Page last updated: 2024-10-21

phenytoin and Ischemia

phenytoin has been researched along with Ischemia in 12 studies

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back."3.72Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism? ( Holmes, LB; Huang, T; Lyon, HM, 2003)
" We hypothesized that retrograde spinal cord venous perfusion with phenytoin, a neuronal voltage-dependent sodium channel antagonist, would provide protection during prolonged spinal cord ischemia."3.70Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection. ( Gangemi, JJ; Kern, JA; Kron, IL; Ross, SD; Shockey, KS; Tribble, CG, 2000)
"After treatment of ischemia and/or failure, specific antiarrhythmic agents, conventional and investigational, alone or in combination, are systematically selected."1.26Ventricular ectopy: etiology, evaluation, and therapy. ( Reid, PR; Vlay, SC, 1982)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19905 (41.67)18.7374
1990's1 (8.33)18.2507
2000's6 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rekling, JC1
Lyon, HM1
Holmes, LB1
Huang, T1
Mahajan, RP1
Batra, YK1
Rajeev, S1
Vlay, SC1
Reid, PR1
Jund, R1
Kastenbauer, E1
Gangemi, JJ1
Kern, JA1
Ross, SD1
Shockey, KS1
Kron, IL1
Tribble, CG1
McLean, CR1
Cheng, KS1
Clifton, MA1
Miyamoto, TA1
Miyamoto, KJ1
Santiago-Delpín, EA1
Vivoni, V1
Suárez, A1
Román-Franco, AA1
Rao, VK1
Feldman, PD1
Dibbell, DG1
Keltner, JL2
Becker, B1
Gay, AJ1
Podos, SM1
Ellenberger, C1
Burde, RM1

Trials

1 trial available for phenytoin and Ischemia

ArticleYear
Acute optic neuropathy. Treatment with diphenylhydantoin.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1974, Volume: 91, Issue:6

    Topics: Administration, Oral; Adult; Aged; Capsules; Female; Humans; Ischemia; Male; Middle Aged; Optic Nerv

1974

Other Studies

11 other studies available for phenytoin and Ischemia

ArticleYear
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
    Neuroscience letters, 2003, Jan-02, Volume: 335, Issue:3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured;

2003
Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:12

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Female; Gest

2003
Intravenous phenytoin and percutaneous arterial cannulation: the purple-glove syndrome.
    European journal of anaesthesiology, 2007, Volume: 24, Issue:10

    Topics: Adult; Anticonvulsants; Catheterization, Peripheral; Extravasation of Diagnostic and Therapeutic Mat

2007
Ventricular ectopy: etiology, evaluation, and therapy.
    The American journal of medicine, 1982, Volume: 73, Issue:6

    Topics: Adrenergic beta-Antagonists; Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Aprindine; Arrhyth

1982
Susceptibility of isolated rat facial nerve to anaerobic stress.
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 1997, Volume: 254 Suppl 1

    Topics: Action Potentials; Anaerobiosis; Anesthetics, Local; Animals; Anticonvulsants; Cyanides; Disease Mod

1997
Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection.
    The Annals of thoracic surgery, 2000, Volume: 69, Issue:6

    Topics: Animals; Aortic Aneurysm; Dose-Response Relationship, Drug; Female; Ischemia; Male; Neurologic Exami

2000
Fatal case of accidental intra-arterial phenytoin injection.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2002, Volume: 23, Issue:4

    Topics: Accidents; Aged; Aged, 80 and over; Anticonvulsants; Arm; Epilepsy; Fatal Outcome; Female; Gangrene;

2002
Is retrograde perfusion necessary for spinal cord protection?
    The Annals of thoracic surgery, 2002, Volume: 73, Issue:4

    Topics: Animals; Ischemia; Neuroprotective Agents; Perfusion; Phenytoin; Rabbits; Sodium Channel Blockers; S

2002
Protection of organs during experimental ischemia.
    Surgery, gynecology & obstetrics, 1978, Volume: 147, Issue:5

    Topics: Ampicillin; Animals; Chlorpheniramine; Dogs; Hindlimb; Intestine, Small; Ischemia; Methylprednisolon

1978
Extravasation injury to the hand by intravenous phenytoin. Report of three cases.
    Journal of neurosurgery, 1988, Volume: 68, Issue:6

    Topics: Amputation, Surgical; Extravasation of Diagnostic and Therapeutic Materials; Female; Hand; Humans; I

1988
Effect of diphenylhydantoin in ischemic optic neuritis.
    Transactions of the American Ophthalmological Society, 1972, Volume: 70

    Topics: Adult; Aged; Eye; Female; Fixation, Ocular; Follow-Up Studies; Humans; Ischemia; Kinetics; Male; Mid

1972