kaolinite and Ischemia

The authors found that cavities in the spinal cord of dogs appearing after the intracisternal administration of kaolin are not due to ischemic softening, but rather to distention and subsequent rupture of the central canal. Ischemic lesions could be produced and were found to have a quite different histopathology; this supports the hydrodynamic hypothesis of cavitary myelopathy following adhesive arachnoiditis, probably as a compensatory mechanism to the associated hydrocephalus. The similarities to human syringomyelia are discussed.

Topics: Animals; Arachnoiditis; Dogs; Ischemia; Kaolin; Spinal Cord; Spinal Cord Diseases; Syringomyelia; Time Factors