2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Ischemia in 13 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats." | 7.83 | Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway. ( Meng, FM; Xue, FS; Zhang, JQ; Zhang, W, 2016) |
| "To evaluate the role of the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt)/hypoxia-inducible factor 1α (HIF-1α) signaling pathway in the protection by dexmedetomidine against lung ischemia-reperfusion injury (IRI) in rats." | 3.83 | Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway. ( Meng, FM; Xue, FS; Zhang, JQ; Zhang, W, 2016) |
| " 5-Aminolevulinic acid in combination with sodium ferrous citrate (ALA/SFC) has been shown to up-regulate heme oxygenase-1 (HO-1) and decrease macrophage infiltration and renal cell apoptosis in renal ischemia injury mice." | 3.83 | 5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through MAPK-Nrf-2-HO-1 signaling cascade. ( Chen, J; Fujino, M; Ito, H; Li, XK; Nakajima, M; Nishio, Y; Takahashi, K; Tanaka, T; Zhao, L; Zhao, M; Zhu, P; Zhuang, J, 2016) |
| "Retinal neovascularization was examined by adenosine diphosphatase staining after 5 days in room air and was quantitated histologically by counting the neovascular endothelial cell nuclei anterior to the inner limiting membrane." | 1.35 | Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization. ( Dong, JQ; Li, XX; Yan, Z; Yu, WZ; Zou, H, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Li, JZ | 1 |
| Zhou, XX | 1 |
| Wu, WY | 1 |
| Qiang, HF | 1 |
| Xiao, GS | 1 |
| Wang, Y | 1 |
| Li, G | 1 |
| Wu, J | 1 |
| Li, Q | 2 |
| Wang, X | 1 |
| Yu, S | 1 |
| Li, L | 1 |
| Wu, X | 1 |
| Chen, Y | 1 |
| Zhao, J | 1 |
| Zhao, Y | 1 |
| Hou, Y | 1 |
| Ryu, CH | 1 |
| Jun, JA | 1 |
| Kim, SM | 1 |
| Jeong, CH | 1 |
| Jeun, SS | 1 |
| Du, Z | 1 |
| Zan, T | 1 |
| Huang, X | 1 |
| Sheng, L | 1 |
| Li, H | 2 |
| Zhang, W | 1 |
| Zhang, JQ | 1 |
| Meng, FM | 1 |
| Xue, FS | 1 |
| Okyere, B | 1 |
| Giridhar, K | 1 |
| Hazy, A | 1 |
| Chen, M | 1 |
| Keimig, D | 1 |
| Bielitz, RC | 1 |
| Xie, H | 1 |
| He, JQ | 1 |
| Huckle, WR | 1 |
| Theus, MH | 1 |
| Zhao, M | 1 |
| Zhu, P | 1 |
| Fujino, M | 1 |
| Nishio, Y | 1 |
| Chen, J | 1 |
| Ito, H | 1 |
| Takahashi, K | 1 |
| Nakajima, M | 1 |
| Tanaka, T | 1 |
| Zhao, L | 1 |
| Zhuang, J | 1 |
| Li, XK | 1 |
| Russo, R | 1 |
| Cavaliere, F | 1 |
| Berliocchi, L | 1 |
| Nucci, C | 1 |
| Gliozzi, M | 1 |
| Mazzei, C | 1 |
| Tassorelli, C | 1 |
| Corasaniti, MT | 1 |
| Rotiroti, D | 1 |
| Bagetta, G | 1 |
| Morrone, LA | 1 |
| Stubbs, SL | 1 |
| Hsiao, ST | 1 |
| Peshavariya, HM | 1 |
| Lim, SY | 1 |
| Dusting, GJ | 1 |
| Dilley, RJ | 1 |
| Miyazaki, R | 1 |
| Ichiki, T | 1 |
| Hashimoto, T | 1 |
| Ikeda, J | 1 |
| Kamiharaguchi, A | 1 |
| Narabayashi, E | 1 |
| Matsuura, H | 1 |
| Takeda, K | 1 |
| Sunagawa, K | 1 |
| Urban, D | 1 |
| Härtel, FV | 1 |
| Gadiraju, K | 1 |
| Gündüz, D | 1 |
| Aslam, M | 1 |
| Piper, HM | 1 |
| Noll, T | 1 |
| Nakazawa, T | 1 |
| Shimura, M | 1 |
| Tomita, H | 1 |
| Akiyama, H | 1 |
| Yoshioka, Y | 1 |
| Kudou, H | 1 |
| Tamai, M | 1 |
| Yu, WZ | 1 |
| Zou, H | 1 |
| Li, XX | 1 |
| Yan, Z | 1 |
| Dong, JQ | 1 |
13 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Ischemia
| Article | Year |
|---|---|
Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis.
Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cell Survival; Chromones; Concanavalin A; | 2022 |
Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway.
Topics: Animals; Animals, Newborn; Antioxidants; Brain; Brain Ischemia; Cell Nucleus; Cells, Cultured; Chrom | 2013 |
IL-8 enhances the angiogenic potential of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
Topics: Animals; Bone Marrow Cells; Brain; Cells, Cultured; Chromones; Disease Models, Animal; Extracellular | 2014 |
DFO enhances the targeting of CD34-positive cells and improves neovascularization.
Topics: Animals; Antigens, CD34; Bone Marrow Cells; Cell Movement; Chemokine CXCL12; Chromones; Deferoxamine | 2015 |
Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway.
Topics: Animals; Chromones; Dexmedetomidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypnotics | 2016 |
Endothelial-Specific EphA4 Negatively Regulates Native Pial Collateral Formation and Re-Perfusion following Hindlimb Ischemia.
Topics: Animals; Cerebral Veins; Chromones; Endothelium, Vascular; Hindlimb; Ischemia; Mice; Mice, Inbred C5 | 2016 |
5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through MAPK-Nrf-2-HO-1 signaling cascade.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Autophagy; Cell Hypoxia; Chromones; Citric Acid; Enzyme Inh | 2016 |
Modulation of pro-survival and death-associated pathways under retinal ischemia/reperfusion: effects of NMDA receptor blockade.
Topics: Analysis of Variance; Androstadienes; Animals; bcl-Associated Death Protein; Cell Death; Chromones; | 2008 |
Hypoxic preconditioning enhances survival of human adipose-derived stem cells and conditions endothelial cells in vitro.
Topics: Adipose Tissue; Cell Hypoxia; Cell Shape; Cell Survival; Chromones; Culture Media, Conditioned; Cult | 2012 |
Acetylcholinesterase inhibitors attenuate angiogenesis.
Topics: Acetylcholine; Animals; Cells, Cultured; Cholinesterase Inhibitors; Chromones; Donepezil; Hindlimb; | 2012 |
Extracellular ATP attenuates ischemia-induced caspase-3 cleavage in human endothelial cells.
Topics: Adenosine Triphosphate; Apoptosis; Butadienes; Caspase 3; Cells, Cultured; Chromones; Cytoprotection | 2012 |
Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury.
Topics: Animals; Cell Count; Cell Survival; Chromones; Constriction; Enzyme Inhibitors; Fluorescent Dyes; Is | 2003 |
Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization.
Topics: Animals; Animals, Newborn; Apyrase; Cell Movement; Cell Survival; Cells, Cultured; Chromones; Enzyme | 2008 |