diazoxide has been researched along with Ischemia in 21 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve pigs were randomized to global ischemia for 2 hours with a single dose of cold blood (4:1) hyperkalemic cardioplegia alone (n = 6) or with diazoxide (500 μmol/L) (n = 6) and reperfused for 1 hour." | 8.12 | Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia. ( Brady, MB; Cho, BC; Dodd-O, JM; Gaughan, N; Jones, M; Kearney, S; Lawton, JS; Lui, C; Metkus, TS; Suarez-Pierre, A; Thomas, RP; Wang, J; Zhou, X, 2022) |
| "To study the protective mechanism of ischemic preconditioning (IPC) and diazoxide preconditioning (DPC) against myocardium ischemia-reperfusion (I/R) injury." | 7.74 | [Protective effect of ischemia and diazoxide preconditioning on postischemic reperfused myocardium and possible mechanism thereof]. ( Han, JS; Wang, ZW; Yan, DM; Zhu, HY, 2008) |
| " Experimental groups were sham (no pretreatment or ischemia, n = 10), spinal cord injury control (pretreatment with normal saline, n = 27), Nicorandil 1." | 4.31 | Direct and indirect activation of the adenosine triphosphate-sensitive potassium channel to induce spinal cord ischemic metabolic tolerance. ( Aftab, M; Cheng, L; Cleveland, JC; Fullerton, DA; Ghincea, CV; Ikeno, Y; Meng, X; Reece, TB; Roda, GF; Weyant, MJ, 2023) |
| "Twelve pigs were randomized to global ischemia for 2 hours with a single dose of cold blood (4:1) hyperkalemic cardioplegia alone (n = 6) or with diazoxide (500 μmol/L) (n = 6) and reperfused for 1 hour." | 4.12 | Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia. ( Brady, MB; Cho, BC; Dodd-O, JM; Gaughan, N; Jones, M; Kearney, S; Lawton, JS; Lui, C; Metkus, TS; Suarez-Pierre, A; Thomas, RP; Wang, J; Zhou, X, 2022) |
| "To study the protective mechanism of ischemic preconditioning (IPC) and diazoxide preconditioning (DPC) against myocardium ischemia-reperfusion (I/R) injury." | 3.74 | [Protective effect of ischemia and diazoxide preconditioning on postischemic reperfused myocardium and possible mechanism thereof]. ( Han, JS; Wang, ZW; Yan, DM; Zhu, HY, 2008) |
| " For example, ischemia in the perfused heart for 30 min reversibly blocked PEth degradation and seemingly enhanced PEth formation; the block was reversed by ischemic preconditioning (IPC) and by pretreatment with diazoxide, an opener of mitochondrial K(ATP) channels." | 3.72 | Degradation of phosphatidylethanol counteracts the apparent phospholipase D-mediated formation in heart and other organs. ( Brühl, A; Faldum, A; Löffelholz, K, 2003) |
| "IPC or ischemia was induced in rat retina in vivo." | 1.35 | Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning. ( Barone, FC; Dreixler, JC; Du, E; Roth, S; Shaikh, AR, 2009) |
| "Pretreatment with diazoxide significantly reduced the infarct volume from 6." | 1.33 | MitoKATP-channel opener protects against neuronal death in rat venous ischemia. ( Alessandri, B; Heimann, A; Kempski, O; Nakagawa, I, 2005) |
| "Diazoxide pretreatment significantly increased nuclear translocation of p65 which was blocked by protein kinase C (PKC) or nitric oxide synthase (NOS) inhibition." | 1.31 | Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. ( Ashraf, M; Ayub, A; Kudo, M; Wang, Y; Xu, M, 2001) |
| "The diazoxide-mediated increase in the forearm blood flow ratio (infused/control arm) was significantly less pronounced after glibenclamide than after acarbose (290 +/- 58% and 561 +/- 101% respectively; P<0." | 1.31 | Vascular K(ATP) channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes. ( Abbink, EJ; Lutterman, JA; Pickkers, P; Russel, FG; Smits, P; Tack, CJ; van Rosendaal, AJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 11 (52.38) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Breschi, MC | 1 |
| Calderone, V | 1 |
| Martelli, A | 1 |
| Minutolo, F | 1 |
| Rapposelli, S | 1 |
| Testai, L | 1 |
| Tonelli, F | 1 |
| Balsamo, A | 1 |
| Ikeno, Y | 1 |
| Ghincea, CV | 1 |
| Roda, GF | 1 |
| Cheng, L | 1 |
| Aftab, M | 1 |
| Meng, X | 1 |
| Weyant, MJ | 1 |
| Cleveland, JC | 1 |
| Fullerton, DA | 1 |
| Reece, TB | 1 |
| Chen, Y | 1 |
| Zeng, H | 1 |
| Liu, H | 1 |
| Suarez-Pierre, A | 1 |
| Lui, C | 1 |
| Zhou, X | 1 |
| Kearney, S | 1 |
| Jones, M | 1 |
| Wang, J | 1 |
| Thomas, RP | 1 |
| Gaughan, N | 1 |
| Metkus, TS | 1 |
| Brady, MB | 1 |
| Cho, BC | 1 |
| Dodd-O, JM | 1 |
| Lawton, JS | 1 |
| Han, JS | 1 |
| Yan, DM | 1 |
| Wang, ZW | 1 |
| Zhu, HY | 1 |
| Dreixler, JC | 2 |
| Hemmert, JW | 1 |
| Shenoy, SK | 1 |
| Shen, Y | 1 |
| Lee, HT | 1 |
| Shaikh, AR | 2 |
| Rosenbaum, DM | 1 |
| Roth, S | 2 |
| Barone, FC | 1 |
| Du, E | 1 |
| Szabadfi, K | 1 |
| Mester, L | 1 |
| Reglodi, D | 1 |
| Kiss, P | 1 |
| Babai, N | 1 |
| Racz, B | 1 |
| Kovacs, K | 1 |
| Szabo, A | 1 |
| Tamas, A | 1 |
| Gabriel, R | 1 |
| Atlasz, T | 1 |
| Emami, H | 1 |
| Talab, SS | 1 |
| Nezami, BG | 2 |
| Elmi, A | 1 |
| Assa, S | 1 |
| Ostovaneh, MR | 1 |
| Dehpour, AR | 2 |
| Brühl, A | 1 |
| Faldum, A | 1 |
| Löffelholz, K | 1 |
| Nakagawa, I | 1 |
| Alessandri, B | 1 |
| Heimann, A | 1 |
| Kempski, O | 1 |
| Beheshtian, A | 1 |
| Demehri, S | 1 |
| Kiumehr, S | 1 |
| Salmasi, AH | 1 |
| Ghazinezami, B | 1 |
| Rahimpour, S | 1 |
| Amanpour, S | 1 |
| Rabbani, S | 1 |
| Mohagheghi, MA | 1 |
| Raval, AP | 1 |
| Dave, KR | 1 |
| DeFazio, RA | 1 |
| Perez-Pinzon, MA | 1 |
| Shahid, M | 1 |
| Tauseef, M | 1 |
| Sharma, KK | 1 |
| Fahim, M | 1 |
| Reeves, WB | 1 |
| Shah, SV | 1 |
| Wang, Y | 1 |
| Kudo, M | 1 |
| Xu, M | 1 |
| Ayub, A | 1 |
| Ashraf, M | 1 |
| Abbink, EJ | 1 |
| Pickkers, P | 1 |
| van Rosendaal, AJ | 1 |
| Lutterman, JA | 1 |
| Tack, CJ | 1 |
| Russel, FG | 1 |
| Smits, P | 1 |
| Itskovitz, HD | 1 |
| Miller, L | 1 |
| Ural, W | 1 |
| Zapp, J | 1 |
| White, R | 1 |
| Hellman, B | 2 |
| Idahl, LA | 2 |
| Pohl, JE | 1 |
| Thurston, H | 1 |
| Swales, JD | 1 |
| Danielsson, A | 1 |
1 review available for diazoxide and Ischemia
| Article | Year |
|---|---|
Novel neuroprotective strategies in ischemic retinal lesions.
Topics: Animals; Benzimidazoles; Diazoxide; Disease Models, Animal; Ischemia; Neuroprotective Agents; Pituit | 2010 |
20 other studies available for diazoxide and Ischemia
| Article | Year |
|---|---|
New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
Topics: Adenosine Triphosphate; Animals; Aorta; Benzopyrans; Cardiotonic Agents; Ischemia; L-Lactate Dehydro | 2006 |
Direct and indirect activation of the adenosine triphosphate-sensitive potassium channel to induce spinal cord ischemic metabolic tolerance.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Ischemia; Male; Mice; Mice, Inbred C57BL; Nicorandil; Ni | 2023 |
MiR-21 participates in the neuroprotection of diazoxide against hypoxic-ischemia encephalopathy by targeting PDCD4.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Diazoxide; Humans; Hypoxia-Ischemia, Brain; Infan | 2022 |
Diazoxide preserves myocardial function in a swine model of hypothermic cardioplegic arrest and prolonged global ischemia.
Topics: Adenosine Triphosphate; Animals; Cardioplegic Solutions; Diazoxide; Heart Arrest, Induced; Ischemia; | 2022 |
[Protective effect of ischemia and diazoxide preconditioning on postischemic reperfused myocardium and possible mechanism thereof].
Topics: Animals; Diazoxide; Immunohistochemistry; Ischemia; Ischemic Preconditioning, Myocardial; Male; Micr | 2008 |
The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning.
Topics: Androstadienes; Animals; Apoptosis; Blotting, Western; Chlorpropamide; Diazoxide; Dose-Response Rela | 2009 |
Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Anisomycin; Diazoxide | 2009 |
Na(+)-H+ exchange inhibition attenuates ischemic injury in rat random pattern skin flap: the role of mitochondrial ATP-sensitive potassium channels.
Topics: Amiloride; Animals; Dermatologic Surgical Procedures; Diazoxide; Glyburide; Ion Channel Gating; Isch | 2013 |
Degradation of phosphatidylethanol counteracts the apparent phospholipase D-mediated formation in heart and other organs.
Topics: Animals; Brain; Diazoxide; Glycerophospholipids; Half-Life; Intestine, Small; Ischemia; Myocardium; | 2003 |
MitoKATP-channel opener protects against neuronal death in rat venous ischemia.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Brain Edema; Brain Infarction; Cell Death; Ce | 2005 |
ATP-sensitive potassium channels mediate the anti-ischemic properties of ischemic and pharmacologic preconditioning in rat random-pattern skin flap.
Topics: Adenosine; Adenosine Triphosphate; Animals; Dermatologic Surgical Procedures; Diazoxide; Glyburide; | 2006 |
epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Diazoxide; Enzyme Inhibitors; Hippocampus; Immun | 2007 |
Brief femoral artery ischaemia provides protection against myocardial ischaemia-reperfusion injury in rats: the possible mechanisms.
Topics: Animals; Arginine; Blood Pressure; Creatine Kinase, MB Form; Diazoxide; Disease Models, Animal; Femo | 2008 |
Activation of potassium channels contributes to hypoxic injury in proximal tubules.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Diazoxide; DNA Damage; Dose-Response Relation | 1994 |
Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.
Topics: Acetophenones; Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agen | 2001 |
Vascular K(ATP) channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes.
Topics: Acarbose; Acetylcholine; Cross-Over Studies; Diabetes Mellitus, Type 2; Diazoxide; Dipyridamole; Dou | 2002 |
Inactivation of angiotensin in shock.
Topics: Aminocaproates; Angiotensin II; Animals; Blood Pressure; Chromatography, Thin Layer; Diazoxide; Dogs | 1969 |
[Control of ATP levels in stimulated pancreatic B-cells].
Topics: Adenosine Triphosphate; Animals; Butyrates; Carbutamide; Cyclic AMP; Diazoxide; Epinephrine; Glucago | 1969 |
Hypertension with renal impairment: influence of intensive therapy.
Topics: Adolescent; Adult; Chronic Disease; Creatinine; Diazoxide; Female; Glomerulonephritis; Humans; Hyper | 1974 |
Levels of -ketoglutarate and glutamate in stimulated pancreatic -cells.
Topics: Animals; Carbutamide; Chemical Phenomena; Chemistry; Depression, Chemical; Diazoxide; Female; Fluoro | 1970 |