5-hydroxydecanoate has been researched along with Ischemia in 10 studies
5-hydroxydecanoic acid: Potassium Channel Blocker; RN refers to parent cpd
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used adenosine A1 receptor agonist N6-1(phenyl-2R-isopropyl)-adenosine (PIA), A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), and ATP-sensitive K+ (KATP) channel blockers sodium 5-hydroxydecanoate (5-HD) and glibenclamide (Glib), as probes to investigate the role and mechanism of adenosine in ischemic preconditioning (IPC) of noncontractile skeletal muscle against infarction, using the pig latissimus dorsi muscle flap model." | 7.69 | Effector mechanism of adenosine in acute ischemic preconditioning of skeletal muscle against infarction. ( Forrest, CR; He, W; Neligan, P; Pang, CY; Xu, H; Zhong, A, 1997) |
| "Severe sustained ventricular tachyarrhythmias developed on reflow in the controls and in the 5-HD exposed hearts." | 5.32 | Effects of barium and 5-hydroxydecanoate on the electrophysiologic response to acute regional ischemia and reperfusion in rat hearts. ( Baiardi, G; Petrich, ER; Zumino, AP, 2003) |
| " In this study, we investigated whether TZDs affect onset, spectral characteristics, and mortality of ischemic ventricular fibrillation (VF) and whether such effects are recapitulated by a non-selective K(ATP) blocker (glyburide) or a mitochondrial K(ATP) blocker (5-hydroxydecanoate)." | 3.78 | Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fibrillation in pigs. ( Greyson, CR; Lu, L; Reiter, MJ; Sarraf, M; Schwartz, GG; Ye, S, 2012) |
| "We used adenosine A1 receptor agonist N6-1(phenyl-2R-isopropyl)-adenosine (PIA), A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), and ATP-sensitive K+ (KATP) channel blockers sodium 5-hydroxydecanoate (5-HD) and glibenclamide (Glib), as probes to investigate the role and mechanism of adenosine in ischemic preconditioning (IPC) of noncontractile skeletal muscle against infarction, using the pig latissimus dorsi muscle flap model." | 3.69 | Effector mechanism of adenosine in acute ischemic preconditioning of skeletal muscle against infarction. ( Forrest, CR; He, W; Neligan, P; Pang, CY; Xu, H; Zhong, A, 1997) |
| "Pretreatment with diazoxide significantly reduced the infarct volume from 6." | 1.33 | MitoKATP-channel opener protects against neuronal death in rat venous ischemia. ( Alessandri, B; Heimann, A; Kempski, O; Nakagawa, I, 2005) |
| "Severe sustained ventricular tachyarrhythmias developed on reflow in the controls and in the 5-HD exposed hearts." | 1.32 | Effects of barium and 5-hydroxydecanoate on the electrophysiologic response to acute regional ischemia and reperfusion in rat hearts. ( Baiardi, G; Petrich, ER; Zumino, AP, 2003) |
| "Diazoxide pretreatment significantly increased nuclear translocation of p65 which was blocked by protein kinase C (PKC) or nitric oxide synthase (NOS) inhibition." | 1.31 | Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. ( Ashraf, M; Ayub, A; Kudo, M; Wang, Y; Xu, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gozen, A | 1 |
| Demiryurek, S | 1 |
| Taskin, A | 1 |
| Ciralik, H | 1 |
| Bilinc, H | 1 |
| Kara, S | 1 |
| Aydin, A | 1 |
| Aksoy, N | 1 |
| Ceylan, H | 1 |
| Wang, C | 1 |
| Hu, SM | 1 |
| Xie, H | 1 |
| Qiao, SG | 1 |
| Liu, H | 1 |
| Liu, CF | 1 |
| Sarraf, M | 1 |
| Lu, L | 1 |
| Ye, S | 1 |
| Reiter, MJ | 1 |
| Greyson, CR | 1 |
| Schwartz, GG | 1 |
| Baiardi, G | 1 |
| Zumino, AP | 1 |
| Petrich, ER | 1 |
| Nakagawa, I | 1 |
| Alessandri, B | 1 |
| Heimann, A | 1 |
| Kempski, O | 1 |
| Friedrichs, GS | 1 |
| Abreu, JN | 1 |
| Black, SC | 1 |
| Chi, L | 1 |
| Lucchesi, BR | 1 |
| Pang, CY | 1 |
| Neligan, P | 1 |
| Zhong, A | 1 |
| He, W | 1 |
| Xu, H | 1 |
| Forrest, CR | 1 |
| Sakamoto, K | 1 |
| Kuwagata, M | 1 |
| Nakahara, T | 1 |
| Ishii, K | 1 |
| Kong, X | 1 |
| Tweddell, JS | 1 |
| Gross, GJ | 1 |
| Baker, JE | 1 |
| Wang, Y | 1 |
| Kudo, M | 1 |
| Xu, M | 1 |
| Ayub, A | 1 |
| Ashraf, M | 1 |
10 other studies available for 5-hydroxydecanoate and Ischemia
| Article | Year |
|---|---|
Protective activity of ischemic preconditioning on rat testicular ischemia: effects of Y-27632 and 5-hydroxydecanoic acid.
Topics: Amides; Animals; Decanoic Acids; Enzyme Inhibitors; Hydroxy Acids; Ischemia; Ischemic Preconditionin | 2013 |
Role of mitochondrial ATP-sensitive potassium channel-mediated PKC-ε in delayed protection against myocardial ischemia/reperfusion injury in isolated hearts of sevoflurane-preconditioned rats.
Topics: Animals; Anti-Arrhythmia Agents; Blotting, Western; Caspase 8; Decanoic Acids; Heart; Hemodynamics; | 2015 |
Thiazolidinedione drugs promote onset, alter characteristics, and increase mortality of ischemic ventricular fibrillation in pigs.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Vessels; Death, Sudden, Cardiac; Decanoic Acids; Female; G | 2012 |
Effects of barium and 5-hydroxydecanoate on the electrophysiologic response to acute regional ischemia and reperfusion in rat hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Barium; Decanoic Acids; Electroencephalography; | 2003 |
MitoKATP-channel opener protects against neuronal death in rat venous ischemia.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Brain Edema; Brain Infarction; Cell Death; Ce | 2005 |
5-hydroxydecanoate fails to attenuate ventricular fibrillation in a conscious canine model of sudden cardiac death.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Blood Pressure; Death, Sudden, Cardiac; Decanoic | 1996 |
Effector mechanism of adenosine in acute ischemic preconditioning of skeletal muscle against infarction.
Topics: Adenosine; Animals; Decanoic Acids; Glyburide; Hydroxy Acids; Infarction; Ischemia; Ischemic Precond | 1997 |
Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K(+) channel.
Topics: Adenosine Triphosphate; Animals; Cell Size; Decanoic Acids; Hydroxy Acids; Ion Channel Gating; Ische | 2001 |
Sarcolemmal and mitochondrial K(atp)channels mediate cardioprotection in chronically hypoxic hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzamides; Decanoic Acids; Heart; Hemodynamics; Hydroxy Acids; Hyp | 2001 |
Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.
Topics: Acetophenones; Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agen | 2001 |