bupivacaine has been researched along with Ischemia in 40 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bupivacaine and lidocaine were reacted with the membrane preparations at cardiotoxically relevant concentrations and their membrane interactivities were determined by measuring fluorescence polarization." | 1.38 | Cardiotoxic local anesthetics increasingly interact with biomimetic membranes under ischemia-like acidic conditions. ( Mizogami, M; Shigemi, K; Tsuchiya, H; Ueno, T, 2012) |
| "A female drug abuser inadvertently injected an intravenous injection of an oral anorexiant, phentaramine (Preludin), into her own brachial artery." | 1.26 | Inadvertent intra-arterial injection of phentaramine: a complication of drug abuse. ( Hamer, R; Phelps, D, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (30.00) | 18.7374 |
| 1990's | 15 (37.50) | 18.2507 |
| 2000's | 9 (22.50) | 29.6817 |
| 2010's | 3 (7.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Schnedl, C | 1 |
| Fürstner, M | 1 |
| Hausegger, KA | 1 |
| Panov, VM | 1 |
| Fesenko, UA | 1 |
| Kutsyn, VM | 1 |
| Keskinbora, K | 1 |
| Aydinli, I | 1 |
| Tsuchiya, H | 1 |
| Mizogami, M | 1 |
| Ueno, T | 1 |
| Shigemi, K | 1 |
| Wu, X | 1 |
| Liu, Y | 1 |
| Chen, X | 1 |
| Sun, Q | 1 |
| Tang, R | 1 |
| Wang, W | 1 |
| Yu, Z | 1 |
| Xie, M | 1 |
| Smoot, EC | 1 |
| Colpitts, R | 1 |
| Bittner, Ch | 1 |
| Zuber, M | 1 |
| Eisner, L | 1 |
| Breschan, C | 1 |
| Kraschl, R | 1 |
| Jost, R | 1 |
| Marhofer, P | 1 |
| Likar, R | 2 |
| Al-Rawi, OY | 1 |
| Pennefather, SH | 1 |
| Page, RD | 1 |
| Dave, I | 1 |
| Russell, GN | 1 |
| Carlson, BM | 2 |
| Faulkner, JA | 1 |
| Smith, BE | 1 |
| Fischer, HB | 1 |
| Scott, PV | 1 |
| Stoner, HB | 1 |
| Marshall, HW | 1 |
| Hamer, R | 1 |
| Phelps, D | 1 |
| Hickey, NC | 1 |
| Wilkes, MP | 1 |
| Howes, D | 1 |
| Watt, J | 1 |
| Shearman, CP | 1 |
| Loken, RG | 1 |
| Coupland, SG | 1 |
| Deschênes, MC | 1 |
| Naesh, O | 1 |
| Haljamäe, H | 1 |
| Hindberg, I | 1 |
| Holm, J | 1 |
| Jivegård, L | 1 |
| Wennmalm, A | 1 |
| Mehta, Y | 1 |
| Juneja, R | 1 |
| Sutcliffe, NP | 1 |
| Mostafa, SM | 1 |
| Gannon, J | 1 |
| Harper, SJ | 1 |
| Pavy, TJ | 1 |
| Doyle, DL | 1 |
| Kessell, G | 1 |
| Barker, I | 1 |
| Valdivielso Serna, A | 1 |
| González Bravo, MN | 1 |
| Monleón Luque, M | 1 |
| Casado Flores, J | 1 |
| Tetzlaff, JE | 1 |
| Dilger, J | 1 |
| Yap, E | 1 |
| Smith, MP | 1 |
| Schoenwald, PK | 1 |
| Lévecque, JP | 1 |
| Ladagnous, JF | 1 |
| Saïssy, JM | 1 |
| Kapral, S | 1 |
| Gollmann, G | 1 |
| Bachmann, D | 1 |
| Prohaska, B | 1 |
| Jandrasits, O | 1 |
| Weinstabl, C | 1 |
| Lehofer, F | 1 |
| Ozzeybek, D | 1 |
| Koca, U | 1 |
| Elar, Z | 1 |
| Olguner, M | 1 |
| Hakgüder, G | 1 |
| Khalyfa, A | 1 |
| Carlson, JA | 1 |
| Wang, E | 1 |
| Ceballos, A | 1 |
| Cabezudo, L | 1 |
| Bovaira, M | 1 |
| Fenollosa, P | 1 |
| Moro, B | 1 |
| Nitecki, SS | 1 |
| Kleiser, A | 1 |
| Ofer, A | 1 |
| Karram, T | 1 |
| Engel, A | 1 |
| Eisenberg, E | 1 |
| Hoffman, A | 1 |
| Heard, CM | 1 |
| LaJohn, S | 1 |
| Fletcher, JE | 1 |
| Casals Merchán, M | 1 |
| Eshan, F | 1 |
| Martínez Mañas, F | 1 |
| Alonso Gómez, A | 1 |
| Benlloch Petit, R | 1 |
| Bausili Pons, JM | 1 |
| Hall-Craggs, EC | 1 |
| Dyszkiewicz, W | 1 |
| Slaczka, K | 1 |
| Perkins, G | 1 |
| Johansen, K | 1 |
| Murphy, T | 1 |
| Pavlin, E | 1 |
| Ledbetter, D | 1 |
| Tobias, JD | 1 |
| Haun, SE | 1 |
| Helfaer, M | 1 |
| Nichols, DG | 1 |
| Sakio, H | 1 |
| Hirose, K | 1 |
| Okuda, C | 1 |
| Weber, S | 1 |
| Bennett, CR | 1 |
| Jones, NF | 1 |
| Sanchez, V | 1 |
| Segedin, ER | 1 |
| Moser, M | 1 |
| Pallares, VS | 1 |
| Dyson, A | 1 |
| Henderson, AM | 1 |
| Baron, HC | 1 |
| LaRaja, RD | 1 |
| Rossi, G | 1 |
| Atkinson, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance[NCT02139982] | Phase 1 | 110 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Skin temperature was measured at the thenar. change= 30min after brachial plexus block minus baseline (NCT02139982)
Timeframe: Baseline,30 min after brachial plexus block
| Intervention | ℃ (Mean) |
|---|---|
| Group A(Phase 2) | 1.18 |
| Group B(Phase 2) | 1.91 |
| Group C(Phase 2) | 2.27 |
| Group D(Phase 2) | 2.32 |
| Group E(Phase 2) | 2.44 |
| Group F(Phase 2) | 2.43 |
Success of Brachial Plexus Block(BPB) was defined as the absence of sensation to in all innervation areas of above four nerves (musculocutaneous, ulnar, radial, and median nerves) 30min. after the BPB and no pain during the surgery. (NCT02139982)
Timeframe: 30 min after brachial plexus block
| Intervention | participants (Number) |
|---|---|
| Group A(Phase 2) | 1 |
| Group B(Phase 2) | 9 |
| Group C(Phase 2) | 11 |
| Group D(Phase 2) | 12 |
| Group E(Phase 2) | 13 |
| Group F(Phase 2) | 13 |
The cross-sectional area(CSA, cm2) of Radial/ulnar Artery was assessed with B-mode imaging. Probe was kept perpendicular to the long axis of the artery to obtain the largest oval arterial section. The image at end diastole was chosen and measured with the cine loop. (NCT02139982)
Timeframe: baseline(t0), 30 min after specific nerve block(t1), 30 min after brachial plexus block(t2)
| Intervention | cm^2 (Mean) | |||||
|---|---|---|---|---|---|---|
| CSA of radial artery T0 | CSA of radial artery T1 | CSA of radial artery T2 | CAS of ulnar artery T0 | CAS of ulnar artery T1 | CAS of ulnar artery T2 | |
| Group MC(Phase 1) | 0.051 | 0.053 | 0.073 | 0.039 | 0.039 | 0.061 |
| Group ME (Phase 1) | 0.051 | 0.069 | 0.073 | 0.050 | 0.056 | 0.069 |
| Group RA (Phase 1) | 0.040 | 0.044 | 0.061 | 0.043 | 0.044 | 0.068 |
| Group UL( Phase 1) | 0.051 | 0.053 | 0.074 | 0.039 | 0.059 | 0.061 |
"These parameters included peak systolic velocity (PSV, cm/s), end-diastolic velocity (EDV, cm/s), time average maximum velocity (TAMAX), resistance index (RI), and pulsatility index (PI),The cross-sectional area of the artery imaging.Blood flow (BF) = TAMAX× CSA×60s.~Relative ratio of hemodymanic parameter=30 min after brachial plexus block divide by baseline" (NCT02139982)
Timeframe: baseline, 30 min after brachial plexus block
| Intervention | ratio (Median) | ||||
|---|---|---|---|---|---|
| relative ratio of PSV | Relative ratio of TAMAX | Relative ratio of BF | Relative ratio of PI | Relative ratio of RI | |
| Group A(Phase 2) | 1.031371 | 1.21 | 1.40 | 0.75 | 0.91 |
| Group B(Phase 2) | 1.15 | 1.56 | 1.87 | 0.61 | 0.87 |
| Group C(Phase 2) | 1.19 | 1.84 | 2.10 | 0.53 | 0.85 |
| Group D(Phase 2) | 1.19 | 2.09 | 2.54 | 0.47 | 0.84 |
| Group E(Phase 2) | 1.29 | 2.34 | 3.18 | 0.44 | 0.81 |
| Group F(Phase 2) | 1.43 | 2.57 | 3.53 | 0.43 | 0.82 |
These parameters included peak systolic velocity (PSV, cm/s), end-diastolic velocity (EDV, cm/s), time average maximum velocity (TAMAX),and was measured by Pulsed-wave Doppler(PWD) ultrasound. (NCT02139982)
Timeframe: baseline(t0), 30 min after specific nerve block(t1), 30 min after brachial plexus block(t2)
| Intervention | cm/s (Mean) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PSV of radial artery T0 | PSV of radial artery T1 | PSV of radial artery T2 | EDV of radial artery T0 | EDV of radial artery T1 | EDV of radial artery T2 | TAMAX of radial artery T0 | TAMAX of radial artery T1 | TAMAX of radial artery T2 | PSV of ulnar artery T0 | PSV of ulnar artery T1 | PSV of ulnar artery T2 | EDV of ulnar artery T0 | EDV of ulnar artery T1 | EDV of ulnar artery T2 | TAMAX of ulnar artery T0 | TAMAX of ulnar artery T1 | TAMAX of ulnar artery T2 | |
| Group MC(Phase 1) | 40.9 | 40.7 | 58.0 | 3.4 | 3.6 | 19.4 | 10.2 | 10.4 | 32.0 | 42.5 | 40.2 | 56.9 | 5.9 | 5.1 | 19.6 | 11.2 | 10.9 | 27.8 |
| Group ME (Phase 1) | 42.6 | 52.4 | 58.5 | 5.5 | 16.1 | 18.0 | 11.5 | 24.8 | 29.7 | 43.9 | 45.1 | 62.8 | 5.3 | 7.4 | 20.2 | 11.1 | 11.9 | 29.0 |
| Group RA (Phase 1) | 47.6 | 50.5 | 69.6 | 6.0 | 9.3 | 21.1 | 13.1 | 18.4 | 33.3 | 51.1 | 53.9 | 68.4 | 6.0 | 6.2 | 18.8 | 14.0 | 14.0 | 30.5 |
| Group UL( Phase 1) | 39.6 | 40.9 | 60.1 | 5.8 | 5.7 | 20.4 | 11.4 | 11.2 | 31.0 | 45.8 | 60.5 | 68.7 | 7.9 | 21.6 | 26.9 | 14.9 | 29.9 | 36.8 |
Skin temperature(Ts) was measured at four different points within the cutaneous innervation areas of the musculocutaneous(lateral skin of forearm), ulnar(hypothenar region), radial (thumb-index web) and median(thenar) Specific points were located with skin marker to provide consistency of measurement. (NCT02139982)
Timeframe: baseline, 30 min after specific nerve block, 30 min after brachial plexus block
| Intervention | ℃ (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ts MC t0 | Ts MC t1 | Ts MC t2 | Ts UL t0 | Ts UL t1 | Ts UL t2 | Ts RA t0 | Ts RA t1 | Ts RA t2 | Ts ME t0 | Ts ME t1 | Ts ME t2 | |
| Group MC(Phase 1) | 30.0 | 29.9 | 31.3 | 29.1 | 29.0 | 31.9 | 30.5 | 30.5 | 32.6 | 28.9 | 29.0 | 32.4 |
| Group ME (Phase 1) | 30.0 | 30.4 | 33.7 | 29.7 | 29.8 | 32.9 | 30.1 | 32.7 | 33.9 | 29.8 | 33.3 | 33.7 |
| Group RA (Phase 1) | 30.2 | 30.1 | 33.4 | 29.5 | 29.6 | 32.6 | 29.5 | 29.7 | 32.2 | 29.5 | 29.5 | 32.0 |
| Group UL( Phase 1) | 29.8 | 30.0 | 31.1 | 30.1 | 32.4 | 32.6 | 30.5 | 30.5 | 33.2 | 30.0 | 30.1 | 32.7 |
1 review available for bupivacaine and Ischemia
| Article | Year |
|---|---|
The regeneration of skeletal muscle fibers following injury: a review.
Topics: Anesthetics, Local; Animals; Athletic Injuries; Bupivacaine; Cats; Humans; Ischemia; Muscle Contract | 1983 |
5 trials available for bupivacaine and Ischemia
| Article | Year |
|---|---|
Perineural morphine in patients with chronic ischemic lower extremity pain: efficacy and long-term results.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Double-Blind Method; Female; Humans; Isc | 2009 |
The effect of thoracic epidural bupivacaine and an intravenous adrenaline infusion on gastric tube blood flow during esophagectomy.
Topics: Aged; Analgesia, Epidural; Anastomosis, Surgical; Anesthetics, Local; Blood Flow Velocity; Blood Pre | 2008 |
Epidural anaesthesia prolonged into the postoperative period prevents stress response and platelet hyperaggregability after peripheral vascular surgery.
Topics: Aged; Allylamine; Anesthesia, Epidural; Anesthesia, General; Arteriosclerosis; Bupivacaine; Drug Com | 1994 |
The effect of epidural blockade on gastric intramucosal pH in the peri-operative period.
Topics: Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Gastric Mucosa; Humans; Hydrogen-Ion Concentr | 1996 |
The effects of thoracic epidural anesthesia on intraoperative visceral perfusion and metabolism.
Topics: Abdomen; Anesthesia, Epidural; Anesthetics, Local; Blood Pressure; Body Temperature; Bupivacaine; Ca | 1999 |
34 other studies available for bupivacaine and Ischemia
| Article | Year |
|---|---|
Topics: Adult; Anesthesia, Local; Brachial Plexus Neuritis; Bupivacaine; Contrast Media; Drug Delivery Syste | 2020 |
[Improvement of approach to performance of lumbar sympathetic blockade in patients with tissue ischemia of the lower extremities].
Topics: Adult; Aged; Anesthetics, Local; Aorta; Autonomic Nerve Block; Bupivacaine; Humans; Ischemia; Leg; L | 2014 |
Cardiotoxic local anesthetics increasingly interact with biomimetic membranes under ischemia-like acidic conditions.
Topics: Anesthetics, Local; Bupivacaine; Cardiolipins; Cardiotoxins; Cell Membrane; Glycerophospholipids; Hy | 2012 |
Involvement of TREK-1 activity in astrocyte function and neuroprotection under simulated ischemia conditions.
Topics: Animals; Apoptosis; Astrocytes; Bupivacaine; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cocultu | 2013 |
Wound complications of infusion pain pump therapy.
Topics: Anesthetics; Arthroplasty, Replacement, Knee; Bupivacaine; Drug Therapy, Combination; Epinephrine; H | 2002 |
[Acute ischemia of the hand in a drug addict after accidental intra-arterial injection].
Topics: Adult; Bupivacaine; Compartment Syndromes; Fasciotomy; Hand; Heparin; Humans; Illicit Drugs; Injecti | 2002 |
Axillary brachial plexus block for treatment of severe forearm ischemia after arterial cannulation in an extremely low birth-weight infant.
Topics: Amputation, Surgical; Anesthetics, Local; Brachial Plexus; Bupivacaine; Catheterization, Peripheral; | 2004 |
Continuous sciatic nerve block.
Topics: Aged; Amputation, Surgical; Anesthesia, Conduction; Bupivacaine; Foot; Gangrene; Humans; Ischemia; M | 1984 |
Neural pathways mediating the inhibition of shivering by nonthermal afferent impulses from ischemic limbs.
Topics: Afferent Pathways; Animals; Body Temperature; Bupivacaine; Colon; Differential Threshold; Extremitie | 1982 |
Inadvertent intra-arterial injection of phentaramine: a complication of drug abuse.
Topics: Adult; Arm; Autonomic Nerve Block; Bupivacaine; Constriction, Pathologic; Female; Humans; Injections | 1981 |
The effect of epidural anaesthesia on peripheral resistance and graft flow following femorodistal reconstruction.
Topics: Aged; Anesthesia, Epidural; Arteriovenous Shunt, Surgical; Bupivacaine; Case-Control Studies; Female | 1995 |
The electroretinogram during orbital compression following intraorbital regional block for cataract surgery.
Topics: Adult; Anesthesia, Local; Bupivacaine; Cataract Extraction; Electroretinography; Female; Humans; Isc | 1994 |
Continuous axillary block for ischemia following failed radial artery cannulation.
Topics: Aged; Autonomic Nerve Block; Axilla; Bupivacaine; Catheterization, Peripheral; Fingers; Humans; Isch | 1994 |
Prevention of phantom limb pain by infusion of local anaesthetic into the sciatic nerve.
Topics: Aged; Amputation, Surgical; Analgesia; Anesthetics, Local; Bupivacaine; Fatal Outcome; Humans; Injec | 1996 |
Leg ischaemia in an infant following accidental intra-arterial administration of atracurium treated with caudal anaesthesia.
Topics: Anesthesia, Caudal; Atracurium; Bupivacaine; Humans; Infant; Injections, Intra-Arterial; Ischemia; L | 1996 |
[Digital ischemia of the lower limb: reversion via sympathetic blockage].
Topics: Anesthetics, Local; Bupivacaine; Female; Humans; Infant; Ischemia; Necrosis; Toes | 1997 |
Cauda equina syndrome after spinal anaesthesia in a patient with severe vascular disease.
Topics: Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cauda Equina; Electromyography; Epinephrine; Hu | 1998 |
[Analgesia by continuous tibial nerve block after ischemia and amputation].
Topics: Aged; Amputation, Surgical; Analgesia; Bupivacaine; Clonidine; Humans; Ischemia; Leg; Male; Nerve Bl | 1997 |
Glycerol trinitrate plus epidural sympathetic block in the ischemia of glans penis.
Topics: Anesthesia, Epidural; Anesthetics, Local; Anticoagulants; Autonomic Nerve Block; Bupivacaine; Child; | 1999 |
Toxin injury-dependent switched expression between EF-1 alpha and its sister, S1, in rat skeletal muscle.
Topics: Actins; Anesthetics, Local; Animals; Blotting, Western; Bupivacaine; Ischemia; Muscle, Skeletal; Nec | 1999 |
Spinal cord stimulation: a possible therapeutic alternative for chronic mesenteric ischaemia.
Topics: Abdominal Pain; Aged; Analgesics, Opioid; Anesthetics, Local; Autonomic Nerve Block; Bupivacaine; Ce | 2000 |
Severe ergot-induced lower limb ischaemia treated by epidural local anaesthetic.
Topics: Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Drug Overdose; Ergotamine; Female; Humans; Isc | 2000 |
An accidental ringblock of the great toe?
Topics: Adolescent; Anesthesia, Local; Anesthetics, Local; Arthrogryposis; Bupivacaine; Epinephrine; Foot; H | 2001 |
[Combined subarachnoid-epidural anesthesia technique using a double catheter in lower limb revascularization surgery].
Topics: Aged; Amputation, Surgical; Anesthesia, Epidural; Anesthetics, Local; Bupivacaine; Catheterization; | 2000 |
Ischemic muscle as a model of regeneration.
Topics: Animals; Bupivacaine; Ischemia; Models, Biological; Muscles; Rats; Regeneration | 1978 |
[Treatment of pain caused by ischemia of the lower extremities by way of continuous marcain infusion into the extradural lumbar region].
Topics: Adult; Aged; Bupivacaine; Humans; Infusions, Parenteral; Ischemia; Leg; Lumbosacral Region; Middle A | 1976 |
Interpleural anaesthesia in the management of upper limb ischaemia. A report of three cases.
Topics: Adult; Anesthesia, Conduction; Bupivacaine; Catheterization; Female; Fingers; Horner Syndrome; Human | 1991 |
Digital ischemia complicating pneumococcal sepsis: reversal with sympathetic blockade.
Topics: Adult; Autonomic Nerve Block; Bupivacaine; Female; Fingers; Humans; Ischemia; Pneumococcal Infection | 1991 |
Use of continuous caudal block to relieve lower-extremity ischemia caused by vasculitis in a child with meningococcemia.
Topics: Autonomic Nerve Block; Bupivacaine; Female; Humans; Infant; Ischemia; Leg; Meningococcal Infections; | 1989 |
[The participation of the sympathetic nervous system in thromboxane A2 release induced by limb ischemia].
Topics: Animals; Bupivacaine; Dogs; Ischemia; Labetalol; Leg; Sympathetic Nervous System; Thromboxane A2; Th | 1989 |
Improvement in blood flow during lower extremity microsurgical free tissue transfer associated with epidural anesthesia.
Topics: Anesthesia, Epidural; Bupivacaine; Humans; Intraoperative Complications; Ischemia; Leg; Male; Middle | 1988 |
Role of lumbar sympathectomy in the pediatric intensive care unit.
Topics: Autonomic Nerve Block; Bupivacaine; Child, Preschool; Female; Foot; Humans; Infant; Intensive Care U | 1988 |
Continuous axillary brachial plexus blockade following intra-arterial injection of nicotinic acid.
Topics: Adult; Autonomic Nerve Block; Brachial Plexus; Bupivacaine; Hand; Humans; Injections, Intra-Arterial | 1987 |
Continuous epidural analgesia in the heparinized vascular surgical patient: a retrospective review of 912 patients.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Bupivacaine; Catheterization; Female; Heparin; | 1987 |