melatonin and Ischemia studies

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

Excerpt	Relevance	Reference
"These studies demonstrate a significant neuroprotective efficacy of melatonin in term neonatal models of hypoxia-ischaemia, and suggest melatonin is a strong candidate for translation to clinical trials in babies with moderate-severe NE."	9.22	Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia. ( Golay, X; Han, HJ; Meehan, C; Miller, SL; Pang, R; Robertson, NJ, 2022)
"Melatonin promptly reversed ischemia-induced sleep disturbances."	8.02	Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats. ( Hao, SM; Huang, ZL; Qiu, MH; Qu, WM; Sun, FY; Zhong, ZG, 2021)
"The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR)."	8.02	Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model. ( Brandão, JCM; Camargo, CR; Leite, AA; Marinho, M; Oliveira-Junior, IS; Reiter, RJ; Sakae, TM, 2021)
" To address this, we investigated the effect of melatonin on ischemia-induced fibrosis."	7.96	Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. ( Han, YS; Lee, JH; Lee, SH, 2020)
"The article studies the effect of melatonin on the intensity of free radical oxidation, the functioning of the enzymatic components of the antioxidant system and their transcriptional regulation in rats with experimental cerebral ischemia/reperfusion of the brain."	7.91	Transcriptional Regulation of Antioxidant Enzymes Activity and Modulation of Oxidative Stress by Melatonin in Rats Under Cerebral Ischemia / Reperfusion Conditions. ( de Carvalho, MAP; Kryl'skii, ED; Popova, TN; Razuvaev, GA; Safonova, OA; Stolyarova, AO, 2019)
" Study groups were formed as follows: (1) control group, (2) ischemia group, (3) selenium + ischemia group, (4) melatonin + ischemia group, and (5) selenium + melatonin + ischemia group."	7.91	Effects of Selenium and Melatonin on Ocular Ischemic Syndrome. ( Telek, HH, 2019)
"We tested the hypothesis that daily melatonin treatment protects endothelial lineage and functional integrity against the aging process, oxidative stress/endothelial denudation (ED), and toxic environment and restored blood flow in murine critical limb ischemia (CLI)."	7.88	Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice. ( Chai, HT; Chen, KH; Chen, YL; Chua, S; Chung, SY; Huang, CR; Huang, TH; Lee, FY; Li, YC; Luo, CW; Sheu, JJ; Sun, CK; Sung, PH; Yip, HK, 2018)
"Aortic occlusion, Injury, Ischemia/Reperfusion, Liver, Melatonin."	7.83	The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping. ( Adali, F; Bali, A; Celep, RB; Celik, S; Gonul, Y; Koçak, A; Ozkececi, ZT; Ozsoy, M; Tosun, M, 2016)
"Treatment with melatonin reduced/prevented functional and morphological changes induced by chronic ischemia on penile structure and function."	7.83	Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia. ( Andersson, KE; Mitsui, T; Nomiya, M; Sawada, N; Takeda, M; Zarifpour, M, 2016)
"Melatonin exerts a protective effect during hepatic ischemia-reperfusion (I/R) injury through modulation of the apoptotic cell death program."	7.81	Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling. ( Gim, SA; Koh, PO, 2015)
"This experimental study was designed to produce ischemia-reperfusion (I/R) injury in rat corpus cavernosum by inducing 1 h of priapism and investigating the effects of melatonin on the levels of oxidative injury parameters."	7.76	An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. ( Akbas, A; Atılgan, D; Erdemir, F; Erkorkmaz, U; Parlaktas, BS; Uluocak, N; Yasar, A, 2010)
"The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart."	7.73	Ischemia-reperfusion injury--antiarrhythmic effect of melatonin associated with reduced recovering of contractility. ( Béder, I; Pancza, D; Styk, J; Vazan, R, 2005)
" melatonin (4 + 4 mg/kg, after induction of ischemia and at reperfusion onset) administered either alone or in combination with the thrombolytic tissue-plasminogen activator (t-PA, 10 mg/kg), on cerebral laser Doppler flow (LDF) and ischemic injury were studied after 30 min of middle cerebral artery (MCA) thread occlusion in male C57BL/6 mice."	7.72	Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator. ( Hermann, DM; Kilic, E; Kilic, U; Reiter, RJ; Yulug, B, 2004)
"This study was designed to study the effects of Melatonin (Mel) and N-Acetylcystein (NAC) on hepatic ischemia/reperfusion (I/R) injury in rats."	7.72	Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. ( Arbak, S; Ayanoğlu-Dülger, G; Ersoy, Y; Kaçmaz, A; Sehirli, AO; Sener, G; Tosun, O, 2003)
" Herein, we examined the effect of melatonin on the neutrophil apoptosis in ischemia and reperfusion of the human liver."	7.72	Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion. ( Chen, HM; Chen, JC; Chiu, TF; Ng, CJ, 2003)
"As a potent free radical scavenger and antioxidant, melatonin protects brain tissue against ischemia-reperfusion injury, partly via suppression of ischemia-induced production of nitric oxide, when given before ischemia-reperfusion or within 2 hr of onset of ischemia."	7.72	Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. ( Cheung, RT; Pei, Z, 2003)
"Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed."	5.91	Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023)
"Melatonin (15 mg/kg) was administered 5 min after HI."	5.91	MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Dell'Orto, V; Perrone, S; Vanzolini, T; Weiss, MD, 2023)
"Melatonin treatment reversed the harmful effects of hyperglycemia on EPC through adenosine monophosphate-activated protein kinase-related mechanisms to increase eNOS phosphorylation and heme oxygenase-1 expression."	5.72	Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning. ( Chen, CY; Chou, RH; Huang, HL; Huang, PH; Kuo, CS; Lin, SJ; Tsai, HY; Wei, JH, 2022)
"Melatonin treatment significantly inhibited the above changes through modulating α7nAChR."	5.72	Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood-Brain Barrier Through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss. ( Chen, S; Hu, X; Jin, X; Li, F; Li, H; Li, Y; Liu, W; Sun, Y; Zhang, J; Zhang, X; Zhao, X; Zheng, GQ, 2022)
"Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration."	5.62	Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia. ( Cui, K; Huang, R; Liang, X; Lin, J; Liu, Y; Lu, X; Shi, Y; Tang, X; Xu, Y; Ye, D; Yu, S, 2021)
"Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects."	5.42	Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects. ( An, H; Jiang, C; Yang, B; Zhang, H; Zhao, D; Zhou, L, 2015)
"Melatonin has been widely studied as a protective agent against oxidative stress."	5.40	Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. ( Buendia, I; Cuadrado, A; Egea, J; León, R; López, MG; Negredo, P; Parada, E; Romero, A, 2014)
"Melatonin augmented the increase in the eNOS mRNA level, whereas it reduced the increase in the iNOS mRNA level."	5.34	Effect of melatonin on altered expression of vasoregulatory genes during hepatic ischemia/reperfusion. ( Choi, SM; Lee, SM; Park, SW, 2007)
"Melatonin was either infused during both the ischemia and reperfusion periods or only late in the ischemia period and throughout reperfusion."	5.30	Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. ( El-Sokkary, GH; Kim, SJ; Manchester, LC; Qi, W; Reiter, RJ; Tan, DX, 1998)
"These studies demonstrate a significant neuroprotective efficacy of melatonin in term neonatal models of hypoxia-ischaemia, and suggest melatonin is a strong candidate for translation to clinical trials in babies with moderate-severe NE."	5.22	Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia. ( Golay, X; Han, HJ; Meehan, C; Miller, SL; Pang, R; Robertson, NJ, 2022)
" This study aimed to determine the rate of fat peroxidation and tissue protein as an indicator of tissue degradation after ischemia and reperfusion following induction of superior mesenteric artery occlusion in the intestine and to evaluate the protective effect of melatonin as a free radical scavenger and antioxidants in rats."	4.12	Protective effect of melatonin as an antioxidant in the intestine of rats with superior mesenteric arterial occlusion. ( Xi, Z; Yu, B; Yuan, X, 2022)
"The aim of this experiment was to investigate the role of melatonin and spirulina on multiorgan damage induced by ischemia/reperfusion injury (IR) in a rat model."	4.12	Protective role of melatonin and spirulina in aortic occlusion-reperfusion model in rats. ( Akduman, H; Dilli, D; Salar, S; Sarı, E; Taşoğlu, İ; Tümer, NB; Yumuşak, N, 2022)
"Melatonin promptly reversed ischemia-induced sleep disturbances."	4.02	Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats. ( Hao, SM; Huang, ZL; Qiu, MH; Qu, WM; Sun, FY; Zhong, ZG, 2021)
"The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR)."	4.02	Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model. ( Brandão, JCM; Camargo, CR; Leite, AA; Marinho, M; Oliveira-Junior, IS; Reiter, RJ; Sakae, TM, 2021)
" To address this, we investigated the effect of melatonin on ischemia-induced fibrosis."	3.96	Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. ( Han, YS; Lee, JH; Lee, SH, 2020)
"The article studies the effect of melatonin on the intensity of free radical oxidation, the functioning of the enzymatic components of the antioxidant system and their transcriptional regulation in rats with experimental cerebral ischemia/reperfusion of the brain."	3.91	Transcriptional Regulation of Antioxidant Enzymes Activity and Modulation of Oxidative Stress by Melatonin in Rats Under Cerebral Ischemia / Reperfusion Conditions. ( de Carvalho, MAP; Kryl'skii, ED; Popova, TN; Razuvaev, GA; Safonova, OA; Stolyarova, AO, 2019)
" Study groups were formed as follows: (1) control group, (2) ischemia group, (3) selenium + ischemia group, (4) melatonin + ischemia group, and (5) selenium + melatonin + ischemia group."	3.91	Effects of Selenium and Melatonin on Ocular Ischemic Syndrome. ( Telek, HH, 2019)
"Treatment with melatonin reduced/prevented functional and morphological changes induced by chronic ischemia on penile structure and function."	3.83	Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia. ( Andersson, KE; Mitsui, T; Nomiya, M; Sawada, N; Takeda, M; Zarifpour, M, 2016)
"Aortic occlusion, Injury, Ischemia/Reperfusion, Liver, Melatonin."	3.83	The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping. ( Adali, F; Bali, A; Celep, RB; Celik, S; Gonul, Y; Koçak, A; Ozkececi, ZT; Ozsoy, M; Tosun, M, 2016)
"Melatonin exerts a protective effect during hepatic ischemia-reperfusion (I/R) injury through modulation of the apoptotic cell death program."	3.81	Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling. ( Gim, SA; Koh, PO, 2015)
" The rats were then randomly allocated to fracture, fracture-ischemia, fracture- ischemia-melatonin, and fracture-ischemia-CAPE groups."	3.80	The effects of melatonin and caffeic acid phenethyl ester (CAPE) on fracture healing under ischemic conditions. ( Aşçı, M; Bostan, B; Erdem, M; Gülabi, D; Güneş, T; Köseoğlu, RD, 2014)
"This experimental study was designed to produce ischemia-reperfusion (I/R) injury in rat corpus cavernosum by inducing 1 h of priapism and investigating the effects of melatonin on the levels of oxidative injury parameters."	3.76	An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. ( Akbas, A; Atılgan, D; Erdemir, F; Erkorkmaz, U; Parlaktas, BS; Uluocak, N; Yasar, A, 2010)
"The effect of melatonin on reperfusion arrhythmias and postischemic contractile dysfunction was studied in the isolated rat heart."	3.73	Ischemia-reperfusion injury--antiarrhythmic effect of melatonin associated with reduced recovering of contractility. ( Béder, I; Pancza, D; Styk, J; Vazan, R, 2005)
" Herein, we examined the effect of melatonin on the neutrophil apoptosis in ischemia and reperfusion of the human liver."	3.72	Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion. ( Chen, HM; Chen, JC; Chiu, TF; Ng, CJ, 2003)
"This study was designed to study the effects of Melatonin (Mel) and N-Acetylcystein (NAC) on hepatic ischemia/reperfusion (I/R) injury in rats."	3.72	Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. ( Arbak, S; Ayanoğlu-Dülger, G; Ersoy, Y; Kaçmaz, A; Sehirli, AO; Sener, G; Tosun, O, 2003)
" melatonin (4 + 4 mg/kg, after induction of ischemia and at reperfusion onset) administered either alone or in combination with the thrombolytic tissue-plasminogen activator (t-PA, 10 mg/kg), on cerebral laser Doppler flow (LDF) and ischemic injury were studied after 30 min of middle cerebral artery (MCA) thread occlusion in male C57BL/6 mice."	3.72	Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator. ( Hermann, DM; Kilic, E; Kilic, U; Reiter, RJ; Yulug, B, 2004)
"Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which results in high amounts of circulating reactive oxygen species (ROS) and reactive nitrogen species (RNS)."	2.66	Oxidative stress: Normal pregnancy versus preeclampsia. ( Abad, C; Chiarello, DI; Marín, R; Mate, A; Rojas, D; Sobrevia, L; Toledo, F; Vázquez, CM, 2020)
"Melatonin (15 mg/kg) was administered 5 min after HI."	1.91	MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia. ( Albertini, MC; Balduini, W; Buonocore, G; Carloni, S; Dell'Orto, V; Perrone, S; Vanzolini, T; Weiss, MD, 2023)
"Finally, hemodynamic index changes, infarct size, CK-MB levels, mitochondrial functional endpoints, and expression of mitochondrial biogenesis genes (SIRT-1/PGC-1α/NRF-2/TFAM) were assessed."	1.91	Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. ( Badalzadeh, R; Chodari, L; Ghaffari, S; Høilund-Carlsen, PF; Mokhtari, B; Yasami, M, 2023)
"Melatonin treatment reversed the harmful effects of hyperglycemia on EPC through adenosine monophosphate-activated protein kinase-related mechanisms to increase eNOS phosphorylation and heme oxygenase-1 expression."	1.72	Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning. ( Chen, CY; Chou, RH; Huang, HL; Huang, PH; Kuo, CS; Lin, SJ; Tsai, HY; Wei, JH, 2022)
"Melatonin treatment significantly inhibited the above changes through modulating α7nAChR."	1.72	Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood-Brain Barrier Through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss. ( Chen, S; Hu, X; Jin, X; Li, F; Li, H; Li, Y; Liu, W; Sun, Y; Zhang, J; Zhang, X; Zhao, X; Zheng, GQ, 2022)
"Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration."	1.62	Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia. ( Cui, K; Huang, R; Liang, X; Lin, J; Liu, Y; Lu, X; Shi, Y; Tang, X; Xu, Y; Ye, D; Yu, S, 2021)
"Treatment with melatonin rescued replicative senescence by enhancing mitophagy and mitochondrial function through upregulation of heat shock 70 kDa protein 1L (HSPA1L)."	1.56	Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway. ( Lee, JH; Lee, SH; Noh, H; Song, KH; Yoon, YM, 2020)
"Melatonin is a free radical scavenger and broad-spectrum antioxidant with immunomodulatory effects."	1.42	Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects. ( An, H; Jiang, C; Yang, B; Zhang, H; Zhao, D; Zhou, L, 2015)
"Melatonin has been widely studied as a protective agent against oxidative stress."	1.40	Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. ( Buendia, I; Cuadrado, A; Egea, J; León, R; López, MG; Negredo, P; Parada, E; Romero, A, 2014)
"Melatonin augmented the increase in the eNOS mRNA level, whereas it reduced the increase in the iNOS mRNA level."	1.34	Effect of melatonin on altered expression of vasoregulatory genes during hepatic ischemia/reperfusion. ( Choi, SM; Lee, SM; Park, SW, 2007)
"Melatonin treatment in I/R rats reversed these changes (P < 0."	1.32	Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats. ( Kaçmaz, A; Ozkan, S; Sener, G; Tilki, M; User, Y; Yeğen, BC, 2003)
"Melatonin and PGE1 were found to be effective in reducing the hepatic ischaemia reperfusion damage in rats."	1.32	The effects of melatonin and prostaglandin E1 analogue on experimental hepatic ischaemia reperfusion damage. ( Akkus, MA; Aygen, E; Bülbüller, N; Cetinkaya, Z; Cifter, C; Dogru, O; Ilhan, YS, 2003)
"Melatonin was either infused during both the ischemia and reperfusion periods or only late in the ischemia period and throughout reperfusion."	1.30	Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. ( El-Sokkary, GH; Kim, SJ; Manchester, LC; Qi, W; Reiter, RJ; Tan, DX, 1998)

Research

Studies (61)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants With Delayed Recovery of Liver Function

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (4.92)	18.2507
2000's	13 (21.31)	29.6817
2010's	22 (36.07)	24.3611
2020's	23 (37.70)	2.80

Authors	Studies
Sarı, E	1
Dilli, D	1
Taşoğlu, İ	1
Akduman, H	1
Yumuşak, N	1
Tümer, NB	1
Salar, S	1
Hao, SM	1
Zhong, ZG	1
Qu, WM	1
Huang, ZL	1
Sun, FY	1
Qiu, MH	1
Hosseinzadeh, MH	1
Goodarzi, A	1
Malekan, M	1
Ebrahimzadeh, MA	1
Pang, R	2
Han, HJ	1
Meehan, C	1
Golay, X	1
Miller, SL	1
Robertson, NJ	2
Yuan, X	1
Xi, Z	1
Yu, B	1
Bseiso, EA	1
AbdEl-Aal, SA	1
Nasr, M	1
Sammour, OA	1
El Gawad, NAA	1
Peña-Mercado, E	1
Garcia-Lorenzana, M	1
Huerta-Yepez, S	1
Cruz-Ledesma, A	1
Beltran-Vargas, NE	1
Coskun, A	1
Yegen, C	1
Arbak, S	2
Attaallah, W	1
Gunal, O	1
Elmas, MA	1
Ucal, Y	1
Can, O	1
Baş, B	1
Yildirim, Z	1
Seckin, I	1
Demirci, S	1
Serteser, M	1
Ozpinar, A	1
Belce, A	1
Basdemir, G	1
Moldur, DE	1
Derelioglu, EI	1
Yozgatli, TK	1
Erdemgil, Y	1
Unsal, I	1
Zhang, T	1
Ouyang, H	1
Liu, S	1
Xiong, L	1
Zhong, Z	1
Wang, Q	1
Qiu, Z	1
Ding, Y	1
Zhou, W	1
Wang, X	1
Kuo, CS	1
Chen, CY	1
Huang, HL	1
Tsai, HY	1
Chou, RH	1
Wei, JH	1
Huang, PH	1
Lin, SJ	1
Luchetti, F	3
Nasoni, MG	3
Burattini, S	3
Mohammadi, A	3
Pagliarini, M	3
Canonico, B	3
Ambrogini, P	3
Balduini, W	4
Reiter, RJ	7
Carloni, S	4
Mokhtari, B	1
Høilund-Carlsen, PF	1
Chodari, L	1
Yasami, M	1
Badalzadeh, R	1
Ghaffari, S	1
Yang, H	1
Zhang, Z	1
Ding, X	1
Jiang, X	1
Tan, L	1
Lin, C	1
Xu, L	1
Li, G	1
Lu, L	1
Qin, Z	1
Feng, X	1
Li, M	1
Zhang, H	2
Li, S	1
Jin, Y	1
Sabir, H	1
Maes, E	1
Zweyer, M	1
Schleehuber, Y	1
Imam, FB	1
Silverman, J	1
White, Y	1
Pasca, AM	1
Maltepe, E	1
Bernis, ME	1
Albertini, MC	1
Vanzolini, T	1
Perrone, S	1
Weiss, MD	1
Buonocore, G	1
Dell'Orto, V	1
Azedi, F	1
Mehrpour, M	1
Talebi, S	1
Zendedel, A	1
Kazemnejad, S	1
Mousavizadeh, K	1
Beyer, C	1
Zarnani, AH	1
Joghataei, MT	1
Telek, HH	1
Lee, JH	4
Yoon, YM	2
Song, KH	1
Noh, H	1
Lee, SH	4
Han, YS	3
Lin, Y	1
Liu, J	2
Bai, R	1
Shi, J	1
Zhu, X	1
Guo, J	1
Zhang, W	1
Liu, H	1
Liu, Z	1
Huang, R	1
Xu, Y	1
Lu, X	1
Tang, X	1
Lin, J	1
Cui, K	1
Yu, S	1
Shi, Y	1
Ye, D	1
Liu, Y	1
Liang, X	1
Leite, AA	1
Brandão, JCM	1
Sakae, TM	1
Marinho, M	1
Camargo, CR	1
Oliveira-Junior, IS	1
Chen, S	1
Sun, Y	1
Li, F	1
Zhang, X	2
Hu, X	1
Zhao, X	1
Li, Y	1
Li, H	1
Zhang, J	1
Liu, W	1
Zheng, GQ	1
Jin, X	1
Lee, FY	1
Sun, CK	2
Sung, PH	2
Chen, KH	1
Chua, S	1
Sheu, JJ	1
Chung, SY	1
Chai, HT	1
Chen, YL	1
Huang, TH	1
Huang, CR	1
Li, YC	1
Luo, CW	1
Yip, HK	2
Jung, SK	1
Chiarello, DI	1
Abad, C	1
Rojas, D	1
Toledo, F	1
Vázquez, CM	1
Mate, A	1
Sobrevia, L	1
Marín, R	1
Kryl'skii, ED	1
Popova, TN	1
Safonova, OA	1
Stolyarova, AO	1
Razuvaev, GA	1
de Carvalho, MAP	1
Ritzenthaler, T	1
Lhommeau, I	1
Douillard, S	1
Cho, TH	1
Brun, J	1
Patrice, T	1
Nighoghossian, N	1
Claustrat, B	1
Hemadi, M	1
Shokri, S	1
Moramezi, F	1
Nikbakht, R	1
Sobhani, A	1
Parada, E	1
Buendia, I	1
León, R	1
Negredo, P	1
Romero, A	1
Cuadrado, A	1
López, MG	1
Egea, J	1
Erdem, M	1
Gülabi, D	1
Aşçı, M	1
Bostan, B	1
Güneş, T	1
Köseoğlu, RD	1
Griebling, TL	1
Wang, F	1
Zhou, H	1
Du, Z	1
Chen, X	1
Zhu, F	1
Wang, Z	1
Zhang, Y	1
Lin, L	1
Qian, M	1
Li, X	1
Hao, A	1
Halladin, NL	1
Gim, SA	1
Koh, PO	1
Zhou, L	1
Zhao, D	1
An, H	1
Jiang, C	1
Yang, B	1
Sawada, N	2
Nomiya, M	2
Zarifpour, M	2
Mitsui, T	1
Takeda, M	1
Andersson, KE	2
Ozsoy, M	1
Gonul, Y	1
Ozkececi, ZT	1
Bali, A	1
Celep, RB	1
Koçak, A	1
Adali, F	1
Tosun, M	1
Celik, S	1
Lee, MS	1
Yin, TC	1
Chiang, JY	1
Uluocak, N	1
Atılgan, D	1
Erdemir, F	1
Parlaktas, BS	1
Yasar, A	1
Erkorkmaz, U	1
Akbas, A	1
Deykun, K	1
Pometlova, M	1
Schutova, B	1
Mares, J	1
Tao, RR	1
Huang, JY	1
Shao, XJ	1
Ye, WF	1
Tian, Y	1
Liao, MH	1
Fukunaga, K	1
Lou, YJ	1
Han, F	1
Lu, YM	1
Burmeister, DM	1
Campeau, L	1
Yamaguchi, O	1
Jaworek, J	1
Leja-Szpak, A	1
Bonior, J	1
Nawrot, K	1
Tomaszewska, R	1
Stachura, J	1
Sendur, R	1
Pawlik, W	1
Brzozowski, T	1
Konturek, SJ	1
Pei, Z	1
Cheung, RT	1
Chen, JC	1
Ng, CJ	1
Chiu, TF	1
Chen, HM	1
Sener, G	2
Tosun, O	1
Sehirli, AO	1
Kaçmaz, A	2
Ersoy, Y	1
Ayanoğlu-Dülger, G	1
Okatani, Y	1
Wakatsuki, A	1
Enzan, H	1
Miyahara, Y	1
User, Y	1
Ozkan, S	1
Tilki, M	1
Yeğen, BC	1
Bülbüller, N	1
Cetinkaya, Z	1
Akkus, MA	1
Cifter, C	1
Ilhan, YS	1
Dogru, O	1
Aygen, E	1
Kilic, E	1
Kilic, U	1
Yulug, B	1
Hermann, DM	1
Ates, B	1
Yilmaz, I	1
Geckil, H	1
Iraz, M	1
Birincioglu, M	1
Fiskin, K	1
Barun, S	1
Ekingen, G	1
Mert Vural, I	1
Türkyilmaz, Z	1
Başaklar, C	1
Kale, N	1
Sevim Ercan, Z	1
Sarioğlu, Y	1
Vazan, R	1
Pancza, D	1
Béder, I	1
Styk, J	1
Park, SW	1
Choi, SM	1
Lee, SM	1
Mias, C	1
Trouche, E	1
Seguelas, MH	1
Calcagno, F	1
Dignat-George, F	1
Sabatier, F	1
Piercecchi-Marti, MD	1
Daniel, L	1
Bianchi, P	1
Calise, D	1
Bourin, P	1
Parini, A	1
Cussac, D	1
Cazevieille, C	1
Osborne, NN	1
Tan, DX	1
Manchester, LC	1
Qi, W	1
Kim, SJ	1
El-Sokkary, GH	1
Lopez-Gonzalez, MA	1
Guerrero, JM	1
Rojas, F	1
Osuna, C	1
Delgado, F	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Determine the Effects of Selenium and Melatonin on Ocular Ischemic Syndrome[NCT04005222]	Early Phase 1	28 participants (Actual)	Interventional	2014-05-31	Completed
The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial[NCT03386435]		160 participants (Actual)	Interventional	2016-08-22	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The incidence of delayed recovery of hepatic function (DRHF) were used as surrogate parameters indicating the possible benefits of RIPC. DRHF was defined based on a proposal by the International Study Group of Liver Surgery, as follows: an impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased PT INR and concomitant hyperbilirubinemia (considering the normal limits of the local laboratory) on or after postoperative day 5. The normal upper limits of PT and bilirubin in our institutional laboratory were 1.30 INR and 1.2 mg/dL, respectively. If either the PT INR or serum bilirubin concentration was preoperatively elevated, DRHF was defined by an increasing PT INR and increasing serum bilirubin concentration on or after postoperative day 5 (compared with the values of the previous day). (NCT03386435)
Timeframe: postoperative 7 days

Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days

Intervention	Participants (Count of Participants)
RIPC	5
Control	0

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal aspartate aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy. (NCT03386435)
Timeframe: within 7 days after operation

Postoperative Liver Regeneration

Intervention	IU/L (Mean)
RIPC	145
Control	152

The postoperative liver regeneration index (LRI) at postoperative 1 month ) was used as surrogate parameters indicating the possible benefits of RIPC. The LRI was defined as [(VLR - VFLR)/VFLR)] × 100, where VLR is the volume of the liver remnant and VFLR is the volume of the future liver remnant. Liver volume was calculated by CT volumetry using 3-mm-thick dynamic CT images. The graft weight was subtracted from the total liver volume to define the future liver remnant. (NCT03386435)
Timeframe: 1 month

The Maximal Alanine Aminotransferase Level Within 7 Postoperative Days

Intervention	percentage of liver volume (Mean)
RIPC	83.3
Control	94.9

The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal alanine aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy (NCT03386435)
Timeframe: within 7 days after operation

Article	Year
Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia. Annals of clinical and translational neurology, 2022, Volume: 9, Issue:6 Topics: Animals; Brain Diseases; Humans; Hypothermia, Induced; Hypoxia; Infant, Newborn; Infant, Newborn, Di	2022
Oxidative stress: Normal pregnancy versus preeclampsia. Biochimica et biophysica acta. Molecular basis of disease, 2020, 02-01, Volume: 1866, Issue:2 Topics: Animals; Antioxidants; Endothelial Cells; Female; Free Radicals; Humans; Ischemia; Melatonin; Oxidat	2020
Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries. Danish medical journal, 2015, Volume: 62, Issue:4 Topics: Angioplasty, Balloon, Coronary; Animals; Antioxidants; Disease Models, Animal; Female; Humans; Infla	2015
Melatonin enhances survival and preserves functional integrity of stem cells: A review. Journal of pineal research, 2017, Volume: 62, Issue:2 Topics: Animals; Antioxidants; Humans; Ischemia; Melatonin; Stem Cell Transplantation; Stem Cells	2017

Article	Year
Protective role of melatonin and spirulina in aortic occlusion-reperfusion model in rats. Journal of food biochemistry, 2022, Volume: 46, Issue:4 Topics: Animals; Antioxidants; Female; Ischemia; Male; Melatonin; Rats; Rats, Wistar; Reperfusion; Reperfusi	2022
Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats. Brain and behavior, 2021, Volume: 11, Issue:10 Topics: Animals; Circadian Rhythm; Dietary Supplements; Ischemia; Male; Melatonin; Rats; Rats, Sprague-Dawle	2021
Melatonin increased hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase: A hypothesis for treating anaemia, ischaemia, and covid-19. Clinical and experimental pharmacology & physiology, 2022, Volume: 49, Issue:6 Topics: Anemia; COVID-19; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Melatonin; P	2022
Protective effect of melatonin as an antioxidant in the intestine of rats with superior mesenteric arterial occlusion. Cellular and molecular biology (Noisy-le-Grand, France), 2022, Jan-02, Volume: 67, Issue:4 Topics: Animals; Antioxidants; Intestines; Ischemia; Male; Malondialdehyde; Melatonin; Rats; Rats, Wistar; R	2022
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality. Drug delivery, 2022, Volume: 29, Issue:1 Topics: Animals; Brain; Brain Ischemia; Ischemia; Lipids; Melatonin; Nanocapsules; Sheep	2022
Effect of melatonin on electrical impedance and biomarkers of damage in a gastric ischemia/reperfusion model. PloS one, 2022, Volume: 17, Issue:8 Topics: Animals; Biomarkers; Critical Illness; Electric Impedance; Gastric Mucosa; Ischemia; Male; Melatonin	2022
Melatonin in preservation solutions prevents ischemic injury in rat kidneys. PloS one, 2022, Volume: 17, Issue:8 Topics: Adenosine; Allopurinol; Animals; Glucosamine; Glucose; Glutathione; Histidine; Insulin; Ischemia; Ki	2022
pH/Thermosensitive dual-responsive hydrogel based sequential delivery for site-specific acute limb ischemia treatment. Journal of materials chemistry. B, 2022, 10-05, Volume: 10, Issue:38 Topics: Alginates; Allyl Compounds; Cellulose; Delayed-Action Preparations; Humans; Hydrogels; Hydrogen Sulf	2022
Melatonin Improves Ischemia-Induced Circulation Recovery Impairment in Mice with Streptozotocin-Induced Diabetes by Improving the Endothelial Progenitor Cells Functioning. International journal of molecular sciences, 2022, Aug-30, Volume: 23, Issue:17 Topics: Animals; Diabetes Mellitus, Experimental; Endothelial Progenitor Cells; Hindlimb; Humans; Hydrogen P	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin Attenuates Ischemic-like Cell Injury by Promoting Autophagosome Maturation via the Sirt1/FoxO1/Rab7 Axis in Hippocampal HT22 Cells and in Organotypic Cultures. Cells, 2022, 11-21, Volume: 11, Issue:22 Topics: Autophagosomes; Forkhead Box Protein O1; Hippocampus; Humans; Ischemia; Melatonin; Sirtuin 1	2022
Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat. Molecular biology reports, 2023, Volume: 50, Issue:4 Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Infarction; Ischemia; Male; Mel	2023
RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats. Journal of pineal research, 2023, Volume: 75, Issue:1 Topics: Animals; Animals, Newborn; ARNTL Transcription Factors; Arylalkylamine N-Acetyltransferase; Circadia	2023
Remote ischemic preconditioning-induced late cardioprotection: possible role of melatonin-mitoKATP-H2S signaling pathway. Acta cirurgica brasileira, 2023, Volume: 38 Topics: Animals; Ischemia; Ischemic Preconditioning; Ischemic Preconditioning, Myocardial; KATP Channels; Me	2023
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial. Scientific reports, 2023, 06-10, Volume: 13, Issue:1 Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemas	2023
MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia. Journal of molecular neuroscience : MN, 2023, Volume: 73, Issue:9-10 Topics: Animals; Animals, Newborn; Biomarkers; Brain; Brain Injuries; Female; Hypoxia-Ischemia, Brain; Ische	2023
Melatonin regulates neuroinflammation ischemic stroke damage through interactions with microglia in reperfusion phase. Brain research, 2019, 11-15, Volume: 1723 Topics: Animals; Brain Ischemia; Inflammation; Ischemia; Male; Melatonin; Microglia; Neuroimmunomodulation;	2019
Effects of Selenium and Melatonin on Ocular Ischemic Syndrome. BioMed research international, 2019, Volume: 2019 Topics: Aged; Aged, 80 and over; Eye; Female; Glutathione; Humans; Ischemia; Male; Malondialdehyde; Melatoni	2019
Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the HSPA1L-mitophagy pathway. Aging cell, 2020, Volume: 19, Issue:3 Topics: Animals; Cells, Cultured; Cellular Senescence; Disease Models, Animal; Gene Knockdown Techniques; HS	2020
Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. Biochemical and biophysical research communications, 2020, 04-30, Volume: 525, Issue:2 Topics: Animals; Fibrosis; Inflammation; Ischemia; Melatonin; Mice; MicroRNAs; Myoblasts; Peroxisome Prolife	2020
Mitochondria-Inspired Nanoparticles with Microenvironment-Adapting Capacities for On-Demand Drug Delivery after Ischemic Injury. ACS nano, 2020, 09-22, Volume: 14, Issue:9 Topics: Drug Delivery Systems; Humans; Ischemia; Melatonin; Mitochondria; Nanoparticles; Pharmaceutical Prep	2020
Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia. Journal of pineal research, 2021, Volume: 71, Issue:1 Topics: Animals; Animals, Newborn; Hypoxia; Ischemia; Melatonin; Mice; Mice, Inbred C57BL; Neuroprotective A	2021
Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model. Clinics (Sao Paulo, Brazil), 2021, Volume: 76 Topics: Acetylcysteine; Acute Lung Injury; Animals; Ischemia; Melatonin; Rats; Rats, Wistar; Reperfusion; Re	2021
Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood-Brain Barrier Through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss. Cellular and molecular neurobiology, 2022, Volume: 42, Issue:7 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood-Brain Barrier; HMGB1 Protein; Ischemia; Isch	2022
Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice. Journal of pineal research, 2018, Volume: 65, Issue:2 Topics: Animals; Cellular Senescence; Endothelial Cells; Hindlimb; Ischemia; Male; Melatonin; Mice; Oxidativ	2018
Melatonin protects mesenchymal stem cells from autophagy-mediated death under ischaemic ER-stress conditions by increasing prion protein expression. Cell proliferation, 2019, Volume: 52, Issue:2 Topics: Animals; Antioxidants; Autophagy; Cells, Cultured; Endoplasmic Reticulum Stress; Hindlimb; Ischemia;	2019
Transcriptional Regulation of Antioxidant Enzymes Activity and Modulation of Oxidative Stress by Melatonin in Rats Under Cerebral Ischemia / Reperfusion Conditions. Neuroscience, 2019, 05-15, Volume: 406 Topics: Animals; Antioxidants; Brain; Brain Ischemia; Free Radicals; Ischemia; Male; Melatonin; Nerve Tissue	2019
Dynamics of oxidative stress and urinary excretion of melatonin and its metabolites during acute ischemic stroke. Neuroscience letters, 2013, Jun-07, Volume: 544 Topics: Aged; Comorbidity; Female; France; Humans; Ischemia; Male; Melatonin; Metabolism; Middle Aged; Oxida	2013
Potential use of melatonin supplementation to protect vitrified testicular grafts from hypoxic-ischaemic damage. Andrologia, 2014, Volume: 46, Issue:5 Topics: Animals; Culture Media; Hypoxia; In Situ Nick-End Labeling; In Vitro Techniques; Ischemia; Male; Mel	2014
Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression. Journal of pineal research, 2014, Volume: 56, Issue:2 Topics: Animals; CA1 Region, Hippocampal; Cell Line, Tumor; Cells, Cultured; Glucose; Heme Oxygenase-1; Huma	2014
The effects of melatonin and caffeic acid phenethyl ester (CAPE) on fracture healing under ischemic conditions. Acta orthopaedica et traumatologica turcica, 2014, Volume: 48, Issue:3 Topics: Animals; Antioxidants; Caffeic Acids; Disease Models, Animal; Fracture Fixation, Intramedullary; Fra	2014
Re: Effect of melatonin on chronic bladder-ischaemia-associated changes in rat bladder function. The Journal of urology, 2014, Volume: 192, Issue:2 Topics: Animals; Ischemia; Male; Melatonin; Urinary Bladder	2014
Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. European journal of pharmacology, 2015, Feb-05, Volume: 748 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Hypoxia; Cell Survival; Cellular Mic	2015
Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling. The Journal of surgical research, 2015, Volume: 198, Issue:1 Topics: Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemia; Liver; M	2015
Melatonin prevents lung injury induced by hepatic ischemia-reperfusion through anti-inflammatory and anti-apoptosis effects. International immunopharmacology, 2015, Volume: 29, Issue:2 Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Cytoki	2015
Melatonin Improves Erectile Function in Rats With Chronic Lower Body Ischemia. The journal of sexual medicine, 2016, Volume: 13, Issue:2 Topics: Animals; Antioxidants; Atherosclerosis; Cholesterol, Dietary; Chronic Disease; Disease Models, Anima	2016
The protective effect of melatonin on remote organ liver ischemia and reperfusion injury following aortic clamping. Annali italiani di chirurgia, 2016, Volume: 87 Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Aorta, Abdominal; Aspartate A	2016
Potentiation of biological effects of mesenchymal stem cells in ischemic conditions by melatonin via upregulation of cellular prion protein expression. Journal of pineal research, 2017, Volume: 62, Issue:2 Topics: Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Proliferation; Disease Models, Animal; Flo	2017
An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. International urology and nephrology, 2010, Volume: 42, Issue:4 Topics: Animals; Antioxidants; Disease Models, Animal; Ischemia; Male; Melatonin; Penis; Priapism; Rats; Rat	2010
Modulations of behavioral consequences of minor cortical ischemic lesion by application of free radicals scavengers. General physiology and biophysics, 2011, Volume: 30, Issue:3 Topics: Animals; Behavior, Animal; Brain Ischemia; Cognition; Cyclic N-Oxides; Feedback, Sensory; Free Radic	2011
Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial cells: a potential vasoprotective effect of melatonin. Journal of pineal research, 2013, Volume: 54, Issue:3 Topics: Analysis of Variance; Antioxidants; Cell Line; Endothelial Cells; Glucose; Histocytochemistry; Human	2013
Effect of melatonin on chronic bladder-ischaemia-associated changes in rat bladder function. BJU international, 2013, Volume: 112, Issue:2 Topics: Animals; Chronic Disease; Ischemia; Male; Melatonin; Rats; Rats, Sprague-Dawley; Urinary Bladder	2013
Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion. Journal of pineal research, 2003, Volume: 34, Issue:1 Topics: Adjuvants, Immunologic; Animals; Ceruletide; Interleukin-10; Ischemia; Male; Melatonin; Pancreas; Pa	2003
Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. Journal of pineal research, 2003, Volume: 34, Issue:3 Topics: Animals; Astrocytes; Cell Death; Cell Hypoxia; Cells, Cultured; Dose-Response Relationship, Drug; Gl	2003
Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion. Journal of pineal research, 2003, Volume: 34, Issue:4 Topics: Apoptosis; CD18 Antigens; Cells, Cultured; Cholecystectomy, Laparoscopic; Hepatectomy; Humans; Ische	2003
Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life sciences, 2003, May-02, Volume: 72, Issue:24 Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Female; Free Radical Scavengers; Glutathione; Isc	2003
Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver. European journal of pharmacology, 2003, May-23, Volume: 469, Issue:1-3 Topics: Animals; Ischemia; Liver; Male; Melatonin; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Reperfus	2003
Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats. Journal of pineal research, 2003, Volume: 35, Issue:3 Topics: Abdomen; Animals; Compartment Syndromes; Free Radical Scavengers; Glutathione; Ischemia; Lipid Perox	2003
The effects of melatonin and prostaglandin E1 analogue on experimental hepatic ischaemia reperfusion damage. International journal of clinical practice, 2003, Volume: 57, Issue:10 Topics: Alanine Transaminase; Alprostadil; Animals; Antioxidants; Aspartate Aminotransferases; Erythrocytes;	2003
Melatonin reduces disseminate neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable as an add-on treatment to tissue-plasminogen activator. Journal of pineal research, 2004, Volume: 36, Issue:3 Topics: Animals; Brain Ischemia; Caspase 3; Caspase Inhibitors; Cell Death; Coronary Disease; Corpus Striatu	2004
Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage. Journal of pineal research, 2004, Volume: 37, Issue:3 Topics: Animals; Antioxidants; Catalase; Glutathione Peroxidase; Intestinal Mucosa; Intestines; Ischemia; Li	2004
The effects of melatonin on electrical field stimulation-evoked biphasic twitch responses in the ipsilateral and contralateral rat vasa deferentia after unilateral testicular torsion/detorsion. Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 371, Issue:5 Topics: Animals; Antioxidants; Electric Stimulation; Ischemia; Male; Melatonin; Muscle Contraction; Rats; Ra	2005
Ischemia-reperfusion injury--antiarrhythmic effect of melatonin associated with reduced recovering of contractility. General physiology and biophysics, 2005, Volume: 24, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Free Radical Scavengers; Ischemia; Male; Mela	2005
Effect of melatonin on altered expression of vasoregulatory genes during hepatic ischemia/reperfusion. Archives of pharmacal research, 2007, Volume: 30, Issue:12 Topics: Alanine Transaminase; Animals; Carbon Monoxide; Gene Expression Regulation; Heme Oxygenase-1; Ischem	2007
Ex vivo pretreatment with melatonin improves survival, proangiogenic/mitogenic activity, and efficiency of mesenchymal stem cells injected into ischemic kidney. Stem cells (Dayton, Ohio), 2008, Volume: 26, Issue:7 Topics: Animals; Bone Marrow Cells; Cell Proliferation; Cell Survival; Fibroblast Growth Factor 2; Hepatocyt	2008
Retinal neurones containing kainate receptors are influenced by exogenous kainate and ischaemia while neurones lacking these receptors are not -- melatonin counteracts the effects of ischaemia and kainate. Brain research, 1997, Apr-25, Volume: 755, Issue:1 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; I	1997
Ischemia/reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. Journal of pineal research, 1998, Volume: 25, Issue:3 Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Ascorbic Acid; Dose-Response Relationship, Drug; Free R	1998
Melatonin and other antioxidants prolong the postmortem activity of the outer hair cells of the organ of Corti: its relation to the type of death. Journal of pineal research, 1999, Volume: 27, Issue:2 Topics: Animals; Antioxidants; Female; Hair Cells, Auditory, Outer; Ischemia; Melatonin; Otoacoustic Emissio	1999

melatonin and Ischemia