Page last updated: 2024-12-06

erythrityl tetranitrate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Erythrityl Tetranitrate: A vasodilator with general properties similar to NITROGLYCERIN. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020) [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

erythrityl tetranitrate : Erythritol in which each of the hydroxy groups has been converted to the corresponding nitrate ester. It is a vasodilator with properties similar to nitroglycerin. It is usually used diluted with lactose or other suitable inert excipients, in order to minimise the risk of explosion; undiluted erythrityl tetranitrate can be exploded by percussion or excessive heat. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5284553
CHEMBL ID2107583
CHEBI ID60072
SCHEMBL ID119876
MeSH IDM0007686

Synonyms (54)

Synonym
(2r,3s)-3,4-bis(nitrooxy)butane-1,2-diyl dinitrate
1,2,3,4-butanetetralyl tetranitrate
eritrityl tetranitrate (inn)
cardilate (tn)
erythrityl tetranitrate (usan)
D04051
etn ,
nsc-106566
nitroerythrol
eritrityl tetranitrate
nitroerythrite
meso-erythritol tetranitrate
erythrol tetranitrate
erythrityl tetranitrate
tetranitrol
nitroerythrit
7297-25-8
erythritol tetranitrate
(2r*,3s)-rel-1,2,3,4-butanetetroltetranitrate
DB01613
einecs 230-734-9
tetranitrato de eritritilo [inn-spanish]
eritrityli tetranitras [inn-latin]
nsc 106566
tetranitrate d'erithrityle
tetranitrate d'eritrityle [inn-french]
eritritile tetranitrato [dcit]
1,2,3,4-butanetetrol, tetranitrate, (r*,s*)-
erythrityl tetranitrate [usan]
tetranitrate d'eritrityle
eritrityli tetranitras
CHEBI:60072 ,
(2r*,3s*)-3,4-bis(nitrooxy)butane-1,2-diyl dinitrate
tetranitrato de eritritilo
[(2r,3s)-1,3,4-trinitrooxybutan-2-yl] nitrate
CHEMBL2107583
c01da13
unii-35x333p19d
35x333p19d ,
eritritile tetranitrato
eritrityl tetranitrate [inn]
erythrityl tetranitrate [usan:usp]
erythrityl tetranitrate [vandf]
eritrityl tetranitrate [who-dd]
1,2,3,4-butanetetrol, 1,2,3,4-tetranitrate, (2r,3s)-rel-
erythrityl tetranitrate [mi]
eritrityl tetranitrate [mart.]
SCHEMBL119876
DTXSID9022990
(2s,3r)-2,3,4-tris(nitrooxy)butyl nitrate
Q417174
EN300-18567364
(2r,3s)-1,3,4-tris(nitrooxy)butan-2-yl nitrate
AKOS040751717

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The bioavailability or oral, sublingual, and chewable tablets or erythrityl tetranitrate (ETN) was evaluated in 15 normal men."( Digital plethysmography for assessing erythrityl tetranitrate bioavailability.
Bronson, EC; Erb, RJ; Hannemann, RE; Hull, JH; Long, RA; Starbuck, RR; Stoltman, WP; Williams, EJ, 1981
)
0.26

Dosage Studied

ExcerptRelevanceReference
"A reliable, sensitive, and specific assay for isosorbide dinitrate pentaerythritol tetranitrate, and erythrityl tetranitrate in sublingual, uncoated, sustained-release, and chewable dosage forms, using high-performance liquid chromatography, is described."( High-performance liquid chromatographic determination of the nitrate esters isosorbide dinitrate, pentaerythritol tetranitrate, and erythrityl tetranitrate in various tablet forms.
Olsen, CS; Scroggins, HS, 1984
)
0.27
" Values for area under the response intensity curve (AUC), maximum response intensity (Imax), and time lapse from dosing to peak response (tmax) were obtained by computer processing and converted to intensity values and AUC segments for specific time intervals."( Digital plethysmography for assessing erythrityl tetranitrate bioavailability.
Bronson, EC; Erb, RJ; Hannemann, RE; Hull, JH; Long, RA; Starbuck, RR; Stoltman, WP; Williams, EJ, 1981
)
0.26
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
vasodilator agentA drug used to cause dilation of the blood vessels.
explosiveA substance capable of undergoing rapid and highly exothermic decomposition.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
nitrate esterAny member of the class of nitrates resulting from the esterification of nitric acid with an alcohol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (53)

TimeframeStudies, This Drug (%)All Drugs %
pre-199048 (90.57)18.7374
1990's3 (5.66)18.2507
2000's1 (1.89)29.6817
2010's1 (1.89)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials11 (18.97%)5.53%
Reviews1 (1.72%)6.00%
Case Studies1 (1.72%)4.05%
Observational0 (0.00%)0.25%
Other45 (77.59%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]