pd 98059 has been researched along with Ischemia in 11 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin exerts a protective effect during hepatic ischemia-reperfusion (I/R) injury through modulation of the apoptotic cell death program." | 7.81 | Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling. ( Gim, SA; Koh, PO, 2015) |
| "Melatonin exerts a protective effect during hepatic ischemia-reperfusion (I/R) injury through modulation of the apoptotic cell death program." | 3.81 | Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling. ( Gim, SA; Koh, PO, 2015) |
| " In vivo experiments in rats revealed that Egr-1 protein increases, whereas 11beta-HSD2 mRNA decreases, in kidney tissue after unilateral renal ischemia and in humans the renal activity of 11beta-HSD2 as assessed by the urinary ratio of (tetrahydrocortisol+5alpha-tetrahydrocortisol)/tetrahydrocortisone declined when volunteers were exposed to hypoxemia at high altitude up to 7000 m." | 3.72 | Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1. ( Dick, B; Ferrari, P; Frey, BM; Frey, FJ; Heiniger, CD; Kostadinova, RM; Rochat, MK; Serra, A, 2003) |
| "Quercitrin treatment also increased the expression of E-cadherin, and PD98059 abrogated the upregulation of E-cadherin induced by quercitrin." | 1.43 | Quercitrin treatment protects endothelial progenitor cells from oxidative damage via inducing autophagy through extracellular signal-regulated kinase. ( Bai, J; Li, M; Qu, L; Wu, Y; Zhang, X; Zhi, K; Zhou, S, 2016) |
| "NGF-induced mitogen-activated protein kinase type 1 or 2 (ERK1/2) phosphorylation in C2C12 cells and in a dose-response fashion stimulated PGE2 release, both effects antagonized by VLO5 and PD98059." | 1.42 | Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2. ( Ettinger, K; Lazarovici, P; Marcinkiewicz, C; Nevo, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Li, JZ | 1 |
| Zhou, XX | 1 |
| Wu, WY | 1 |
| Qiang, HF | 1 |
| Xiao, GS | 1 |
| Wang, Y | 1 |
| Li, G | 1 |
| Hou, Y | 1 |
| Ryu, CH | 1 |
| Jun, JA | 1 |
| Kim, SM | 1 |
| Jeong, CH | 1 |
| Jeun, SS | 1 |
| Ettinger, K | 2 |
| Nevo, Y | 2 |
| Marcinkiewicz, C | 2 |
| Lazarovici, P | 2 |
| Gim, SA | 1 |
| Koh, PO | 1 |
| Zhi, K | 1 |
| Li, M | 1 |
| Bai, J | 1 |
| Wu, Y | 1 |
| Zhou, S | 1 |
| Zhang, X | 1 |
| Qu, L | 1 |
| Seki, T | 1 |
| Itoh, H | 1 |
| Nakamachi, T | 1 |
| Endo, K | 1 |
| Wada, Y | 1 |
| Nakamura, K | 1 |
| Shioda, S | 1 |
| Lecht, S | 1 |
| Arien-Zakay, H | 1 |
| Cohen, G | 1 |
| Aga-Mizrachi, S | 1 |
| Yanay, N | 1 |
| Saragovi, HU | 1 |
| Nedev, H | 1 |
| Heiniger, CD | 1 |
| Kostadinova, RM | 1 |
| Rochat, MK | 1 |
| Serra, A | 1 |
| Ferrari, P | 1 |
| Dick, B | 1 |
| Frey, BM | 1 |
| Frey, FJ | 1 |
| Chao, W | 1 |
| Shen, Y | 1 |
| Zhu, X | 1 |
| Zhao, H | 1 |
| Novikov, M | 1 |
| Schmidt, U | 1 |
| Rosenzweig, A | 1 |
| Kilic, E | 1 |
| Kilic, U | 1 |
| Soliz, J | 1 |
| Bassetti, CL | 1 |
| Gassmann, M | 1 |
| Hermann, DM | 1 |
| Martín, ME | 1 |
| Muñoz, FM | 1 |
| Salinas, M | 1 |
| Fando, JL | 1 |
11 other studies available for pd 98059 and Ischemia
| Article | Year |
|---|---|
Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis.
Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cell Survival; Chromones; Concanavalin A; | 2022 |
IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
Topics: Animals; Bone Marrow Cells; Brain; Cells, Cultured; Chromones; Disease Models, Animal; Extracellular | 2014 |
Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2.
Topics: Cell Line; Dinoprostone; Disintegrins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent | 2015 |
Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling.
Topics: Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemia; Liver; M | 2015 |
Quercitrin treatment protects endothelial progenitor cells from oxidative damage via inducing autophagy through extracellular signal-regulated kinase.
Topics: Animals; Antioxidants; Autophagy; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Pro | 2016 |
Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure.
Topics: Animals; Cell Death; Cyclic AMP; Flavonoids; Humans; Intraocular Pressure; Ischemia; Male; Pituitary | 2011 |
Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model.
Topics: ADAM Proteins; ADAM12 Protein; Animals; Autocrine Communication; Cell Line; Cell Proliferation; Flav | 2012 |
Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Antimycin A; Cell Hypoxia; Cell Line; Cortison | 2003 |
Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation.
Topics: Adenoviridae; Androstadienes; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Casp | 2005 |
Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.
Topics: Androstadienes; Animals; bcl-X Protein; Brain; Brain Ischemia; Enzyme Activation; Enzyme Inhibitors; | 2005 |
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells.
Topics: Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Survival; Enzyme Inhibitors; Eukaryotic | 2000 |