cinnamophilin
Description
cinnamophilin: a lignan isolated from Cinnamomum philippinense; thromboxane receptor antagonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 169883 |
CHEMBL ID | 3638037 |
MeSH ID | M0233258 |
Synonyms (8)
Synonym |
---|
cinnamophilin |
(2r,3s)-1,4-bis(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutan-1-one |
154677-96-0 |
1-butanone, 1,4-bis(4-hydroxy-3-methoxyphenyl)-2,3-dimethyl-, (r*,s*)- |
(r*,s*)-1,4-bis(4-hydroxy-3-methoxyphenyl)-2,3-dimethyl-1-butanone |
CHEMBL3638037 |
DTXSID80935043 |
1,4-bis(4-hydroxy-3-methoxyphenyl)-2,3-dimethylbutan-1-one |
Research Excerpts
Overview
Cinnamophilin was found to be a thromboxane A2 (TXA2) receptor blocking agent in human platelet, rat aorta and guinea-pig trachea. U-46619-induced aggregation of human-PRP, contraction ofRat aortic rings and Guinean tracheal rings with pA2 values of 7.3 +/- 0.2, 6.3 (+0.2) and 5.2 (-0.1)
Excerpt | Reference | Relevance |
---|---|---|
"3. Cinnamophilin was found to be a thromboxane A2 (TXA2) receptor blocking agent in human platelet, rat aorta and guinea-pig trachea as revealed by its competitive antagonism of U-46619-induced aggregation of human-PRP, contraction of rat aortic rings and guinea-pig tracheal rings with pA2 values of 7.3 +/- 0.2, 6.3 +/- 0.1 and 5.2 +/- 0.2, respectively." | ( Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor. Teng, CM; Wu, TS; Yu, SM, 1994) | 1.08 |
"Cinnamophilin was found to be a thromboxane A2 receptor blocking agent in these tissues as revealed by its competitive antagonism of the U-46619 (9,11-dideoxymethanoepoxy-9 alpha,11 alpha-prostaglandin F2 alpha)-induced contraction of rat aorta and guinea-pig trachea and aggregation of rabbit platelets with pA2 values of 7.3 +/- 0.2, 5.2 +/- 0.1 and 6.3 +/- 0.3, respectively." | ( Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense. Ko, FN; Lee, JY; Teng, CM; Wu, TS; Yu, SM, 1994) | 2.45 |
Research
Studies (12)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (25.00) | 18.2507 |
2000's | 4 (33.33) | 29.6817 |
2010's | 4 (33.33) | 24.3611 |
2020's | 1 (8.33) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 15.46
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (15.46) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 13 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |