phenobarbital has been researched along with Ischemia in 19 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The experiments on rats have shown that total hepatic ischemia reduces the content of microsomal cytochromes P-450 and b5 and causes amidopyrine and aniline disturbances over a 2-3-week post-ischemic period." | 3.67 | [Structural-functional aspects of the postischemic recovery of the hepatocyte endoplasmic network in rats]. ( Dolgov, AV; Grek, OR; Sharapov, VI; Shkurupiĭ, VA; Sokirchenko, IA, 1986) |
| "Sixty-three infants with neonatal seizures were studied in terms of etiology, seizure type, electroencephalograms, and outcome." | 1.27 | Neonatal seizures: a reappraisal. ( Nogen, AG, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (73.68) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rekling, JC | 1 |
| Nogen, AG | 1 |
| Bilenko, MV | 1 |
| Kagan, VE | 1 |
| Velikhanova, DM | 1 |
| Komarov, PG | 1 |
| Zakharova, MV | 1 |
| Shkurupiĭ, VA | 2 |
| Grek, OR | 2 |
| González-Flecha, B | 1 |
| Cutrin, JC | 1 |
| Boveris, A | 1 |
| Branum, GD | 1 |
| Selim, N | 1 |
| Liu, X | 1 |
| Whalen, R | 1 |
| Boyer, TD | 1 |
| Ferrero, ME | 1 |
| Orsi, R | 1 |
| Bernelli-Zazzera, A | 1 |
| Nordström, CH | 2 |
| Calderini, G | 1 |
| Rehncrona, S | 2 |
| Siesjö, BK | 1 |
| Astrup, J | 1 |
| Ragnotti, G | 1 |
| Aletti, MG | 1 |
| Presta, M | 1 |
| Yasuda, H | 1 |
| Nakanishi, M | 2 |
| Tsumagari, T | 1 |
| Nakajima, A | 1 |
| Ibrahim, MZ | 1 |
| Lindstrom, TD | 1 |
| Hanssen, BR | 1 |
| Bendele, AM | 1 |
| Sharapov, VI | 1 |
| Sokirchenko, IA | 1 |
| Dolgov, AV | 1 |
| Allen, JG | 1 |
| Seawright, AA | 1 |
| Uther, JB | 1 |
| Guyton, AC | 1 |
| Passonneau, JV | 1 |
| Lowry, OH | 1 |
| Döring, HJ | 1 |
| Olbrisch, RR | 1 |
| Schmahl, FW | 1 |
| Betz, E | 1 |
| Talke, H | 1 |
| Hohorst, HJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Triangulation, Eye of the Needle and Stone Direct Targeting Percutaneous Renal Access Techniques of Nephrolithotomy : Randomized Controlled Trial[NCT04846699] | 150 participants (Anticipated) | Observational | 2021-04-20 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for phenobarbital and Ischemia
| Article | Year |
|---|---|
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; | 2003 |
Neonatal seizures: a reappraisal.
Topics: Age Factors; Anticonvulsants; Electroencephalography; Female; Humans; Hypoxia; Infant, Newborn; Isch | 1984 |
[Protective action of antioxidants and microsomal monooxygenase inducers in ischemic and reoxygenation damage to the liver].
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Enzyme Induction; Ischemia; Lipid Peroxides; Liver; | 1983 |
[Effect of preliminary phenobarbital and ziksorin administration on reparative processes in the liver parenchyma after ischemic damage].
Topics: Acute Disease; Animals; Benzhydryl Compounds; Ischemia; Liver; Liver Regeneration; Male; Microscopy, | 1994 |
Time course and mechanism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion.
Topics: Animals; Free Radicals; Hydrogen Peroxide; Ischemia; Liver; Luminescent Measurements; Male; Mitochon | 1993 |
Ischaemia and reperfusion injury of rat liver increases expression of glutathione S-transferase A1/A2 in zone 3 of the hepatic lobule.
Topics: Animals; Gene Expression Regulation, Enzymologic; Glutathione Transferase; In Situ Hybridization; Is | 1998 |
Effects of ischemia on drug-metabolizing microsomal enzymes in rat liver.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Biotransformation; Cytochrome P-450 Enzyme | 1978 |
Effects of phenobarbital anaesthesia on postischemic cerebral blood flow and oxygen consumption in the rat.
Topics: Brain; Cerebrovascular Circulation; Ischemia; Oxygen Consumption; Phenobarbital | 1977 |
Rate of rise in extracellular potassium in the ischemic rat brain and the effect of preischemic metabolic rate: evidence for a specific effect of phenobarbitone.
Topics: Animals; Brain; Extracellular Space; Ischemia; Phenobarbital; Potassium; Rats | 1977 |
Inhibition of protein synthesis in ischaemic liver from phenobarbitone-treated rat.
Topics: Animals; Cytosol; Ischemia; Liver; Male; Phenobarbital; Protein Biosynthesis; Rats; Ribosomes | 1979 |
The mechanism of action of a novel cerebral protective drug against anoxia I. The effect on cerebral energy demand.
Topics: Animals; Animals, Newborn; Brain; Energy Metabolism; Ischemia; Kinetics; Male; Mice; Phenobarbital; | 1979 |
Glycogen and its related enzymes of metabolism in the central nervous system.
Topics: 1,4-alpha-Glucan Branching Enzyme; Adenine Nucleotides; Adrenal Cortex Hormones; Animals; Blood Gluc | 1975 |
Effects of hepatic ischemia-reperfusion injury on the hepatic mixed function oxidase system in rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochromes b5; Ischemia; Isoenzymes; Lipid Peroxidation; L | 1990 |
[Structural-functional aspects of the postischemic recovery of the hepatocyte endoplasmic network in rats].
Topics: Aminopyrine; Aniline Compounds; Animals; Cytochromes; Endoplasmic Reticulum; Ischemia; Liver; Male; | 1986 |
The effect of prior treatment with phenobarbitone, dicophane (DDT) and beta-diethylaminoethyl phenylpropyl acetate (SKF 525A) on experimental intoxication of sheep with the plant Myoporum deserti Cunn.
Topics: Animals; Bilirubin; Biopsy; DDT; Edema; Eosinophils; Gallbladder; Gastrointestinal Hemorrhage; Ische | 1973 |
Cardiovascular regulation following changes in central nervous perfusion pressure in the unanesthetised rabbit.
Topics: Anesthesia, Intravenous; Animals; Aorta; Blood Pressure; Brain; Carotid Sinus; Central Nervous Syste | 1973 |
Metabolite flux in single neurons during ischemia and anesthesia.
Topics: Adenosine Triphosphate; Anesthesia; Animals; Brain; Creatine; Electric Stimulation; Glucose; Glycoge | 1971 |
[Electrocorticogram, steady potential of the brain and energy-rich phosphate fractions of the cerebral cortex during anesthetic overdosage, ischemia and cyanide poisoning].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Anesthetics; Animals; Cerebral Cortex; Chloral Hydrate; | 1970 |
[Energy rich phosphates and metabolites of energy metabolism in the cerebral cortex in the cat].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Brain Chemistry; Cats; Cerebral Cortex; Creati | 1965 |