver, MR, 1987)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199013 (76.47)18.7374
1990's2 (11.76)18.2507
2000's1 (5.88)29.6817
2010's1 (5.88)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, WY1
Koh, EJ1
Lee, SM1
Kaz'min, AI1
Pavlova, GA1
Travkin, AA1
Mitskevich, VA1
Davis, JM1
Gute, DC1
Jones, S1
Krsmanovic, A1
Korthuis, RJ1
Sugino, H1
Shimada, H1
Tsuchimoto, K1
Hartmann, JF1
Becker, RA1
Cohen, MM1
Gerzić, Z1
Dukić, V1
Milicević, M1
Huismans, H1
Dinn, RF1
Yang, HT1
Terjung, RL1
Okyayuz-Baklouti, I1
Beykirch, H1
Reuter, W1
Voigt, H1
Herrmann, W1
Tikhonov, VP1
Statsenko, ME1
McCollum, PT1
Kent, P1
O'Driscoll, K1
Carey, D1
Stanley, ST1
Weil von der Ahe, CA1
Moore, DJ1
Shanik, DG1
Ellermann, J1
Gründer, W1
Keller, T1
Barker, JH1
Menger, MD1
Sack, FU1
Messmer, K1
Silver, MR1
Kroboth, PD1
Mavrelis, PG1
Doumanian, H1
Lee, BY1
Berkowitz, P1
Savitsky, JP1
May, GS1
Brobst, J1
McCann, WJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Single-blinded Placebo-controlled Trial of Ischemic Preconditioning in Raynaud's Phenomenon (RP)[NCT02506062]21 participants (Actual)Interventional2015-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

17 other studies available for theobromine and Ischemia

ArticleYear
A combination of ischemic preconditioning and allopurinol protects against ischemic injury through a nitric oxide-dependent mechanism.
    Nitric oxide : biology and chemistry, 2012, Jan-01, Volume: 26, Issue:1

    Topics: Adenosine Deaminase; Alanine Transaminase; Allopurinol; Animals; Arginine; Cyclic GMP; Glutathione;

2012
[Trental treatment of spinal and radicular ischemic syndromes in spinal diseases].
    Ortopediia travmatologiia i protezirovanie, 1981, Issue:12

    Topics: Adolescent; Adult; Aged; Drug Evaluation; Female; Humans; Ischemia; Kyphosis; Male; Microcirculation

1981
Ischemic preconditioning prevents postischemic P-selectin expression in the rat small intestine.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Adenosine; Adenosine Deaminase; Animals; Antibodies, Monoclonal; Ischemia; Ischemic Preconditioning;

1999
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats.
    Japanese journal of pharmacology, 2001, Volume: 87, Issue:2

    Topics: Adenosine; Animals; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Ischemia; Ischemic Preco

2001
Effects of pentoxifylline on cerebral ultrastructure of normal and ischemic gerbils.
    Neurology, 1977, Volume: 27, Issue:1

    Topics: Animals; Brain; Cerebral Cortex; Female; Gerbillinae; Hippocampus; Ischemia; Male; Mitochondria; Pen

1977
[Drug therapy of chronic tissue ischemia with improvement of microcirculation].
    Acta chirurgica Iugoslavica, 1978, Volume: 25, Issue:1

    Topics: Adult; Blood Vessel Prosthesis; Chronic Disease; Extremities; Humans; Ischemia; Ischemic Attack, Tra

1978
[Acute ischemia of the optic nerve (with a color plate)].
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 1978, Volume: 176, Issue:2

    Topics: Acute Disease; Female; Humans; Ischemia; Middle Aged; Nicotinic Acids; Optic Nerve; Optic Nerve Dise

1978
The influence of pentoxifylline and torbafylline on muscle blood flow in animals with peripheral arterial insufficiency.
    Journal of clinical pharmacology, 1990, Volume: 30, Issue:8

    Topics: Animals; Drug Evaluation, Preclinical; Hindlimb; Ischemia; Male; Pentoxifylline; Physical Exertion;

1990
The effects of torbafylline on blood flow, pO2 and function of rat ischaemic skeletal muscle.
    European journal of pharmacology, 1989, Jul-04, Volume: 166, Issue:1

    Topics: Acute Disease; Animals; Blood Pressure; Erythrocytes; Hindlimb; Ischemia; Lactates; Male; Microspher

1989
[Lipid metabolism and peripheral hemodynamics in arteriosclerosis obliterans treated with nifedipine--a comparison with pentoxifylline].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1989, Feb-01, Volume: 44, Issue:3

    Topics: Arteriosclerosis Obliterans; Hemodynamics; Humans; Ischemia; Leg; Lipids; Male; Middle Aged; Nifedip

1989
[Pharmacologic correction of the adverse effects of beta-adrenoblockaders on the kidneys in patients with hypertension].
    Klinicheskaia meditsina, 1989, Volume: 67, Issue:3

    Topics: Adult; Aged; Female; Humans; Hypertension; Ischemia; Kidney; Male; Middle Aged; Pentoxifylline; Prop

1989
Intravenous pentoxifylline in the treatment of rest pain: a preliminary report.
    Annals of vascular surgery, 1989, Volume: 3, Issue:3

    Topics: Aged; Female; Humans; Injections, Intravenous; Ischemia; Leg; Male; Pain; Pentoxifylline; Pilot Proj

1989
Effect of pentoxifylline on the ischemic rat kidney monitored by 31P NMR spectroscopy in vivo.
    Biomedica biochimica acta, 1988, Volume: 47, Issue:6

    Topics: Adenine Nucleotides; Animals; Energy Metabolism; Ischemia; Kidney; Magnetic Resonance Spectroscopy;

1988
[Nutritive skin circulation in partial ischemia: effect of various vasoactive substances].
    VASA. Zeitschrift fur Gefasskrankheiten, 1988, Volume: 17, Issue:1

    Topics: Animals; Furans; Ischemia; Mice; Mice, Hairless; Nafronyl; Pentoxifylline; Pyrrolidines; Regional Bl

1988
Pentoxifylline in end-stage renal disease.
    Drug intelligence & clinical pharmacy, 1987, Volume: 21, Issue:12

    Topics: Adult; Dose-Response Relationship, Drug; Female; Hand; Humans; Ischemia; Kidney Failure, Chronic; Pe

1987
Pentoxifylline for mesenteric ischemia.
    The American journal of gastroenterology, 1987, Volume: 82, Issue:2

    Topics: Humans; Ischemia; Mesenteric Arteries; Mesenteric Vascular Occlusion; Pentoxifylline; Theobromine

1987
Pentoxifylline treatment of moderate to severe chronic occlusive arterial disease.
    Clinical cardiology, 1985, Volume: 8, Issue:3

    Topics: Aged; Arterial Occlusive Diseases; Exercise Test; Humans; Intermittent Claudication; Ischemia; Leg;

1985