fluorouracil has been researched along with Ischemia in 15 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After cisplatin / 5-fluorouracil chemotherapy for nasopharyngeal carcinoma, an 18-year female patient developed aortobifemoral embolism." | 7.76 | Aortobifemoral embolism in an 18-year old patient following cisplatin and 5-fluorouracil chemotherapy for nasopharyngeal carcinoma. ( Bode, U; Born, M; Fleischhack, G; Heinrich, N; Hoebert, E; Simon, A; Verrel, F, 2010) |
| "During a regular MR control, the patient developed anaphylactic reaction to Gadolinium, and after that a rectosigmoid ischemia with total necrosis of the posterior rectal wall was diagnosed and surgically treated with Hartmann procedure." | 3.91 | Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication. ( Calvisi, G; Carlei, F; Di Sibio, A; Di Staso, M; Giuliani, A; Lombardi, L; Marchese, M; Romano, L; Romanzi, F; Schietroma, M, 2019) |
| "After cisplatin / 5-fluorouracil chemotherapy for nasopharyngeal carcinoma, an 18-year female patient developed aortobifemoral embolism." | 3.76 | Aortobifemoral embolism in an 18-year old patient following cisplatin and 5-fluorouracil chemotherapy for nasopharyngeal carcinoma. ( Bode, U; Born, M; Fleischhack, G; Heinrich, N; Hoebert, E; Simon, A; Verrel, F, 2010) |
| "Gastrointestinal perforation is a known risk factor of unknown etiology associated with the use of bevacizumab." | 1.35 | [Ischemic anastomotic bowel perforation during treatment with bevacizumab 10 months after surgery]. ( Abbrederis, K; Kremer, M; Schuhmacher, C, 2008) |
| "Pathology of the optic nerves revealed demyelination." | 1.29 | Ocular toxicity following high dose chemotherapy and autologous transplant. ( Elkordy, M; Hulette, C; Hussein, A; Jaffe, GJ; Khawly, JA; Peters, WP; Rubin, P; Vredenburgh, JJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giuliani, A | 1 |
| Romanzi, F | 1 |
| Di Sibio, A | 1 |
| Calvisi, G | 1 |
| Lombardi, L | 1 |
| Marchese, M | 1 |
| Di Staso, M | 1 |
| Schietroma, M | 1 |
| Carlei, F | 1 |
| Romano, L | 1 |
| Ryan, EM | 1 |
| Hanly, A | 1 |
| Morrin, MM | 1 |
| McNamara, DA | 1 |
| Abaci, HE | 1 |
| Shen, YI | 1 |
| Tan, S | 1 |
| Gerecht, S | 1 |
| Naito, H | 1 |
| Kidoya, H | 1 |
| Sato, Y | 1 |
| Takakura, N | 1 |
| Heinrich, N | 1 |
| Born, M | 1 |
| Hoebert, E | 1 |
| Verrel, F | 1 |
| Simon, A | 1 |
| Bode, U | 1 |
| Fleischhack, G | 1 |
| Garrett, WV | 1 |
| Brown, JR | 1 |
| Pickering, D | 1 |
| Andrews, SM | 1 |
| Abbrederis, K | 1 |
| Kremer, M | 1 |
| Schuhmacher, C | 1 |
| Rubin, P | 1 |
| Hulette, C | 1 |
| Khawly, JA | 1 |
| Elkordy, M | 1 |
| Hussein, A | 1 |
| Vredenburgh, JJ | 1 |
| Jaffe, GJ | 1 |
| Peters, WP | 1 |
| Allerton, R | 1 |
| Cwikiel, M | 1 |
| Albertsson, M | 1 |
| Kinhult, S | 1 |
| Eskilsson, J | 1 |
| Marre, P | 1 |
| Bentata, M | 1 |
| Lenormand, Y | 1 |
| Seguier, JC | 1 |
| Sinda, P | 1 |
| Vowden, P | 1 |
| Wilkinson, D | 1 |
| Kester, RC | 1 |
| Mack, P | 1 |
| Tranberg, KG | 1 |
| Strenram, U | 1 |
| Jeppsson, B | 2 |
| Widlus, D | 1 |
| Bengmark, S | 2 |
| Eibl-Eibesfeldt, B | 1 |
| Storz, V | 1 |
| Kummermehr, J | 1 |
| Schalhorn, A | 1 |
| Puntis, M | 1 |
1 review available for fluorouracil and Ischemia
| Article | Year |
|---|---|
Acute mesenteric ischaemia associated with 5-FU, cisplatin and vincristine chemotherapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineopl | 1996 |
14 other studies available for fluorouracil and Ischemia
| Article | Year |
|---|---|
Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication.
Topics: Aged; Anaphylaxis; Anus Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Chemoradiotherapy; Colon, Si | 2019 |
Unusual ischemic complication of bevacizumab treatment for metastatic colorectal carcinoma.
Topics: Abdominal Pain; Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Co | 2013 |
Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease.
Topics: Animals; Atherosclerosis; Capillary Permeability; Endothelial Cells; Endothelium, Vascular; Fluorour | 2014 |
Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.
Topics: Angiogenesis Inhibitors; Animals; Bone Marrow Cells; Cell Cycle Proteins; Cell Line; Cell Proliferat | 2009 |
Aortobifemoral embolism in an 18-year old patient following cisplatin and 5-fluorouracil chemotherapy for nasopharyngeal carcinoma.
Topics: Adolescent; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Aortic Diseases; Arterial O | 2010 |
Critical limb ischaemia associated with chemotherapy for breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fingers; | 2004 |
[Ischemic anastomotic bowel perforation during treatment with bevacizumab 10 months after surgery].
Topics: Anastomosis, Surgical; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Huma | 2008 |
Ocular toxicity following high dose chemotherapy and autologous transplant.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Cispl | 1996 |
5-fluorouracil-induced small bowel toxicity in patients with colorectal carcinoma.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Endothelium, Vascular; Fluorouracil; | 2000 |
[Acute intestinal ischemia after two treatments with 5-fluorouracil by continuous venous infusion].
Topics: Adult; Carcinoma, Squamous Cell; Fluorouracil; Humans; Infusions, Intravenous; Intestine, Small; Isc | 1992 |
Treatment of digital ischaemia associated with chemotherapy using the prostacyclin analogue iloprost.
Topics: Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Combined Modality Therapy; Female; Finger | 1991 |
RNA labelling with 3H-orotic acid and 3H-fluorouracil of rat liver tumour following transient hepatic arterial ischaemia.
Topics: Animals; DNA, Neoplasm; Fluorouracil; Hepatic Artery; Ischemia; Liver Neoplasms; Male; Orotic Acid; | 1988 |
Basic investigations on interaction of 5-fluorouracil and tumor ischemia in the treatment of liver malignancies.
Topics: Adenocarcinoma; Animals; Combined Modality Therapy; Female; Fluorouracil; Humans; Ischemia; Liver Ne | 1988 |
Hepatic dearterialization in cancer: new perspectives.
Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Fluorour | 1986 |