Page last updated: 2024-10-28

lidocaine and Ischemia

lidocaine has been researched along with Ischemia in 112 studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"To compare the effectiveness of intravenous lidocaine and intravenous morphine in decreasing pain in patients with critical limb ischaemia."9.20Comparison of intravenous lidocaine versus morphine in alleviating pain in patients with critical limb ischaemia. ( Aghaie Meybodi, M; Saeedi, M; Shakoor, D; Vahidi, E, 2015)
"To investigate effects of lidocaine hydrochloride administered IV on mucosal inflammation in ischemia-injured jejunum of horses treated with flunixin meglumine."9.14Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses. ( Blikslager, AT; Campbell, NB; Cook, VL; Davis, JL; Jones Shults, J; Marshall, JF; McDowell, MR, 2009)
" Fortunately, digital ischemia can be reversed with phentolamine."9.12Phentolamine Rescue for Digital Ischemia Following Lidocaine with Epinephrine Local Anesthesia: Case Presentation, Review of the Literature and Treatment Options. ( Hewitt, C; Smith, VJ; Van Demark, RE, 2021)
"A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery."7.77Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets. ( Bellemann, N; Boeckler, D; Hyhlik-Duerr, A; Kauczor, HU; Radeleff, B; Sommer, CM; Stampfl, U; Weber, MA, 2011)
"The direct injection of lidocaine into the clamped aorta results in a rapidly change in SCEP in the threat of ischemia and can be used to make an early detection of the segmental arteries perfusing to the spinal cord."7.70The effect of direct lidocaine injection into the clamped aortic segment on the spinal evoked potential: early diagnosis for spinal cord ischemia. ( Ataka, K; Nohara, H; Okada, M; Yamashita, C; Yoshimura, N, 1999)
"We used field potential recording techniques to examine whether felbamate (FBM), lamotrigine (LTG), and lidocaine (LID) protect against the irreversible functional damage induced by transient ischemia."7.70An electrophysiological analysis of the protective effects of felbamate, lamotrigine, and lidocaine on the functional recovery from in vitro ischemia in rat neocortical slices. ( Bernardi, G; Guatteo, E; Mercuri, NB; Siniscalchi, A; Zona, C, 1998)
"A quantitative liver test based on the formation of the lidocaine metabolite monoethylglycinexylidide (MEGX), was used to evaluate the effect of hemorrhagic shock at 40 mmHg for 90 min on Sprague-Dawley rats."7.69MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock. ( Baue, AE; Chandel, B; Jellinek, M; Kurtz, M; Matthews, M; Rana, WU; Shapiro, MJ, 1995)
"Mild ischemia was induced in segments of jejunum and large colon."6.84Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia. ( Bauck, AG; Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Vickroy, TW, 2017)
"Labetalol was found to be less effective in preventing tissue necrosis."5.28Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989)
"To compare the effectiveness of intravenous lidocaine and intravenous morphine in decreasing pain in patients with critical limb ischaemia."5.20Comparison of intravenous lidocaine versus morphine in alleviating pain in patients with critical limb ischaemia. ( Aghaie Meybodi, M; Saeedi, M; Shakoor, D; Vahidi, E, 2015)
"To investigate effects of lidocaine hydrochloride administered IV on mucosal inflammation in ischemia-injured jejunum of horses treated with flunixin meglumine."5.14Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses. ( Blikslager, AT; Campbell, NB; Cook, VL; Davis, JL; Jones Shults, J; Marshall, JF; McDowell, MR, 2009)
" Riluzole, Lidocaine and Lamotrigine were given prior to renal ischemia only (IO) or IRI."4.12Pharmacological prevention of renal ischemia-reperfusion injury in a rat model. ( Deng, Y; Li, RW; Smith, PN; Weiss, S; Yang, YL, 2022)
" The lower cell counts of caspase- and calprotectin-positive cells in group X may indicate a beneficial effect of xylazine on ischaemia/reperfusion injury."4.02Preconditioning with lidocaine and xylazine in experimental equine jejunal ischaemia. ( Kästner, S; König, K; Neudeck, S; Pfarrer, C; Rohn, K; Twele, L; Verhaar, N, 2021)
"A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery."3.77Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets. ( Bellemann, N; Boeckler, D; Hyhlik-Duerr, A; Kauczor, HU; Radeleff, B; Sommer, CM; Stampfl, U; Weber, MA, 2011)
"Lidocaine and thiopental improve recovery when administrated during hypoxia and ischemia; however, the effect of pre- or postinsult treatment alone is unknown."3.73Pre- or postinsult administration of lidocaine or thiopental attenuates cell death in rat hippocampal slice cultures caused by oxygen-glucose deprivation. ( Bergold, PJ; Cao, H; Cottrell, JE; Kass, IS, 2005)
"The principal finding of the present study with rat spinal cord slices was the novel demonstration of the [Ca2+]o-independent effect of ischemia on norepinephrine release and its antagonism by tetrodotoxin and low temperature (10 degrees C)."3.70Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices. ( Bencsics, A; Nakai, T; Sato, T; Uchihashi, Y; Umeda, E; Vizi, ES, 1998)
"A quantitative liver test based on the formation of the lidocaine metabolite monoethylglycinexylidide (MEGX), was used to evaluate the effect of hemorrhagic shock at 40 mmHg for 90 min on Sprague-Dawley rats."3.69MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock. ( Baue, AE; Chandel, B; Jellinek, M; Kurtz, M; Matthews, M; Rana, WU; Shapiro, MJ, 1995)
"Epidural lidocaine compared to epidural saline hastens the recovery of gastrointestinal motility in rats after a 30-min period of bowel ischemia."3.69Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat. ( Eimerl, D; Haskel, Y; Schiffman, J; Udassin, R, 1994)
"Antiarrhythmic drugs, such as lidocaine, quinidine, and procainamide, have been shown to be effective against postischemic reperfusion injury in isolated rat lungs."3.69Amelioration of postischemic reperfusion injury by antiarrhythmic drugs in isolated perfused rat lung. ( Das, KC; Misra, HP, 1994)
"The present investigation was designed to study the interaction of temperature, lidocaine, and ischemia during intravenous regional anesthesia (IVRA) of the arm."3.67Interaction of lidocaine and hypothermia in Bier blocks in volunteers. ( Haasio, J; Heavner, JE; Kytta, J; Leinonen, L; Rosenberg, PH, 1989)
" Hypothermia, thiopental, magnesium, lidocaine, and naloxone were used to pretreat the spinal cord prior to ischemia."3.67Protection against experimental ischemic spinal cord injury. ( Foltz, R; Goodman, JC; Grossman, RG; Robertson, CS, 1986)
"A 45-year-old man with an internal carotid artery occlusion, cerebral hemispheric infarction, and an ipsilateral central retinal artery occlusion developed anterior segment necrosis after retrobulbar injection of lidocaine hydrochloride (Xylocaine) for treatment of an occlusion of the central retinal artery."3.66Anterior segment necrosis following treatment of central retinal artery occlusion: a clinicopathologic case report. ( Marcus, DF; Reeser, FH; Weidaw, CD, 1978)
"Potassium chloride (KCl) given subcutaneously in high concentrations causes necrosis of skin, possibly from vasoconstriction around the injection site."3.65Lidocaine treatment of experimental cutaneous lesions from potassium chloride injection. ( Behnia, R; Wilkinson, CJ, 1977)
"Mild ischemia was induced in segments of jejunum and large colon."2.84Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia. ( Bauck, AG; Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Vickroy, TW, 2017)
"Our data suggest that control of postoperative pain is a major determinant of surgical-wound infection and should be given the same consideration as maintaining adequate vascular volume and normothermia."2.69Postoperative pain and subcutaneous oxygen tension. ( Akça, O; Arkiliç, CF; Heinz, T; Hellwagner, K; Kapral, S; Kurz, A; Lackner, FX; Melischek, M; Scheck, T; Sessler, DI, 1999)
"The rat Langendorff-perfused isolated heart, anaesthetised rat and rat ventricular myocyte preparations were utilised in a series of blinded and randomised studies to investigate the antiarrhythmic effectiveness, adverse effects and mechanism of action of OCT2013, compared with lidocaine."1.72OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine. ( Chowdhury, RA; Curtis, MJ; Firth, J; Hesketh, LM; MacLeod, KT; Mahoney-Sanchez, L; Mazzacuva, F; Ogrodzinski, S; Patterson, LH; Peters, NS; Sikkel, MB; Tzortzis, KN; Wilder, CDE; Winter, J, 2022)
"In this exceptional case, the unusual Horner syndrome manifestations related to unilateral ptosis, miosis, and anisocoria were simultaneously developed with skin ischemia, paresthesia, and asymmetric flushing after the administration of IANB anesthesia."1.39Concomitant horner and harlequin syndromes after inferior alveolar nerve block anesthesia. ( Chen, YJ; Fang, WH; Huang, RY; Mau, LP; Shieh, YS, 2013)
"Bupivacaine and lidocaine were reacted with the membrane preparations at cardiotoxically relevant concentrations and their membrane interactivities were determined by measuring fluorescence polarization."1.38Cardiotoxic local anesthetics increasingly interact with biomimetic membranes under ischemia-like acidic conditions. ( Mizogami, M; Shigemi, K; Tsuchiya, H; Ueno, T, 2012)
"A 51-year-old woman described paresthesias in her right thumb, index, and middle fingers consistent with carpal tunnel syndrome."1.35Digital ischemia after carpal tunnel injection: a case report. ( Brault, JS; Payne, JM, 2008)
"Postoperative pain was controlled by use of multimodal analgesia."1.33[Bilateral polyradiculitis after an epidural block: a rare, serious complication]. ( Aguilar, JL; Ferrer, AM; Mira, MD; Peláez, R; Segura, MC, 2006)
"Drug effects on ischaemia-induced arrhythmias were assessed simultaneously in the same rabbits."1.31RSD1019 suppresses ischaemia-induced monophasic action potential shortening and arrhythmias in anaesthetized rabbits. ( Barrett, TD; MacLeod, BA; Walker, MJ, 2000)
"Lidocaine was infused into the portal vein, and the concentration of lidocaine in hepatic outflow was measured with FPIA."1.30[The effects of vasoconstrictors on distribution of ischemic tissue flow in isolated perfused rat liver]. ( Asada, A; Fujimori, M; Kariya, N; Nishi, S; Shimazu, K; Umemoto, Y, 1997)
"Nicardipine was greater than papaverine in inducing relaxation."1.30Drug-induced vasodilation in an in vitro and in vivo study: the effects of nicardipine, papaverine, and lidocaine on the rabbit carotid artery. ( Cromeens, DM; Evans, GR; Gherardini, G; Gürlek, A; Joly, GA; Kilbourn, RG; Langstein, H; Lundeberg, T; Sukumaran, AV; Wang, B; Williams, J, 1997)
"In intact rats subjected to hemorrhagic shock, lidocaine pretreatment also facilitated shock resuscitation and reduced ultrastructural damage."1.28Gastric and cardiac organoprotection by lidocaine. ( Cho, CH; DeRolf, S; Keith, JC; Misra, HP; Pfeiffer, CJ; Pfeiffer, DC, 1989)
"Labetalol was found to be less effective in preventing tissue necrosis."1.28Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989)
"After treatment of ischemia and/or failure, specific antiarrhythmic agents, conventional and investigational, alone or in combination, are systematically selected."1.26Ventricular ectopy: etiology, evaluation, and therapy. ( Reid, PR; Vlay, SC, 1982)

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-199041 (36.61)18.7374
1990's32 (28.57)18.2507
2000's17 (15.18)29.6817
2010's16 (14.29)24.3611
2020's6 (5.36)2.80

Authors

AuthorsStudies
Deng, Y1
Li, RW1
Yang, YL1
Weiss, S1
Smith, PN1
Hesketh, LM1
Sikkel, MB1
Mahoney-Sanchez, L1
Mazzacuva, F1
Chowdhury, RA1
Tzortzis, KN1
Firth, J1
Winter, J1
MacLeod, KT1
Ogrodzinski, S1
Wilder, CDE1
Patterson, LH1
Peters, NS1
Curtis, MJ1
Van Demark, RE1
Hewitt, C1
Smith, VJ1
Rougereau, G1
El Khoury, G1
Châtelain, L1
Zadegan, F1
El Khoury, E1
Ollat, D1
Verhaar, N1
Pfarrer, C1
Neudeck, S1
König, K1
Rohn, K1
Twele, L1
Kästner, S1
Rajiah, E1
McKean, AR1
Bain, C1
Bauck, AG1
Grosche, A1
Morton, AJ1
Graham, AS1
Vickroy, TW1
Freeman, DE1
Totty, J1
Forsyth, J1
Mekako, A1
Chetter, I1
Huang, RY1
Chen, YJ1
Fang, WH1
Mau, LP1
Shieh, YS1
Bruttini, C1
Esposti, R1
Bolzoni, F1
Cavallari, P1
Vahidi, E1
Shakoor, D1
Aghaie Meybodi, M1
Saeedi, M1
Panov, VM1
Fesenko, UA1
Kutsyn, VM1
Payne, JM1
Brault, JS1
Cook, VL2
Jones Shults, J2
McDowell, MR1
Campbell, NB2
Davis, JL2
Marshall, JF1
Blikslager, AT2
Hormozi, AK1
Zendehnam, H1
Hosseini, SN1
Rasti, M1
Rostami, K1
Hamraz, H1
Denkler, K1
Williams, JV1
Williams, LR1
Colbert, SD1
Revington, PJ1
Noël, B1
Radeleff, B1
Stampfl, U1
Sommer, CM1
Bellemann, N1
Hyhlik-Duerr, A1
Weber, MA1
Boeckler, D1
Kauczor, HU1
Tsuchiya, H1
Mizogami, M1
Ueno, T1
Shigemi, K1
Cui, J1
McQuillan, PM1
Blaha, C1
Kunselman, AR1
Sinoway, LI1
Granfeldt, A1
Soliman, D1
Wang, L2
Hamming, KS1
Yang, W1
Fatehi, M1
Carter, CC1
Clanachan, AS1
Light, PE1
Efe, E1
Resim, S1
Bulut, BB1
Eren, M1
Garipardic, M1
Ozkan, F1
Ozkan, KU1
Fortune, B1
Cull, G1
Van Buskirk, EM1
Cioffi, GA1
Erkasap, N1
Ates, E1
Erkasap, S1
Kaygisiz, Z1
Sharma, A1
Gupta, A2
Bandyopadhyay, S1
Vinekar, AS1
Ram, J1
Dogra, MR1
ROMANO, M1
MILES, DW1
JAMES, JL1
CLARK, DE1
WHITWAM, JG1
THORNE, J1
SORBIE, C1
CHACHA, P1
NAHOR, A1
MILLIKEN, J1
MINTON, R1
FINE, J1
Graven-Nielsen, T1
Mense, S1
Arendt-Nielsen, L2
Lan, W1
Harmon, D1
Wang, JH1
Ghori, K1
Shorten, G1
Redmond, P1
Karaçal, N1
Ambarcioğlu, O1
Topal, U1
Mamedov, T1
Kutlu, N1
Agarwal, P1
Agrawal, PK1
Sharma, D1
Baghel, KD1
Cao, H1
Kass, IS1
Cottrell, JE1
Bergold, PJ1
Ascione, R1
Talpahewa, S1
Rajakaruna, C1
Reeves, BC1
Lovell, AT1
Cohen, A1
Angelini, GD1
Gandevia, SC1
Smith, JL1
Crawford, M1
Proske, U1
Taylor, JL1
Mira, MD1
Peláez, R1
Segura, MC1
Ferrer, AM1
Aguilar, JL1
McDowell, M1
Vlay, SC1
Reid, PR1
Riberti, C1
Costa, P1
Lefèvre, JC1
Chassagne, JF1
Babalola, GO1
Oke, BO1
Kirpatovskiĭ, VI1
Onishchenko, NA1
Lubiako, AA1
Danilov, MA1
Bogoiavlenskaia, TA1
Boas, RA1
Covino, BG1
Shahnarian, A1
Bernauer, W1
Hardy, SJ1
Agostini, DE1
Bühler-Singer, S1
Hiller, D1
Boateng, B1
Albrecht, HP1
Seidel, C1
Hornstein, OP1
Das, KC1
Misra, HP2
Chandel, B1
Shapiro, MJ1
Kurtz, M1
Rana, WU1
Matthews, M1
Jellinek, M1
Baue, AE1
Miller, RM1
Loken, RG1
Coupland, SG1
Deschênes, MC1
Udassin, R1
Eimerl, D1
Schiffman, J1
Haskel, Y1
Serwatka, LM1
Grohmann, G1
Pöhlmann, G1
Eidner, G1
Friedman, DB1
Brennum, J1
Sztuk, F2
Hansen, OB1
Clifford, PS1
Bach, FW1
Mitchell, JH1
Secher, NH1
Naesh, O1
Haljamäe, H1
Skielboe, M1
Andersen, P1
Ibsen, A1
Hindberg, I1
Maynard, ND1
Bihari, DJ1
Dalton, RN1
Beale, R1
Smithies, MN1
Mason, RC1
Kariya, N1
Umemoto, Y1
Shimazu, K1
Nishi, S1
Asada, A1
Fujimori, M1
Jund, R1
Kastenbauer, E1
Leclercq, I1
Saliez, A1
Wallemacq, PE1
Horsmans, Y1
Lambotte, L1
Evans, GR1
Gherardini, G1
Gürlek, A1
Langstein, H1
Joly, GA1
Cromeens, DM1
Sukumaran, AV1
Williams, J1
Kilbourn, RG1
Wang, B1
Lundeberg, T1
Sylaidis, P1
Logan, A1
Olinga, P1
Merema, MT1
Hof, IH1
De Jager, MH1
De Jong, KP1
Slooff, MJ1
Meijer, DK1
Groothuis, GM1
Uchihashi, Y1
Bencsics, A1
Umeda, E1
Nakai, T1
Sato, T1
Vizi, ES1
Murali, KS1
Nayeem, N1
Brinkmann, A1
Calzia, E1
Träger, K1
Radermacher, P1
Siniscalchi, A1
Zona, C1
Guatteo, E1
Mercuri, NB1
Bernardi, G1
Tomori, H1
Shiraishi, M1
Koga, H1
Toure, M1
Taira, K1
Higa, T1
Okuhama, Y1
Hiroyasu, S1
Muto, Y1
Baumgarten, KM1
Gerstenblith, G1
Weiss, RG1
Nohara, H1
Okada, M1
Yamashita, C1
Ataka, K1
Yoshimura, N1
Ahlquist, M1
Franzén, O1
Follis, FM1
Blisard, KS1
Varvitsiotis, PS1
Pett, SB1
Temes, RT1
Wernly, JA1
Ong, HS1
Soo, KC1
Joseph, VT1
Tan, SY1
Jeyaraj, PR1
Akça, O1
Melischek, M1
Scheck, T1
Hellwagner, K1
Arkiliç, CF1
Kurz, A1
Kapral, S1
Heinz, T1
Lackner, FX1
Sessler, DI1
Barrett, TD1
MacLeod, BA1
Walker, MJ1
Grey, MJ1
Ladouceur, M1
Andersen, JB1
Nielsen, JB1
Sinkjaer, T1
De Monaco, D1
De Monaco, A1
Kammer, E1
Noever, G1
Grimby, L1
Hannerz, J1
Weidaw, CD1
Marcus, DF1
Reeser, FH1
Osborn, JL1
Hook, JB1
Bailie, MD1
Behnia, R1
Wilkinson, CJ1
Keskitalo, E1
Persson, G1
Sundt, TM1
Ueda, M1
Kimoto, S1
Matsuda, S1
Kawakami, M1
Mroishige, E1
Matsumura, S1
Takeda, H1
Svensson, LG1
Crawford, ES1
Patel, V1
McLean, TR1
Jones, JW1
DeBakey, ME1
Nilius, J1
von Bary, S1
Pfeiffer, CJ1
Keith, JC1
Cho, CH1
DeRolf, S1
Pfeiffer, DC1
Heavner, JE1
Leinonen, L1
Haasio, J1
Kytta, J1
Rosenberg, PH1
Aycock, BG1
Hawtof, DB1
Moody, SB1
Rowinski, W1
Ruka, M1
Stuart, F1
Buckingham, F1
Baron, HC1
LaRaja, RD1
Rossi, G1
Atkinson, D1
Grek, OR1
Sharapov, VI1
Sokirchenko, IA1
Shkurupiĭ, VA1
Robertson, CS1
Foltz, R1
Grossman, RG1
Goodman, JC1
Gearhart, JP1
Jeffs, RD1
Sörensen, SE1
Pantridge, JF2
Geddes, JS2
Adgey, AA1
Almici, C1
Lazzaroni, G1
Djindjin, R1
Mamo, H1
Saimot, G1
Houdart, R1
Széplaki, S1
Szmandra, J1
Széplaki, Z1
Coltart, DJ1
Berndt, TB1
Kernoff, R1
Harrison, DC1
Harris, WH1
Kerstein, MD1
Bergentz, SE1
Lewis, DH1
James, TN1
Bear, ES1
Frink, RJ1
Urthaler, F1
Di Giacomo, G1
Beyer, A1
Thieler, H1
Müller, H1
Bartkowski, S1
Polaczek-Kornecki, T1
Atkinson, DI1
Trias, A1
Shanks, CA1
McLeod, JG1
Urquhart-Hay, D1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
High Dose Intravenous Lidocaine vs Hydromorphone for Acute Abdominal Pain in the Emergency Department: A Randomized, Comparative Efficacy Trial[NCT04398316]Phase 4187 participants (Anticipated)Interventional2021-02-18Recruiting
The Venous Distension Reflex and Orthostatic Hypertension[NCT03496792]30 participants (Anticipated)Interventional2020-03-10Recruiting
Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964]550 participants (Actual)Interventional2009-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Center for Epidemiological Studies Depression Scale (CES-D)

"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-1.27
Placebo-0.89

Change in Center for Epidemiological Studies Depression Scale (CES-D)

"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.57
Placebo0.16

Change in Cognitive Function From Baseline

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery

Interventionunits on a scale (Mean)
Lidocaine0.09
Placebo0.07

Change in Cognitive Function From Baseline Characterized as Continuous Cognitive Change

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

Interventionunits on a scale (Mean)
Lidocaine0.07
Placebo0.07

Change in Duke Activity Status Index (DASI)

"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine6.3
Placebo6.96

Change in Duke Activity Status Index (DASI)

"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-10.98
Placebo-11.67

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.05
Placebo0.07

Change in Neurological Function, as Measured by the National Institutes of Health Stroke Scale (NIHSS)

The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.05
Placebo0.04

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.02
Placebo-0.02

Change in Neurological Function, as Measured by the Western Perioperative Neurologic Scale (WPNS)

The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.04
Placebo-0.01

Change in Perceived Social Support

"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine0.71
Placebo-1.16

Change in Perceived Social Support

"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine1.23
Placebo-0.49

Change in Social Activity

"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.20
Placebo0.03

Change in Social Activity

"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine0.95
Placebo1.59

Change in Spielberger State Anxiety Inventory (STAI)

"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-6.70
Placebo-6.39

Change in Spielberger State Anxiety Inventory (STAI)

"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-7.12
Placebo-6.31

Change in Symptom Limitations

Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-1.39
Placebo-1.48

Change in Symptom Limitations

Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-0.67
Placebo-0.8

Change in the Cognitive Difficulties Scale

"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.46
Placebo-1.02

Change in the Cognitive Difficulties Scale

"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine-3
Placebo-3.21

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year

Interventionunits on a scale (Mean)
Lidocaine-0.15
Placebo-0.31

Change in the Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL)

"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks

Interventionunits on a scale (Mean)
Lidocaine2.46
Placebo2.1

Count of Participants With a Decline of Greater Than or Equal to One Standard Deviation in One or More of Five Cognitive Domain Scores Reported as a Dichotomous Post-operative Cognitive Deficit (POCD) Outcome

To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery

InterventionParticipants (Count of Participants)
Lidocaine87
Placebo83

Change in Study 36-Item Short Form Health Survey (SF-36)

The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year

,
Interventionunits on a scale (Mean)
1 year Change Work Activities1 year Change General health perception
Lidocaine-1.37-0.28
Placebo-1.42-0.43

Change in Study 36-Item Short Form Health Survey (SF-36)

The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks

,
Interventionunits on a scale (Mean)
6-Week Change Work activities6-Week Change General health perception
Lidocaine2.71-0.004
Placebo3-0.03

Transcerebral Activation Gradient of Platelet-neutrophil Conjugates

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-0.150.02-0.73-0.10
Placebo-0.43-0.73-0.400.19

Transcerebral Activation Gradients of Monocytes

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-4.22-2.46-0.341.21
Placebo-0.041.832.640.54

Transcerebral Activation Gradients of Neutrophils

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-2.020.560.581.04
Placebo-0.080.171.19-0.68

Transcerebral Activation Gradients of Platelets

Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal

,
InterventionMean linear fluorescence intensity-MLFI (Mean)
BaselineCross-clamp removalEnd of Bypass6 hours post cross-clamp removal
Lidocaine-0.030.030.330.37
Placebo0.350.430.050.27

Reviews

6 reviews available for lidocaine and Ischemia

ArticleYear
Phentolamine Rescue for Digital Ischemia Following Lidocaine with Epinephrine Local Anesthesia: Case Presentation, Review of the Literature and Treatment Options.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2021, Volume: 74, Issue:11

    Topics: Anesthesia, Local; Epinephrine; Humans; Ischemia; Lidocaine; Phentolamine

2021
WALANT in hand surgery: Ischemic complications and their medicolegal implications in France: A systematic review of the literature and of French legal databases.
    Hand surgery & rehabilitation, 2022, Volume: 41, Issue:2

    Topics: Anesthesia, Local; Epinephrine; Hand; Humans; Ischemia; Lidocaine

2022
Amaurosis, ophthalmoplegia, ptosis, mydriasis and periorbital blanching following inferior alveolar nerve anaesthesia.
    Oral and maxillofacial surgery, 2011, Volume: 15, Issue:1

    Topics: Adult; Amaurosis Fugax; Anesthesia, Dental; Anesthesia, General; Anesthesia, Local; Blepharoptosis;

2011
Organ dysfunction following regional and global ischemia/reperfusion. Intervention with postconditioning and adenocaine.
    Danish medical journal, 2012, Volume: 59, Issue:8

    Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Drug Combinations; Heart Arrest; Humans; Ischemia; Ische

2012
Monitoring the hepato-splanchnic region in the critically ill patient. Measurement techniques and clinical relevance.
    Intensive care medicine, 1998, Volume: 24, Issue:6

    Topics: Anesthetics, Local; Carbon Dioxide; Cell Hypoxia; Critical Care; Digestive System Diseases; Gastric

1998
[Digital nerve block anaesthesia: historical development and two cases of finger-tip necrosis, a rare complication].
    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V..., 2002, Volume: 34, Issue:1

    Topics: Adult; Aged; Anesthesia, Local; Epinephrine; Female; Fingers; History, 19th Century; History, 20th C

2002

Trials

8 trials available for lidocaine and Ischemia

ArticleYear
Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia.
    American journal of veterinary research, 2017, Volume: 78, Issue:8

    Topics: Animals; Cyclooxygenase 2; Horse Diseases; Horses; Inflammation; Intestinal Mucosa; Ischemia; Jejuna

2017
Comparison of intravenous lidocaine versus morphine in alleviating pain in patients with critical limb ischaemia.
    Emergency medicine journal : EMJ, 2015, Volume: 32, Issue:7

    Topics: Administration, Intravenous; Adult; Aged; Analgesics, Opioid; Critical Illness; Double-Blind Method;

2015
Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses.
    American journal of veterinary research, 2009, Volume: 70, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Female; Gene Expression Regulation, Enzy

2009
Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial.
    The Annals of thoracic surgery, 2006, Volume: 81, Issue:1

    Topics: Aged; Alanine Transaminase; Amylases; Aspartate Aminotransferases; Blood Glucose; Carbohydrates; Car

2006
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
    Equine veterinary journal, 2008, Volume: 40, Issue:4

    Topics: Anesthetics, Local; Animals; Clonixin; Electric Impedance; Female; Horse Diseases; Horses; Infusions

2008
Postoperative pain and subcutaneous oxygen tension.
    Lancet (London, England), 1999, Jul-03, Volume: 354, Issue:9172

    Topics: Adolescent; Adult; Anesthetics, Local; Female; Humans; Injections, Intra-Articular; Ischemia; Knee;

1999
Complications after removal of mandibular third molars with special reference to local anaesthetics with different vasoactive properties.
    Odontologisk revy, 1975, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Alveolar Process; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Deglu

1975
Choice of anesthetic agents for intravenous regional anesthesia.
    Acta anaesthesiologica Scandinavica. Supplementum, 1969, Volume: 36

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Benzoates; Central Nervous System; Clinical Trials

1969

Other Studies

98 other studies available for lidocaine and Ischemia

ArticleYear
Pharmacological prevention of renal ischemia-reperfusion injury in a rat model.
    ANZ journal of surgery, 2022, Volume: 92, Issue:3

    Topics: Animals; Glutathione; Humans; Ischemia; Kidney; Lamotrigine; Lidocaine; Rats; Reperfusion Injury; Ri

2022
OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.
    British journal of pharmacology, 2022, Volume: 179, Issue:9

    Topics: Animals; Anti-Arrhythmia Agents; Ischemia; Lidocaine; Myocardial Ischemia; Prodrugs; Rats; Rats, Wis

2022
Preconditioning with lidocaine and xylazine in experimental equine jejunal ischaemia.
    Equine veterinary journal, 2021, Volume: 53, Issue:1

    Topics: Animals; Horse Diseases; Horses; Ischemia; Lidocaine; Reperfusion Injury; Xylazine

2021
Accidental adrenaline auto-injector-induced digital ischaemia: a proposed treatment algorithm.
    BMJ case reports, 2021, Apr-28, Volume: 14, Issue:4

    Topics: Adult; Algorithms; Epinephrine; Humans; Ischemia; Lidocaine; Male; Phentolamine

2021
Life-threatening intraoperative anaphylaxis as a result of chlorhexidine present in Instillagel.
    BMJ case reports, 2017, Aug-21, Volume: 2017

    Topics: Aged; Anaphylaxis; Anti-Infective Agents, Local; Chlorhexidine; Diagnosis, Differential; Drug Combin

2017
Concomitant horner and harlequin syndromes after inferior alveolar nerve block anesthesia.
    Journal of endodontics, 2013, Volume: 39, Issue:12

    Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Autonomic Nervous System Diseases; Epinephrine; Face;

2013
Ischemic block of the forearm abolishes finger movements but not their associated anticipatory postural adjustments.
    Experimental brain research, 2014, Volume: 232, Issue:6

    Topics: Action Potentials; Adaptation, Physiological; Adult; Anesthetics, Local; Biomechanical Phenomena; El

2014
[Improvement of approach to performance of lumbar sympathetic blockade in patients with tissue ischemia of the lower extremities].
    Klinichna khirurhiia, 2014, Issue:6

    Topics: Adult; Aged; Anesthetics, Local; Aorta; Autonomic Nerve Block; Bupivacaine; Humans; Ischemia; Leg; L

2014
Digital ischemia after carpal tunnel injection: a case report.
    Archives of physical medicine and rehabilitation, 2008, Volume: 89, Issue:8

    Topics: Carpal Tunnel Syndrome; Female; Fingers; Glucocorticoids; Humans; Injections; Ischemia; Lidocaine; M

2008
Epinephrine's effect in varying concentrations on the end artery organ in an animal model.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2010, Volume: 20, Issue:2

    Topics: Anesthetics, Local; Animals; Arteries; Double-Blind Method; Ear; Epinephrine; Ischemia; Lidocaine; M

2010
Myth of not using lidocaine with epinephrine in the digits.
    American family physician, 2010, May-15, Volume: 81, Issue:10

    Topics: Anesthetics, Local; Drug Therapy, Combination; Epinephrine; Fingers; Humans; Ischemia; Lidocaine

2010
Anesthesia for ingrowing toenail surgery.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2010, Volume: 36, Issue:8

    Topics: Anesthetics, Local; Humans; Ischemia; Lidocaine; Nails, Ingrown; Nerve Block; Regional Blood Flow; T

2010
Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets.
    Cardiovascular and interventional radiology, 2011, Volume: 34, Issue:5

    Topics: Acute Disease; Adult; Alprostadil; Anesthetics, Local; Anti-Anxiety Agents; Fibrinolytic Agents; Flu

2011
Cardiotoxic local anesthetics increasingly interact with biomimetic membranes under ischemia-like acidic conditions.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:6

    Topics: Anesthetics, Local; Bupivacaine; Cardiolipins; Cardiotoxins; Cell Membrane; Glycerophospholipids; Hy

2012
Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans.
    American journal of physiology. Heart and circulatory physiology, 2012, Aug-15, Volume: 303, Issue:4

    Topics: Adult; Afferent Pathways; Albumins; Analysis of Variance; Anesthetics, Local; Blood Pressure; Female

2012
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2

    Topics: Acetanilides; Animals; Animals, Newborn; Calcium; Calcium Signaling; Cardiac Glycosides; Electrophys

2012
Successful treatment with enoxaparin of glans ischemia due to local anesthesia after circumcision.
    Pediatrics, 2013, Volume: 131, Issue:2

    Topics: Anesthesia, Local; Child; Circumcision, Male; Enoxaparin; Epinephrine; Fibrin Fibrinogen Degradation

2013
Factors affecting the use of multifocal electroretinography to monitor function in a primate model of glaucoma.
    Documenta ophthalmologica. Advances in ophthalmology, 2002, Volume: 105, Issue:2

    Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Animals; Electroretinography; Glau

2002
Lidocaine-containing Euro-Collins solution prevents renal injury in the isolated perfused canine kidney exposed to prolonged cold ischemia.
    Physiological research, 2002, Volume: 51, Issue:5

    Topics: Anesthetics, Local; Animals; Cold Temperature; Dogs; Glomerular Filtration Rate; Hypertonic Solution

2002
Necrosis of the eyelids and sclera after retrobulbar anesthesia.
    Journal of cataract and refractive surgery, 2003, Volume: 29, Issue:4

    Topics: Anesthesia, Local; Anesthetics, Local; Arterial Occlusive Diseases; Epinephrine; Eyelid Diseases; Ey

2003
A severe chronic ischemic patient--a case report.
    Journal of the American Podiatry Association, 1961, Volume: 51

    Topics: Corrinoids; Disease; Hematinics; Humans; Ischemia; Leg; Lidocaine; Vitamin B 12

1961
SITE OF ACTION OF 'INTRAVENOUS REGIONAL ANAESTHESIA'.
    Journal of neurology, neurosurgery, and psychiatry, 1964, Volume: 27

    Topics: Anesthesia; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthesia, Local; Electromyography; Hu

1964
REFLEX RESPONSES IN MAN EVOKED BY GAMMA EFFERENT ACTIVATION.
    Nature, 1964, Aug-08, Volume: 203

    Topics: Cold Temperature; Ischemia; Lidocaine; Muscle Spindles; Neural Conduction; Neurophysiology; Pharmaco

1964
REGIONAL ANAESTHESIA BY THE INTRAVENOUS ROUTE.
    British medical journal, 1965, Apr-10, Volume: 1, Issue:5440

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Forearm Injuries; Fractures, Bone; Hand Injuries; H

1965
TECHNIQUE OF CELIAC BLOCKADE FOR RELIEF OF SPLANCHNIC ISCHEMIA.
    JAMA, 1965, May-17, Volume: 192

    Topics: Animals; Autonomic Nerve Block; Celiac Plexus; Dogs; Ethanol; Ischemia; Lidocaine; Rabbits; Shock; S

1965
Painful and non-painful pressure sensations from human skeletal muscle.
    Experimental brain research, 2004, Volume: 159, Issue:3

    Topics: Adult; Afferent Pathways; Anesthetics, Local; Female; Humans; Ischemia; Lidocaine; Male; Mechanorece

2004
The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:11

    Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Local; Cell Adhesion Molecules; Endothelial Ce

2004
Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): enhancement of flap survival by EMLA.
    The Journal of surgical research, 2005, Volume: 124, Issue:1

    Topics: Administration, Topical; Animals; Graft Survival; Ischemia; Lidocaine; Lidocaine, Prilocaine Drug Co

2005
Intravenous infusion for the treatment of diabetic and ischaemic non-healing pedal ulcers.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2005, Volume: 19, Issue:2

    Topics: Adult; Case-Control Studies; Debridement; Diabetic Foot; Female; Foot; Foot Ulcer; Gentamicins; Hepa

2005
Pre- or postinsult administration of lidocaine or thiopental attenuates cell death in rat hippocampal slice cultures caused by oxygen-glucose deprivation.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:4

    Topics: Animals; Cell Death; Cell Hypoxia; Glucose; Hippocampus; Ischemia; Lidocaine; Neuroprotective Agents

2005
Motor commands contribute to human position sense.
    The Journal of physiology, 2006, Mar-15, Volume: 571, Issue:Pt 3

    Topics: Efferent Pathways; Humans; Ischemia; Kinesthesis; Lidocaine; Motor Neurons; Muscle, Skeletal; Nerve

2006
[Bilateral polyradiculitis after an epidural block: a rare, serious complication].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:9

    Topics: Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthet

2006
Ventricular ectopy: etiology, evaluation, and therapy.
    The American journal of medicine, 1982, Volume: 73, Issue:6

    Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Aprindine; Arrhyth

1982
[Clinical experience with the combination of dextran 40, dihydroergotoxine, lidocaine in intravenous perfusion in the prevention of postoperative ischemia of skin flaps].
    Minerva chirurgica, 1984, May-31, Volume: 39, Issue:10

    Topics: Dextrans; Dihydroergotoxine; Drug Therapy, Combination; Humans; Ischemia; Lidocaine; Necrosis; Surgi

1984
Intravenous regional analgesia for surgery of the limbs in goats.
    The veterinary quarterly, 1983, Volume: 5, Issue:4

    Topics: Amputation, Surgical; Anesthesia, Conduction; Anesthesia, Intravenous; Animals; Extremities; Goats;

1983
[Pharmacological protection of the kidneys from ischemic damage. The effectiveness of anti-ischemia protection of the kidneys in simulating the terminal state in the donors].
    Vestnik Akademii meditsinskikh nauk SSSR, 1982, Issue:9

    Topics: Animals; Death; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Humans; Hypotension; Isc

1982
Analgesic responses to i.v. lignocaine.
    British journal of anaesthesia, 1982, Volume: 54, Issue:5

    Topics: Adult; Aged; Humans; Ischemia; Lidocaine; Middle Aged; Pain; Pain, Intractable

1982
Effect of antiarrhythmics on the release of adenosine in rat hearts with coronary occlusion and reperfusion.
    European journal of pharmacology, 1995, Sep-05, Volume: 283, Issue:1-3

    Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Electrocardiography; Heart; Ischemia; Lidocaine; Male; R

1995
Accidental epinephrine auto-injector-induced digital ischemia reversed by phentolamine digital block.
    The Journal of the American Osteopathic Association, 1995, Volume: 95, Issue:6

    Topics: Adult; Epinephrine; Humans; Injections, Subcutaneous; Ischemia; Lidocaine; Male; Needlestick Injurie

1995
[Disordered cutaneous microcirculation in diabetic neuropathic foot ulcer. Is modification by retrograde transvenous perfusion therapy possible?].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1995, Volume: 46, Issue:6

    Topics: Adult; Aged; Blood Flow Velocity; Chemotherapy, Cancer, Regional Perfusion; Dexamethasone; Diabetic

1995
Amelioration of postischemic reperfusion injury by antiarrhythmic drugs in isolated perfused rat lung.
    Environmental health perspectives, 1994, Volume: 102 Suppl 10

    Topics: Animals; Anti-Arrhythmia Agents; In Vitro Techniques; Ischemia; Lidocaine; Lung; Male; Organ Size; P

1994
MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock.
    Shock (Augusta, Ga.), 1995, Volume: 3, Issue:1

    Topics: Animals; Biotransformation; Ischemia; Lidocaine; Liver; Liver Function Tests; Male; Microsomes, Live

1995
Cutaneous ischemia caused by local anesthesia containing a vasoconstrictor.
    The Journal of dermatologic surgery and oncology, 1994, Volume: 20, Issue:10

    Topics: Epinephrine; Humans; Ischemia; Lidocaine; Skin

1994
The electroretinogram during orbital compression following intraorbital regional block for cataract surgery.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:9

    Topics: Adult; Anesthesia, Local; Bupivacaine; Cataract Extraction; Electroretinography; Female; Humans; Isc

1994
Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat.
    Anesthesiology, 1994, Volume: 80, Issue:4

    Topics: Anesthesia, Epidural; Animals; Disease Models, Animal; Gastrointestinal Motility; Intestines; Ischem

1994
Cutaneous ischemia caused by local anesthesia containing a vasoconstrictor in a patient with meralgia paresthetica.
    The Journal of dermatologic surgery and oncology, 1994, Volume: 20, Issue:3

    Topics: Adult; Epinephrine; Humans; Ischemia; Lidocaine; Nerve Compression Syndromes; Paresthesia; Skin; Thi

1994
[Optimizing analgesia and procedure of retrograde venous perfusion in treatment of patients with peripheral arterial occlusive diseases].
    VASA. Zeitschrift fur Gefasskrankheiten, 1994, Volume: 23, Issue:1

    Topics: Arterial Occlusive Diseases; Diabetic Foot; Humans; Ischemia; Leg; Lidocaine; Mepivacaine; Nerve Blo

1994
The effect of epidural anaesthesia with 1% lidocaine on the pressor response to dynamic exercise in man.
    The Journal of physiology, 1993, Volume: 470

    Topics: Adult; Anesthesia, Epidural; Bicycling; Blood Pressure; Cardiac Output; Cold Temperature; Electric S

1993
Purine metabolite washout and platelet aggregation at reflow after tourniquet ischemia: effect of intravenous regional lidocaine.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:8

    Topics: Aged; Aged, 80 and over; Anesthetics, Local; Female; Humans; Hypoxanthine; Hypoxanthines; Ischemia;

1995
Liver function and splanchnic ischemia in critically ill patients.
    Chest, 1997, Volume: 111, Issue:1

    Topics: Critical Illness; Gastric Mucosa; Hemodynamics; Humans; Hydrogen-Ion Concentration; Indocyanine Gree

1997
[The effects of vasoconstrictors on distribution of ischemic tissue flow in isolated perfused rat liver].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:1

    Topics: Adenosine Triphosphate; Animals; Biotransformation; Epinephrine; In Vitro Techniques; Ischemia; Lido

1997
Susceptibility of isolated rat facial nerve to anaerobic stress.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1997, Volume: 254 Suppl 1

    Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod

1997
The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat.
    Hepatology (Baltimore, Md.), 1997, Volume: 26, Issue:5

    Topics: Animals; Bilirubin; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzymes; F

1997
Drug-induced vasodilation in an in vitro and in vivo study: the effects of nicardipine, papaverine, and lidocaine on the rabbit carotid artery.
    Plastic and reconstructive surgery, 1997, Volume: 100, Issue:6

    Topics: Administration, Topical; Anastomosis, Surgical; Animals; Blood Pressure; Carotid Arteries; Dose-Resp

1997
Digital blocks with adrenaline. An old dogma refuted.
    Journal of hand surgery (Edinburgh, Scotland), 1998, Volume: 23, Issue:1

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Epinephrine; Female; Fingers; Hand; Humans; Ischemia;

1998
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver.
    Xenobiotica; the fate of foreign compounds in biological systems, 1998, Volume: 28, Issue:4

    Topics: Animals; Cold Temperature; Coumarins; Cryopreservation; Hot Temperature; Humans; In Vitro Techniques

1998
Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices.
    European journal of pharmacology, 1998, Apr-10, Volume: 346, Issue:2-3

    Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Cold Temperature; H

1998
Accidental digital injection of adrenaline from an autoinjector device.
    Journal of accident & emergency medicine, 1998, Volume: 15, Issue:4

    Topics: Accidents, Occupational; Adrenergic alpha-Antagonists; Adult; Anesthetics, Local; Epinephrine; Finge

1998
An electrophysiological analysis of the protective effects of felbamate, lamotrigine, and lidocaine on the functional recovery from in vitro ischemia in rat neocortical slices.
    Synapse (New York, N.Y.), 1998, Volume: 30, Issue:4

    Topics: Action Potentials; Animals; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; F

1998
Protective effects of lidocaine in hepatic ischemia/reperfusion injury in vitro.
    Transplantation proceedings, 1998, Volume: 30, Issue:7

    Topics: Animals; Aspartate Aminotransferases; In Vitro Techniques; Ischemia; Lidocaine; Liver; Liver Circula

1998
High extracellular K+ during hypoxic preconditioning episodes attenuates the post-ischemic contractile and ionic benefits of preconditioning.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1

    Topics: Animals; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Edetic Acid; Hypoxia; Is

1999
The effect of direct lidocaine injection into the clamped aortic segment on the spinal evoked potential: early diagnosis for spinal cord ischemia.
    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 1999, Volume: 5, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Aorta; Blood Pressure; Constriction; Dogs; El

1999
Pulpal ischemia in man: effects on detection threshold, A-delta neural response and sharp dental pain.
    Endodontics & dental traumatology, 1999, Volume: 15, Issue:1

    Topics: Adult; Afferent Pathways; Anesthetics, Local; Cold Temperature; Dental Pulp; Dental Pulp Test; Epine

1999
Selective protection of gray and white matter during spinal cord ischemic injury.
    The Annals of thoracic surgery, 1999, Volume: 67, Issue:5

    Topics: Animals; Brain; Disease Models, Animal; Evaluation Studies as Topic; Excitatory Amino Acid Antagonis

1999
The viability of liver graft for transplantation after prolonged warm ischaemia.
    Annals of the Academy of Medicine, Singapore, 1999, Volume: 28, Issue:1

    Topics: Alanine Transaminase; Animals; Bilirubin; Graft Survival; Ischemia; Lidocaine; Liver; Liver Function

1999
RSD1019 suppresses ischaemia-induced monophasic action potential shortening and arrhythmias in anaesthetized rabbits.
    British journal of pharmacology, 2000, Volume: 131, Issue:3

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Bridged Bi

2000
Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans.
    The Journal of physiology, 2001, Aug-01, Volume: 534, Issue:Pt 3

    Topics: Adrenergic alpha-Agonists; Adult; Anesthetics, Local; Ankle; Clonidine; Cold Temperature; Electromyo

2001
Disturbances in voluntary recruitment order of low and high frequency motor units on blockades of proprioceptive afferent activity.
    Acta physiologica Scandinavica, 1976, Volume: 96, Issue:2

    Topics: Action Potentials; Afferent Pathways; Cold Temperature; Electric Stimulation; Ischemia; Lidocaine; M

1976
Anterior segment necrosis following treatment of central retinal artery occlusion: a clinicopathologic case report.
    Annals of ophthalmology, 1978, Volume: 10, Issue:2

    Topics: Arterial Occlusive Diseases; Epinephrine; Eye; Eye Diseases; Humans; Ischemia; Lidocaine; Male; Midd

1978
Control of renin release. Effects of d-propranolol and renal denervation on furosemide-induced renin release in the dog.
    Circulation research, 1977, Volume: 41, Issue:4

    Topics: Animals; Denervation; Dogs; Furosemide; Ischemia; Kidney; Lidocaine; Male; Propranolol; Renin; Stere

1977
Lidocaine treatment of experimental cutaneous lesions from potassium chloride injection.
    Anesthesiology, 1977, Volume: 47, Issue:5

    Topics: Animals; Guinea Pigs; Ischemia; Lidocaine; Necrosis; Potassium Chloride; Skin; Skin Diseases; Vasoco

1977
Management of ischemic complications after subarachnoid hemorrhage.
    Journal of neurosurgery, 1975, Volume: 43, Issue:4

    Topics: Adult; Aged; Brain; Female; Humans; Intracranial Aneurysm; Ischemia; Ischemic Attack, Transient; Iso

1975
Antiarrhythmic effect of aprindine on several types of ventricular arrhythmias.
    Japanese journal of pharmacology, 1975, Volume: 25, Issue:5

    Topics: Ajmaline; Animals; Anti-Arrhythmia Agents; Aprindine; Cats; Dogs; Epinephrine; Female; Guinea Pigs;

1975
Spinal oxygenation, blood supply localization, cooling, and function with aortic clamping.
    The Annals of thoracic surgery, 1992, Volume: 54, Issue:1

    Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Constriction; Humans; Ischemia; Lidocaine; Male; Oxygen

1992
[Retrograde venous perfusion in treatment of diabetic gangrene].
    VASA. Supplementum, 1991, Volume: 32

    Topics: Cefmenoxime; Diabetic Angiopathies; Female; Gangrene; Heparin; Humans; Infusions, Intravenous; Ische

1991
Gastric and cardiac organoprotection by lidocaine.
    Acta physiologica Hungarica, 1989, Volume: 73, Issue:2-3

    Topics: Animals; Dogs; Female; Heart; In Vitro Techniques; Ischemia; Lidocaine; Male; Microscopy, Electron;

1989
Interaction of lidocaine and hypothermia in Bier blocks in volunteers.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:1

    Topics: Adult; Anesthesia, Conduction; Electric Stimulation; Evoked Potentials, Somatosensory; Hand; Humans;

1989
Treatment of peripheral ischemia secondary to lidocaine containing epinephrine.
    Annals of plastic surgery, 1989, Volume: 23, Issue:1

    Topics: Animals; Epinephrine; Foot; Ischemia; Labetalol; Lidocaine; Models, Biological; Necrosis; Phentolami

1989
Amelioration of the ischemic damage of the dog kidney subjected to 90 minutes of warm ischemia by lidocaine pretreatment and low-dose dopamine infusion on revascularization.
    Advances in experimental medicine and biology, 1987, Volume: 212

    Topics: Animals; Body Temperature; Dogs; Dopamine; Infusions, Intravenous; Ischemia; Kidney; Kidney Transpla

1987
Continuous epidural analgesia in the heparinized vascular surgical patient: a retrospective review of 912 patients.
    Journal of vascular surgery, 1987, Volume: 6, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Bupivacaine; Catheterization; Female; Heparin;

1987
[Prevention, using alpha-tocopherol and lidocaine, of damage to the monooxygenase system activity and ultrastructure of hepatocytes following acute ischemia of the liver].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 104, Issue:12

    Topics: Acute Disease; Animals; Ischemia; Lidocaine; Liver; Male; Oxygenases; Rats; Vitamin E

1987
Protection against experimental ischemic spinal cord injury.
    Journal of neurosurgery, 1986, Volume: 64, Issue:4

    Topics: Animals; Aorta, Abdominal; Evoked Potentials, Somatosensory; Hypothermia, Induced; Ischemia; Lidocai

1986
The use of topical vasodilators as an adjunct in infant renal surgery.
    The Journal of urology, 1985, Volume: 134, Issue:2

    Topics: Administration, Topical; Female; Humans; Infant; Infant, Newborn; Intraoperative Care; Intraoperativ

1985
Local toxic effects of anaesthetics and contrast media in urethrography.
    Acta radiologica: diagnosis, 1972, Volume: 12, Issue:2

    Topics: Anesthetics, Local; Animals; Blood Flow Velocity; Capillary Fragility; Capillary Permeability; Cells

1972
A mobile intensive-care unit in the management of myocardial infarction.
    Lancet (London, England), 1967, Aug-05, Volume: 2, Issue:7510

    Topics: Adult; Aged; Ambulances; Electric Countershock; Electrocardiography; Female; Heart Arrest; Heart Mas

1967
Prognosis after recovery from ventricular fibrillation complicating ischaemic heart-disease.
    Lancet (London, England), 1967, Aug-05, Volume: 2, Issue:7510

    Topics: Anti-Bacterial Agents; Anticoagulants; Female; Follow-Up Studies; Furosemide; Glucose; Heart Arrest;

1967
[Drug therapy of acute cerebral ischemia. Clinical study].
    Giornale di clinica medica, 1974, Volume: 55, Issue:12

    Topics: Brain; Dextrans; Dihydroergotoxine; Ergoloid Mesylates; Humans; Intracranial Arteriosclerosis; Intra

1974
[Paroxysmal tetaniform contractures during selective arteriography of the Adamkiewicz's artery].
    La Presse medicale, 1969, Sep-20, Volume: 77, Issue:38

    Topics: Abdominal Muscles; Angiography; Aortography; Contracture; Diazepam; Hemangioma; Humans; Interneurons

1969
[Lidocaine therapy of coronary ischemia and angina pectoris].
    Munchener medizinische Wochenschrift (1950), 1972, Nov-10, Volume: 114, Issue:45

    Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Coronary Disease; Coronary Vessels; Electrocardi

1972
Antiarrhythmic and circulatory effects of Astra W36095, a new lidocaine-like agent.
    The American journal of cardiology, 1974, Volume: 34, Issue:1

    Topics: Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chemical Phenomena;

1974
The clearance of red blood cells from the cadaver kidney.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1970, Volume: 2, Issue:4

    Topics: Animals; Body Weight; Cadaver; Chromium Radioisotopes; Dextrans; Edema; Erythrocytes; Female; Hepari

1970
Pharmacologic production of atrioventricular block with and without initial bundle branch block.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 179, Issue:2

    Topics: Acetylcholine; Adenosine Triphosphate; Animals; Arteries; Arteriovenous Shunt, Surgical; Dogs; Drug

1971
[Bier's intravenous regional anesthesia. Clinical experiences with xylocaine].
    Zeitschrift fur arztliche Fortbildung, 1971, Oct-15, Volume: 65, Issue:20

    Topics: Ambulatory Care; Anesthesia, Conduction; Extremities; Female; Humans; Injections, Intravenous; Ische

1971
[The use of the preparation POR-8 (ornithine 8--vasopressin) as an ischemic drug in infiltration anesthesia with lignocaine].
    Przeglad lekarski, 1969, Volume: 25, Issue:7

    Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics; Humans; Ischemia; Lidocaine; Middle Aged; O

1969
The mode of action of intravenous regional anesthetics.
    Acta anaesthesiologica Scandinavica. Supplementum, 1969, Volume: 36

    Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Humans; Ischemia; Lidocaine; Time Factors

1969
The use intravenous regional anaesthesia in orthopedic surgery.
    Acta anaesthesiologica Scandinavica. Supplementum, 1969, Volume: 36

    Topics: Amputation, Surgical; Anesthesia, Conduction; Anesthesia, Intravenous; Extremities; Fracture Fixatio

1969
Nerve conduction studies in regional intravenous analgesia using 1 per cent lignocaine.
    British journal of anaesthesia, 1970, Volume: 42, Issue:12

    Topics: Action Potentials; Adult; Anesthesia, Conduction; Anesthesia, Intravenous; Electric Stimulation; For

1970
Paraplegia following epidural analgesia.
    Anaesthesia, 1969, Volume: 24, Issue:3

    Topics: Anesthesia, Spinal; Epinephrine; Humans; Ischemia; Lidocaine; Male; Middle Aged; Necrosis; Neurologi

1969