theophylline has been researched along with Ischemia in 46 studies
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The sum of pain scores (accumulation of VAS scores) was attenuated by theophylline, 691 [200-1550 (median and 25-75% percentiles)], compared with placebo, 1231 (545-1675), P < 0." | 9.11 | Experimentally induced ischaemic pain in healthy humans is attenuated by the adenosine receptor antagonist theophylline. ( Karelov, A; Segerdahl, M, 2004) |
| "To study the hypothesis that endogenous adenosine is a mediator of the ischaemic pain sensation, the effect of the adenosine receptor blocker theophylline (5." | 9.06 | Theophylline decreases pain in the ischaemic forearm test. ( Jonzon, B; Kaijser, L; Sylvén, C, 1989) |
| "The TEA-Stroke trial (The Theophylline in Acute Ischemic Stroke) was an investigator-initiated 2-center, proof-of-concept, phase II clinical study with a randomized, double-blinded, placebo-controlled design." | 7.96 | Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. ( Andersen, G; Bach, FW; Eskildsen, HW; Hansen, MB; Hjort, N; Johansen, MB; Mikkelsen, IK; Modrau, B; Mouridsen, K; Nielsen, A; Povlsen, JP; Yavarian, Y; Østergaard, L, 2020) |
| "Ischemia was induced for 1 h in both eyes by elevation of intraocular pressure above systolic arterial pressure." | 5.29 | Post-ischemic hyperemia in the cat retina: the effects of adenosine receptor blockade. ( Roth, S, 1995) |
| "The sum of pain scores (accumulation of VAS scores) was attenuated by theophylline, 691 [200-1550 (median and 25-75% percentiles)], compared with placebo, 1231 (545-1675), P < 0." | 5.11 | Experimentally induced ischaemic pain in healthy humans is attenuated by the adenosine receptor antagonist theophylline. ( Karelov, A; Segerdahl, M, 2004) |
| "To study the hypothesis that endogenous adenosine is a mediator of the ischaemic pain sensation, the effect of the adenosine receptor blocker theophylline (5." | 5.06 | Theophylline decreases pain in the ischaemic forearm test. ( Jonzon, B; Kaijser, L; Sylvén, C, 1989) |
| "The TEA-Stroke trial (The Theophylline in Acute Ischemic Stroke) was an investigator-initiated 2-center, proof-of-concept, phase II clinical study with a randomized, double-blinded, placebo-controlled design." | 3.96 | Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. ( Andersen, G; Bach, FW; Eskildsen, HW; Hansen, MB; Hjort, N; Johansen, MB; Mikkelsen, IK; Modrau, B; Mouridsen, K; Nielsen, A; Povlsen, JP; Yavarian, Y; Østergaard, L, 2020) |
| "To evaluate the early therapeutic alternatives such as bosentan, an endothelin receptor blocker, theophylline, an adenosin receptor blocker, and a nonselective phosphodiesterase enzyme inhibitor, zinc protoporphyrin (ZnPP), a heme oxygenase 1 inhibitor, for the therapy of ischemic priapism in the rat models." | 3.79 | Second pathways in the pathophysiology of ischemic priapism and treatment alternatives. ( Firdolas, F; Karakeci, A; Ogras, MS; Orhan, I; Ozan, T; Unus, I, 2013) |
| " In additional experimental groups, 8 sulfophenyl-theophylline (SPT, 10 mg/kg), an adenosine receptor inhibitor, was intravenously injected before the 40 min myocardial ischemia (SPT, MPC + SPT and RPC + SPT groups, respectively)." | 3.70 | Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of "remote preconditioning". ( Inubushi, T; Kinoshita, M; Mitsunami, K; Morikawa, S; Nakae, I; Takaoka, A; Yabe, T, 1999) |
| "This study was designed to determine, through the measurement of oxygen consumption (QO2), whether pretreatment and posttreatment with theophylline, verapamil, and mannitol provide protection from damage in the cortex and medulla of rat kidneys subjected to 60 and 120 minutes of ischemia." | 3.68 | Effects of theophylline, verapamil, and mannitol on oxygen consumption of ischemic rat kidneys. ( Homma, S; Kuramochi, G, 1993) |
| "The effect of adenosine (ADO) on the recovery of cellular adenine nucleotides (AN) was evaluated in the cultured cells deprived of oxygen and substrates (ischemia) and in nonischemic cells (control)." | 3.68 | Roles of adenosine and theophylline on the recovery of adenine nucleotides in postischemic cultured renal tubular cells. ( Cadnapaphornchai, P; Golembieski, A; Kellner, D; McDonald, FD, 1991) |
| "Patients with cardiac Syndrome X are hypersensitive to potential pain stimuli, including adenosine." | 2.69 | Analgesic effects of adenosine in syndrome X are counteracted by theophylline: a double-blind placebo-controlled study. ( Eriksson, BE; Sadigh, B; Svedenhag, J; Sylvén, C, 2000) |
| "Aminophylline has been shown to reduce severe renal dysfunction in neonates after perinatal asphyxia." | 1.62 | Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia. ( Cho, SH; Chock, VY; Frymoyer, A, 2021) |
| "Ischemia was induced by active hypoperfusion of the circumflex coronary artery territory." | 1.33 | How to distinguish between ischemic and nonischemic postsystolic thickening: a strain rate imaging study. ( Bijnens, B; Broscheit, JA; Claus, P; Ertl, G; Strotmann, JM; Sutherland, GR; Voelker, W; Weidemann, F, 2006) |
| "Brief ischemia was reported to protect various cells against injury induced by subsequent ischemia-reperfusion, and this phenomenon is known as ischemic preconditioning." | 1.32 | Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. ( Ishii, K; Kuwagata, M; Nakahara, T; Saito, M; Sakamoto, K; Yonoki, Y, 2004) |
| "Adenosine appears to be a crucial effector in IPC." | 1.31 | The liver protective effect of ischemic preconditioning may be mediated by adenosine. ( Delbro, D; Friman, S; Gustafsson, B; Nilsson, B; Wallin, M, 2000) |
| "Ischemia was induced for 1 h in both eyes by elevation of intraocular pressure above systolic arterial pressure." | 1.29 | Post-ischemic hyperemia in the cat retina: the effects of adenosine receptor blockade. ( Roth, S, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (50.00) | 18.7374 |
| 1990's | 10 (21.74) | 18.2507 |
| 2000's | 9 (19.57) | 29.6817 |
| 2010's | 2 (4.35) | 24.3611 |
| 2020's | 2 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Chock, VY | 1 |
| Cho, SH | 1 |
| Frymoyer, A | 1 |
| Modrau, B | 1 |
| Andersen, G | 1 |
| Mikkelsen, IK | 1 |
| Nielsen, A | 1 |
| Hansen, MB | 1 |
| Johansen, MB | 1 |
| Eskildsen, HW | 1 |
| Povlsen, JP | 1 |
| Yavarian, Y | 1 |
| Mouridsen, K | 1 |
| Østergaard, L | 1 |
| Bach, FW | 1 |
| Hjort, N | 1 |
| Karakeci, A | 1 |
| Firdolas, F | 1 |
| Ozan, T | 1 |
| Unus, I | 1 |
| Ogras, MS | 1 |
| Orhan, I | 1 |
| Johnson, NP | 1 |
| Lance Gould, K | 1 |
| Segerdahl, M | 1 |
| Karelov, A | 1 |
| Sakamoto, K | 2 |
| Yonoki, Y | 1 |
| Kuwagata, M | 2 |
| Saito, M | 1 |
| Nakahara, T | 2 |
| Ishii, K | 2 |
| Genescà, M | 1 |
| Sola, A | 1 |
| Azuara, D | 1 |
| De Oca, J | 1 |
| Hotter, G | 1 |
| Weidemann, F | 1 |
| Broscheit, JA | 1 |
| Bijnens, B | 1 |
| Claus, P | 1 |
| Sutherland, GR | 1 |
| Voelker, W | 1 |
| Ertl, G | 1 |
| Strotmann, JM | 1 |
| Creutzig, A | 1 |
| Dau, D | 1 |
| Alexander, K | 1 |
| Osborn, JL | 1 |
| Hoversten, LG | 1 |
| DiBona, GF | 1 |
| Roth, S | 2 |
| Takeyoshi, I | 3 |
| Kokudo, Y | 2 |
| Zhang, S | 2 |
| Nakamura, K | 2 |
| Ikoma, A | 2 |
| Suzuki, T | 1 |
| Zhu, Y | 2 |
| Todo, S | 3 |
| Kuramochi, G | 1 |
| Homma, S | 1 |
| Starzl, TE | 1 |
| Wakabayashi, H | 1 |
| Maeba, T | 1 |
| Maeta, H | 1 |
| Murase, N | 1 |
| Ostwald, P | 1 |
| Park, SS | 1 |
| Toledano, AY | 1 |
| Pell, TJ | 1 |
| Baxter, GF | 1 |
| Yellon, DM | 1 |
| Drew, GM | 1 |
| Takaoka, A | 1 |
| Nakae, I | 1 |
| Mitsunami, K | 1 |
| Yabe, T | 1 |
| Morikawa, S | 1 |
| Inubushi, T | 1 |
| Kinoshita, M | 1 |
| Eriksson, BE | 1 |
| Sadigh, B | 1 |
| Svedenhag, J | 1 |
| Sylvén, C | 2 |
| Nilsson, B | 1 |
| Friman, S | 1 |
| Wallin, M | 1 |
| Gustafsson, B | 1 |
| Delbro, D | 1 |
| Sugino, H | 1 |
| Shimada, H | 1 |
| Tsuchimoto, K | 1 |
| Liem, DA | 1 |
| Verdouw, PD | 1 |
| Ploeg, H | 1 |
| Kazim, S | 1 |
| Duncker, DJ | 1 |
| Yoshikawa, K | 1 |
| Adachi, K | 1 |
| Halprin, KM | 1 |
| Levine, V | 1 |
| Ahlström, P | 1 |
| Thalmann, I | 1 |
| Thalmann, R | 1 |
| Ise, I | 1 |
| Haddy, FJ | 1 |
| Sakai, K | 1 |
| Akima, M | 1 |
| Nabata, H | 1 |
| Osswald, H | 1 |
| Schmitz, HJ | 1 |
| Kemper, R | 1 |
| Lebedev, AA | 1 |
| Dubishchev, AV | 1 |
| Gafner, F | 1 |
| Cadnapaphornchai, P | 1 |
| Kellner, D | 1 |
| Golembieski, A | 1 |
| McDonald, FD | 1 |
| Deray, G | 1 |
| Martinez, F | 1 |
| Cacoub, P | 1 |
| Baumelou, B | 1 |
| Baumelou, A | 1 |
| Jacobs, C | 1 |
| Jonzon, B | 1 |
| Kaijser, L | 1 |
| Grossmann, K | 1 |
| Knischka, A | 1 |
| Rao, KR | 1 |
| Mahesh, SV | 1 |
| Rao, PN | 1 |
| Sollevi, A | 1 |
| Hellman, B | 1 |
| Idahl, LA | 1 |
| Hansteen, V | 1 |
| Lorentsen, E | 1 |
| Wollenberger, A | 1 |
| Kleitke, B | 1 |
| Heiss, WD | 1 |
| Davis, E | 1 |
| Rozov, H | 1 |
| Vahlensieck, W | 1 |
| Förster, KH | 1 |
| Müller, KH | 1 |
| Serradimigni, A | 1 |
| Bory, M | 1 |
| Poggi, L | 1 |
| Audier, M | 1 |
| Stoner, HB | 1 |
| Little, RA | 1 |
| Skalkeas, G | 1 |
| Balas, P | 1 |
| Katsogianis, A | 1 |
| Bakoulas, G | 1 |
| Karagianakos, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784] | Phase 1 | 18 participants (Anticipated) | Interventional | 2024-06-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for theophylline and Ischemia
| Article | Year |
|---|---|
Bioassay and pharmacologic evaluation of the adenosine hypothesis.
Topics: Adenosine; Adenosine Monophosphate; Animals; Biological Assay; Coronary Circulation; Hyperemia; Hypo | 1977 |
Cardiovascular effects of adenosine in man; possible clinical implications.
Topics: Adenosine; Cardiovascular Diseases; Cardiovascular System; Humans; Hypoxia; Ischemia; Purines; Recep | 1986 |
3 trials available for theophylline and Ischemia
| Article | Year |
|---|---|
Experimentally induced ischaemic pain in healthy humans is attenuated by the adenosine receptor antagonist theophylline.
Topics: Adult; Blood Pressure; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ischemia; Male; | 2004 |
Analgesic effects of adenosine in syndrome X are counteracted by theophylline: a double-blind placebo-controlled study.
Topics: Adenosine; Analgesics; Analysis of Variance; Cross-Over Studies; Double-Blind Method; Exercise Test; | 2000 |
Theophylline decreases pain in the ischaemic forearm test.
Topics: Adult; Blood Flow Velocity; Clinical Trials as Topic; Double-Blind Method; Forearm; Humans; Ischemia | 1989 |
41 other studies available for theophylline and Ischemia
| Article | Year |
|---|---|
Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia.
Topics: Acute Kidney Injury; Aminophylline; Asphyxia Neonatorum; Biomarkers; Creatinine; Female; Humans; Hyp | 2021 |
Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemia; Male; Middle | 2020 |
Second pathways in the pathophysiology of ischemic priapism and treatment alternatives.
Topics: Adenosine Deaminase; Animals; Antihypertensive Agents; Apoptosis; Bosentan; Endothelin Receptor Anta | 2013 |
Dipyridamole reversal using theophylline during aminophylline shortage.
Topics: Aminophylline; Dipyridamole; Drug Substitution; Humans; Ischemia; Theophylline; Therapeutic Equivale | 2011 |
Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina.
Topics: Adrenergic alpha-Antagonists; Animals; Enzyme Inhibitors; Intraocular Pressure; Ischemia; Ischemic P | 2004 |
Apoptosis inhibition during preservation by fructose-1,6-diphosphate and theophylline in rat intestinal transplantation.
Topics: Adenosine; Adenosine Triphosphate; Animals; Apoptosis; Bacterial Translocation; Disease Models, Anim | 2005 |
How to distinguish between ischemic and nonischemic postsystolic thickening: a strain rate imaging study.
Topics: Adrenergic beta-Antagonists; Animals; Aortic Valve; Aortic Valve Insufficiency; Blood Pressure; Card | 2006 |
[Transcutaneous oxygen pressure during intra-arterial infusions].
Topics: Adult; Aged; Arterial Occlusive Diseases; Female; Humans; Infusions, Intra-Arterial; Ischemia; Leg; | 1984 |
Impaired blood flow autoregulation in nonfiltering kidneys: effects of theophylline administration.
Topics: Adenosine; Animals; Dogs; Homeostasis; Ischemia; Kidney; Renal Circulation; Theophylline; Vascular R | 1983 |
Post-ischemic hyperemia in the cat retina: the effects of adenosine receptor blockade.
Topics: Adenosine; Animals; Blood Flow Velocity; Cats; Choroid; Hemodynamics; Hyperemia; Ischemia; Microsphe | 1995 |
Susceptibility to ischemia: the large bowel versus the small bowel.
Topics: Animals; Dogs; Electrophysiology; Female; Glucose; Intestinal Mucosa; Intestine, Large; Intestine, S | 1994 |
Effects of theophylline, verapamil, and mannitol on oxygen consumption of ischemic rat kidneys.
Topics: Animals; Ischemia; Kidney; Male; Mannitol; Oxygen Consumption; Rats; Rats, Wistar; Theophylline; Ver | 1993 |
Effect of ischemia on the canine large bowel: a comparison with the small intestine.
Topics: Adenosine Triphosphate; Animals; Cold Temperature; Colon; Dextrans; Dogs; Electrophysiology; Energy | 1996 |
Effect of glucose introduction to the lumen during cold ischemia in rat small bowel.
Topics: Animals; Cold Temperature; Glucose; Intestinal Mucosa; Intestine, Small; Ischemia; Male; Muscle, Smo | 1996 |
Adenosine receptor blockade and nitric oxide synthase inhibition in the retina: impact upon post-ischemic hyperemia and the electroretinogram.
Topics: Analysis of Variance; Animals; Arginine; Cats; Choroid; Electroretinography; Hyperemia; Ischemia; Mi | 1997 |
Renal ischemia preconditions myocardium: role of adenosine receptors and ATP-sensitive potassium channels.
Topics: Animals; Ischemia; Ischemic Preconditioning, Myocardial; Kidney; Potassium Channels; Purinergic P1 R | 1998 |
Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of "remote preconditioning".
Topics: Adenosine Triphosphate; Animals; Energy Metabolism; Hydrogen-Ion Concentration; Infusions, Intraveno | 1999 |
The liver protective effect of ischemic preconditioning may be mediated by adenosine.
Topics: Adenosine; Alanine Transaminase; Animals; Ischemia; Ischemic Preconditioning; Liver; Liver Circulati | 2000 |
Late preconditioning in rat retina: involvement of adenosine and ATP-sensitive K(+) channel.
Topics: Adenosine Triphosphate; Animals; Cell Size; Decanoic Acids; Hydroxy Acids; Ion Channel Gating; Ische | 2001 |
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats.
Topics: Adenosine; Animals; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Ischemia; Ischemic Preco | 2001 |
Sites of action of adenosine in interorgan preconditioning of the heart.
Topics: Adenosine; Animals; Blood Pressure; Coronary Vessels; Ganglionic Blockers; Heart Rate; Hexamethonium | 2002 |
Cyclic AMP in skin: effects of acute ischaemia.
Topics: Animals; Cyclic AMP; Epinephrine; Freezing; Ischemia; Propranolol; Skin; Swine; Theophylline; Time F | 1975 |
Cyclic AMP and adenylate cyclase in the inner ear.
Topics: Action Potentials; Adenosine Triphosphatases; Adenylyl Cyclases; Animals; Barbiturates; Brain; Bucla | 1975 |
A possible purinergic mechanism for reactive ischemia in isolated, cross-circulated rat kidney.
Topics: Animals; Cross Circulation; In Vitro Techniques; Ischemia; Kidney; Male; Muscle, Smooth, Vascular; P | 1979 |
Tissue content of adenosine, inosine and hypoxanthine in the rat kidney after ischemia and postischemic recirculation.
Topics: Adenosine; Animals; Hypoxanthines; Inosine; Ischemia; Kidney; Rats; Regional Blood Flow; Theophyllin | 1977 |
[Kidney function and mitochondrial metabolism in excluded renal blood flow against a background of diuretic action].
Topics: Animals; Diuretics; Drug Combinations; Ethacrynic Acid; Female; Furosemide; Ischemia; Kidney; Kidney | 1978 |
[Experiences with drug therapy in association with ischaemic vascular disease of the fundus oculi (author's transl)].
Topics: Adult; Aged; Drug Combinations; Fundus Oculi; Glaucoma; Heptaminol; Humans; Ischemia; Middle Aged; N | 1977 |
Roles of adenosine and theophylline on the recovery of adenine nucleotides in postischemic cultured renal tubular cells.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cells, C | 1991 |
A role for adenosine calcium and ischemia in radiocontrast-induced intrarenal vasoconstriction.
Topics: Acute Kidney Injury; Adenosine; Animals; Biological Transport, Active; Calcium; Contrast Media; Diat | 1990 |
[Intra-arterial therapy of arterial occlusive diseases of the extremities].
Topics: Actihaemyl; Adenosine Triphosphate; Anti-Bacterial Agents; Arterial Occlusive Diseases; Drug Therapy | 1987 |
Massive perfusion with vasodilators for ischaemic retinopathy and optic nerve diseases--a new approach.
Topics: Humans; Ischemia; Optic Nerve Diseases; Perfusion; Retina; Theophylline; Xanthinol Niacinate | 1987 |
[Control of ATP levels in stimulated pancreatic B-cells].
Topics: Adenosine Triphosphate; Animals; Butyrates; Carbutamide; Cyclic AMP; Diazoxide; Epinephrine; Glucago | 1969 |
Vasodilator drugs in the treatment of peripheral arterial insufficiency.
Topics: Adult; Aged; Aminophylline; Angiotensin II; Arteriosclerosis Obliterans; Drug Evaluation; Female; Fo | 1974 |
Ribonucleic acid and protein synthesis in rat heart mitochondria isolated after aortic constriction, strenuous physical exercise, total myocardial ischemia, and theophylline treatment.
Topics: Animals; Cardiomegaly; Cell Nucleus; Cell-Free System; Chloramphenicol; Coronary Circulation; Cyclic | 1973 |
[Drug-induced reaction patterns of regional cerebral blood flow (author's transl)].
Topics: Administration, Oral; Benzamides; Benzoates; Blood Pressure; Brain; Cerebrovascular Circulation; Cer | 1974 |
The effects of xanthinol nicotinate on the small blood vessels.
Topics: Amino Alcohols; Arteriosclerosis; Blood Viscosity; Conjunctiva; Diabetic Angiopathies; Erythrocyte A | 1973 |
[Preservation of kidney transplants].
Topics: Adrenal Cortex Hormones; Animals; Bicarbonates; Buffers; Coumarins; Dogs; Humans; Hyperbaric Oxygena | 1968 |
[Treatment problems in acute circulation disorders of the inner ear using low molecular dextrans].
Topics: Acute Disease; Blood Coagulation; Blood Coagulation Disorders; Blood Platelets; Deafness; Dextrans; | 1972 |
[Medical treatment of acute arterial obliteration in the limbs].
Topics: Acute Disease; Adult; Aged; Arteriosclerosis Obliterans; Drug Synergism; Female; Fibrinolytic Agents | 1968 |
Studies on the mechanism of shock. The effect of cocaine and theophylline on the temperature response to injury in the cold-acclimated rat.
Topics: Acclimatization; Animals; Body Temperature; Body Temperature Regulation; Catecholamines; Cocaine; Co | 1969 |
A new approach to the treatment of ischemic conditions of the extremities: continous intraarterial infusion therapy.
Topics: Amputation, Surgical; Arteries; Blood Circulation; Body Temperature; Brachial Artery; Dextrans; Fema | 1969 |