tranexamic acid has been researched along with Ischemia in 10 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This prospective nested magnetic resonance imaging (MRI) substudy of a randomized clinical trial (RCT) recruited participants from the multicenter, double-blind, placebo-controlled, phase 3 RCT (Tranexamic Acid for Hyperacute Primary Intracerebral Hemorrhage [TICH-2]) from July 1, 2015, to September 30, 2017, and conducted follow-up to 90 days after participants were randomized to either the tranexamic acid or placebo group." | 9.51 | Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial. ( Al-Shahi Salman, R; Bath, PM; Casado, AM; Dineen, RA; England, TJ; Gallagher, R; Law, ZK; Morgan, PS; Pszczolkowski, S; Roberts, I; Sprigg, N; Swienton, D; Werring, DJ; Woodhouse, LJ, 2022) |
| "This prospective nested magnetic resonance imaging (MRI) substudy of a randomized clinical trial (RCT) recruited participants from the multicenter, double-blind, placebo-controlled, phase 3 RCT (Tranexamic Acid for Hyperacute Primary Intracerebral Hemorrhage [TICH-2]) from July 1, 2015, to September 30, 2017, and conducted follow-up to 90 days after participants were randomized to either the tranexamic acid or placebo group." | 5.51 | Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial. ( Al-Shahi Salman, R; Bath, PM; Casado, AM; Dineen, RA; England, TJ; Gallagher, R; Law, ZK; Morgan, PS; Pszczolkowski, S; Roberts, I; Sprigg, N; Swienton, D; Werring, DJ; Woodhouse, LJ, 2022) |
| "Within 2245 included ICSRs on tranexamic acid, we identified 29 reports of adverse renal vascular and ischemic conditions, 42 reports of pulmonary thrombotic and embolic conditions, and 41 reports of peripheral embolism and thrombosis." | 4.02 | Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data. ( Burden, AM; Heesen, M; Stämpfli, D; Weiler, S; Weiniger, CF, 2021) |
| "New Zealand White rabbits were randomly divided into two groups: a simple ischemia group and a group injected with tranexamic acid before left hilar occlusion." | 3.70 | Reduction of post-ischemic lung reperfusion injury by fibrinolytic activity suppression. ( Edagawa, M; Maruyama, M; Matsuzaki, Y; Onitsuka, T; Shibata, K; Shibuya, K; Yoshida, E, 1999) |
| "Trauma and hemorrhagic shock (T/HS) is a major cause of morbidity and mortality." | 1.72 | Continuous enteral protease inhibition as a novel treatment for experimental trauma/hemorrhagic shock. ( Aletti, F; DeLano, FA; Kistler, EB; Maffioli, E; Mu, H; Schmid-Schönbein, GW; Tedeschi, G, 2022) |
| "Tranexamic acid (TXA) is a common antifibrinolytic agent used to minimize bleeding in cardiac surgery." | 1.48 | Tranexamic Acid Dosing for Cardiac Surgical Patients With Chronic Renal Dysfunction: A New Dosing Regimen. ( Beattie, WS; Bojko, B; Jerath, A; Looby, N; Pang, KS; Pawliszyn, J; Reyes-Garces, N; Vasiljevic, T; Wąsowicz, M; Wijeysundera, D; Yang, QJ; Yau, TM, 2018) |
| "Intestinal ischemia is associated with high morbidity and mortality, but the underlying mechanisms are uncertain." | 1.38 | Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall. ( Chang, M; Kistler, EB; Schmid-Schönbein, GW, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pszczolkowski, S | 1 |
| Sprigg, N | 1 |
| Woodhouse, LJ | 1 |
| Gallagher, R | 1 |
| Swienton, D | 1 |
| Law, ZK | 1 |
| Casado, AM | 1 |
| Roberts, I | 1 |
| Werring, DJ | 1 |
| Al-Shahi Salman, R | 1 |
| England, TJ | 1 |
| Morgan, PS | 1 |
| Bath, PM | 1 |
| Dineen, RA | 1 |
| Masaryk, J | 1 |
| Vidan, J | 1 |
| ŠteŇo, B | 1 |
| Stämpfli, D | 1 |
| Weiler, S | 1 |
| Weiniger, CF | 1 |
| Burden, AM | 1 |
| Heesen, M | 1 |
| Aletti, F | 1 |
| DeLano, FA | 1 |
| Maffioli, E | 1 |
| Mu, H | 1 |
| Schmid-Schönbein, GW | 3 |
| Tedeschi, G | 1 |
| Kistler, EB | 2 |
| Jerath, A | 1 |
| Yang, QJ | 1 |
| Pang, KS | 1 |
| Looby, N | 1 |
| Reyes-Garces, N | 1 |
| Vasiljevic, T | 1 |
| Bojko, B | 1 |
| Pawliszyn, J | 1 |
| Wijeysundera, D | 1 |
| Beattie, WS | 1 |
| Yau, TM | 1 |
| Wąsowicz, M | 1 |
| Altshuler, AE | 1 |
| Lamadrid, I | 1 |
| Li, D | 1 |
| Ma, SR | 1 |
| Kurre, L | 1 |
| Penn, AH | 1 |
| Chang, M | 1 |
| Edagawa, M | 1 |
| Yoshida, E | 1 |
| Matsuzaki, Y | 1 |
| Shibuya, K | 1 |
| Shibata, K | 1 |
| Onitsuka, T | 1 |
| Maruyama, M | 1 |
| Nwose, PE | 1 |
| Regueira, FM | 1 |
| Sierra, A | 1 |
| Diez-Caballero, A | 1 |
| Hernández, JL | 1 |
| Pardo, F | 1 |
| Cienfuegos, JA | 1 |
| Kondo, M | 1 |
| Yoshikawa, T | 1 |
| Takemura, S | 1 |
| Yokoe, N | 1 |
| Kawai, K | 1 |
| Masuda, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Tranexamic Acid in Patients With Varying Renal Function Undergoing Cardiac Surgery With the Use of Cardiopulmonary Bypass[NCT01609686] | 49 participants (Actual) | Observational | 2012-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for tranexamic acid and Ischemia
| Article | Year |
|---|---|
Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial.
Topics: Aged; Antifibrinolytic Agents; Cerebral Hemorrhage; Double-Blind Method; Female; Hematoma; Humans; I | 2022 |
9 other studies available for tranexamic acid and Ischemia
| Article | Year |
|---|---|
[Acute Limb Ischemia after Total Hip Arthroplasty in a High-Risk Patient - Is Tranexamic Acid to Blame?]
Topics: Administration, Topical; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Loss, Surgic | 2020 |
Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data.
Topics: Adolescent; Adult; Antifibrinolytic Agents; Databases, Factual; Embolism; Female; Humans; Ischemia; | 2021 |
Continuous enteral protease inhibition as a novel treatment for experimental trauma/hemorrhagic shock.
Topics: Animals; Disease Models, Animal; Humans; Intestine, Small; Ischemia; Protease Inhibitors; Rats; Rats | 2022 |
Tranexamic Acid Dosing for Cardiac Surgical Patients With Chronic Renal Dysfunction: A New Dosing Regimen.
Topics: Aged; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Drug Administrat | 2018 |
Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition.
Topics: Animals; Intestinal Mucosa; Intestine, Small; Ischemia; Male; Permeability; Rats; Rats, Wistar; Seri | 2014 |
Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall.
Topics: Animals; Cadherins; Celiac Artery; Chymotrypsin; Constriction, Pathologic; Intestinal Mucosa; Intest | 2012 |
Reduction of post-ischemic lung reperfusion injury by fibrinolytic activity suppression.
Topics: Animals; Antifibrinolytic Agents; Fibrinolysis; Ischemia; Lung; Male; Pulmonary Circulation; Pulmona | 1999 |
Effect of treatment with tranexamic acid on complement activation and ischemia reperfusion in liver transplantation in pigs.
Topics: Animals; Aspartate Aminotransferases; Complement Activation; Ischemia; Liver Transplantation; Malond | 1999 |
Hemorrhagic necrosis of the intestinal mucosa associated with disseminated intravascular coagulation.
Topics: Animals; Blood Coagulation Factors; Complement System Proteins; Disseminated Intravascular Coagulati | 1978 |