oxytetracycline--anhydrous and Ischemia

The article analyses the immediate and late-term results of treatment of patients suffering from thromboangiitis of the lower limbs with acute forms of thromboses of the main arteries and shunts (13 persons) and chronic arterial insufficiency (60 patients). The treatment consisted in intraarterial drug infusion with the use of fibrinolysis activators (celiasa, awelysin) as well as other pathogenetically aimed agents in the form of microcrystal suspensions (hydrocortisone, oxytetracycline, zinc insulin). Regional thrombolysis in acute thrombosis allowed authentic lysis of fresh thrombi in the main arteries in two patients (15%). Local thrombolysis with subsequent course of arterial infusion made possible effective arrest of the local ischemic syndrome in patients with III-IV degree arterial insufficiency and affection of the distal arterial bed and allowed the limb to be preserved during a follow-up period of 2 years in 92.5% of patients.

Topics: Acute Disease; Adult; Chronic Disease; Femoral Artery; Fibrinolytic Agents; Follow-Up Studies; Humans; Hydrocortisone; Infusions, Intra-Arterial; Ischemia; Leg; Male; Middle Aged; Oxytetracycline; Streptokinase; Thromboangiitis Obliterans; Thrombolytic Therapy; Thrombosis; Zinc

Factors of decisive importance for the fate of the intestine following circulatory occlusion incluse the bacterial flora of the intestine, intravascular thrombosis peripheral to the level of occlusion, and the capacity of the collateral circulation. Standardized ischaemia of the small intestine was produced in the rat by ligation of a given number of mesentric end arcades. The passive absorption of radioiodide from a defined, central loop within the ischaemic intestinal segment-as an expression of the exchange circulation of the intestinal mucosa-was determined 14 days after induction of the ischaemia. Different forms of treatment were studied. In Sprague-Dawley rats the effect of heparin, oxitetracycline (OCD) and a combination of these two drugs was examined both concerning the survival of the animals and with regard to the available exchange circulation in the mucosa of the ischaemic intestinal segment. The survival frequency was increased in all treatment groups. The exchange circulation in the ischaemic segment was improved significantly by ODC-treatment and by treatment with heparin and ODC combined. Treatment with heparin alone gave no improvement of the mucosal circulation.

Topics: Animals; Blood Coagulation; Body Weight; Drug Combinations; Hematocrit; Heparin; Intestinal Mucosa; Intestine, Small; Ischemia; Male; Microcirculation; Oxytetracycline; Rats

Topics: Gangrene; Geriatrics; Humans; Injections; Injections, Intra-Arterial; Ischemia; Leg; Oxytetracycline; Peripheral Vascular Diseases