indomethacin has been researched along with Ischemia in 82 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although a 150 mg dose of aspirin reduced urinary dinor-TxB2 levels by over 75 per cent, it had no effect on the course of the chronic recurrent form of angina pectoris due to vasospasm ("vasotonic angina")." | 9.05 | Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. ( FitzGerald, GA; Friesinger, GC; Maas, RL; Oates, JA; Roberts, LJ; Robertson, D; Robertson, RM, 1981) |
| "Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus." | 7.69 | Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 7.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| "Indomethacin can reduce the microvascular permeability induced by repeated ischemia." | 7.67 | The effect of antihistamines and indomethacin on microvascular permeability changes due to repeated pressure-induced local ischemia. ( Ehira, T; Romanus, M, 1988) |
| "This study evaluates the effects of Indomethacin (IND), Prostaglandin E1 (PGE1), and Ibuprofen (IBP) in a bowel ischemia model." | 7.66 | Comparative effects of indomethacin, prostaglandin E1, and ibuprofen on bowel ischemia. ( Cikrit, D; Grosfeld, JL; Gross, K; Kamman, K; Katz, S; Ross, D; Weber, TR; Wolfe, M, 1983) |
| "The effect of indomethacin (10 mg/kg) on the distribution of cortical blood flow during postocclusive reactive hyperemia was evaluated in denervated kidneys of anesthetized rabbits by the radioactive microsphere technique." | 7.65 | Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits. ( Aizawa, C; Honda, N, 1977) |
| "The aim of the study was to investigate the time course of neutrophil activation after skeletal muscle ischemia in humans and to assess the effect of xanthine oxidase inhibitor allopurinol or cyclooxygenase inhibitor indomethacin." | 5.08 | Neutrophil activation after skeletal muscle ischemia in humans. ( Bühren, V; Dike, J; Fiebrich, M; Rose, S; Weber, P, 1998) |
| " Although a 150 mg dose of aspirin reduced urinary dinor-TxB2 levels by over 75 per cent, it had no effect on the course of the chronic recurrent form of angina pectoris due to vasospasm ("vasotonic angina")." | 5.05 | Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. ( FitzGerald, GA; Friesinger, GC; Maas, RL; Oates, JA; Roberts, LJ; Robertson, D; Robertson, RM, 1981) |
| " Therefore, the objective of the present study was to directly investigate the role of ClC-2 in mucosal repair by evaluating mucosal recovery in ischemia-injured intestinal mucosa treated with the selective ClC-2 agonist lubiprostone." | 3.74 | Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone. ( Blikslager, AT; Engelke, KJ; Moeser, AJ; Nighot, PK; Ueno, R, 2007) |
| " We compared ECS with University of Wisconsin (UW) solution, with and without added indomethacin, in single PAF preservation in an in vivo rabbit model of warm ischemia-reperfusion lung injury." | 3.69 | Comparison of Eurocollins and University of Wisconsin solution in single flush preservation of the ischemic reperfused lung: an in vivo rabbit model. ( Balkhy, HH; Connolly, RJ; Diehl, JT; Peterson, MB; Zhang, X, 1995) |
| "Long-term indomethacin treatment during pregnancy may lead to the development of renal failure and irreversible renal damage with cystic dilatation of developing nephrons in an exposed fetus." | 3.69 | Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin. ( Bavoux, F; Carlus, C; Delezoide, AL; Gubler, MC; Narcy, F; van der Heijden, BJ, 1994) |
| "The role of eicosanoids as one of the main shock mediators was demonstrated in experiments anesthetized dogs with modeled postischemic shock using premedication with indometacin and/or quercetin." | 3.69 | [The role of the eicosanoids in the development of a postischemic shock reaction]. ( Sahach, VF; Zhukova, AV, 1996) |
| "Indomethacin induces ulceration in the rat jejunum with sparing of the ileum." | 3.69 | Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin. ( Anthony, A; Dhillon, AP; Pounder, RE; Wakefield, AJ, 1997) |
| "To determine the relative importance of patent ductus arteriosus, indomethacin, and intestinal distension as factors that promote terminal ileum ischemia, eight near-term fetal lambs were surgically prepared by in situ cannulation of the proximal and distal ends of a loop of terminal ileum, formalin infiltration of the ductus arteriosus, and placement of a snare around the ductus arteriosus to control its patency." | 3.68 | Patent ductus arteriosus, indomethacin, and intestinal distension: effects on intestinal blood flow and oxygen consumption. ( Alpan, G; Clyman, RI; Lin, E; Meyers, RL, 1991) |
| "The role of PGF2 alpha in circulatory shock of intestinal origin was investigated in anesthetized dogs by measuring PGF2 alpha levels in superior mesenteric vein, right ventricle, aorta, and femoral vein during superior mesenteric artery occlusion-induced shock by comparing the circulatory effects of exogenous PGF2 alpha injected into either the superior mesenteric or the femoral vein and by inhibiting of prostanoid synthesis with indomethacin." | 3.67 | Role of PGF2 alpha in the superior mesenteric artery-induced shock. ( Mózes, T; Wieszt, E; Zahajszky, T, 1989) |
| "Indomethacin can reduce the microvascular permeability induced by repeated ischemia." | 3.67 | The effect of antihistamines and indomethacin on microvascular permeability changes due to repeated pressure-induced local ischemia. ( Ehira, T; Romanus, M, 1988) |
| "The effects of anti-inflammatory steroids and BW-755C (both of which inhibit the formation of prostaglandins and leukotrienes) were studied in ischemia-induced edema and necrosis of the rabbit ear utilizing an occlusion reperfusion model." | 3.67 | Salvage of ischemic rabbit ear by BW-755C and steroids, but not by indomethacin. ( Chaudhuri, G; Hayden, B; Soderberg, R; Zarem, H, 1987) |
| "This study evaluates the effects of Indomethacin (IND), Prostaglandin E1 (PGE1), and Ibuprofen (IBP) in a bowel ischemia model." | 3.66 | Comparative effects of indomethacin, prostaglandin E1, and ibuprofen on bowel ischemia. ( Cikrit, D; Grosfeld, JL; Gross, K; Kamman, K; Katz, S; Ross, D; Weber, TR; Wolfe, M, 1983) |
| "To evaluate the effect of prostaglandin inhibition on the renal blood flow of the ischemic kidney, we administered indomethacin to 10 anesthetized dogs with renal artery stenosis and contralateral nephrectomy." | 3.66 | Paradoxical increase of renal blood flow in anesthetized hypertensive dog treated with indomethacin. ( Kedar, A; Moore, R; Murphy, GP; Wajsman, Z; Williams, P, 1979) |
| "The effect of meclofenamate and indomethacin on renal blood flow and renal vascular resistance was determined under basal experimental conditions and during renal ischemia in pentobarbital-anesthetized dogs." | 3.65 | Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature. ( Satoh, S; Zimmerman, BG, 1975) |
| "The effect of indomethacin (10 mg/kg) on the distribution of cortical blood flow during postocclusive reactive hyperemia was evaluated in denervated kidneys of anesthetized rabbits by the radioactive microsphere technique." | 3.65 | Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits. ( Aizawa, C; Honda, N, 1977) |
| "In two series of experiments we studied the effects of indomethacin on (a) coronary reactive hyperemia and, (b) renal blood flow, autoregulation, and reactive dilation." | 3.65 | Effects of indomethacin on local blood flow regulation in canine heart and kidney. ( Ehrhart, IC; Haddy, FJ; Owen, TL; Scott, JB; Weidner, WJ, 1975) |
| "This hyperemia was significantly (p less than 0." | 2.65 | Cigarette smoking, prostaglandins and reactive hyperemia. ( Wennmalm, A, 1979) |
| "Indomethacin treatment induced a better renal function (serum urea) when compared to control animals at 24, 48 and 72 h (219+/-54." | 1.33 | Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury. ( Câmara, NO; Cenedeze, MA; Feitoza, CQ; Gonçalves, GM; Pacheco-Silva, A; Pinheiro, HS; Santos, OF, 2005) |
| "5." | 1.30 | Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats. ( Fu, LW; Longhurst, JC, 1998) |
| "Dazoxiben pretreatment also moderated the rise of plasma prostacyclin, but it augmented circulating prostaglandin E2 following the release of SAO." | 1.27 | Inhibition of thromboxane biosynthesis in splanchnic ischemia shock. ( Glenn, TM; Oei, HH; Robson, RD; Sakane, Y; Zoganas, HC, 1986) |
| "Dogs treated with indomethacin prior to SAO shock did not exhibit a significant increase in portal venous PGF2alpha." | 1.26 | Release of prostaglandin F2alpha during splanchnic artery occlusion shock. ( Bridenbaugh, GA; Flynn, JT; Lefer, AM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (57.32) | 18.7374 |
| 1990's | 20 (24.39) | 18.2507 |
| 2000's | 9 (10.98) | 29.6817 |
| 2010's | 6 (7.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schneider, R | 1 |
| Meusel, M | 1 |
| Betz, B | 1 |
| Held, C | 1 |
| Möller-Ehrlich, K | 1 |
| Büttner-Herold, M | 1 |
| Wanner, C | 1 |
| Gekle, M | 1 |
| Sauvant, C | 1 |
| Chen, Y | 1 |
| Chang, KT | 1 |
| Lian, DW | 1 |
| Lu, H | 1 |
| Roy, S | 1 |
| Laksmi, NK | 1 |
| Low, Y | 1 |
| Krishnaswamy, G | 1 |
| Pierro, A | 1 |
| Ong, CC | 1 |
| Nakagiri, A | 1 |
| Murakami, M | 1 |
| Nakamori, Y | 1 |
| Komatsu, Y | 1 |
| Kotani, T | 1 |
| Kojima, S | 1 |
| Takeuchi, K | 1 |
| Roganović, J | 1 |
| Radenković, M | 1 |
| Stojić, D | 1 |
| Loh, AH | 1 |
| Ong, LY | 1 |
| Liew, WK | 1 |
| Arkachaisri, T | 1 |
| Lee, VK | 1 |
| Narasimhan, KL | 1 |
| Jacobsen, AS | 1 |
| Martínez-Revelles, S | 1 |
| Caracuel, L | 1 |
| Márquez-Martín, A | 1 |
| Dantas, A | 1 |
| Oliver, E | 1 |
| D'Ocon, P | 1 |
| Vila, E | 1 |
| Mizutani, A | 1 |
| Okajima, K | 1 |
| Uchiba, M | 1 |
| Isobe, H | 1 |
| Harada, N | 1 |
| Mizutani, S | 1 |
| Noguchi, T | 1 |
| Feitoza, CQ | 1 |
| Câmara, NO | 1 |
| Pinheiro, HS | 1 |
| Gonçalves, GM | 1 |
| Cenedeze, MA | 1 |
| Pacheco-Silva, A | 1 |
| Santos, OF | 1 |
| Fu, LW | 3 |
| Longhurst, JC | 5 |
| Moeser, AJ | 1 |
| Nighot, PK | 1 |
| Engelke, KJ | 1 |
| Ueno, R | 1 |
| Blikslager, AT | 3 |
| Joviliano, EE | 1 |
| Piccinato, CE | 1 |
| Cherri, J | 1 |
| Viaro, F | 1 |
| Moryia, T | 1 |
| Celotto, AC | 1 |
| Bonaventura, D | 1 |
| Evora, PR | 1 |
| Domoki, F | 1 |
| Zimmermann, A | 1 |
| Tóth-Szuki, V | 1 |
| Busija, DW | 1 |
| Bari, F | 1 |
| Kirk, RM | 1 |
| Granger, DN | 1 |
| Rutili, G | 1 |
| McCord, JM | 1 |
| Solanki, V | 1 |
| Murray, AW | 1 |
| Rubio, CA | 1 |
| Kollberg, B | 1 |
| Johansson, C | 1 |
| Rodensjö, M | 1 |
| Lorenzini, P | 1 |
| Kitagawa, H | 1 |
| Kurahashi, K | 1 |
| Fujiwara, M | 1 |
| Johnston, C | 1 |
| Carey, F | 1 |
| Forder, RA | 1 |
| Haworth, D | 1 |
| Grosfeld, JL | 1 |
| Kamman, K | 1 |
| Gross, K | 1 |
| Cikrit, D | 1 |
| Ross, D | 1 |
| Wolfe, M | 1 |
| Katz, S | 1 |
| Weber, TR | 1 |
| Montgomery, SB | 1 |
| Jose, PA | 1 |
| Slotkoff, LM | 1 |
| Lilienfield, LS | 1 |
| Eisner, GM | 1 |
| Robertson, RM | 1 |
| Robertson, D | 1 |
| Roberts, LJ | 1 |
| Maas, RL | 1 |
| FitzGerald, GA | 1 |
| Friesinger, GC | 1 |
| Oates, JA | 1 |
| Sparks, HV | 1 |
| Kramer, HJ | 1 |
| Schüürmann, J | 1 |
| Wassermann, C | 1 |
| Düsing, R | 1 |
| Hotter, G | 1 |
| Closa, D | 1 |
| Gelpí, E | 1 |
| Prats, N | 1 |
| Roselló-Catafau, J | 1 |
| Cristol, JP | 1 |
| Thiemermann, C | 1 |
| Mitchell, JA | 1 |
| Walder, C | 1 |
| Vane, JR | 1 |
| Balkhy, HH | 1 |
| Peterson, MB | 1 |
| Connolly, RJ | 1 |
| Zhang, X | 1 |
| Diehl, JT | 1 |
| van der Heijden, BJ | 1 |
| Carlus, C | 1 |
| Narcy, F | 1 |
| Bavoux, F | 1 |
| Delezoide, AL | 1 |
| Gubler, MC | 1 |
| Dolan, RW | 1 |
| Kerr, D | 1 |
| Arena, S | 1 |
| Arad, I | 1 |
| Bar-Oz, B | 1 |
| Amit, Y | 1 |
| Ergaz, Z | 1 |
| Peleg, O | 1 |
| Hicks, RC | 1 |
| Moss, J | 1 |
| Higman, DJ | 1 |
| Greenhalgh, RM | 1 |
| Powell, JT | 1 |
| Zhukova, AV | 1 |
| Sahach, VF | 1 |
| Sare, M | 1 |
| Bozkurt, S | 1 |
| Onuk, E | 1 |
| Oguz, M | 1 |
| Gurel, M | 1 |
| Ercan, S | 1 |
| Pan, HL | 1 |
| Anthony, A | 1 |
| Pounder, RE | 1 |
| Dhillon, AP | 1 |
| Wakefield, AJ | 1 |
| Rose, S | 1 |
| Fiebrich, M | 1 |
| Weber, P | 2 |
| Dike, J | 1 |
| Bühren, V | 1 |
| Azadzoi, KM | 1 |
| Krane, RJ | 1 |
| Saenz de Tejada, I | 1 |
| Goldstein, I | 1 |
| Siroky, MB | 1 |
| Naylor, HL | 1 |
| Shoemaker, JK | 1 |
| Brock, RW | 1 |
| Hughson, RL | 1 |
| Chahal, PS | 1 |
| Rendig, SV | 1 |
| Pell, SM | 1 |
| Young, KM | 2 |
| Zimmel, DN | 1 |
| Campbell, NB | 1 |
| Little, D | 1 |
| Argenzio, RA | 1 |
| Del Beccaro, EJ | 1 |
| Heggers, JP | 1 |
| Robson, MC | 1 |
| Sicard, GA | 1 |
| Anderson, CB | 1 |
| Etheredge, EE | 1 |
| Kedar, A | 1 |
| Wajsman, Z | 1 |
| Williams, P | 1 |
| Moore, R | 1 |
| Murphy, GP | 1 |
| Nowak, J | 1 |
| Wennmalm, A | 2 |
| Spielman, WS | 1 |
| Osswald, H | 1 |
| Horton, R | 1 |
| Zipser, R | 1 |
| Anggård, E | 1 |
| Larsson, C | 1 |
| Satoh, S | 1 |
| Zimmerman, BG | 1 |
| Messina, EJ | 1 |
| Weiner, R | 1 |
| Kaley, G | 1 |
| Aizawa, C | 1 |
| Honda, N | 1 |
| Oken, DE | 1 |
| Needleman, P | 3 |
| Key, SL | 1 |
| Isakson, PC | 1 |
| Kulkarni, PS | 1 |
| Owen, TL | 1 |
| Ehrhart, IC | 1 |
| Weidner, WJ | 1 |
| Scott, JB | 1 |
| Haddy, FJ | 1 |
| Gross, DM | 1 |
| Mujovic, VM | 1 |
| Jubiz, W | 1 |
| Fisher, JW | 1 |
| Flynn, JT | 1 |
| Bridenbaugh, GA | 1 |
| Lefer, AM | 1 |
| Rotto, DM | 1 |
| Kaufman, MP | 1 |
| Stahl, GL | 1 |
| Meyers, RL | 1 |
| Alpan, G | 1 |
| Lin, E | 1 |
| Clyman, RI | 1 |
| Kamata, T | 1 |
| Kawano, J | 1 |
| Barber, JD | 1 |
| Moss, NG | 1 |
| Mózes, T | 1 |
| Wieszt, E | 1 |
| Zahajszky, T | 1 |
| Perrett, D | 1 |
| Watson, A | 1 |
| Rolston, D | 1 |
| Gower, JD | 1 |
| Healing, G | 1 |
| Fuller, BJ | 1 |
| Simpkin, S | 1 |
| Green, CJ | 1 |
| Ehira, T | 1 |
| Romanus, M | 2 |
| Haugan, A | 1 |
| Kirkebø, A | 1 |
| Hsueh, W | 1 |
| Gonzalez-Crussi, F | 1 |
| Arroyave, JL | 1 |
| Hayden, B | 1 |
| Soderberg, R | 1 |
| Zarem, H | 1 |
| Chaudhuri, G | 1 |
| Proctor, KG | 1 |
| Shatkin, S | 1 |
| Kaminski, PM | 1 |
| Falck, JR | 1 |
| Capdevila, JH | 1 |
| Magal, E | 1 |
| Goldin, E | 1 |
| Harel, S | 1 |
| Yavin, E | 1 |
| Fernández Alonso, A | 1 |
| Martínez Rodríguez, E | 1 |
| Vega Alvarez, JA | 1 |
| Gower, J | 1 |
| Fuller, B | 1 |
| Green, C | 1 |
| Oei, HH | 1 |
| Zoganas, HC | 1 |
| Sakane, Y | 1 |
| Robson, RD | 1 |
| Glenn, TM | 1 |
| Henrich, WL | 1 |
| Brater, DC | 1 |
| Campbell, WB | 1 |
| Nannmark, U | 1 |
| Sennerby, L | 1 |
| Albrektsson, T | 1 |
| Hirose, F | 1 |
| Mizui, T | 1 |
| Shimono, N | 1 |
| Doteuchi, M | 1 |
| McGiff, JC | 1 |
| Crowshaw, K | 1 |
| Itskovitz, HD | 1 |
| Douglas, JR | 1 |
| Jakschik, B | 1 |
| Stoecklein, PB | 1 |
| Johnson, EM | 1 |
| Jaffe, BM | 1 |
| Parker, CW | 1 |
| Marshall, GR | 1 |
| Saarnivaara, L | 1 |
| Mattila, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| RIC-NEC Phase II Feasibility Randomized Controlled Trial: Remote Ischemic Conditioning in Necrotizing Enterocolitis[NCT05279664] | Phase 2 | 78 participants (Anticipated) | Interventional | 2022-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for indomethacin and Ischemia
| Article | Year |
|---|---|
Interactions between the renal prostaglandins and the renin--angiotensin system.
Topics: Angiotensin II; Animals; Arachidonic Acids; Blood Pressure; Indomethacin; Ischemia; Kidney; Prostagl | 1976 |
Prostaglandins and renal function.
Topics: Angiotensin II; Animals; Blood Pressure; Bradykinin; Dogs; Eledoisin; Indomethacin; Ischemia; Kidney | 1974 |
6 trials available for indomethacin and Ischemia
| Article | Year |
|---|---|
Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flu | 1984 |
Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Arteries; Aspirin; Clinical Trials as Topic; Coron | 1981 |
Neutrophil activation after skeletal muscle ischemia in humans.
Topics: Adolescent; Adult; Allopurinol; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Female; Humans; Indome | 1998 |
Prostaglandin inhibition causes an increase in reactive hyperaemia after ischaemic exercise in human forearm.
Topics: Adult; Cyclooxygenase Inhibitors; Forearm; Humans; Hyperemia; Ibuprofen; Indomethacin; Ischemia; Mal | 1999 |
Cigarette smoking, prostaglandins and reactive hyperemia.
Topics: Adult; Female; Forearm; Humans; Hyperemia; Indomethacin; Ischemia; Male; Middle Aged; Prostaglandin | 1979 |
The effect of codeine and indomethacin on the ischaemic forearm pain in man.
Topics: Adult; Analgesia; Clinical Trials as Topic; Codeine; Drug Antagonism; Female; Forearm; Humans; Indom | 1967 |
74 other studies available for indomethacin and Ischemia
| Article | Year |
|---|---|
Oat1/3 restoration protects against renal damage after ischemic AKI.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Glomerular Filtration Rate; Indomethac | 2015 |
The role of ischemia in necrotizing enterocolitis.
Topics: Age of Onset; Biomarkers; Enterocolitis, Necrotizing; Glucose Transporter Type 1; Humans; Hypoxia; H | 2016 |
Roles of NADPH oxidase in occurrence of gastric damage and expression of cyclooxygenase-2 during ischemia/reperfusion in rat stomachs.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Gastric M | 2009 |
Pathogenic importance of cysteinyl leukotrienes in development of gastric lesions induced by ischemia/reperfusion in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Chromones; Gastric Ac | 2010 |
ACh- and VIP-induced vasorelaxation in rabbit facial artery after carotid artery occlusion.
Topics: Acetylcholine; Animals; Arteries; Bradykinin; Carotid Artery Diseases; Carotid Artery, Common; Colfo | 2010 |
Multiple indomethacin-induced colonic perforations in an adolescent.
Topics: Abdomen, Acute; Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Colectomy | 2011 |
Increased endothelin-1 vasoconstriction in mesenteric resistance arteries after superior mesenteric ischaemia-reperfusion.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Endothelin-1; Free Radical Scavengers; In Vitro T | 2012 |
Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production.
Topics: 6-Ketoprostaglandin F1 alpha; Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory Agents, No | 2003 |
Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2005 |
Interactions between histamine and bradykinin in stimulation of ischaemically sensitive cardiac afferents in felines.
Topics: Action Potentials; Animals; Bradykinin; Cats; Cyclooxygenase Inhibitors; Drug Interactions; Female; | 2005 |
Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone.
Topics: Alprostadil; Animals; Bumetanide; Chloride Channel Agonists; Chloride Channels; Chlorides; CLC-2 Chl | 2007 |
In vitro pharmacological study of femoral artery vascular reactivity after inferior canine hindlimb ischemia/reperfusion: effects of in vivo nitric oxide blocker infusion.
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Endothelium-Dependent Relaxing Factors; Endothelium, Vascu | 2007 |
Acetazolamide induces indomethacin and ischaemia-sensitive pial arteriolar vasodilation in the piglet.
Topics: Acetazolamide; Animals; Animals, Newborn; Arterioles; Carbonic Anhydrase Inhibitors; Cardiovascular | 2008 |
Factors determining the site of chronic gastroduodenal ulcers.
Topics: Animals; Aspirin; Chronic Disease; Diet; Digestive System; Duodenum; Gastric Acid; Gastric Mucins; G | 1982 |
Superoxide radicals in feline intestinal ischemia.
Topics: Animals; Blood Pressure; Blood Proteins; Capillary Permeability; Cats; Cimetidine; Endotoxins; Femal | 1981 |
The effect of ischemia on cyclic adenosine 3',5'monophosphate accumulation in mouse skin.
Topics: Adenosine; Animals; Animals, Newborn; Cold Temperature; Cyclic AMP; Dinoprostone; Female; Histamine; | 1982 |
Acute gastric erosions in the rat. I. Microangiography.
Topics: Angiography; Animals; Gastric Mucosa; Indomethacin; Ischemia; Male; Microcirculation; Necrosis; Rats | 1981 |
Test for postischaemic hyperaemia: a means of clinical assessment of microcirculatory reactivity in tissues of patients with liability to seasonal ischaemic noxae.
Topics: Adult; Arthritis; Bronchitis; Female; Humans; Hyperemia; Indomethacin; Iodine; Ischemia; Male; Micro | 1984 |
Water-immersion stress induces mucosal ischemia due to thromboxane A2-like substance and ulcer formation in rats.
Topics: Animals; Gastric Acid; Gastric Mucosa; Humans; Imidazoles; Immersion; Indomethacin; Ischemia; Male; | 1984 |
Comparative effects of indomethacin, prostaglandin E1, and ibuprofen on bowel ischemia.
Topics: Alprostadil; Animals; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Ibuprofen; Indomet | 1983 |
The regulation of intrarenal blood flow in the dog during ischemia.
Topics: Animals; Aorta; Blood Pressure; Constriction; Dogs; Female; Hemodynamics; Hemorrhage; Hypotension; I | 1980 |
Mechanism of vasodilation during and after ischemic exercise.
Topics: Adenosine; Animals; Dogs; Forelimb; Indomethacin; Ischemia; Physical Exertion; Prostaglandins E; Tri | 1980 |
Prostaglandin-independent protection by furosemide from oliguric ischemic renal failure in conscious rats.
Topics: Animals; Anuria; Female; Furosemide; Indomethacin; Ischemia; Kidney; Prostaglandins E; Rats | 1980 |
Role of xanthine oxidase and eicosanoids in development of pancreatic ischemia-reperfusion injury.
Topics: 6-Ketoprostaglandin F1 alpha; Allopurinol; Animals; Biomarkers; Cyclooxygenase Inhibitors; Dinoprost | 1995 |
Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calcium; Dexamethasone; Endothelium, Vascular; Enzyme | 1993 |
Comparison of Eurocollins and University of Wisconsin solution in single flush preservation of the ischemic reperfused lung: an in vivo rabbit model.
Topics: Adenosine; Allopurinol; Animals; Blood Pressure; Glutathione; Hypertonic Solutions; Indomethacin; In | 1995 |
Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin.
Topics: Adult; Anuria; Dilatation, Pathologic; Female; Fetal Death; Humans; Immunohistochemistry; Indomethac | 1994 |
Reducing ischemia-reperfusion injury in rat island groin flaps by dexamethasone and BW755C.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ant | 1995 |
Neonatal limb ischemia following maternal indomethacin treatment in twin pregnancies.
Topics: Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Infant, Newborn; Infant, Premature; Ischemi | 1995 |
The influence of diabetes on the vasomotor responses of saphenous vein and the development of infra-inguinal vein graft stenosis.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Blood Vessel Prosthesis; Bradykinin; Calcimycin; Coll | 1997 |
[The role of the eicosanoids in the development of a postischemic shock reaction].
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Eicosanoids; Hemodynamics; Hindlimb; Indomethacin; Ischemi | 1996 |
The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury.
Topics: Alkaline Phosphatase; Allopurinol; Animals; Antioxidants; Creatine Kinase; Cyclooxygenase Inhibitors | 1996 |
Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors.
Topics: Abdomen; Afferent Pathways; Animals; Bile Ducts; Blood Pressure; Cats; Chlorpheniramine; Dimaprit; D | 1997 |
Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ileum; Indomethacin; Intestinal Mucosa; Ischemia; | 1997 |
Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats.
Topics: Adrenergic Fibers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Electrophysiology; Female | 1998 |
Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemia-induced increased contraction of cavernosal smooth muscle.
Topics: Animals; Arginine; Arteriosclerosis; Electric Stimulation; Enzyme Inhibitors; Hypercholesterolemia; | 1999 |
Reflex cardiovascular response to brief abdominal visceral ischemia is mediated in part by prostaglandins.
Topics: Abdomen; Animals; Aspirin; Blood Pressure; Cardiovascular Agents; Cardiovascular System; Cats; Cyclo | 1999 |
PGE2 triggers recovery of transmucosal resistance via EP receptor cross talk in porcine ischemia-injured ileum.
Topics: Animals; Calcimycin; Calcium Signaling; Culture Techniques; Cyclic AMP; Dinoprostone; Drug Synergism | 2001 |
Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2002 |
Preventing the prostaglandin effect on dermal ischemia in the burn wound.
Topics: Animals; Aspirin; Burns; Female; Guinea Pigs; Indomethacin; Ischemia; Methylprednisolone; Prostaglan | 1978 |
Prostaglandin-mediated renal injury during hypothermic pulsatile perfusion.
Topics: Animals; Cold Temperature; Dogs; Imidazoles; Indomethacin; Ischemia; Kidney; Organ Preservation; Per | 1979 |
Paradoxical increase of renal blood flow in anesthetized hypertensive dog treated with indomethacin.
Topics: Animals; Blood Pressure; Dogs; Erythropoietin; Female; Hypertension; Indomethacin; Ischemia; Kidney; | 1979 |
A study on the role of endogenous prostaglandins in the development of exercise-induced and post-occlusive hyperemia in human limbs.
Topics: Adult; Arteries; Female; Humans; Indomethacin; Ischemia; Isometric Contraction; Leg; Male; Muscles; | 1979 |
Characterization of the postocclusive response of renal blood flow in the cat.
Topics: Adenosine; Angiotensin II; Animals; Blood Flow Velocity; Cats; Indomethacin; Ischemia; Kidney; Meclo | 1978 |
Prostaglandins: renin release and renal function.
Topics: Animals; Bartter Syndrome; Dogs; Homeostasis; Humans; Indomethacin; Ischemia; Kallikreins; Kidney; K | 1978 |
Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature.
Topics: Angiotensin II; Animals; Cyclooxygenase Inhibitors; Dogs; Female; Indomethacin; Injections, Intra-Ar | 1975 |
Arteriolar reactive hyperemia: modification by inhibitors of prostaglandin synthesis.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Bradykinin; Hyperemia; Indomethacin; Ischemia; Male; Micro | 1977 |
Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits.
Topics: Animals; Blood Pressure; Denervation; Hyperemia; Indomethacin; Ischemia; Kidney; Kidney Cortex; Rabb | 1977 |
Local mechanisms in the pathogenesis of acute renal failure.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Cell Membrane Permeability; Dose-Response Relationship | 1976 |
Relationship between oxygen tension, coronary vasodilation and prostaglandin biosynthesis in the isolated rabbit heart.
Topics: Animals; Coronary Circulation; Coronary Vessels; Hypoxia; Indomethacin; Ischemia; Male; Myocardium; | 1975 |
Effects of indomethacin on local blood flow regulation in canine heart and kidney.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dogs; Electrocardiography; Female; | 1975 |
Enhanced erythropoietin and prostaglandin E production in the dog following renal artery constriction.
Topics: Animals; Blood Pressure; Constriction; Dogs; Female; Indomethacin; Ischemia; Kidney; Prostaglandins | 1976 |
Release of prostaglandin F2alpha during splanchnic artery occlusion shock.
Topics: Animals; Blood Proteins; Cathepsins; Dogs; Indomethacin; Ischemia; Ligation; Male; Mesenteric Arteri | 1976 |
Ischemically sensitive abdominal visceral afferents: response to cyclooxygenase blockade.
Topics: Abdomen; Afferent Pathways; Animals; Aspirin; Cats; Cyclooxygenase Inhibitors; Gallbladder; Indometh | 1991 |
Patent ductus arteriosus, indomethacin, and intestinal distension: effects on intestinal blood flow and oxygen consumption.
Topics: Animals; Animals, Newborn; Blood Flow Velocity; Ductus Arteriosus, Patent; Female; Ileum; Indomethac | 1991 |
[Clinical problems in the treatment and physiopathology of drug-induced peptic ulcers].
Topics: Animals; Endothelins; Endothelium, Vascular; Ethanol; Gastric Mucosa; Indomethacin; Ischemia; Male; | 1991 |
Reduced renal perfusion pressure causes prostaglandin-dependent excitation of R2 chemoreceptors in rats.
Topics: Afferent Pathways; Animals; Chemoreceptor Cells; Indomethacin; Ischemia; Kidney; Male; Meclofenamic | 1990 |
Role of PGF2 alpha in the superior mesenteric artery-induced shock.
Topics: Animals; Blood Pressure; Dinoprost; Dogs; Hemodynamics; Indomethacin; Intestinal Mucosa; Intestines; | 1989 |
Qualitative and quantitative studies on the nucleotides of intestinal mucosa.
Topics: Animals; Aspirin; Chromatography, High Pressure Liquid; Indomethacin; Intestinal Mucosa; Ischemia; J | 1989 |
Protection against oxidative damage in cold-stored rabbit kidneys by desferrioxamine and indomethacin.
Topics: Animals; Cold Temperature; Deferoxamine; In Vitro Techniques; Indomethacin; Ischemia; Kidney; Kidney | 1989 |
The effect of antihistamines and indomethacin on microvascular permeability changes due to repeated pressure-induced local ischemia.
Topics: Animals; Capillary Permeability; Cricetinae; Diphenhydramine; Histamine H1 Antagonists; Histamine H2 | 1988 |
Local renal ischemia during burn shock in rat effected by thromboxane A2 and serotonin.
Topics: Animals; Blood Pressure; Burns; Indomethacin; Ischemia; Ketanserin; Kidney Cortex; Male; Phentolamin | 1986 |
Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.
Topics: Alprostadil; Animals; Blood Pressure; Catechols; Chromones; Diethylcarbamazine; Disease Models, Anim | 1986 |
Salvage of ischemic rabbit ear by BW-755C and steroids, but not by indomethacin.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Anti-Inflammatory Agents; Ear | 1987 |
Modulation of arteriolar blood flow by inhibitors of arachidonic acid oxidation after thermal injury: possible role for a novel class of vasodilator metabolites.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acids; Arterioles | 1988 |
Acute uteroplacental ischemic embryo: lactic acid accumulation and prostaglandin production in the fetal rat brain.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Benzoquinones; Brain; Cycloox | 1988 |
[Effects of prostaglandin E2 on experimental mesenteric ischemia in rats].
Topics: Animals; Creatine Kinase; Dinoprostone; Female; Histocytochemistry; Indomethacin; Intestinal Mucosa; | 1987 |
Lipid peroxidation in the cortex and medulla of rabbit kidneys subjected to cold ischaemia and the value of protective agents.
Topics: Animals; Cold Temperature; Deferoxamine; Imidazoles; In Vitro Techniques; Indomethacin; Ischemia; Ki | 1987 |
Inhibition of thromboxane biosynthesis in splanchnic ischemia shock.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cardiac Output; Dogs; Female; Glucuronidase; | 1986 |
Renal hemodynamic effects of therapeutic plasma levels of sulindac sulfide during hemorrhage.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dogs; Glome | 1986 |
Indomethacin, (-)-terbutaline (beta 2 agonist), and (+)-terbutaline in acute inflammation induced by repeated ischemia in hamster cheek pouch.
Topics: Animals; Capillary Permeability; Cricetinae; Disease Models, Animal; Female; Indomethacin; Inflammat | 1985 |
Gastric antral ulcers induced by a combination of acid, indomethacin and ischemia in rats.
Topics: Animals; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Ischemia; Male; Pyloric Antrum; Rats; Rats | 1985 |
Release of renal prostaglandin by catecholamines: relationship to renal endocrine function.
Topics: Angiotensin II; Animals; Aorta; Catecholamines; Dopamine; Electric Stimulation; Endocrine Glands; Ep | 1974 |
Renal concentrations of prostaglandin E in acute and chronic renal ischemia.
Topics: Acute Disease; Animals; Blood Pressure; Chromatography; Chronic Disease; Indomethacin; Ischemia; Kid | 1972 |