Page last updated: 2024-10-27

fluorouracil and Ischemia

fluorouracil has been researched along with Ischemia in 15 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"After cisplatin / 5-fluorouracil chemotherapy for nasopharyngeal carcinoma, an 18-year female patient developed aortobifemoral embolism."7.76Aortobifemoral embolism in an 18-year old patient following cisplatin and 5-fluorouracil chemotherapy for nasopharyngeal carcinoma. ( Bode, U; Born, M; Fleischhack, G; Heinrich, N; Hoebert, E; Simon, A; Verrel, F, 2010)
"During a regular MR control, the patient developed anaphylactic reaction to Gadolinium, and after that a rectosigmoid ischemia with total necrosis of the posterior rectal wall was diagnosed and surgically treated with Hartmann procedure."3.91Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication. ( Calvisi, G; Carlei, F; Di Sibio, A; Di Staso, M; Giuliani, A; Lombardi, L; Marchese, M; Romano, L; Romanzi, F; Schietroma, M, 2019)
"After cisplatin / 5-fluorouracil chemotherapy for nasopharyngeal carcinoma, an 18-year female patient developed aortobifemoral embolism."3.76Aortobifemoral embolism in an 18-year old patient following cisplatin and 5-fluorouracil chemotherapy for nasopharyngeal carcinoma. ( Bode, U; Born, M; Fleischhack, G; Heinrich, N; Hoebert, E; Simon, A; Verrel, F, 2010)
"Gastrointestinal perforation is a known risk factor of unknown etiology associated with the use of bevacizumab."1.35[Ischemic anastomotic bowel perforation during treatment with bevacizumab 10 months after surgery]. ( Abbrederis, K; Kremer, M; Schuhmacher, C, 2008)
"Pathology of the optic nerves revealed demyelination."1.29Ocular toxicity following high dose chemotherapy and autologous transplant. ( Elkordy, M; Hulette, C; Hussein, A; Jaffe, GJ; Khawly, JA; Peters, WP; Rubin, P; Vredenburgh, JJ, 1996)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's4 (26.67)18.2507
2000's4 (26.67)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giuliani, A1
Romanzi, F1
Di Sibio, A1
Calvisi, G1
Lombardi, L1
Marchese, M1
Di Staso, M1
Schietroma, M1
Carlei, F1
Romano, L1
Ryan, EM1
Hanly, A1
Morrin, MM1
McNamara, DA1
Abaci, HE1
Shen, YI1
Tan, S1
Gerecht, S1
Naito, H1
Kidoya, H1
Sato, Y1
Takakura, N1
Heinrich, N1
Born, M1
Hoebert, E1
Verrel, F1
Simon, A1
Bode, U1
Fleischhack, G1
Garrett, WV1
Brown, JR1
Pickering, D1
Andrews, SM1
Abbrederis, K1
Kremer, M1
Schuhmacher, C1
Rubin, P1
Hulette, C1
Khawly, JA1
Elkordy, M1
Hussein, A1
Vredenburgh, JJ1
Jaffe, GJ1
Peters, WP1
Allerton, R1
Cwikiel, M1
Albertsson, M1
Kinhult, S1
Eskilsson, J1
Marre, P1
Bentata, M1
Lenormand, Y1
Seguier, JC1
Sinda, P1
Vowden, P1
Wilkinson, D1
Kester, RC1
Mack, P1
Tranberg, KG1
Strenram, U1
Jeppsson, B2
Widlus, D1
Bengmark, S2
Eibl-Eibesfeldt, B1
Storz, V1
Kummermehr, J1
Schalhorn, A1
Puntis, M1

Reviews

1 review available for fluorouracil and Ischemia

ArticleYear
Acute mesenteric ischaemia associated with 5-FU, cisplatin and vincristine chemotherapy.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1996, Volume: 8, Issue:2

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineopl

1996

Other Studies

14 other studies available for fluorouracil and Ischemia

ArticleYear
Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication.
    Annali italiani di chirurgia, 2019, Jun-26, Volume: 8

    Topics: Aged; Anaphylaxis; Anus Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Chemoradiotherapy; Colon, Si

2019
Unusual ischemic complication of bevacizumab treatment for metastatic colorectal carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Oct-20, Volume: 31, Issue:30

    Topics: Abdominal Pain; Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Co

2013
Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease.
    Scientific reports, 2014, May-13, Volume: 4

    Topics: Animals; Atherosclerosis; Capillary Permeability; Endothelial Cells; Endothelium, Vascular; Fluorour

2014
Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.
    Journal of biochemistry, 2009, Volume: 145, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Bone Marrow Cells; Cell Cycle Proteins; Cell Line; Cell Proliferat

2009
Aortobifemoral embolism in an 18-year old patient following cisplatin and 5-fluorouracil chemotherapy for nasopharyngeal carcinoma.
    VASA. Zeitschrift fur Gefasskrankheiten, 2010, Volume: 39, Issue:3

    Topics: Adolescent; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Aortic Diseases; Arterial O

2010
Critical limb ischaemia associated with chemotherapy for breast cancer.
    Journal of the Royal Society of Medicine, 2004, Volume: 97, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fingers;

2004
[Ischemic anastomotic bowel perforation during treatment with bevacizumab 10 months after surgery].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2008, Volume: 79, Issue:4

    Topics: Anastomosis, Surgical; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Huma

2008
Ocular toxicity following high dose chemotherapy and autologous transplant.
    Bone marrow transplantation, 1996, Volume: 18, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Cispl

1996
5-fluorouracil-induced small bowel toxicity in patients with colorectal carcinoma.
    Cancer, 2000, Aug-01, Volume: 89, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Endothelium, Vascular; Fluorouracil;

2000
[Acute intestinal ischemia after two treatments with 5-fluorouracil by continuous venous infusion].
    Gastroenterologie clinique et biologique, 1992, Volume: 16, Issue:10

    Topics: Adult; Carcinoma, Squamous Cell; Fluorouracil; Humans; Infusions, Intravenous; Intestine, Small; Isc

1992
Treatment of digital ischaemia associated with chemotherapy using the prostacyclin analogue iloprost.
    European journal of vascular surgery, 1991, Volume: 5, Issue:5

    Topics: Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Combined Modality Therapy; Female; Finger

1991
RNA labelling with 3H-orotic acid and 3H-fluorouracil of rat liver tumour following transient hepatic arterial ischaemia.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1988, Volume: 14, Issue:6

    Topics: Animals; DNA, Neoplasm; Fluorouracil; Hepatic Artery; Ischemia; Liver Neoplasms; Male; Orotic Acid;

1988
Basic investigations on interaction of 5-fluorouracil and tumor ischemia in the treatment of liver malignancies.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1988, Volume: 110

    Topics: Adenocarcinoma; Animals; Combined Modality Therapy; Female; Fluorouracil; Humans; Ischemia; Liver Ne

1988
Hepatic dearterialization in cancer: new perspectives.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1986, Volume: 18, Issue:3-4

    Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Fluorour

1986