ketamine has been researched along with Ischemia in 34 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketamine in sub-dissociative doses has been shown to have analgesic effects in various pain conditions, including neuropathic and phantom-limb pain, where conventional treatment has often failed." | 9.08 | The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. ( Gustafsson, LL; Hasselström, J; Heller, A; Persson, J; Svensson, JO; Wiklund, B, 1998) |
| "The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery." | 9.06 | Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989) |
| "The present study was performed to compare haemodynamic variables at baseline and the incidence of ventricular fibrillation during the early phase of ischaemia in swine during pentobarbital or medetomidine-ketamine-fentanyl anaesthesia." | 7.72 | Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine. ( Grund, F; Ilebekk, A; Kirkebøen, KA; Sjaastad, I; Tjomsland, O, 2004) |
| "Ischemic pain was induced by the submaximum effort tourniquet technique." | 6.67 | The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. ( Ekblom, A; Segerdahl, M; Sollevi, A, 1994) |
| "Ketamine is a lipophilic, general anesthetic." | 6.48 | Ketamine for pain: an update of uses in palliative care. ( Prommer, EE, 2012) |
| "S-ketamine was administered at therapeutic human doses, 2, 4 and 5 mg/kg BW/h for up to 18 h." | 5.72 | Eighteen-hour inhibitory effect of s-ketamine on potassium- and ischemia-induced spreading depolarizations in the gyrencephalic swine brain. ( Dreier, JP; Geyer, M; Hartings, JA; Kentar, M; Sánchez-Porras, R; Santos, E; Trenado, C; Woitzik, J; Zerelles, R, 2022) |
| "Ketamine pretreatment was administered by intraperitoneal injections at doses of 100, 50, 12." | 5.36 | Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats. ( Alarcón-Galván, G; Ballesteros-Elizondo, RG; Cámara-Lemarroy, CR; Cordero-Pérez, P; Fernández-Garza, NE; Guzmán-De La Garza, FJ, 2010) |
| "Ketamine in sub-dissociative doses has been shown to have analgesic effects in various pain conditions, including neuropathic and phantom-limb pain, where conventional treatment has often failed." | 5.08 | The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. ( Gustafsson, LL; Hasselström, J; Heller, A; Persson, J; Svensson, JO; Wiklund, B, 1998) |
| "The analgesic efficiency of ketamine and pethidine was compared in experimental ischemic pain and postoperative pain after oral surgery." | 5.06 | Comparison of ketamine and pethidine in experimental and postoperative pain. ( Hustveit, O; Maurset, A; Skoglund, LA; Øye, I, 1989) |
| "Here we examined the effects of ischemia preconditioning and ketamine, an NMDA receptor antagonist, on the activation and its nucleus translocation of ERK5 in hippocampal CA1 region." | 3.75 | Action of ERK5 in ischemic tolerance suggests its probable participation in the signaling mechanism. ( Guan, QH; Qi, SH; Wang, M; Zhang, GY, 2009) |
| "The aim of this study was to investigate any possible protective effect of ketamine in acute muscular ischaemia and reperfusion injury by measuring malondialdehyde using thiobarbituric acid assay in rats." | 3.73 | The effect of ketamine on acute muscular ischaemia reperfusion in rats. ( Aypar, U; Dal, D; Iskit, AB; Salman, AE; Salman, MA, 2005) |
| "The present study was performed to compare haemodynamic variables at baseline and the incidence of ventricular fibrillation during the early phase of ischaemia in swine during pentobarbital or medetomidine-ketamine-fentanyl anaesthesia." | 3.72 | Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine. ( Grund, F; Ilebekk, A; Kirkebøen, KA; Sjaastad, I; Tjomsland, O, 2004) |
| " In cell cultures, CgTx inhibited hypoxia-induced 45Ca accumulation and neuronal injury minimally, compared to the NMDA antagonist ketamine." | 3.68 | Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury. ( Clark, WM; Madden, KP; Marcoux, FW; Probert, AW; Rivier, J; Weber, ML; Zivin, JA, 1990) |
| " Selected compounds were then tested for their ability to produce ketamine appropriate responding in monkeys and/or to show neuroprotective effects in a baby rat hypoxia/ischemia model." | 3.68 | Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines. ( de Costa, B; France, CP; Jacobson, AE; Mattson, MV; Olney, JW; Price, MT; Rice, KC; Thurkauf, A; Woods, JH, 1990) |
| "Ischemic pain was induced by the submaximum effort tourniquet technique." | 2.67 | The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. ( Ekblom, A; Segerdahl, M; Sollevi, A, 1994) |
| "Ketamine is a lipophilic, general anesthetic." | 2.48 | Ketamine for pain: an update of uses in palliative care. ( Prommer, EE, 2012) |
| "S-ketamine was administered at therapeutic human doses, 2, 4 and 5 mg/kg BW/h for up to 18 h." | 1.72 | Eighteen-hour inhibitory effect of s-ketamine on potassium- and ischemia-induced spreading depolarizations in the gyrencephalic swine brain. ( Dreier, JP; Geyer, M; Hartings, JA; Kentar, M; Sánchez-Porras, R; Santos, E; Trenado, C; Woitzik, J; Zerelles, R, 2022) |
| "Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P < 0." | 1.42 | Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model. ( Cheung, CW; Choi, SW; Irwin, M; Liman, S; Ng, KF; Qiu, Q; Tai, W; Wong, KL, 2015) |
| "Mannitol flux was greater in ischemic tissues than in reperfused tissues." | 1.37 | In vitro and in vivo responses of mucosa from the large colon of horses to ischemia and reperfusion. ( Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Polyak, MM, 2011) |
| "Ketamine pretreatment was administered by intraperitoneal injections at doses of 100, 50, 12." | 1.36 | Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats. ( Alarcón-Galván, G; Ballesteros-Elizondo, RG; Cámara-Lemarroy, CR; Cordero-Pérez, P; Fernández-Garza, NE; Guzmán-De La Garza, FJ, 2010) |
| "Retinal ischemia was induced for 60 min in one eye of 18 albino rabbits by raising intraocular pressure above the systolic blood pressure." | 1.28 | Ketamine suppresses ischemic injury in the rabbit retina. ( Blair, NP; Eappen, DC; Moy, JJ; Shah, GK; Takahashi, A; Tsukahara, Y; Viana, MA, 1992) |
| "Halothane alone was of no benefit." | 1.28 | Protecting the ischemic spinal cord during aortic clamping. The influence of anesthetics and hypothermia. ( Facundus, EC; Hollier, LH; Money, SR; Naslund, TC; Skenderis, BS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.82) | 18.7374 |
| 1990's | 15 (44.12) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 7 (20.59) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, L | 1 |
| Zhang, Y | 1 |
| Sánchez-Porras, R | 1 |
| Kentar, M | 1 |
| Zerelles, R | 1 |
| Geyer, M | 1 |
| Trenado, C | 1 |
| Hartings, JA | 1 |
| Woitzik, J | 1 |
| Dreier, JP | 1 |
| Santos, E | 1 |
| Zarate, MA | 1 |
| Chang, EI | 1 |
| Wood, CE | 1 |
| Zipper, R | 1 |
| Younger, A | 1 |
| Tipton, T | 1 |
| Jackson, B | 1 |
| Prasad, M | 1 |
| Hayden, G | 1 |
| Stec, A | 1 |
| Tawfic, QA | 1 |
| Eipe, N | 1 |
| Penning, J | 1 |
| Liman, S | 1 |
| Cheung, CW | 1 |
| Wong, KL | 1 |
| Tai, W | 1 |
| Qiu, Q | 1 |
| Ng, KF | 1 |
| Choi, SW | 1 |
| Irwin, M | 1 |
| Yu, HM | 1 |
| Xu, J | 1 |
| Li, C | 1 |
| Zhou, C | 1 |
| Zhang, F | 1 |
| Han, D | 1 |
| Zhang, GY | 2 |
| Qi, SH | 1 |
| Guan, QH | 1 |
| Wang, M | 1 |
| Guzmán-De La Garza, FJ | 1 |
| Cámara-Lemarroy, CR | 1 |
| Ballesteros-Elizondo, RG | 1 |
| Alarcón-Galván, G | 1 |
| Cordero-Pérez, P | 1 |
| Fernández-Garza, NE | 1 |
| Graham, AS | 1 |
| Grosche, A | 1 |
| Morton, AJ | 1 |
| Polyak, MM | 1 |
| Freeman, DE | 1 |
| Prommer, EE | 1 |
| Grund, F | 1 |
| Tjomsland, O | 1 |
| Sjaastad, I | 1 |
| Ilebekk, A | 1 |
| Kirkebøen, KA | 1 |
| Choi, SJ | 1 |
| Kim, MH | 1 |
| Lim, SW | 1 |
| Gwak, MS | 1 |
| Salman, AE | 1 |
| Dal, D | 1 |
| Salman, MA | 1 |
| Iskit, AB | 1 |
| Aypar, U | 1 |
| Capel, MM | 1 |
| Jenkins, R | 1 |
| Jefferson, M | 1 |
| Thomas, DM | 1 |
| Segerdahl, M | 1 |
| Ekblom, A | 1 |
| Sollevi, A | 1 |
| de Haan, P | 1 |
| Kalkman, CJ | 1 |
| Vanicky, I | 1 |
| Jacobs, MJ | 1 |
| Drummond, JC | 1 |
| Urch, CE | 1 |
| Chamberlain, JH | 1 |
| Oye, I | 1 |
| Persson, J | 1 |
| Hasselström, J | 1 |
| Wiklund, B | 1 |
| Heller, A | 1 |
| Svensson, JO | 1 |
| Gustafsson, LL | 1 |
| Haupt, H | 1 |
| Scheibe, F | 1 |
| Rebentisch, E | 1 |
| Miyamoto, TA | 1 |
| Miyamoto, KJ | 1 |
| Mitchell, AC | 1 |
| Fallon, MT | 1 |
| Bavister, PH | 1 |
| Longnecker, DE | 1 |
| Louzada-Júnior, P | 1 |
| Dias, JJ | 1 |
| Santos, WF | 1 |
| Lachat, JJ | 1 |
| Bradford, HF | 1 |
| Coutinho-Netto, J | 1 |
| Tsukahara, Y | 1 |
| Blair, NP | 1 |
| Eappen, DC | 1 |
| Moy, JJ | 1 |
| Takahashi, A | 1 |
| Shah, GK | 1 |
| Viana, MA | 1 |
| Naslund, TC | 1 |
| Hollier, LH | 1 |
| Money, SR | 1 |
| Facundus, EC | 1 |
| Skenderis, BS | 1 |
| Zhou, M | 1 |
| Ma, T | 1 |
| Tseng, MT | 1 |
| Madden, KP | 1 |
| Clark, WM | 1 |
| Marcoux, FW | 1 |
| Probert, AW | 1 |
| Weber, ML | 1 |
| Rivier, J | 1 |
| Zivin, JA | 1 |
| Sher, GD | 1 |
| Mitchell, D | 1 |
| Martinez-Arizala, A | 1 |
| Rigamonti, DD | 1 |
| Long, JB | 1 |
| Kraimer, JM | 1 |
| Holaday, JW | 1 |
| Thurkauf, A | 1 |
| de Costa, B | 1 |
| Mattson, MV | 1 |
| France, CP | 1 |
| Price, MT | 1 |
| Olney, JW | 1 |
| Woods, JH | 1 |
| Jacobson, AE | 1 |
| Rice, KC | 1 |
| Bird, AC | 1 |
| Lavin, MJ | 1 |
| Maurset, A | 1 |
| Skoglund, LA | 1 |
| Hustveit, O | 1 |
| Øye, I | 1 |
1 review available for ketamine and Ischemia
| Article | Year |
|---|---|
Ketamine for pain: an update of uses in palliative care.
Topics: Anesthetics, Dissociative; Humans; Ischemia; Ketamine; Neoplasms; Neuralgia; Pain; Palliative Care; | 2012 |
4 trials available for ketamine and Ischemia
| Article | Year |
|---|---|
The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers.
Topics: Adenosine; Adult; Drug Interactions; Drug Therapy, Combination; Female; Humans; Ischemia; Ketamine; | 1994 |
The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans.
Topics: Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Arteriosclerosis Obliterans; Chromatography | 1998 |
A single infusion of intravenous ketamine improves pain relief in patients with critical limb ischaemia: results of a double blind randomised controlled trial.
Topics: Aged; Analgesics; Analgesics, Opioid; Anxiety; Depression; Double-Blind Method; Extremities; Female; | 2002 |
Comparison of ketamine and pethidine in experimental and postoperative pain.
Topics: Adult; Female; Humans; Ischemia; Ketamine; Meperidine; Naloxone; Pain; Pain, Postoperative; Visual P | 1989 |
29 other studies available for ketamine and Ischemia
| Article | Year |
|---|---|
Discovery of novel ketamine-inspired derivatives as a protective agent against renal ischemic/reperfusion injury in Wistar rats.
Topics: Animals; Apoptosis; Ischemia; Ketamine; Kidney; NF-kappa B; Protective Agents; Rats; Rats, Wistar; R | 2022 |
Eighteen-hour inhibitory effect of s-ketamine on potassium- and ischemia-induced spreading depolarizations in the gyrencephalic swine brain.
Topics: Animals; Brain; Cortical Spreading Depression; Humans; Ischemia; Ketamine; Potassium; Swine | 2022 |
Effects of ketamine on the fetal transcriptomic response to umbilical cord occlusion: comparison with hypoxic hypoxia in the cerebral cortex.
Topics: Animals; Cerebral Cortex; DNA, Bacterial; Excitatory Amino Acid Antagonists; Female; Fetal Hypoxia; | 2018 |
Ischemic priapism in pediatric patients: Spontaneous detumescence with ketamine sedation.
Topics: Adolescent; Deep Sedation; Humans; Ischemia; Ketamine; Male; Penis; Priapism; Retrospective Studies | 2018 |
Ultra-low-dose ketamine infusion for ischemic limb pain.
Topics: Adult; Analgesics; Dose-Response Relationship, Drug; Humans; Ischemia; Ketamine; Leg; Male; Pain; Tr | 2014 |
Preventive Treatment with Ketamine Attenuates the Ischaemia-Reperfusion Response in a Chronic Postischaemia Pain Model.
Topics: Analgesics; Animals; Behavior, Animal; Chronic Disease; Complex Regional Pain Syndromes; Disease Mod | 2015 |
Coupling between neuronal nitric oxide synthase and glutamate receptor 6-mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death.
Topics: Animals; Cell Death; Disease Models, Animal; Disks Large Homolog 4 Protein; Dithiothreitol; Enzyme I | 2008 |
Action of ERK5 in ischemic tolerance suggests its probable participation in the signaling mechanism.
Topics: Active Transport, Cell Nucleus; Animals; Enzyme Activation; Excitatory Amino Acid Antagonists; Hippo | 2009 |
Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats.
Topics: Analysis of Variance; Animals; Antithrombin III; Disease Models, Animal; Excitatory Amino Acid Antag | 2010 |
In vitro and in vivo responses of mucosa from the large colon of horses to ischemia and reperfusion.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Colon; Diazepam; Electric Impedance; Horse | 2011 |
Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine.
Topics: Anesthesia; Anesthetics; Animals; Constriction; Coronary Vessels; Female; Fentanyl; Hemodynamics; Is | 2004 |
Effect of ketamine on apoptosis by energy deprivation in astroglioma cells using flow cytometry system.
Topics: Anesthetics, Dissociative; Annexin A5; Apoptosis; Astrocytes; Astrocytoma; Brain; Carbonyl Cyanide m | 2005 |
The effect of ketamine on acute muscular ischaemia reperfusion in rats.
Topics: Anesthetics, Dissociative; Animals; Female; Ischemia; Ketamine; Lipid Peroxidation; Lipid Peroxides; | 2005 |
Use of ketamine for ischemic pain in end-stage renal failure.
Topics: Adult; Analgesics; Humans; Ischemia; Ketamine; Kidney Failure, Chronic; Male; Pain | 2008 |
Effect of mild hypothermia and the 21-aminosteroid U-74389G on neurologic and histopathologic outcome after transient spinal cord ischemia in the rabbit.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Body Temperature; Bo | 1998 |
Ketamine analgesia in vasculitic pain.
Topics: Aged; Aged, 80 and over; Analgesia; Anesthetics, Dissociative; Drug Therapy, Combination; Fatal Outc | 1998 |
Ketamine analgesia, NMDA receptors and the gates of perception.
Topics: Analgesics; Arteriosclerosis; Chronic Disease; Excitatory Amino Acid Antagonists; Humans; Ion Channe | 1998 |
Improvement in inner ear blood flow by nitric oxide following experimentally induced cochlear thrombosis in anesthetized guinea pigs.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Anesthetics, Dissociative; Anesthetics, Intraven | 1998 |
A word of caution in extrapolating the riluzole spinal cord injury protective effects obtained in a rabbit model under ketamine anesthesia.
Topics: Anesthetics, Dissociative; Animals; Cardiopulmonary Bypass; Disease Models, Animal; Drug Synergism; | 1999 |
Influence of anaesthetic agents on the survival of rats following acute ischaemia of the bowel.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Pressure; Carbon Dioxide; Halothane; | 1979 |
Glutamate release in experimental ischaemia of the retina: an approach using microdialysis.
Topics: Amino Acids; Animals; Dialysis; Glutamates; Glutamic Acid; Ischemia; Ketamine; Male; Rabbits; Reperf | 1992 |
Ketamine suppresses ischemic injury in the rabbit retina.
Topics: Animals; Electroretinography; Female; Injections; Intraocular Pressure; Ischemia; Ketamine; Male; Ra | 1992 |
Protecting the ischemic spinal cord during aortic clamping. The influence of anesthetics and hypothermia.
Topics: Anesthetics; Animals; Aorta, Abdominal; Constriction; Halothane; Hypothermia, Induced; Intraoperativ | 1992 |
Effects of taurine and ketamine on bovine retinal membrane lipid peroxidation.
Topics: Animals; Ascorbic Acid; Cadmium; Cadmium Chloride; Calcium; Cattle; Dextromethorphan; Female; Ischem | 1991 |
Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Hypoxia; Injections; Ischemia; Ketamine | 1990 |
N-methyl-D-aspartate receptors mediate responses of rat dorsal horn neurones to hindlimb ischemia.
Topics: Animals; Anterior Horn Cells; Hindlimb; Injections, Spinal; Ischemia; Ketamine; Male; Pain; Physical | 1990 |
Effects of NMDA receptor antagonists following spinal ischemia in the rabbit.
Topics: Animals; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Hindlimb; Ischemia; Keta | 1990 |
Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines.
Topics: Animals; Animals, Newborn; Binding Sites; Brain; Chemical Phenomena; Chemistry; Discrimination, Psyc | 1990 |
Ketamine and retinal ischemia.
Topics: Animals; Ischemia; Ketamine; Perfusion; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |