quinacrine has been researched along with Ischemia in 16 studies
Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of quinacrine on malondialdehyde (MDA) as an index of lipid peroxidation, activities of phospholipase A2 (PLA2), and myeloperoxidase (MPO)--a neutrophil granulocyte maker in plasma--was examined in rats following ischemia and reperfusion." | 7.67 | Influence of quinacrine on plasma malondialdehyde after small intestinal ischemia and reperfusion. ( Otamiri, TA, 1988) |
| "Hemorrhagic shock was obtained by bleeding into a reservoir for 15 min or 1 h." | 5.26 | Juxtaglomerular cell activity during hemorrhage and ischemia as revealed by quinacrine histofluorescence. ( Alund, M, 1980) |
| " Pretreatment with a nonspecific phospholipase A2 inhibitor (methylprednisolone, dexamethasone, or quinacrine) was ineffective in diminishing the reperfusion injury in either case." | 3.68 | Reperfusion mucosal damage after complete intestinal ischemia in the dog: the effects of antioxidant and phospholipase A2 inhibitor therapy. ( Boros, M; Karácsony, G; Kaszaki, J; Nagy, S, 1993) |
| " In the absence of an inhibitor, ischemia and reperfusion caused increased mucosal permeability to sodium fluorescein, increased N-acetyl-glucosaminidase release from the mucosa into the lumen, increased malondialdehyde content, and increased myeloperoxidase and phospholipase A2 (PLA2) activities in the mucosa." | 3.67 | Role of phospholipase A2 and oxygenated free radicals in mucosal damage after small intestinal ischemia and reperfusion. ( Otamiri, T; Tagesson, C, 1989) |
| "The influence of quinacrine on malondialdehyde (MDA) as an index of lipid peroxidation, activities of phospholipase A2 (PLA2), and myeloperoxidase (MPO)--a neutrophil granulocyte maker in plasma--was examined in rats following ischemia and reperfusion." | 3.67 | Influence of quinacrine on plasma malondialdehyde after small intestinal ischemia and reperfusion. ( Otamiri, TA, 1988) |
| "Hemorrhagic shock was obtained by bleeding into a reservoir for 15 min or 1 h." | 1.26 | Juxtaglomerular cell activity during hemorrhage and ischemia as revealed by quinacrine histofluorescence. ( Alund, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Korolev, DV | 1 |
| Shulmeyster, GA | 1 |
| Evreinova, NV | 1 |
| Syrovatkina, MS | 1 |
| Istomina, MS | 1 |
| Postnov, VN | 1 |
| Aleksandrov, IV | 1 |
| Krasichkov, AS | 1 |
| Galagudza, MM | 1 |
| CARAZO, A | 1 |
| EISEMAN, B | 1 |
| Nemoto, O | 1 |
| Aoyagi, T | 1 |
| Miura, Y | 1 |
| Alund, M | 1 |
| Koike, K | 1 |
| Moore, EE | 1 |
| Moore, FA | 1 |
| Kim, FJ | 1 |
| Carl, VS | 1 |
| Banerjee, A | 1 |
| Meleagros, L | 1 |
| Ghatei, MA | 1 |
| Bloom, SR | 1 |
| Boros, M | 1 |
| Karácsony, G | 1 |
| Kaszaki, J | 1 |
| Nagy, S | 1 |
| McAnulty, JF | 3 |
| Huang, XQ | 2 |
| Tabuchi, K | 1 |
| Ito, Z | 1 |
| Tsuji, S | 1 |
| Wada, T | 1 |
| Takahashi, K | 1 |
| Hara, A | 1 |
| Kusakari, J | 1 |
| Otamiri, T | 3 |
| Tagesson, C | 2 |
| Otamiri, TA | 1 |
| Otani, H | 1 |
| Engelman, RM | 1 |
| Rousou, JA | 1 |
| Breyer, RH | 1 |
| Das, DK | 1 |
| Franzén, L | 1 |
| Lindmark, D | 1 |
16 other studies available for quinacrine and Ischemia
| Article | Year |
|---|---|
Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots.
Topics: Chitosan; Early Diagnosis; Fluorescent Dyes; Humans; Ischemia; Magnetite Nanoparticles; Molecular St | 2022 |
ROLE OF AMMONIA IN ISCHEMIC RENAL DAMAGE; EFFECT OF ATABRINE ON AMMONIA PRODUCTION.
Topics: Ammonia; Blood Chemical Analysis; Blood Pressure; Creatine; Creatinine; Dogs; Ischemia; Kidney; Kidn | 1965 |
Phospholipase A2 activity modulates "ischemic effect" in pig skin.
Topics: Animals; Cyclic AMP; Ischemia; Melitten; Phospholipases; Phospholipases A; Phospholipases A2; Quinac | 1983 |
Juxtaglomerular cell activity during hemorrhage and ischemia as revealed by quinacrine histofluorescence.
Topics: Animals; Carbon Radioisotopes; Cytoplasmic Granules; Ischemia; Juxtaglomerular Apparatus; Kidney; Ma | 1980 |
Gut phospholipase A2 mediates neutrophil priming and lung injury after mesenteric ischemia-reperfusion.
Topics: Animals; Enzyme Activation; Intestines; Ischemia; Kinetics; Lung Diseases; Male; N-Formylmethionine | 1995 |
Atrial natriuretic peptide and glucagon release in experimental intestinal ischaemia and reperfusion.
Topics: Allopurinol; Animals; Atrial Natriuretic Factor; Blood Pressure; Free Radicals; Glucagon; Intestines | 1994 |
Reperfusion mucosal damage after complete intestinal ischemia in the dog: the effects of antioxidant and phospholipase A2 inhibitor therapy.
Topics: Allopurinol; Animals; Antioxidants; Dexamethasone; Dogs; Female; Ileum; Intestinal Mucosa; Ischemia; | 1993 |
The effects of administering quinacrine during ultraprofound hypothermia on warm ischemic kidney cortex tissue.
Topics: Adenosine Triphosphate; Animals; Hypothermia, Induced; In Vitro Techniques; Ischemia; Kidney Cortex; | 1996 |
Nonesterified fatty acid content of rabbit kidney cortex slices after warm ischemia and low temperature preservation.
Topics: Animals; Evaluation Studies as Topic; Fatty Acids, Nonesterified; In Vitro Techniques; Ischemia; Kid | 1996 |
The effect of calcium on hypothermia-facilitated resuscitation of warm ischemic kidney tissue slices: a role for the mitochondrial permeability transition pore?
Topics: Adenosine Triphosphate; Aerobiosis; Animals; Calcium; Cold Temperature; Cyclosporine; Fatty Acids, N | 1998 |
The contribution of phospholipase A2 to the cochlear dysfunction induced by transient ischemia.
Topics: Action Potentials; Animals; Cochlea; Cochlear Microphonic Potentials; Dendrites; Differential Thresh | 2000 |
Role of phospholipase A2 and oxygenated free radicals in mucosal damage after small intestinal ischemia and reperfusion.
Topics: Acetylglucosaminidase; Animals; Catalase; Free Radicals; Ileum; Intestinal Mucosa; Ischemia; Malondi | 1989 |
Influence of quinacrine on plasma malondialdehyde after small intestinal ischemia and reperfusion.
Topics: Animals; Intestine, Small; Ischemia; Malonates; Malondialdehyde; Peroxidase; Phospholipases A; Phosp | 1988 |
Enhanced prostaglandin synthesis due to phospholipid breakdown in ischemic-reperfused myocardium. Control of its production by a phospholipase inhibitor or free radical scavengers.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Catalase; Female; Heart; | 1986 |
Quinacrine prevention of intestinal ischaemic mucosal damage is partly mediated through inhibition of intraluminal phospholipase A2.
Topics: Acetylglucosaminidase; Animals; Ileum; Intestinal Mucosa; Ischemia; Lysophosphatidylcholines; Male; | 1988 |
Increased phospholipase A2 and decreased lysophospholipase activity in the small intestinal mucosa after ischaemia and revascularisation.
Topics: Animals; Female; Intestinal Mucosa; Intestine, Small; Ischemia; Lysophospholipase; Malondialdehyde; | 1987 |