| Assay ID | Title | Year | Journal | Article |
|---|
| AID303147 | Displacement of radio ligand from alpha-2A adrenergic receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303118 | Metabolic stability in mouse liver microsomes | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303207 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 100 mg/kg, po after 2 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303202 | Drug level in Sprague-Dawley rat brain at 100 mg/kg, po after 2 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303173 | Displacement of radio ligand from dopamine D1 receptor at 10 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303201 | Drug level in Sprague-Dawley rat brain at 100 mg/kg, po after 1 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303178 | Displacement of radio ligand from Sigma 2 receptor at 10 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303140 | Oral bioavailability in dog at 5 mg/kg | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303123 | AUC in rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303187 | Drug level in Sprague-Dawley rat brain at 3 mg/kg, ip after 2 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303144 | Increase in GABA level in rat frontal cortex at 10 mg/kg, sc | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303100 | Inhibition of human 5HT3 receptor expressed in CHO cells at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID452551 | Agonist activity at 5HT6 receptor | 2009 | Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
| Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts. |
| AID303167 | Displacement of radio ligand from Kainate receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303169 | Displacement of radio ligand from glycine receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303163 | Displacement of radio ligand from muscarinic M3 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303139 | Oral bioavailability in rat at 10 mg/kg | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303159 | Displacement of radio ligand from histamine H2 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303133 | Half life in dog at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303134 | Half life in dog at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303110 | Permeability in parallel artificial membrane | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303160 | Displacement of radio ligand from histamine H3 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303138 | Volume of distribution in dog at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303168 | Displacement of radio ligand from NMDA receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303179 | Drug level in Sprague-Dawley rat plasma at 3 mg/kg, ip after 0.25 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303114 | Inhibition of human CYP2C8 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303137 | Volume of distribution in rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303198 | Drug level in Sprague-Dawley rat plasma at 100 mg/kg, po after 4 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303122 | Metabolic stability in human liver microsomes | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303188 | Drug level in Sprague-Dawley rat brain at 3 mg/kg, ip after 4 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303189 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 3 mg/kg, ip after 0.25 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303121 | Metabolic stability in monkey liver microsomes | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303166 | Displacement of radio ligand from AMPA receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303157 | Displacement of radio ligand from dopamine D4 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303185 | Drug level in Sprague-Dawley rat brain at 3 mg/kg, ip after 0.5 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303206 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 100 mg/kg, po after 1 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303156 | Displacement of radio ligand from dopamine D3 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303132 | Half life in rat at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303152 | Displacement of radio ligand from adenosine 1 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303111 | Inhibition of human CYP1A2 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303103 | Displacement of [3H]5-HT from human 5HT1B receptor expressed in CHO cells at 1 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID369091 | Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting | 2009 | Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
| Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. |
| AID303181 | Drug level in Sprague-Dawley rat plasma at 3 mg/kg, ip after 1 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303184 | Drug level in Sprague-Dawley rat brain at 3 mg/kg, ip after 0.25 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303199 | Drug level in Sprague-Dawley rat brain at 100 mg/kg, po after 0.25 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303146 | Displacement of radio ligand from alpha-1B adrenergic receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303170 | Displacement of radio ligand from Purinergic P2Y receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303124 | AUC in rat at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303145 | Displacement of radio ligand from alpha-1A adrenergic receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303172 | Displacement of radio ligand from Sigma 2 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303190 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 3 mg/kg, ip after 0.5 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303203 | Drug level in Sprague-Dawley rat brain at 100 mg/kg, po after 4 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID438045 | Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cells | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. |
| AID303153 | Displacement of radio ligand from adenosine 2 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303097 | Inhibition of human 5HT2B receptor expressed in CHO cells | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID438047 | Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production after 10 mins by radioimmunoassay | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. |
| AID303177 | Displacement of radio ligand from beta-2 adrenergic receptor at 10 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID1249634 | Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells after 120 mins by scintillation counter | 2015 | Journal of medicinal chemistry, Oct-22, Volume: 58, Issue:20
| Therapeutic Potential of 5-HT6 Receptor Agonists. |
| AID303125 | AUC in dog at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303115 | Inhibition of human CYP2C9 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303142 | Decrease in water intake in schedule-induced polydipsia rat model | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303113 | Inhibition of human CYP2C19 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303175 | Displacement of radio ligand from alpha-2B adrenergic receptor at 10 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303165 | Displacement of radio ligand from muscarinic M5 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303094 | Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303204 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 100 mg/kg, po after 0.25 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303155 | Displacement of radio ligand from dopamine D2 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303208 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 100 mg/kg, po after 4 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303126 | AUC in dog at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303180 | Drug level in Sprague-Dawley rat plasma at 3 mg/kg, ip after 0.5 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303098 | Inhibition of human 5HT2C receptor expressed in CHO cells | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303116 | Inhibition of human CYP2D6 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303130 | Tmax in dog at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303192 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 3 mg/kg, ip after 2 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303171 | Displacement of radio ligand from Sigma 1 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303128 | Cmax in dog at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303197 | Drug level in Sprague-Dawley rat plasma at 100 mg/kg, po after 2 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303131 | Half life in rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303205 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 100 mg/kg, po after 0.5 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303109 | Aqueous solubility at pH 8 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID438046 | Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as induction of cAMP production at 0.0001 to 10 uM after 10 mins by radioimmunoassay | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. |
| AID303129 | Tmax in rat at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303149 | Displacement of radio ligand from alpha-2C adrenergic receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303151 | Displacement of radio ligand from beta-2 adrenergic receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303191 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 3 mg/kg, ip after 1 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303158 | Displacement of radio ligand from histamine H1 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303120 | Metabolic stability in dog liver microsomes | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303112 | Inhibition of human CYP2A6 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303143 | Effect on water intake in non-SIP rat model | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303127 | Cmax in rat at 10 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303174 | Displacement of radio ligand from alpha-2A adrenergic receptor at 10 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303119 | Metabolic stability in rat liver microsomes | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303200 | Drug level in Sprague-Dawley rat brain at 100 mg/kg, po after 0.5 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303108 | Aqueous solubility at pH 3 to 6 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303106 | Displacement of [125I]DOI from human 5HT2A receptor expressed in CHO cells at 1 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303150 | Displacement of radio ligand from beta-1 adrenergic receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303095 | Agonist activity at human 5HT6 receptor expressed in HeLa cells assessed as cAMP production | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID452550 | Binding affinity to 5HT6 receptor | 2009 | Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
| Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts. |
| AID303161 | Displacement of radio ligand from muscarinic M1 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303099 | Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303186 | Drug level in Sprague-Dawley rat brain at 3 mg/kg, ip after 1 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303196 | Drug level in Sprague-Dawley rat plasma at 100 mg/kg, po after 1 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303162 | Displacement of radio ligand from muscarinic M2 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303176 | Displacement of radio ligand from beta-1 adrenergic receptor at 10 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303183 | Drug level in Sprague-Dawley rat plasma at 3 mg/kg, ip after 4 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303194 | Drug level in Sprague-Dawley rat plasma at 100 mg/kg, po after 0.25 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303105 | Displacement of [3H]5-HT from human 5HT1F receptor expressed in CHO cells at 1 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303182 | Drug level in Sprague-Dawley rat plasma at 3 mg/kg, ip after 2 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303101 | Inhibition of human 5HT4 receptor expressed in CHO cells at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303102 | Inhibition of human 5HT5 receptor expressed in CHO cells at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303154 | Displacement of radio ligand from dopamine D1 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID1916468 | Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constant | 2021 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 49 | Chemical update on the potential for serotonin 5-HT |
| AID303135 | Clearance in rat at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303104 | Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cells at 1 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303164 | Displacement of radio ligand from muscarinic M4 receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303136 | Clearance in dog at 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303141 | Ratio of drug level in brain to plasma in rat at 3 mg/kg, ip or 100 mg/kg, po | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303148 | Displacement of radio ligand from alpha-2B adrenergic receptor at 100 nM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303107 | Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cells at 1 uM | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303117 | Inhibition of human CYP3A4 | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303193 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 3 mg/kg, ip after 4 hrs | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID303195 | Drug level in Sprague-Dawley rat plasma at 100 mg/kg, po after 0.5 hr | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID1799279 | 5-HT6 Binding Assay from Article 10.1016/j.bmc.2009.08.006: \\Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts.\\ | 2009 | Bioorganic & medicinal chemistry, Oct-15, Volume: 17, Issue:20
| Indene-based frameworks targeting the 5-HT6 serotonin receptor: ring constraint in indenylsulfonamides using cyclic amines and structurally abbreviated counterparts. |
| AID1798074 | Cytochrome P450 Inhibition from Article 10.1021/jm070521y: \\Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.\\ | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID1798073 | Radioligand Labeled Binding Assay from Article 10.1021/jm070521y: \\Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.\\ | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID1798072 | Radioligand Labeled Binding Assay and cAMP Production from Article 10.1021/jm070521y: \\Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.\\ | 2007 | Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23
| Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. |
| AID1345170 | Human 5-HT6 receptor (5-Hydroxytryptamine receptors) | 2008 | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, May, Volume: 33, Issue:6
| Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |