Page last updated: 2024-12-11

davunetide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

davunetide: AL-108 is a nasal systemic formulation; AL-208 is an intravenous formulation; associated with glial proteins regulated by vasoactive intestinal peptide, are shown now to provide protective intervention in a model of fetal alcohol syndrome [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9832404
CHEMBL ID2103826
CHEBI ID177706
SCHEMBL ID239737
MeSH IDM0387224

Synonyms (39)

Synonym
CHEBI:177706
davunetide
(2s)-5-amino-2-[[(2s)-1-[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-[(2s)-2-[[(2s)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopen
211439-12-2
davunetide (usan)
D09401
al 108
napvsipq peptide
l-glutamine, l-asparaginyl-l-alanyl-l-prolyl-l-valyl-l-seryl-l-isoleucyl-l-prolyl-
al208 cpd
napvsipq
al 208
davunetide [usan:inn]
nap peptide
gf00k3iiwe ,
h2n-l-asn-l-ala-l-pro-l-val-l-ser-l-ile-l-pro-l-gln-cooh
al-408
al108 cpd
nap (peptide)
al-208
human activity-dependent neuroprotective protein (adnp)-(354-361)-peptide
d-nap peptide
unii-gf00k3iiwe
al-108
CHEMBL2103826
SCHEMBL239737
influenza pr8 hemagglutinin peptide(110-119)
l-glutamine,l-asparaginyl-l-alanyl-l-prolyl-l-valyl-l-seryl-l-isoleucyl-l-prolyl-
J-013876
influenza pr8 hemagglutinin peptide (110-119)
DB12613
asn-ala-pro-val-ser-ile-pro-gln
l-asparaginyl-l-alanyl-l-prolyl-l-valyl-l-seryl-l-isoleucyl-l-prolyl-l-glutamine
Q27279075
MS-31531
HY-105066
BN172353
CS-0024867
AKOS040744852

Research Excerpts

Overview

NAP (davunetide) is a novel neuroprotective compound with mechanism of action that appears to involve microtubule (MT) stabilization and repair. NAP is an eight amino acid peptide (NAPVSIPQ) that has been shown to provide potent neuroprotection, in vitro and in vivo. Davunetides is an intranasally administered peptide currently being developed for treatment of Alzheimer's disease and related disorders.

ExcerptReferenceRelevance
"NAP (davunetide) is a novel neuroprotective compound with mechanism of action that appears to involve microtubule (MT) stabilization and repair. "( NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport.
Assaf, Y; Giladi, E; Gozes, I; Jouroukhin, Y; Ostritsky, R; Pelled, G, 2013
)
1.42
"Davunetide (NAP) is an eight amino acid peptide that has been shown to provide potent neuroprotection. "( Davunetide (NAP) protects the retina against early diabetic injury by reducing apoptotic death.
Bucolo, C; Castorina, A; D'Agata, V; D'Amico, AG; Drago, F; Federico, C; Marrazzo, G; Scuderi, S, 2014
)
3.29
"NAP (Davunetide) is a peptide whose neuroprotective actions are widely demonstrated, although its biological role on endothelial dysfunctions induced by hyperglycemia remains uninvestigated."( NAP reduces murine microvascular endothelial cells proliferation induced by hyperglycemia.
Cavallaro, S; D'Agata, V; D'Amico, AG; Drago, F; Maugeri, G; Scuderi, S, 2014
)
0.86
"NAP (davunetide) is a clinical octapeptide and reportedly possesses neuroprotective, neurotrophic and cognitive protective properties. "( Protein profiling reveals antioxidant and signaling activities of NAP (Davunetide) in rodent hippocampus exposed to hypobaric hypoxia.
Bhargava, K; Das, M; Sethy, NK; Sharma, NK, 2014
)
1.15
"NAP (davunetide) is an active fragment of activity-dependent neuroprotective protein (ADNP). "( Microtubules, schizophrenia and cognitive behavior: preclinical development of davunetide (NAP) as a peptide-drug candidate.
Gozes, I, 2011
)
1.11
"NAP (davunetide) is an eight amino acid peptide (NAPVSIPQ) that has been shown to provide potent neuroprotection, in vitro and in vivo. "( NAP (davunetide) provides functional and structural neuroprotection.
Gozes, I, 2011
)
1.4
"Davunetide (AL-108, NAP) is an intranasally administered peptide currently being developed for treatment of Alzheimer's disease and related disorders."( Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia.
Ball, MP; Barch, DS; Buchanan, RW; Csernansky, JG; Goff, DC; Gold, JM; Green, MF; Jarskog, F; Javitt, DC; Keefe, RS; Kern, R; Kimhy, D; Lieberman, J; Marder, SR; McEvoy, JP; McMahon, RP; Nolan, KS; Robinson, J; Seidman, LJ, 2012
)
1.37
"Davunetide (NAP) is a leading drug candidate being tested against tauopathy. "( D-NAP prophylactic treatment in the SOD mutant mouse model of amyotrophic lateral sclerosis: review of discovery and treatment of tauopathy.
Gozes, I; Jouroukhin, Y; Ostritsky, R, 2012
)
1.82
"Davunetide is a neurotrophic peptide that can enhance cognitive function in animal models of neurodegeneration."( Effects of davunetide on N-acetylaspartate and choline in dorsolateral prefrontal cortex in patients with schizophrenia.
Barch, DM; Buchanan, RW; Colibazzi, T; Csernansky, JG; Dong, Z; Girgis, RR; Goff, DC; Harms, MP; Jarskog, LF; Javitt, DC; Kangarlu, A; Keefe, RS; Kegeles, LS; Lieberman, JA; Marder, SR; McEvoy, JP; McMahon, RP; Peterson, BS, 2013
)
1.5

Toxicity

ExcerptReferenceRelevance
"AL-108 was generally safe and well tolerated."( A double-blind, placebo-controlled, ascending-dose, randomized study to evaluate the safety, tolerability and effects on cognition of AL-108 after 12 weeks of intranasal administration in subjects with mild cognitive impairment.
Blackwell, A; Gold, M; Hirman, J; Keith, J; Morimoto, BH; Schmechel, D, 2013
)
0.39
" Similarly, data from 10 separate clinical trials of davunetide, investigating safety and efficacy provide evidence that davunetide is generally safe and well-tolerated, and has shown some signs of clinical efficacy."( Davunetide: a review of safety and efficacy data with a focus on neurodegenerative diseases.
Fox, AW; Gold, M; Morimoto, BH; Stewart, AJ, 2013
)
2.08

Bioavailability

ExcerptReferenceRelevance
" Bioavailability studies with [(3)H]NAPVSIPQ indicated that 39% of the total radioactivity comigrated with intact peptide in the fetus 60 min after administration."( Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome.
Abebe, DT; Brenneman, DE; Gozes, I; Hill, JM; Spong, CY, 2001
)
0.31
" Bioavailability studies indicated that NAP penetrates cells and crosses the blood-brain barrier after nasal or systemic administration."( NAP and D-SAL: neuroprotection against the beta amyloid peptide (1-42).
Divinski, I; Gozes, I; Piltzer, I, 2008
)
0.35
" Results showed a dramatically specific increase in brain/body bioavailability with the new formulation, without breaching the blood brain barrier."( The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse.
Giladi, E; Gozes, I; Grigoriadis, N; Lagoudaki, R; Malishkevich, A; Piontkewitz, Y; Sragovich, S; Touloumi, O, 2019
)
0.51

Dosage Studied

ExcerptRelevanceReference
" After dose-response and time-course experiments, the animals were injected with NAP (3 microg/kg) or vehicle intravenously 1 hour after stroke onset."( NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death.
Brenneman, DE; Fridkin, M; Giladi, E; Gozes, I; Grigoriadis, N; Leker, RR; Ovadia, H; Romano, J; Teichner, A, 2002
)
0.31
" Furthermore, dosing was recently completed for a second Phase I clinical trial in healthy adults and elderly volunteers with an intravenous formulation of NAP."( NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP).
Aisen, PS; Dangoor, D; Fox, A; Gozes, I; Holser-Cochav, M; Matsuoka, Y; Morimoto, BH; Newton, P; Sutherland, K; Thal, L; Tiong, J; van Dyck, CH; Vered, K, 2005
)
0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oligopeptideA peptide containing a relatively small number of amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (126)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's58 (46.03)29.6817
2010's62 (49.21)24.3611
2020's6 (4.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.86 (24.57)
Research Supply Index4.91 (2.92)
Research Growth Index6.91 (4.65)
Search Engine Demand Index50.74 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials5 (3.88%)5.53%
Reviews20 (15.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other104 (80.62%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]