lidocaine has been researched along with Ischemia in 112 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Excerpt | Relevance | Reference |
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"To compare the effectiveness of intravenous lidocaine and intravenous morphine in decreasing pain in patients with critical limb ischaemia." | 9.20 | Comparison of intravenous lidocaine versus morphine in alleviating pain in patients with critical limb ischaemia. ( Aghaie Meybodi, M; Saeedi, M; Shakoor, D; Vahidi, E, 2015) |
"To investigate effects of lidocaine hydrochloride administered IV on mucosal inflammation in ischemia-injured jejunum of horses treated with flunixin meglumine." | 9.14 | Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses. ( Blikslager, AT; Campbell, NB; Cook, VL; Davis, JL; Jones Shults, J; Marshall, JF; McDowell, MR, 2009) |
" Fortunately, digital ischemia can be reversed with phentolamine." | 9.12 | Phentolamine Rescue for Digital Ischemia Following Lidocaine with Epinephrine Local Anesthesia: Case Presentation, Review of the Literature and Treatment Options. ( Hewitt, C; Smith, VJ; Van Demark, RE, 2021) |
"A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery." | 7.77 | Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets. ( Bellemann, N; Boeckler, D; Hyhlik-Duerr, A; Kauczor, HU; Radeleff, B; Sommer, CM; Stampfl, U; Weber, MA, 2011) |
"The direct injection of lidocaine into the clamped aorta results in a rapidly change in SCEP in the threat of ischemia and can be used to make an early detection of the segmental arteries perfusing to the spinal cord." | 7.70 | The effect of direct lidocaine injection into the clamped aortic segment on the spinal evoked potential: early diagnosis for spinal cord ischemia. ( Ataka, K; Nohara, H; Okada, M; Yamashita, C; Yoshimura, N, 1999) |
"We used field potential recording techniques to examine whether felbamate (FBM), lamotrigine (LTG), and lidocaine (LID) protect against the irreversible functional damage induced by transient ischemia." | 7.70 | An electrophysiological analysis of the protective effects of felbamate, lamotrigine, and lidocaine on the functional recovery from in vitro ischemia in rat neocortical slices. ( Bernardi, G; Guatteo, E; Mercuri, NB; Siniscalchi, A; Zona, C, 1998) |
"A quantitative liver test based on the formation of the lidocaine metabolite monoethylglycinexylidide (MEGX), was used to evaluate the effect of hemorrhagic shock at 40 mmHg for 90 min on Sprague-Dawley rats." | 7.69 | MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock. ( Baue, AE; Chandel, B; Jellinek, M; Kurtz, M; Matthews, M; Rana, WU; Shapiro, MJ, 1995) |
"Mild ischemia was induced in segments of jejunum and large colon." | 6.84 | Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia. ( Bauck, AG; Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Vickroy, TW, 2017) |
"Labetalol was found to be less effective in preventing tissue necrosis." | 5.28 | Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989) |
"To compare the effectiveness of intravenous lidocaine and intravenous morphine in decreasing pain in patients with critical limb ischaemia." | 5.20 | Comparison of intravenous lidocaine versus morphine in alleviating pain in patients with critical limb ischaemia. ( Aghaie Meybodi, M; Saeedi, M; Shakoor, D; Vahidi, E, 2015) |
"To investigate effects of lidocaine hydrochloride administered IV on mucosal inflammation in ischemia-injured jejunum of horses treated with flunixin meglumine." | 5.14 | Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses. ( Blikslager, AT; Campbell, NB; Cook, VL; Davis, JL; Jones Shults, J; Marshall, JF; McDowell, MR, 2009) |
" Riluzole, Lidocaine and Lamotrigine were given prior to renal ischemia only (IO) or IRI." | 4.12 | Pharmacological prevention of renal ischemia-reperfusion injury in a rat model. ( Deng, Y; Li, RW; Smith, PN; Weiss, S; Yang, YL, 2022) |
" The lower cell counts of caspase- and calprotectin-positive cells in group X may indicate a beneficial effect of xylazine on ischaemia/reperfusion injury." | 4.02 | Preconditioning with lidocaine and xylazine in experimental equine jejunal ischaemia. ( Kästner, S; König, K; Neudeck, S; Pfarrer, C; Rohn, K; Twele, L; Verhaar, N, 2021) |
"A 37-year-old man with known intravenous drug abuse presented in the surgical ambulatory care unit with acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets into the right femoral artery." | 3.77 | Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets. ( Bellemann, N; Boeckler, D; Hyhlik-Duerr, A; Kauczor, HU; Radeleff, B; Sommer, CM; Stampfl, U; Weber, MA, 2011) |
"Lidocaine and thiopental improve recovery when administrated during hypoxia and ischemia; however, the effect of pre- or postinsult treatment alone is unknown." | 3.73 | Pre- or postinsult administration of lidocaine or thiopental attenuates cell death in rat hippocampal slice cultures caused by oxygen-glucose deprivation. ( Bergold, PJ; Cao, H; Cottrell, JE; Kass, IS, 2005) |
"The principal finding of the present study with rat spinal cord slices was the novel demonstration of the [Ca2+]o-independent effect of ischemia on norepinephrine release and its antagonism by tetrodotoxin and low temperature (10 degrees C)." | 3.70 | Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices. ( Bencsics, A; Nakai, T; Sato, T; Uchihashi, Y; Umeda, E; Vizi, ES, 1998) |
"A quantitative liver test based on the formation of the lidocaine metabolite monoethylglycinexylidide (MEGX), was used to evaluate the effect of hemorrhagic shock at 40 mmHg for 90 min on Sprague-Dawley rats." | 3.69 | MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock. ( Baue, AE; Chandel, B; Jellinek, M; Kurtz, M; Matthews, M; Rana, WU; Shapiro, MJ, 1995) |
"Epidural lidocaine compared to epidural saline hastens the recovery of gastrointestinal motility in rats after a 30-min period of bowel ischemia." | 3.69 | Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat. ( Eimerl, D; Haskel, Y; Schiffman, J; Udassin, R, 1994) |
"Antiarrhythmic drugs, such as lidocaine, quinidine, and procainamide, have been shown to be effective against postischemic reperfusion injury in isolated rat lungs." | 3.69 | Amelioration of postischemic reperfusion injury by antiarrhythmic drugs in isolated perfused rat lung. ( Das, KC; Misra, HP, 1994) |
"The present investigation was designed to study the interaction of temperature, lidocaine, and ischemia during intravenous regional anesthesia (IVRA) of the arm." | 3.67 | Interaction of lidocaine and hypothermia in Bier blocks in volunteers. ( Haasio, J; Heavner, JE; Kytta, J; Leinonen, L; Rosenberg, PH, 1989) |
" Hypothermia, thiopental, magnesium, lidocaine, and naloxone were used to pretreat the spinal cord prior to ischemia." | 3.67 | Protection against experimental ischemic spinal cord injury. ( Foltz, R; Goodman, JC; Grossman, RG; Robertson, CS, 1986) |
"A 45-year-old man with an internal carotid artery occlusion, cerebral hemispheric infarction, and an ipsilateral central retinal artery occlusion developed anterior segment necrosis after retrobulbar injection of lidocaine hydrochloride (Xylocaine) for treatment of an occlusion of the central retinal artery." | 3.66 | Anterior segment necrosis following treatment of central retinal artery occlusion: a clinicopathologic case report. ( Marcus, DF; Reeser, FH; Weidaw, CD, 1978) |
"Potassium chloride (KCl) given subcutaneously in high concentrations causes necrosis of skin, possibly from vasoconstriction around the injection site." | 3.65 | Lidocaine treatment of experimental cutaneous lesions from potassium chloride injection. ( Behnia, R; Wilkinson, CJ, 1977) |
"Mild ischemia was induced in segments of jejunum and large colon." | 2.84 | Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia. ( Bauck, AG; Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Vickroy, TW, 2017) |
"Our data suggest that control of postoperative pain is a major determinant of surgical-wound infection and should be given the same consideration as maintaining adequate vascular volume and normothermia." | 2.69 | Postoperative pain and subcutaneous oxygen tension. ( Akça, O; Arkiliç, CF; Heinz, T; Hellwagner, K; Kapral, S; Kurz, A; Lackner, FX; Melischek, M; Scheck, T; Sessler, DI, 1999) |
"The rat Langendorff-perfused isolated heart, anaesthetised rat and rat ventricular myocyte preparations were utilised in a series of blinded and randomised studies to investigate the antiarrhythmic effectiveness, adverse effects and mechanism of action of OCT2013, compared with lidocaine." | 1.72 | OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine. ( Chowdhury, RA; Curtis, MJ; Firth, J; Hesketh, LM; MacLeod, KT; Mahoney-Sanchez, L; Mazzacuva, F; Ogrodzinski, S; Patterson, LH; Peters, NS; Sikkel, MB; Tzortzis, KN; Wilder, CDE; Winter, J, 2022) |
"In this exceptional case, the unusual Horner syndrome manifestations related to unilateral ptosis, miosis, and anisocoria were simultaneously developed with skin ischemia, paresthesia, and asymmetric flushing after the administration of IANB anesthesia." | 1.39 | Concomitant horner and harlequin syndromes after inferior alveolar nerve block anesthesia. ( Chen, YJ; Fang, WH; Huang, RY; Mau, LP; Shieh, YS, 2013) |
"Bupivacaine and lidocaine were reacted with the membrane preparations at cardiotoxically relevant concentrations and their membrane interactivities were determined by measuring fluorescence polarization." | 1.38 | Cardiotoxic local anesthetics increasingly interact with biomimetic membranes under ischemia-like acidic conditions. ( Mizogami, M; Shigemi, K; Tsuchiya, H; Ueno, T, 2012) |
"A 51-year-old woman described paresthesias in her right thumb, index, and middle fingers consistent with carpal tunnel syndrome." | 1.35 | Digital ischemia after carpal tunnel injection: a case report. ( Brault, JS; Payne, JM, 2008) |
"Postoperative pain was controlled by use of multimodal analgesia." | 1.33 | [Bilateral polyradiculitis after an epidural block: a rare, serious complication]. ( Aguilar, JL; Ferrer, AM; Mira, MD; Peláez, R; Segura, MC, 2006) |
"Drug effects on ischaemia-induced arrhythmias were assessed simultaneously in the same rabbits." | 1.31 | RSD1019 suppresses ischaemia-induced monophasic action potential shortening and arrhythmias in anaesthetized rabbits. ( Barrett, TD; MacLeod, BA; Walker, MJ, 2000) |
"Lidocaine was infused into the portal vein, and the concentration of lidocaine in hepatic outflow was measured with FPIA." | 1.30 | [The effects of vasoconstrictors on distribution of ischemic tissue flow in isolated perfused rat liver]. ( Asada, A; Fujimori, M; Kariya, N; Nishi, S; Shimazu, K; Umemoto, Y, 1997) |
"Nicardipine was greater than papaverine in inducing relaxation." | 1.30 | Drug-induced vasodilation in an in vitro and in vivo study: the effects of nicardipine, papaverine, and lidocaine on the rabbit carotid artery. ( Cromeens, DM; Evans, GR; Gherardini, G; Gürlek, A; Joly, GA; Kilbourn, RG; Langstein, H; Lundeberg, T; Sukumaran, AV; Wang, B; Williams, J, 1997) |
"In intact rats subjected to hemorrhagic shock, lidocaine pretreatment also facilitated shock resuscitation and reduced ultrastructural damage." | 1.28 | Gastric and cardiac organoprotection by lidocaine. ( Cho, CH; DeRolf, S; Keith, JC; Misra, HP; Pfeiffer, CJ; Pfeiffer, DC, 1989) |
"Labetalol was found to be less effective in preventing tissue necrosis." | 1.28 | Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989) |
"After treatment of ischemia and/or failure, specific antiarrhythmic agents, conventional and investigational, alone or in combination, are systematically selected." | 1.26 | Ventricular ectopy: etiology, evaluation, and therapy. ( Reid, PR; Vlay, SC, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 41 (36.61) | 18.7374 |
1990's | 32 (28.57) | 18.2507 |
2000's | 17 (15.18) | 29.6817 |
2010's | 16 (14.29) | 24.3611 |
2020's | 6 (5.36) | 2.80 |
Authors | Studies |
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Deng, Y | 1 |
Li, RW | 1 |
Yang, YL | 1 |
Weiss, S | 1 |
Smith, PN | 1 |
Hesketh, LM | 1 |
Sikkel, MB | 1 |
Mahoney-Sanchez, L | 1 |
Mazzacuva, F | 1 |
Chowdhury, RA | 1 |
Tzortzis, KN | 1 |
Firth, J | 1 |
Winter, J | 1 |
MacLeod, KT | 1 |
Ogrodzinski, S | 1 |
Wilder, CDE | 1 |
Patterson, LH | 1 |
Peters, NS | 1 |
Curtis, MJ | 1 |
Van Demark, RE | 1 |
Hewitt, C | 1 |
Smith, VJ | 1 |
Rougereau, G | 1 |
El Khoury, G | 1 |
Châtelain, L | 1 |
Zadegan, F | 1 |
El Khoury, E | 1 |
Ollat, D | 1 |
Verhaar, N | 1 |
Pfarrer, C | 1 |
Neudeck, S | 1 |
König, K | 1 |
Rohn, K | 1 |
Twele, L | 1 |
Kästner, S | 1 |
Rajiah, E | 1 |
McKean, AR | 1 |
Bain, C | 1 |
Bauck, AG | 1 |
Grosche, A | 1 |
Morton, AJ | 1 |
Graham, AS | 1 |
Vickroy, TW | 1 |
Freeman, DE | 1 |
Totty, J | 1 |
Forsyth, J | 1 |
Mekako, A | 1 |
Chetter, I | 1 |
Huang, RY | 1 |
Chen, YJ | 1 |
Fang, WH | 1 |
Mau, LP | 1 |
Shieh, YS | 1 |
Bruttini, C | 1 |
Esposti, R | 1 |
Bolzoni, F | 1 |
Cavallari, P | 1 |
Vahidi, E | 1 |
Shakoor, D | 1 |
Aghaie Meybodi, M | 1 |
Saeedi, M | 1 |
Panov, VM | 1 |
Fesenko, UA | 1 |
Kutsyn, VM | 1 |
Payne, JM | 1 |
Brault, JS | 1 |
Cook, VL | 2 |
Jones Shults, J | 2 |
McDowell, MR | 1 |
Campbell, NB | 2 |
Davis, JL | 2 |
Marshall, JF | 1 |
Blikslager, AT | 2 |
Hormozi, AK | 1 |
Zendehnam, H | 1 |
Hosseini, SN | 1 |
Rasti, M | 1 |
Rostami, K | 1 |
Hamraz, H | 1 |
Denkler, K | 1 |
Williams, JV | 1 |
Williams, LR | 1 |
Colbert, SD | 1 |
Revington, PJ | 1 |
Noël, B | 1 |
Radeleff, B | 1 |
Stampfl, U | 1 |
Sommer, CM | 1 |
Bellemann, N | 1 |
Hyhlik-Duerr, A | 1 |
Weber, MA | 1 |
Boeckler, D | 1 |
Kauczor, HU | 1 |
Tsuchiya, H | 1 |
Mizogami, M | 1 |
Ueno, T | 1 |
Shigemi, K | 1 |
Cui, J | 1 |
McQuillan, PM | 1 |
Blaha, C | 1 |
Kunselman, AR | 1 |
Sinoway, LI | 1 |
Granfeldt, A | 1 |
Soliman, D | 1 |
Wang, L | 2 |
Hamming, KS | 1 |
Yang, W | 1 |
Fatehi, M | 1 |
Carter, CC | 1 |
Clanachan, AS | 1 |
Light, PE | 1 |
Efe, E | 1 |
Resim, S | 1 |
Bulut, BB | 1 |
Eren, M | 1 |
Garipardic, M | 1 |
Ozkan, F | 1 |
Ozkan, KU | 1 |
Fortune, B | 1 |
Cull, G | 1 |
Van Buskirk, EM | 1 |
Cioffi, GA | 1 |
Erkasap, N | 1 |
Ates, E | 1 |
Erkasap, S | 1 |
Kaygisiz, Z | 1 |
Sharma, A | 1 |
Gupta, A | 2 |
Bandyopadhyay, S | 1 |
Vinekar, AS | 1 |
Ram, J | 1 |
Dogra, MR | 1 |
ROMANO, M | 1 |
MILES, DW | 1 |
JAMES, JL | 1 |
CLARK, DE | 1 |
WHITWAM, JG | 1 |
THORNE, J | 1 |
SORBIE, C | 1 |
CHACHA, P | 1 |
NAHOR, A | 1 |
MILLIKEN, J | 1 |
MINTON, R | 1 |
FINE, J | 1 |
Graven-Nielsen, T | 1 |
Mense, S | 1 |
Arendt-Nielsen, L | 2 |
Lan, W | 1 |
Harmon, D | 1 |
Wang, JH | 1 |
Ghori, K | 1 |
Shorten, G | 1 |
Redmond, P | 1 |
Karaçal, N | 1 |
Ambarcioğlu, O | 1 |
Topal, U | 1 |
Mamedov, T | 1 |
Kutlu, N | 1 |
Agarwal, P | 1 |
Agrawal, PK | 1 |
Sharma, D | 1 |
Baghel, KD | 1 |
Cao, H | 1 |
Kass, IS | 1 |
Cottrell, JE | 1 |
Bergold, PJ | 1 |
Ascione, R | 1 |
Talpahewa, S | 1 |
Rajakaruna, C | 1 |
Reeves, BC | 1 |
Lovell, AT | 1 |
Cohen, A | 1 |
Angelini, GD | 1 |
Gandevia, SC | 1 |
Smith, JL | 1 |
Crawford, M | 1 |
Proske, U | 1 |
Taylor, JL | 1 |
Mira, MD | 1 |
Peláez, R | 1 |
Segura, MC | 1 |
Ferrer, AM | 1 |
Aguilar, JL | 1 |
McDowell, M | 1 |
Vlay, SC | 1 |
Reid, PR | 1 |
Riberti, C | 1 |
Costa, P | 1 |
Lefèvre, JC | 1 |
Chassagne, JF | 1 |
Babalola, GO | 1 |
Oke, BO | 1 |
Kirpatovskiĭ, VI | 1 |
Onishchenko, NA | 1 |
Lubiako, AA | 1 |
Danilov, MA | 1 |
Bogoiavlenskaia, TA | 1 |
Boas, RA | 1 |
Covino, BG | 1 |
Shahnarian, A | 1 |
Bernauer, W | 1 |
Hardy, SJ | 1 |
Agostini, DE | 1 |
Bühler-Singer, S | 1 |
Hiller, D | 1 |
Boateng, B | 1 |
Albrecht, HP | 1 |
Seidel, C | 1 |
Hornstein, OP | 1 |
Das, KC | 1 |
Misra, HP | 2 |
Chandel, B | 1 |
Shapiro, MJ | 1 |
Kurtz, M | 1 |
Rana, WU | 1 |
Matthews, M | 1 |
Jellinek, M | 1 |
Baue, AE | 1 |
Miller, RM | 1 |
Loken, RG | 1 |
Coupland, SG | 1 |
Deschênes, MC | 1 |
Udassin, R | 1 |
Eimerl, D | 1 |
Schiffman, J | 1 |
Haskel, Y | 1 |
Serwatka, LM | 1 |
Grohmann, G | 1 |
Pöhlmann, G | 1 |
Eidner, G | 1 |
Friedman, DB | 1 |
Brennum, J | 1 |
Sztuk, F | 2 |
Hansen, OB | 1 |
Clifford, PS | 1 |
Bach, FW | 1 |
Mitchell, JH | 1 |
Secher, NH | 1 |
Naesh, O | 1 |
Haljamäe, H | 1 |
Skielboe, M | 1 |
Andersen, P | 1 |
Ibsen, A | 1 |
Hindberg, I | 1 |
Maynard, ND | 1 |
Bihari, DJ | 1 |
Dalton, RN | 1 |
Beale, R | 1 |
Smithies, MN | 1 |
Mason, RC | 1 |
Kariya, N | 1 |
Umemoto, Y | 1 |
Shimazu, K | 1 |
Nishi, S | 1 |
Asada, A | 1 |
Fujimori, M | 1 |
Jund, R | 1 |
Kastenbauer, E | 1 |
Leclercq, I | 1 |
Saliez, A | 1 |
Wallemacq, PE | 1 |
Horsmans, Y | 1 |
Lambotte, L | 1 |
Evans, GR | 1 |
Gherardini, G | 1 |
Gürlek, A | 1 |
Langstein, H | 1 |
Joly, GA | 1 |
Cromeens, DM | 1 |
Sukumaran, AV | 1 |
Williams, J | 1 |
Kilbourn, RG | 1 |
Wang, B | 1 |
Lundeberg, T | 1 |
Sylaidis, P | 1 |
Logan, A | 1 |
Olinga, P | 1 |
Merema, MT | 1 |
Hof, IH | 1 |
De Jager, MH | 1 |
De Jong, KP | 1 |
Slooff, MJ | 1 |
Meijer, DK | 1 |
Groothuis, GM | 1 |
Uchihashi, Y | 1 |
Bencsics, A | 1 |
Umeda, E | 1 |
Nakai, T | 1 |
Sato, T | 1 |
Vizi, ES | 1 |
Murali, KS | 1 |
Nayeem, N | 1 |
Brinkmann, A | 1 |
Calzia, E | 1 |
Träger, K | 1 |
Radermacher, P | 1 |
Siniscalchi, A | 1 |
Zona, C | 1 |
Guatteo, E | 1 |
Mercuri, NB | 1 |
Bernardi, G | 1 |
Tomori, H | 1 |
Shiraishi, M | 1 |
Koga, H | 1 |
Toure, M | 1 |
Taira, K | 1 |
Higa, T | 1 |
Okuhama, Y | 1 |
Hiroyasu, S | 1 |
Muto, Y | 1 |
Baumgarten, KM | 1 |
Gerstenblith, G | 1 |
Weiss, RG | 1 |
Nohara, H | 1 |
Okada, M | 1 |
Yamashita, C | 1 |
Ataka, K | 1 |
Yoshimura, N | 1 |
Ahlquist, M | 1 |
Franzén, O | 1 |
Follis, FM | 1 |
Blisard, KS | 1 |
Varvitsiotis, PS | 1 |
Pett, SB | 1 |
Temes, RT | 1 |
Wernly, JA | 1 |
Ong, HS | 1 |
Soo, KC | 1 |
Joseph, VT | 1 |
Tan, SY | 1 |
Jeyaraj, PR | 1 |
Akça, O | 1 |
Melischek, M | 1 |
Scheck, T | 1 |
Hellwagner, K | 1 |
Arkiliç, CF | 1 |
Kurz, A | 1 |
Kapral, S | 1 |
Heinz, T | 1 |
Lackner, FX | 1 |
Sessler, DI | 1 |
Barrett, TD | 1 |
MacLeod, BA | 1 |
Walker, MJ | 1 |
Grey, MJ | 1 |
Ladouceur, M | 1 |
Andersen, JB | 1 |
Nielsen, JB | 1 |
Sinkjaer, T | 1 |
De Monaco, D | 1 |
De Monaco, A | 1 |
Kammer, E | 1 |
Noever, G | 1 |
Grimby, L | 1 |
Hannerz, J | 1 |
Weidaw, CD | 1 |
Marcus, DF | 1 |
Reeser, FH | 1 |
Osborn, JL | 1 |
Hook, JB | 1 |
Bailie, MD | 1 |
Behnia, R | 1 |
Wilkinson, CJ | 1 |
Keskitalo, E | 1 |
Persson, G | 1 |
Sundt, TM | 1 |
Ueda, M | 1 |
Kimoto, S | 1 |
Matsuda, S | 1 |
Kawakami, M | 1 |
Mroishige, E | 1 |
Matsumura, S | 1 |
Takeda, H | 1 |
Svensson, LG | 1 |
Crawford, ES | 1 |
Patel, V | 1 |
McLean, TR | 1 |
Jones, JW | 1 |
DeBakey, ME | 1 |
Nilius, J | 1 |
von Bary, S | 1 |
Pfeiffer, CJ | 1 |
Keith, JC | 1 |
Cho, CH | 1 |
DeRolf, S | 1 |
Pfeiffer, DC | 1 |
Heavner, JE | 1 |
Leinonen, L | 1 |
Haasio, J | 1 |
Kytta, J | 1 |
Rosenberg, PH | 1 |
Aycock, BG | 1 |
Hawtof, DB | 1 |
Moody, SB | 1 |
Rowinski, W | 1 |
Ruka, M | 1 |
Stuart, F | 1 |
Buckingham, F | 1 |
Baron, HC | 1 |
LaRaja, RD | 1 |
Rossi, G | 1 |
Atkinson, D | 1 |
Grek, OR | 1 |
Sharapov, VI | 1 |
Sokirchenko, IA | 1 |
Shkurupiĭ, VA | 1 |
Robertson, CS | 1 |
Foltz, R | 1 |
Grossman, RG | 1 |
Goodman, JC | 1 |
Gearhart, JP | 1 |
Jeffs, RD | 1 |
Sörensen, SE | 1 |
Pantridge, JF | 2 |
Geddes, JS | 2 |
Adgey, AA | 1 |
Almici, C | 1 |
Lazzaroni, G | 1 |
Djindjin, R | 1 |
Mamo, H | 1 |
Saimot, G | 1 |
Houdart, R | 1 |
Széplaki, S | 1 |
Szmandra, J | 1 |
Széplaki, Z | 1 |
Coltart, DJ | 1 |
Berndt, TB | 1 |
Kernoff, R | 1 |
Harrison, DC | 1 |
Harris, WH | 1 |
Kerstein, MD | 1 |
Bergentz, SE | 1 |
Lewis, DH | 1 |
James, TN | 1 |
Bear, ES | 1 |
Frink, RJ | 1 |
Urthaler, F | 1 |
Di Giacomo, G | 1 |
Beyer, A | 1 |
Thieler, H | 1 |
Müller, H | 1 |
Bartkowski, S | 1 |
Polaczek-Kornecki, T | 1 |
Atkinson, DI | 1 |
Trias, A | 1 |
Shanks, CA | 1 |
McLeod, JG | 1 |
Urquhart-Hay, D | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
High Dose Intravenous Lidocaine vs Hydromorphone for Acute Abdominal Pain in the Emergency Department: A Randomized, Comparative Efficacy Trial[NCT04398316] | Phase 4 | 187 participants (Anticipated) | Interventional | 2021-02-18 | Recruiting | ||
The Venous Distension Reflex and Orthostatic Hypertension[NCT03496792] | 30 participants (Anticipated) | Interventional | 2020-03-10 | Recruiting | |||
Lidocaine For Neuroprotection During Cardiac Surgery[NCT00938964] | 550 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -1.27 |
Placebo | -0.89 |
"Center for Epidemiological Studies Depression Scale (CES-D). The CES-D is a 20-item self-report examination designed to measure symptoms of depression. Subjects rate the degree to which they have experienced a range of symptoms of depression, such as I had crying spells and I felt lonely. Scores range from 0 to 60, with higher scores indicating greater depressive symptoms. Scores greater than 16 are typically considered indicative of clinically significant depression." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.57 |
Placebo | 0.16 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 1 year cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement (NCT00938964)
Timeframe: 1 year after surgery
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.09 |
Placebo | 0.07 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.07 |
Placebo | 0.07 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 6.3 |
Placebo | 6.96 |
"The DASI is a 12-item scale of functional capacity that has been found to correlate well with objective measures of maximal exercise capacity. Items reflect activities of personal care, ambulation, household tasks, sexual function, and recreational activities. Activities done with no difficulty receive scores, which are weighted and summed, for a quantitative measure of functional status. Scores range from 0 to 60; a higher-weighted score indicates better function." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -10.98 |
Placebo | -11.67 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.05 |
Placebo | 0.07 |
The National Institutes of Health Stroke Scale (NIHSS) is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The range of scores is from 0 (normal) to 42 (profound effect of stroke on patient). (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.05 |
Placebo | 0.04 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.02 |
Placebo | -0.02 |
The Western perioperative neurologic scale was designed to detect neurologic deficits after cardiac surgery. It includes 14 items classified into eight domains (mentation, speech, cranial nerve function, motor weakness, sensation and cerebellum, reflexes, and gait). Each item is scored from 0 (severe deficit) to3 (normal), and a maximum score of 42 indicates normal neurological function. (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.04 |
Placebo | -0.01 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.71 |
Placebo | -1.16 |
"Perceived Social Support Scale: Twelve items indicate how strongly subjects agree that there is a special person who is around when I am in need and my family really tries to help me. Choices range from very strongly disagree to very strongly agree. Items are summed for a range of 12 to 84, with a high score meaning more social support." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 1.23 |
Placebo | -0.49 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.20 |
Placebo | 0.03 |
"Social Activity: This measure consisted of eight items that indicate the degree of social interaction. Sample items are How often do you talk on the telephone with friends and relatives? and How often do you attend meetings of social groups, clubs, or civic organizations? Scores range from 8 to 32. A lower score indicates more social activity." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 0.95 |
Placebo | 1.59 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -6.70 |
Placebo | -6.39 |
"Spielberger State Anxiety Inventory (STAI): The STAI consists of two 20-item scales that measure anxiety. Representative items include statements such as I feel nervous and I feel worried. These items are rated on a 4-point scale, based on how well they describe the patient's current or typical mood, from not at all to very much so. Scores range from 20 to 80, with higher scores indicating greater anxiety." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -7.12 |
Placebo | -6.31 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -1.39 |
Placebo | -1.48 |
Symptom limitations: Patients were given a list of eight symptoms and asked to rate the degree to which the symptom limited daily activities. The symptoms were angina, shortness of breath, arthritis, back trouble, leg pains, headaches, fatigue, and other. Scores range from 8 to 32, with higher scores indicating greater limitations. (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.67 |
Placebo | -0.8 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.46 |
Placebo | -1.02 |
"Cognitive Difficulties Scale: a 39-item scale, is a self-report assessment of perceived problems in long- and short-term memory, concentration, attention, and psycho-motor coordination. Sample items are I forget errands I planned to do and I fail to recognize people I know. Scores range from 39 to 164, with higher scores indicating greater cognitive difficulty." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -3 |
Placebo | -3.21 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | -0.15 |
Placebo | -0.31 |
"Duke Older Americans Resources and Services Procedures- Instrumental Activities of Daily Living (OARS-IADL): This measure contains six items that assess the ability to perform important tasks for daily living (e.g., Could you prepare your own meals? Could you drive a car?). Scores range from 6 to 24. Higher scores indicate increasing difficulty in engaging in daily activities." (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) |
---|---|
Lidocaine | 2.46 |
Placebo | 2.1 |
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. Each domain score is normally distributed with a mean of zero. A change score was calculated for each domain by subtracting the baseline from the 6-week score. A dichotomous outcome variable of post-operative cognitive deficit was defined as a decline of ≥1 standard deviation in 1 or more of the 5 domains. (NCT00938964)
Timeframe: Preoperative to 6 weeks after surgery
Intervention | Participants (Count of Participants) |
---|---|
Lidocaine | 87 |
Placebo | 83 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 1-year
Intervention | units on a scale (Mean) | |
---|---|---|
1 year Change Work Activities | 1 year Change General health perception | |
Lidocaine | -1.37 | -0.28 |
Placebo | -1.42 | -0.43 |
The Medical Outcomes Study 36-Item Short Form Health Survey (SF-36): The SF-36 was designed to measure general health status. Two scales were used: Work Activities (four items) and General Health (one item). For the work activities scale, the reported score was the sum of four questions, each with values ranging from 1 to 4, the total score could range from 4 to 16. A higher score on Work Activities indicates more health-related problems For the general health question, the patients ranked their health from Excellent (1) to poor (5), the scale ranged from 1 to 5 with 1 being best health and 5 being worst. A high score in General Health indicates poorer health state. (NCT00938964)
Timeframe: baseline, 6-weeks
Intervention | units on a scale (Mean) | |
---|---|---|
6-Week Change Work activities | 6-Week Change General health perception | |
Lidocaine | 2.71 | -0.004 |
Placebo | 3 | -0.03 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -0.15 | 0.02 | -0.73 | -0.10 |
Placebo | -0.43 | -0.73 | -0.40 | 0.19 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -4.22 | -2.46 | -0.34 | 1.21 |
Placebo | -0.04 | 1.83 | 2.64 | 0.54 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removal and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -2.02 | 0.56 | 0.58 | 1.04 |
Placebo | -0.08 | 0.17 | 1.19 | -0.68 |
Paired jugular venous and radial arterial blood samples were drawn at baseline, cross-clamp removal, end of cardiopulmonary bypass, and 6 hours post cross-clamp removalime points and analyzed by fluorescence-activated cell sorting to identify activated platelets. Transcerebral activation gradients were calculated by subtracting arterial values from venous values and were compared between groups (NCT00938964)
Timeframe: Baseline to 6 hours post cross-clamp removal
Intervention | Mean linear fluorescence intensity-MLFI (Mean) | |||
---|---|---|---|---|
Baseline | Cross-clamp removal | End of Bypass | 6 hours post cross-clamp removal | |
Lidocaine | -0.03 | 0.03 | 0.33 | 0.37 |
Placebo | 0.35 | 0.43 | 0.05 | 0.27 |
6 reviews available for lidocaine and Ischemia
Article | Year |
---|---|
Phentolamine Rescue for Digital Ischemia Following Lidocaine with Epinephrine Local Anesthesia: Case Presentation, Review of the Literature and Treatment Options.
Topics: Anesthesia, Local; Epinephrine; Humans; Ischemia; Lidocaine; Phentolamine | 2021 |
WALANT in hand surgery: Ischemic complications and their medicolegal implications in France: A systematic review of the literature and of French legal databases.
Topics: Anesthesia, Local; Epinephrine; Hand; Humans; Ischemia; Lidocaine | 2022 |
Amaurosis, ophthalmoplegia, ptosis, mydriasis and periorbital blanching following inferior alveolar nerve anaesthesia.
Topics: Adult; Amaurosis Fugax; Anesthesia, Dental; Anesthesia, General; Anesthesia, Local; Blepharoptosis; | 2011 |
Organ dysfunction following regional and global ischemia/reperfusion. Intervention with postconditioning and adenocaine.
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Drug Combinations; Heart Arrest; Humans; Ischemia; Ische | 2012 |
Monitoring the hepato-splanchnic region in the critically ill patient. Measurement techniques and clinical relevance.
Topics: Anesthetics, Local; Carbon Dioxide; Cell Hypoxia; Critical Care; Digestive System Diseases; Gastric | 1998 |
[Digital nerve block anaesthesia: historical development and two cases of finger-tip necrosis, a rare complication].
Topics: Adult; Aged; Anesthesia, Local; Epinephrine; Female; Fingers; History, 19th Century; History, 20th C | 2002 |
8 trials available for lidocaine and Ischemia
Article | Year |
---|---|
Effect of lidocaine on inflammation in equine jejunum subjected to manipulation only and remote to intestinal segments subjected to ischemia.
Topics: Animals; Cyclooxygenase 2; Horse Diseases; Horses; Inflammation; Intestinal Mucosa; Ischemia; Jejuna | 2017 |
Comparison of intravenous lidocaine versus morphine in alleviating pain in patients with critical limb ischaemia.
Topics: Administration, Intravenous; Adult; Aged; Analgesics, Opioid; Critical Illness; Double-Blind Method; | 2015 |
Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Female; Gene Expression Regulation, Enzy | 2009 |
Splanchnic organ injury during coronary surgery with or without cardiopulmonary bypass: a randomized, controlled trial.
Topics: Aged; Alanine Transaminase; Amylases; Aspartate Aminotransferases; Blood Glucose; Carbohydrates; Car | 2006 |
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine.
Topics: Anesthetics, Local; Animals; Clonixin; Electric Impedance; Female; Horse Diseases; Horses; Infusions | 2008 |
Postoperative pain and subcutaneous oxygen tension.
Topics: Adolescent; Adult; Anesthetics, Local; Female; Humans; Injections, Intra-Articular; Ischemia; Knee; | 1999 |
Complications after removal of mandibular third molars with special reference to local anaesthetics with different vasoactive properties.
Topics: Adolescent; Adult; Alveolar Process; Analgesics; Anesthesia, Dental; Clinical Trials as Topic; Deglu | 1975 |
Choice of anesthetic agents for intravenous regional anesthesia.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Benzoates; Central Nervous System; Clinical Trials | 1969 |
98 other studies available for lidocaine and Ischemia
Article | Year |
---|---|
Pharmacological prevention of renal ischemia-reperfusion injury in a rat model.
Topics: Animals; Glutathione; Humans; Ischemia; Kidney; Lamotrigine; Lidocaine; Rats; Reperfusion Injury; Ri | 2022 |
OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.
Topics: Animals; Anti-Arrhythmia Agents; Ischemia; Lidocaine; Myocardial Ischemia; Prodrugs; Rats; Rats, Wis | 2022 |
Preconditioning with lidocaine and xylazine in experimental equine jejunal ischaemia.
Topics: Animals; Horse Diseases; Horses; Ischemia; Lidocaine; Reperfusion Injury; Xylazine | 2021 |
Accidental adrenaline auto-injector-induced digital ischaemia: a proposed treatment algorithm.
Topics: Adult; Algorithms; Epinephrine; Humans; Ischemia; Lidocaine; Male; Phentolamine | 2021 |
Life-threatening intraoperative anaphylaxis as a result of chlorhexidine present in Instillagel.
Topics: Aged; Anaphylaxis; Anti-Infective Agents, Local; Chlorhexidine; Diagnosis, Differential; Drug Combin | 2017 |
Concomitant horner and harlequin syndromes after inferior alveolar nerve block anesthesia.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Autonomic Nervous System Diseases; Epinephrine; Face; | 2013 |
Ischemic block of the forearm abolishes finger movements but not their associated anticipatory postural adjustments.
Topics: Action Potentials; Adaptation, Physiological; Adult; Anesthetics, Local; Biomechanical Phenomena; El | 2014 |
[Improvement of approach to performance of lumbar sympathetic blockade in patients with tissue ischemia of the lower extremities].
Topics: Adult; Aged; Anesthetics, Local; Aorta; Autonomic Nerve Block; Bupivacaine; Humans; Ischemia; Leg; L | 2014 |
Digital ischemia after carpal tunnel injection: a case report.
Topics: Carpal Tunnel Syndrome; Female; Fingers; Glucocorticoids; Humans; Injections; Ischemia; Lidocaine; M | 2008 |
Epinephrine's effect in varying concentrations on the end artery organ in an animal model.
Topics: Anesthetics, Local; Animals; Arteries; Double-Blind Method; Ear; Epinephrine; Ischemia; Lidocaine; M | 2010 |
Myth of not using lidocaine with epinephrine in the digits.
Topics: Anesthetics, Local; Drug Therapy, Combination; Epinephrine; Fingers; Humans; Ischemia; Lidocaine | 2010 |
Anesthesia for ingrowing toenail surgery.
Topics: Anesthetics, Local; Humans; Ischemia; Lidocaine; Nails, Ingrown; Nerve Block; Regional Blood Flow; T | 2010 |
Successful thrombolysis and spasmolysis of acute leg ischemia after accidental intra-arterial injection of dissolved flunitrazepam tablets.
Topics: Acute Disease; Adult; Alprostadil; Anesthetics, Local; Anti-Anxiety Agents; Fibrinolytic Agents; Flu | 2011 |
Cardiotoxic local anesthetics increasingly interact with biomimetic membranes under ischemia-like acidic conditions.
Topics: Anesthetics, Local; Bupivacaine; Cardiolipins; Cardiotoxins; Cell Membrane; Glycerophospholipids; Hy | 2012 |
Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans.
Topics: Adult; Afferent Pathways; Albumins; Analysis of Variance; Anesthetics, Local; Blood Pressure; Female | 2012 |
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.
Topics: Acetanilides; Animals; Animals, Newborn; Calcium; Calcium Signaling; Cardiac Glycosides; Electrophys | 2012 |
Successful treatment with enoxaparin of glans ischemia due to local anesthesia after circumcision.
Topics: Anesthesia, Local; Child; Circumcision, Male; Enoxaparin; Epinephrine; Fibrin Fibrinogen Degradation | 2013 |
Factors affecting the use of multifocal electroretinography to monitor function in a primate model of glaucoma.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Animals; Electroretinography; Glau | 2002 |
Lidocaine-containing Euro-Collins solution prevents renal injury in the isolated perfused canine kidney exposed to prolonged cold ischemia.
Topics: Anesthetics, Local; Animals; Cold Temperature; Dogs; Glomerular Filtration Rate; Hypertonic Solution | 2002 |
Necrosis of the eyelids and sclera after retrobulbar anesthesia.
Topics: Anesthesia, Local; Anesthetics, Local; Arterial Occlusive Diseases; Epinephrine; Eyelid Diseases; Ey | 2003 |
A severe chronic ischemic patient--a case report.
Topics: Corrinoids; Disease; Hematinics; Humans; Ischemia; Leg; Lidocaine; Vitamin B 12 | 1961 |
SITE OF ACTION OF 'INTRAVENOUS REGIONAL ANAESTHESIA'.
Topics: Anesthesia; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthesia, Local; Electromyography; Hu | 1964 |
REFLEX RESPONSES IN MAN EVOKED BY GAMMA EFFERENT ACTIVATION.
Topics: Cold Temperature; Ischemia; Lidocaine; Muscle Spindles; Neural Conduction; Neurophysiology; Pharmaco | 1964 |
REGIONAL ANAESTHESIA BY THE INTRAVENOUS ROUTE.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Forearm Injuries; Fractures, Bone; Hand Injuries; H | 1965 |
TECHNIQUE OF CELIAC BLOCKADE FOR RELIEF OF SPLANCHNIC ISCHEMIA.
Topics: Animals; Autonomic Nerve Block; Celiac Plexus; Dogs; Ethanol; Ischemia; Lidocaine; Rabbits; Shock; S | 1965 |
Painful and non-painful pressure sensations from human skeletal muscle.
Topics: Adult; Afferent Pathways; Anesthetics, Local; Female; Humans; Ischemia; Lidocaine; Male; Mechanorece | 2004 |
The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Local; Cell Adhesion Molecules; Endothelial Ce | 2004 |
Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): enhancement of flap survival by EMLA.
Topics: Administration, Topical; Animals; Graft Survival; Ischemia; Lidocaine; Lidocaine, Prilocaine Drug Co | 2005 |
Intravenous infusion for the treatment of diabetic and ischaemic non-healing pedal ulcers.
Topics: Adult; Case-Control Studies; Debridement; Diabetic Foot; Female; Foot; Foot Ulcer; Gentamicins; Hepa | 2005 |
Pre- or postinsult administration of lidocaine or thiopental attenuates cell death in rat hippocampal slice cultures caused by oxygen-glucose deprivation.
Topics: Animals; Cell Death; Cell Hypoxia; Glucose; Hippocampus; Ischemia; Lidocaine; Neuroprotective Agents | 2005 |
Motor commands contribute to human position sense.
Topics: Efferent Pathways; Humans; Ischemia; Kinesthesis; Lidocaine; Motor Neurons; Muscle, Skeletal; Nerve | 2006 |
[Bilateral polyradiculitis after an epidural block: a rare, serious complication].
Topics: Analgesia, Epidural; Anesthesia, Epidural; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthet | 2006 |
Ventricular ectopy: etiology, evaluation, and therapy.
Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Aprindine; Arrhyth | 1982 |
[Clinical experience with the combination of dextran 40, dihydroergotoxine, lidocaine in intravenous perfusion in the prevention of postoperative ischemia of skin flaps].
Topics: Dextrans; Dihydroergotoxine; Drug Therapy, Combination; Humans; Ischemia; Lidocaine; Necrosis; Surgi | 1984 |
Intravenous regional analgesia for surgery of the limbs in goats.
Topics: Amputation, Surgical; Anesthesia, Conduction; Anesthesia, Intravenous; Animals; Extremities; Goats; | 1983 |
[Pharmacological protection of the kidneys from ischemic damage. The effectiveness of anti-ischemia protection of the kidneys in simulating the terminal state in the donors].
Topics: Animals; Death; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Humans; Hypotension; Isc | 1982 |
Analgesic responses to i.v. lignocaine.
Topics: Adult; Aged; Humans; Ischemia; Lidocaine; Middle Aged; Pain; Pain, Intractable | 1982 |
Effect of antiarrhythmics on the release of adenosine in rat hearts with coronary occlusion and reperfusion.
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Electrocardiography; Heart; Ischemia; Lidocaine; Male; R | 1995 |
Accidental epinephrine auto-injector-induced digital ischemia reversed by phentolamine digital block.
Topics: Adult; Epinephrine; Humans; Injections, Subcutaneous; Ischemia; Lidocaine; Male; Needlestick Injurie | 1995 |
[Disordered cutaneous microcirculation in diabetic neuropathic foot ulcer. Is modification by retrograde transvenous perfusion therapy possible?].
Topics: Adult; Aged; Blood Flow Velocity; Chemotherapy, Cancer, Regional Perfusion; Dexamethasone; Diabetic | 1995 |
Amelioration of postischemic reperfusion injury by antiarrhythmic drugs in isolated perfused rat lung.
Topics: Animals; Anti-Arrhythmia Agents; In Vitro Techniques; Ischemia; Lidocaine; Lung; Male; Organ Size; P | 1994 |
MEGX (monoethylglycinexylidide): a novel in vivo test to measure early hepatic dysfunction after hypovolemic shock.
Topics: Animals; Biotransformation; Ischemia; Lidocaine; Liver; Liver Function Tests; Male; Microsomes, Live | 1995 |
Cutaneous ischemia caused by local anesthesia containing a vasoconstrictor.
Topics: Epinephrine; Humans; Ischemia; Lidocaine; Skin | 1994 |
The electroretinogram during orbital compression following intraorbital regional block for cataract surgery.
Topics: Adult; Anesthesia, Local; Bupivacaine; Cataract Extraction; Electroretinography; Female; Humans; Isc | 1994 |
Epidural anesthesia accelerates the recovery of postischemic bowel motility in the rat.
Topics: Anesthesia, Epidural; Animals; Disease Models, Animal; Gastrointestinal Motility; Intestines; Ischem | 1994 |
Cutaneous ischemia caused by local anesthesia containing a vasoconstrictor in a patient with meralgia paresthetica.
Topics: Adult; Epinephrine; Humans; Ischemia; Lidocaine; Nerve Compression Syndromes; Paresthesia; Skin; Thi | 1994 |
[Optimizing analgesia and procedure of retrograde venous perfusion in treatment of patients with peripheral arterial occlusive diseases].
Topics: Arterial Occlusive Diseases; Diabetic Foot; Humans; Ischemia; Leg; Lidocaine; Mepivacaine; Nerve Blo | 1994 |
The effect of epidural anaesthesia with 1% lidocaine on the pressor response to dynamic exercise in man.
Topics: Adult; Anesthesia, Epidural; Bicycling; Blood Pressure; Cardiac Output; Cold Temperature; Electric S | 1993 |
Purine metabolite washout and platelet aggregation at reflow after tourniquet ischemia: effect of intravenous regional lidocaine.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Female; Humans; Hypoxanthine; Hypoxanthines; Ischemia; | 1995 |
Liver function and splanchnic ischemia in critically ill patients.
Topics: Critical Illness; Gastric Mucosa; Hemodynamics; Humans; Hydrogen-Ion Concentration; Indocyanine Gree | 1997 |
[The effects of vasoconstrictors on distribution of ischemic tissue flow in isolated perfused rat liver].
Topics: Adenosine Triphosphate; Animals; Biotransformation; Epinephrine; In Vitro Techniques; Ischemia; Lido | 1997 |
Susceptibility of isolated rat facial nerve to anaerobic stress.
Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod | 1997 |
The monoethylglycinexylidide test does not correctly evaluate lidocaine metabolism after ischemic liver injury in the rat.
Topics: Animals; Bilirubin; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Enzymes; F | 1997 |
Drug-induced vasodilation in an in vitro and in vivo study: the effects of nicardipine, papaverine, and lidocaine on the rabbit carotid artery.
Topics: Administration, Topical; Anastomosis, Surgical; Animals; Blood Pressure; Carotid Arteries; Dose-Resp | 1997 |
Digital blocks with adrenaline. An old dogma refuted.
Topics: Adult; Anesthesia, Local; Anesthetics, Local; Epinephrine; Female; Fingers; Hand; Humans; Ischemia; | 1998 |
Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver.
Topics: Animals; Cold Temperature; Coumarins; Cryopreservation; Hot Temperature; Humans; In Vitro Techniques | 1998 |
Na+ channel block prevents the ischemia-induced release of norepinephrine from spinal cord slices.
Topics: 4-Aminopyridine; Anesthetics, Local; Animals; Calcium; Calcium Channel Blockers; Cold Temperature; H | 1998 |
Accidental digital injection of adrenaline from an autoinjector device.
Topics: Accidents, Occupational; Adrenergic alpha-Antagonists; Adult; Anesthetics, Local; Epinephrine; Finge | 1998 |
An electrophysiological analysis of the protective effects of felbamate, lamotrigine, and lidocaine on the functional recovery from in vitro ischemia in rat neocortical slices.
Topics: Action Potentials; Animals; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; F | 1998 |
Protective effects of lidocaine in hepatic ischemia/reperfusion injury in vitro.
Topics: Animals; Aspartate Aminotransferases; In Vitro Techniques; Ischemia; Lidocaine; Liver; Liver Circula | 1998 |
High extracellular K+ during hypoxic preconditioning episodes attenuates the post-ischemic contractile and ionic benefits of preconditioning.
Topics: Animals; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Edetic Acid; Hypoxia; Is | 1999 |
The effect of direct lidocaine injection into the clamped aortic segment on the spinal evoked potential: early diagnosis for spinal cord ischemia.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Aorta; Blood Pressure; Constriction; Dogs; El | 1999 |
Pulpal ischemia in man: effects on detection threshold, A-delta neural response and sharp dental pain.
Topics: Adult; Afferent Pathways; Anesthetics, Local; Cold Temperature; Dental Pulp; Dental Pulp Test; Epine | 1999 |
Selective protection of gray and white matter during spinal cord ischemic injury.
Topics: Animals; Brain; Disease Models, Animal; Evaluation Studies as Topic; Excitatory Amino Acid Antagonis | 1999 |
The viability of liver graft for transplantation after prolonged warm ischaemia.
Topics: Alanine Transaminase; Animals; Bilirubin; Graft Survival; Ischemia; Lidocaine; Liver; Liver Function | 1999 |
RSD1019 suppresses ischaemia-induced monophasic action potential shortening and arrhythmias in anaesthetized rabbits.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Bridged Bi | 2000 |
Group II muscle afferents probably contribute to the medium latency soleus stretch reflex during walking in humans.
Topics: Adrenergic alpha-Agonists; Adult; Anesthetics, Local; Ankle; Clonidine; Cold Temperature; Electromyo | 2001 |
Disturbances in voluntary recruitment order of low and high frequency motor units on blockades of proprioceptive afferent activity.
Topics: Action Potentials; Afferent Pathways; Cold Temperature; Electric Stimulation; Ischemia; Lidocaine; M | 1976 |
Anterior segment necrosis following treatment of central retinal artery occlusion: a clinicopathologic case report.
Topics: Arterial Occlusive Diseases; Epinephrine; Eye; Eye Diseases; Humans; Ischemia; Lidocaine; Male; Midd | 1978 |
Control of renin release. Effects of d-propranolol and renal denervation on furosemide-induced renin release in the dog.
Topics: Animals; Denervation; Dogs; Furosemide; Ischemia; Kidney; Lidocaine; Male; Propranolol; Renin; Stere | 1977 |
Lidocaine treatment of experimental cutaneous lesions from potassium chloride injection.
Topics: Animals; Guinea Pigs; Ischemia; Lidocaine; Necrosis; Potassium Chloride; Skin; Skin Diseases; Vasoco | 1977 |
Management of ischemic complications after subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Female; Humans; Intracranial Aneurysm; Ischemia; Ischemic Attack, Transient; Iso | 1975 |
Antiarrhythmic effect of aprindine on several types of ventricular arrhythmias.
Topics: Ajmaline; Animals; Anti-Arrhythmia Agents; Aprindine; Cats; Dogs; Epinephrine; Female; Guinea Pigs; | 1975 |
Spinal oxygenation, blood supply localization, cooling, and function with aortic clamping.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Constriction; Humans; Ischemia; Lidocaine; Male; Oxygen | 1992 |
[Retrograde venous perfusion in treatment of diabetic gangrene].
Topics: Cefmenoxime; Diabetic Angiopathies; Female; Gangrene; Heparin; Humans; Infusions, Intravenous; Ische | 1991 |
Gastric and cardiac organoprotection by lidocaine.
Topics: Animals; Dogs; Female; Heart; In Vitro Techniques; Ischemia; Lidocaine; Male; Microscopy, Electron; | 1989 |
Interaction of lidocaine and hypothermia in Bier blocks in volunteers.
Topics: Adult; Anesthesia, Conduction; Electric Stimulation; Evoked Potentials, Somatosensory; Hand; Humans; | 1989 |
Treatment of peripheral ischemia secondary to lidocaine containing epinephrine.
Topics: Animals; Epinephrine; Foot; Ischemia; Labetalol; Lidocaine; Models, Biological; Necrosis; Phentolami | 1989 |
Amelioration of the ischemic damage of the dog kidney subjected to 90 minutes of warm ischemia by lidocaine pretreatment and low-dose dopamine infusion on revascularization.
Topics: Animals; Body Temperature; Dogs; Dopamine; Infusions, Intravenous; Ischemia; Kidney; Kidney Transpla | 1987 |
Continuous epidural analgesia in the heparinized vascular surgical patient: a retrospective review of 912 patients.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Bupivacaine; Catheterization; Female; Heparin; | 1987 |
[Prevention, using alpha-tocopherol and lidocaine, of damage to the monooxygenase system activity and ultrastructure of hepatocytes following acute ischemia of the liver].
Topics: Acute Disease; Animals; Ischemia; Lidocaine; Liver; Male; Oxygenases; Rats; Vitamin E | 1987 |
Protection against experimental ischemic spinal cord injury.
Topics: Animals; Aorta, Abdominal; Evoked Potentials, Somatosensory; Hypothermia, Induced; Ischemia; Lidocai | 1986 |
The use of topical vasodilators as an adjunct in infant renal surgery.
Topics: Administration, Topical; Female; Humans; Infant; Infant, Newborn; Intraoperative Care; Intraoperativ | 1985 |
Local toxic effects of anaesthetics and contrast media in urethrography.
Topics: Anesthetics, Local; Animals; Blood Flow Velocity; Capillary Fragility; Capillary Permeability; Cells | 1972 |
A mobile intensive-care unit in the management of myocardial infarction.
Topics: Adult; Aged; Ambulances; Electric Countershock; Electrocardiography; Female; Heart Arrest; Heart Mas | 1967 |
Prognosis after recovery from ventricular fibrillation complicating ischaemic heart-disease.
Topics: Anti-Bacterial Agents; Anticoagulants; Female; Follow-Up Studies; Furosemide; Glucose; Heart Arrest; | 1967 |
[Drug therapy of acute cerebral ischemia. Clinical study].
Topics: Brain; Dextrans; Dihydroergotoxine; Ergoloid Mesylates; Humans; Intracranial Arteriosclerosis; Intra | 1974 |
[Paroxysmal tetaniform contractures during selective arteriography of the Adamkiewicz's artery].
Topics: Abdominal Muscles; Angiography; Aortography; Contracture; Diazepam; Hemangioma; Humans; Interneurons | 1969 |
[Lidocaine therapy of coronary ischemia and angina pectoris].
Topics: Administration, Oral; Adult; Aged; Angina Pectoris; Coronary Disease; Coronary Vessels; Electrocardi | 1972 |
Antiarrhythmic and circulatory effects of Astra W36095, a new lidocaine-like agent.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Chemical Phenomena; | 1974 |
The clearance of red blood cells from the cadaver kidney.
Topics: Animals; Body Weight; Cadaver; Chromium Radioisotopes; Dextrans; Edema; Erythrocytes; Female; Hepari | 1970 |
Pharmacologic production of atrioventricular block with and without initial bundle branch block.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Arteries; Arteriovenous Shunt, Surgical; Dogs; Drug | 1971 |
[Bier's intravenous regional anesthesia. Clinical experiences with xylocaine].
Topics: Ambulatory Care; Anesthesia, Conduction; Extremities; Female; Humans; Injections, Intravenous; Ische | 1971 |
[The use of the preparation POR-8 (ornithine 8--vasopressin) as an ischemic drug in infiltration anesthesia with lignocaine].
Topics: Adolescent; Adult; Aged; Anesthesia, Local; Anesthetics; Humans; Ischemia; Lidocaine; Middle Aged; O | 1969 |
The mode of action of intravenous regional anesthetics.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Humans; Ischemia; Lidocaine; Time Factors | 1969 |
The use intravenous regional anaesthesia in orthopedic surgery.
Topics: Amputation, Surgical; Anesthesia, Conduction; Anesthesia, Intravenous; Extremities; Fracture Fixatio | 1969 |
Nerve conduction studies in regional intravenous analgesia using 1 per cent lignocaine.
Topics: Action Potentials; Adult; Anesthesia, Conduction; Anesthesia, Intravenous; Electric Stimulation; For | 1970 |
Paraplegia following epidural analgesia.
Topics: Anesthesia, Spinal; Epinephrine; Humans; Ischemia; Lidocaine; Male; Middle Aged; Necrosis; Neurologi | 1969 |