1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol profile

You're describing a **synthetic lipid** with a very specific structure. Let's break down its components and understand its significance in research:

**Structure:**

* **1-hexadecyl:** This part indicates a 16-carbon chain (hexadecane) attached to the first carbon of the glycerol backbone.
* **3-trifluoroethyl:** A trifluoroethyl group (CF3CH2-) is attached to the third carbon of glycerol.
* **glycero-sn-2-phosphomethanol:** This refers to the core structure: glycerol (a three-carbon sugar alcohol) with a phosphate group (PO4) linked to the second carbon (sn-2) and a methanol (CH3OH) group attached to the phosphate.

**Overall:** This synthetic lipid is basically a modified phospholipid with a long hydrocarbon tail, a trifluoroethyl group, and a phosphomethanol head.

**Importance in Research:**

This specific lipid, or variations of it, is likely used in research for several reasons:

* **Cell membrane studies:**
* The long hydrocarbon tail mimics the hydrophobic nature of fatty acid chains found in natural phospholipids, which make up cell membranes.
* The trifluoroethyl group could be used to introduce specific properties or functionalities to the membrane, such as increased fluorogenicity for imaging or altered interactions with other molecules.
* **Drug delivery:**
* The presence of the phosphomethanol head makes this lipid potentially useful for drug delivery applications. The phosphate group can interact with charged drug molecules, while the hydrophobic tail can help embed the drug within a lipid-based delivery system (like liposomes).
* **Material science:**
* Such synthetic lipids can be used to create novel materials with unique properties. For example, they can be incorporated into lipid bilayers or self-assembled structures for applications in biocompatible coatings, sensors, or even drug delivery systems.

**Crucial Information:**

To understand its specific importance in research, you need more context. For example:

* **Where did you encounter this lipid?** A research paper, a chemical database, or a specific lab protocol?
* **What is the research field?** Cell biology, drug development, materials science?
* **What are the specific properties being studied?** Fluidity, permeability, drug encapsulation, etc.?

By providing more details about the context of this lipid, we can better understand its significance in the specific research area.

ID Source	ID
PubMed CID	132064
MeSH ID	M0210609

Synonym
mj-33
hexadecanoic acid, 2-((hydroxymethoxyphosphinyl)oxy)-3-(2,2,2-trifluoroethoxy)propyl ester, (+-)-
1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol
137464-44-9
[2-[hydroxy(methoxy)phosphoryl]oxy-3-(2,2,2-trifluoroethoxy)propyl] hexadecanoate
aztcomapqrbirm-uhfffaoysa-n
DTXSID80929801
2-{[hydroxy(methoxy)phosphoryl]oxy}-3-(2,2,2-trifluoroethoxy)propyl hexadecanoatato(2-)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	8 (34.78)	18.2507
2000's	5 (21.74)	29.6817
2010's	9 (39.13)	24.3611
2020's	1 (4.35)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
mercaptoethanol Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.	1.98	1	alkanethiol; primary alcohol	geroprotector
5,8,11,14-eicosatetraynoic acid 5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).	1.98	1	long-chain fatty acid
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.31	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
iodoacetamide [no description available]	1.98	1
1-methyl-3-isobutylxanthine 1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES. 3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.	2.15	1	3-isobutyl-1-methylxanthine
penicillamine Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.. penicillamine : An alpha-amino acid having the structure of valine substituted at the beta position with a sulfanyl group.	2.15	1	non-proteinogenic alpha-amino acid; penicillamine	antirheumatic drug; chelator; copper chelator; drug allergen
1,2-dipalmitoylphosphatidylcholine 1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.	3.1	5
histidine Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	2.02	1	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
methylamine methyl group : An alkyl group that is the univalent group derived from methane by removal of a hydrogen atom.	1.99	1	methylamines; one-carbon compound; primary aliphatic amine	mouse metabolite
4-bromophenacyl bromide 4-bromophenacyl bromide: phospholipidase A(2) inhibitor; structure	2.69	3
dodecyl sulfate dodecyl sulfate: RN given refers to parent cpd; see also SODIUM DODECYL SULFATE	2.02	1	alkyl sulfate
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.13	1	dialdehyde	biomarker
cyclic cmp Cyclic CMP: A cyclic nucleotide formed from CYTIDINE TRIPHOSPHATE by the action of cytidylate cyclase. It is a potential cyclic nucleotide intracellular mediator of signal transductions.. 3',5'-cyclic CMP : A 3',5'-cyclic pyrimidine nucleotide having cytosine as the nucleobase.	2.15	1	3',5'-cyclic pyrimidine nucleotide	human metabolite
8-bromo cyclic adenosine monophosphate 8-Bromo Cyclic Adenosine Monophosphate: A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.. 8-Br-cAMP : A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.	2	1	3',5'-cyclic purine nucleotide; adenyl ribonucleotide; organobromine compound	antidepressant; protein kinase agonist
dibutyryl cyclic-3',5'-cytidine monophosphate [no description available]	2.15	1
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	2.07	1	amino acid zwitterion; angiotensin II	human metabolite
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.02	1	organic sodium salt	detergent; protein denaturant
lysophosphatidylcholines lysophosphatidylcholine : An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.	2.15	1	1-O-acyl-sn-glycero-3-phosphocholine
diphenylhexatriene Diphenylhexatriene: A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.	2.02	1	alkatriene	fluorochrome
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.39	2	1,2-diacyl-sn-glycero-3-phosphocholine
thiostrepton Thiostrepton: One of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.. thiostrepton : A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent.	2.15	1
glycolipids [no description available]	2.08	1

Condition	Relationship Strength	Studies
Colorectal Cancer [description not available]	2.31	1
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.31	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.08	1
Lung Injury, Acute [description not available]	2.78	3
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	2.78	3
Hyperoxia An abnormal increase in the amount of oxygen in the tissues and organs.	2.11	1
Anoxemia [description not available]	2.13	1
Brain Dead [description not available]	2.13	1
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	2.13	1
Ischemia A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.	2.42	2
Metastase [description not available]	2.07	1
Cancer of Prostate [description not available]	2.07	1
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.07	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.07	1
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	1.99	1

1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol

Cross-References

Synonyms (8)

Research

Studies (23)

Market Indicators

Research Demand Index: 11.49

Study Types