Page last updated: 2024-11-02

pd 98059 and Ischemia

pd 98059 has been researched along with Ischemia in 11 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"Melatonin exerts a protective effect during hepatic ischemia-reperfusion (I/R) injury through modulation of the apoptotic cell death program."7.81Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling. ( Gim, SA; Koh, PO, 2015)
"Melatonin exerts a protective effect during hepatic ischemia-reperfusion (I/R) injury through modulation of the apoptotic cell death program."3.81Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling. ( Gim, SA; Koh, PO, 2015)
" In vivo experiments in rats revealed that Egr-1 protein increases, whereas 11beta-HSD2 mRNA decreases, in kidney tissue after unilateral renal ischemia and in humans the renal activity of 11beta-HSD2 as assessed by the urinary ratio of (tetrahydrocortisol+5alpha-tetrahydrocortisol)/tetrahydrocortisone declined when volunteers were exposed to hypoxemia at high altitude up to 7000 m."3.72Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1. ( Dick, B; Ferrari, P; Frey, BM; Frey, FJ; Heiniger, CD; Kostadinova, RM; Rochat, MK; Serra, A, 2003)
"Quercitrin treatment also increased the expression of E-cadherin, and PD98059 abrogated the upregulation of E-cadherin induced by quercitrin."1.43Quercitrin treatment protects endothelial progenitor cells from oxidative damage via inducing autophagy through extracellular signal-regulated kinase. ( Bai, J; Li, M; Qu, L; Wu, Y; Zhang, X; Zhi, K; Zhou, S, 2016)
"NGF-induced mitogen-activated protein kinase type 1 or 2 (ERK1/2) phosphorylation in C2C12 cells and in a dose-response fashion stimulated PGE2 release, both effects antagonized by VLO5 and PD98059."1.42Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2. ( Ettinger, K; Lazarovici, P; Marcinkiewicz, C; Nevo, Y, 2015)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's6 (54.55)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Li, JZ1
Zhou, XX1
Wu, WY1
Qiang, HF1
Xiao, GS1
Wang, Y1
Li, G1
Hou, Y1
Ryu, CH1
Jun, JA1
Kim, SM1
Jeong, CH1
Jeun, SS1
Ettinger, K2
Nevo, Y2
Marcinkiewicz, C2
Lazarovici, P2
Gim, SA1
Koh, PO1
Zhi, K1
Li, M1
Bai, J1
Wu, Y1
Zhou, S1
Zhang, X1
Qu, L1
Seki, T1
Itoh, H1
Nakamachi, T1
Endo, K1
Wada, Y1
Nakamura, K1
Shioda, S1
Lecht, S1
Arien-Zakay, H1
Cohen, G1
Aga-Mizrachi, S1
Yanay, N1
Saragovi, HU1
Nedev, H1
Heiniger, CD1
Kostadinova, RM1
Rochat, MK1
Serra, A1
Ferrari, P1
Dick, B1
Frey, BM1
Frey, FJ1
Chao, W1
Shen, Y1
Zhu, X1
Zhao, H1
Novikov, M1
Schmidt, U1
Rosenzweig, A1
Kilic, E1
Kilic, U1
Soliz, J1
Bassetti, CL1
Gassmann, M1
Hermann, DM1
Martín, ME1
Muñoz, FM1
Salinas, M1
Fando, JL1

Other Studies

11 other studies available for pd 98059 and Ischemia

ArticleYear
Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis.
    Pharmaceutical biology, 2022, Volume: 60, Issue:1

    Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cell Survival; Chromones; Concanavalin A;

2022
IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
    Cell biology international, 2014, Volume: 38, Issue:9

    Topics: Animals; Bone Marrow Cells; Brain; Cells, Cultured; Chromones; Disease Models, Animal; Extracellular

2014
Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2.
    Journal of basic and clinical physiology and pharmacology, 2015, Volume: 26, Issue:4

    Topics: Cell Line; Dinoprostone; Disintegrins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent

2015
Melatonin attenuates hepatic ischemia through mitogen-activated protein kinase signaling.
    The Journal of surgical research, 2015, Volume: 198, Issue:1

    Topics: Animals; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ischemia; Liver; M

2015
Quercitrin treatment protects endothelial progenitor cells from oxidative damage via inducing autophagy through extracellular signal-regulated kinase.
    Angiogenesis, 2016, Volume: 19, Issue:3

    Topics: Animals; Antioxidants; Autophagy; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Pro

2016
Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure.
    Journal of molecular neuroscience : MN, 2011, Volume: 43, Issue:1

    Topics: Animals; Cell Death; Cyclic AMP; Flavonoids; Humans; Intraocular Pressure; Ischemia; Male; Pituitary

2011
Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model.
    Cellular signalling, 2012, Volume: 24, Issue:12

    Topics: ADAM Proteins; ADAM12 Protein; Animals; Autocrine Communication; Cell Line; Cell Proliferation; Flav

2012
Hypoxia causes down-regulation of 11 beta-hydroxysteroid dehydrogenase type 2 by induction of Egr-1.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:8

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Antimycin A; Cell Hypoxia; Cell Line; Cortison

2003
Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation.
    The Journal of biological chemistry, 2005, Jun-10, Volume: 280, Issue:23

    Topics: Adenoviridae; Androstadienes; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Calcium; Casp

2005
Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:14

    Topics: Androstadienes; Animals; bcl-X Protein; Brain; Brain Ischemia; Enzyme Activation; Enzyme Inhibitors;

2005
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells.
    The Biochemical journal, 2000, Oct-15, Volume: 351 Pt 2

    Topics: Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Survival; Enzyme Inhibitors; Eukaryotic

2000