suramin has been researched along with Ischemia in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response of ATP revealed a hyperbolic profile with maximal velocity of 25." | 1.38 | Characterization of ecto-ATPase activity in the surface of LLC-PK1 cells and its modulation by ischemic conditions. ( Caruso-Neves, C; Costa-Alves, MS; Meyer-Fernandes, JR; Pinheiro, AA; Ribeiro, MC; Wengert, M; Zancan, P, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shinotsuka, T | 1 |
| Yasui, M | 1 |
| Nuriya, M | 1 |
| Ribeiro, MC | 1 |
| Costa-Alves, MS | 1 |
| Wengert, M | 1 |
| Meyer-Fernandes, JR | 1 |
| Zancan, P | 1 |
| Caruso-Neves, C | 1 |
| Pinheiro, AA | 1 |
| Kim, DS | 1 |
| Kwak, SE | 1 |
| Kim, JE | 1 |
| Won, MH | 1 |
| Kang, TC | 1 |
| Pessina, F | 1 |
| Matteucci, G | 1 |
| Esposito, L | 1 |
| Gorelli, B | 1 |
| Valoti, M | 1 |
| Sgaragli, G | 1 |
4 other studies available for suramin and Ischemia
| Article | Year |
|---|---|
Astrocytic gap junctional networks suppress cellular damage in an in vitro model of ischemia.
Topics: Animals; Astrocytes; Calcium Signaling; Carbenoxolone; Cell Hypoxia; Cerebral Cortex; Chelating Agen | 2014 |
Characterization of ecto-ATPase activity in the surface of LLC-PK1 cells and its modulation by ischemic conditions.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antineoplastic Ag | 2012 |
The co-treatments of vigabatrin and P2X receptor antagonists protect ischemic neuronal cell death in the gerbil hippocampus.
Topics: Adenosine Triphosphatases; Animals; Cell Death; Disease Models, Animal; Drug Therapy, Combination; E | 2006 |
Protection of intrinsic nerves of guinea-pig detrusor strips against anoxia/glucopenia and reperfusion injury by taurine.
Topics: Aminoethylphosphonic Acid; Animals; Atropine; Electric Stimulation; Evoked Potentials; Glucose; Guin | 2000 |