maltodextrin and Ischemia

Reactive oxygen species (ROS) are closely related with various pathological disorders. Therefore, real-time detection of ROS is essential for understanding the procedure of diseases and diagnosing the accurate lesion sites. Hydrogen peroxide (H

Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Boron; Fluorescence; Hindlimb; Hydrogen Peroxide; Indocyanine Green; Ischemia; Male; Mice; Mice, Inbred BALB C; Muscles; Nanoparticles; Peripheral Arterial Disease; Photoacoustic Techniques; Platelet Endothelial Cell Adhesion Molecule-1; Polysaccharides; RAW 264.7 Cells; Reactive Oxygen Species; Theranostic Nanomedicine; Ultrasonography

The purpose of this study was to investigate the effect of oral administration of a simple carbohydrate solution on splanchnic circulation and bacterial translocation in endotoxemia. Group 1 was sham control; group 2 was starved for 24 hours; in group 3, endotoxin was administrated at the end of starvation; in group 4, carbohydrate solution was administrated via orogastric route for 24 hours; and in group 5, carbohydrate solution was given and endotoxin was administrated at the end of 24 hours. Splanchnic blood flows were recorded and tissue samples were collected for microbiological analyses. There was a significant increase (P<.05) in the incidence of bacterial translocation in starvation. Endotoxemia decreased distal (P=.021) and midmesenteric (P=.046) flow in starved animals. Oral carbohydrate significantly increased ileal blood flow in starvation (P=.036) and endotoxemia (P=.008). In conclusion, oral carbohydrate solution prevents bacterial translocation during starvation and endotoxemia. The possible mechanism is the improvement in the mesenteric blood flow.

Topics: Animals; Bacterial Translocation; Drug Combinations; Electrolytes; Ischemia; Male; Maltose; Mesentery; Polysaccharides; Rats; Rats, Wistar; Regional Blood Flow; Splanchnic Circulation