Page last updated: 2024-08-24

dexmedetomidine and Ischemia

dexmedetomidine has been researched along with Ischemia in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.70)29.6817
2010's12 (44.44)24.3611
2020's14 (51.85)2.80

Authors

AuthorsStudies
Du, H; Jia, L; Lyu, J; Sheng, M; Yu, H; Yu, W1
Chen, QH; Hu, Q; Huang, YL; Liu, XM; Liu, ZR; Liu, ZY; Wang, WX; Zhang, HG; Zhang, Q; Zhang, XK1
Jiang, Z; Liu, A; Peng, Y; She, C; Xu, Y; Zhu, J1
Li, G; Liu, B; Wei, J; Zhou, J1
Gao, H; Liu, Y; Wang, S; Yin, Y; Yu, J; Zhong, Y1
Chen, S; Cheng, H; Wang, J; Wu, J; Yang, X1
Chen, F; Han, X; He, Y; Hou, M; Leng, Y; Shi, Y; Tan, Z; Xu, Y1
He, H; Li, P; Liu, P1
Cheng, W; Liu, P; Liu, X; Wang, M; Wang, X; Zhao, S1
Hopster, K; Kästner, SBR; König, KS; Neudeck, S; Pfarrer, C; Rohn, K; Verhaar, N1
Chai, X; Gao, J; Geng, Q; Hu, Y; Jiang, J; Liang, X; Shi, S; Tang, C; Wang, J1
Chen, Y; Huang, Y; Luo, H; Song, X; Xiong, B1
Gao, Q; Li, C; Wu, Z; Xu, Y; Xue, H; Zhang, Y; Zhao, P1
Cahilog, Z; Cao, J; Chen, Q; Chen, X; Chen, Y; Gu, J; Hu, L; Lu, K; Lu, S; Ning, J; Yi, B1
Ainiwaer, Y; Geng, Q; He, B; Li, X; Lin, L; Zhang, B; Zhang, J1
Duan, L; Liu, Z; Wang, GM; Wang, SL; Wang, Y; Xia, B1
Pang, Q; Wang, Z; Zhou, W; Zhou, X; Zhou, Y1
Li, GW; Ou, SS; Xiao, XY; Zhou, JH; Zhou, WY; Zhu, YX1
Chen, Y; Dai, JC; Du, J; Fan, X; Li, JM; Wang, MH; Yang, B; Zhang, C; Zhou, J1
Arslan, M; Cavunt-Bayraktar, A; Comu, FM; Kavutcu, M; Kucuk, A; Tosun, M; Yaylak, F1
Dong, J; Tang, J; Yang, L; Zheng, J1
Chen, H; Liu, L; Liu, X; Wang, H; Wang, L; Wang, M1
Atasoy, P; Batislam, E; Gencay, IY; Kisa, U; Tuglu, D; Yilmaz, E; Yuvanc, E1
Meng, FM; Xue, FS; Zhang, JQ; Zhang, W1
Buyukbas, S; Cosar, M; Eser, O; Fidan, H; Mollaoglu, H; Sahin, O; Songur, A; Yaman, M1
Bektaş, S; Can, M; Erol, B; Hanci, V; Mungan, G; Ozkoçak Turan, I; Tokgöz, H; Yurtlu, S1
Akcay, F; Calik, M; Cetin, N; Gundogdu, C; Ingec, M; Isaoglu, U; Kurt, A; Polat, B; Suleyman, H; Yilmaz, M1

Reviews

1 review(s) available for dexmedetomidine and Ischemia

ArticleYear
Dexmedetomidine against intestinal ischemia/reperfusion injury: A systematic review and meta-analysis of preclinical studies.
    European journal of pharmacology, 2023, Nov-15, Volume: 959

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Inflammation; Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2023

Trials

2 trial(s) available for dexmedetomidine and Ischemia

ArticleYear
Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat.
    Life sciences, 2020, Sep-15, Volume: 257

    Topics: Acute Kidney Injury; Aged; Animals; Apoptosis; China; Dexmedetomidine; Endoplasmic Reticulum Stress; Female; Humans; Ischemia; Kidney; Male; Middle Aged; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Prospective Studies; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2020
Effects of dexmedetomidine on the function of distal organs and oxidative stress after lower limb ischaemia-reperfusion in elderly patients undergoing unilateral knee arthroplasty.
    British journal of clinical pharmacology, 2021, Volume: 87, Issue:11

    Topics: Aged; Arthroplasty, Replacement, Knee; Dexmedetomidine; Humans; Ischemia; Oxidative Stress; Reperfusion; Reperfusion Injury

2021

Other Studies

24 other study(ies) available for dexmedetomidine and Ischemia

ArticleYear
Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cognitive Dysfunction; Dexmedetomidine; Hippocampus; Inflammasomes; Ischemia; Liver; Liver Diseases; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirtuins

2020
Dexmedetomidine inhibits mitochondria damage and apoptosis of enteric glial cells in experimental intestinal ischemia/reperfusion injury via SIRT3-dependent PINK1/HDAC3/p53 pathway.
    Journal of translational medicine, 2021, 11-12, Volume: 19, Issue:1

    Topics: Animals; Apoptosis; Dexmedetomidine; Ischemia; Mitochondria; Neuroglia; Protein Kinases; Rats; Reperfusion Injury; Sirtuin 3; Tumor Suppressor Protein p53

2021
Dexmedetomidine Inhibits NF-κB-Transcriptional Activity in Neurons Undergoing Ischemia-Reperfusion by Regulating O-GlcNAcylation of SNW1.
    Journal of neuropathology and experimental neurology, 2022, 09-19, Volume: 81, Issue:10

    Topics: Animals; Dexmedetomidine; Humans; Ischemia; Neuroblastoma; Neurons; NF-kappa B; Nuclear Receptor Coactivators; Rats; Reperfusion

2022
Dexmedetomidine Ameliorated Cognitive Dysfunction Induced by Intestinal Ischemia Reperfusion in Mice with Possible Relation to the Anti-inflammatory Effect Through the Locus Coeruleus Norepinephrine System.
    Neurochemical research, 2022, Volume: 47, Issue:11

    Topics: Adrenergic Antagonists; Animals; Anti-Inflammatory Agents; Benzylamines; Cognitive Dysfunction; Dexmedetomidine; Eosine Yellowish-(YS); Hematoxylin; Ischemia; Locus Coeruleus; Malondialdehyde; Mice; Neuroprotective Agents; Neurotoxins; Norepinephrine; Reperfusion; Reperfusion Injury; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase; Yohimbine

2022
Dexmedetomidine suppresses hippocampal astrocyte pyroptosis in cerebral hypoxic-ischemic neonatal rats by upregulating microRNA-148a-3p to inactivate the STAT/JMJD3 axis.
    International immunopharmacology, 2023, Volume: 121

    Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Caspase 1; Dexmedetomidine; Glucose; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Inflammation; Ischemia; MicroRNAs; Pyroptosis; Rats

2023
DEXMEDETOMIDINE AMELIORATES ACUTE BRAIN INJURY INDUCED BY MYOCARDIAL ISCHEMIA-REPERFUSION VIA UPREGULATING THE HIF-1 PATHWAY.
    Shock (Augusta, Ga.), 2023, Nov-01, Volume: 60, Issue:5

    Topics: Animals; Brain Injuries; Coronary Artery Disease; Dexmedetomidine; Humans; Ischemia; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Reperfusion Injury; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2023
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway.
    Drug design, development and therapy, 2023, Volume: 17

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Dexmedetomidine; Inflammation; Ischemia; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Reperfusion Injury; Signal Transduction; Sirtuin 3

2023
Protective Effects of Dexmedetomidine and Oxycodone in Patients Undergoing Limb Ischemia-Reperfusion.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Nov-29, Volume: 25

    Topics: Adult; Aged; Brain-Derived Neurotrophic Factor; China; Dexmedetomidine; Endothelin-1; Fatty Acid Binding Protein 3; Female; Hemodynamics; Humans; Interleukin-6; Ischemia; Lower Extremity; Male; Malondialdehyde; Middle Aged; Oxycodone; Peripheral Vascular Diseases; Prospective Studies; Random Allocation; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2019
Ischaemic preconditioning and pharmacological preconditioning with dexmedetomidine in an equine model of small intestinal ischaemia-reperfusion.
    PloS one, 2020, Volume: 15, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Horses; Ischemia; Ischemic Preconditioning; Jejunum; Random Allocation; Reperfusion Injury

2020
Dexmedetomidine ameliorates renal ischemia reperfusion-mediated activation of the NLRP3 inflammasome in alveolar macrophages.
    Gene, 2020, Oct-20, Volume: 758

    Topics: Acute Kidney Injury; Acute Lung Injury; Adrenergic alpha-2 Receptor Agonists; AMP-Activated Protein Kinases; Animals; Cell Line; Dexmedetomidine; Enzyme-Linked Immunosorbent Assay; HMGB1 Protein; Ischemia; Macrophages, Alveolar; NADPH Oxidase 4; Nitric Oxide Synthase Type III; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA, Messenger

2020
Dexmedetomidine post-conditioning ameliorates long-term neurological outcomes after neonatal hypoxic ischemia: The role of autophagy.
    Life sciences, 2021, Apr-01, Volume: 270

    Topics: Animals; Animals, Newborn; Autophagy; Brain; Cell Death; Dexmedetomidine; Female; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Ischemia; Ischemic Postconditioning; Male; Microglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley

2021
Dexmedetomidine Attenuates Myocardial Injury Induced by Renal Ischemia/Reperfusion by Inhibiting the HMGB1-TLR4-MyD88-NF-κB Signaling Pathway.
    Annals of clinical and laboratory science, 2021, Volume: 51, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; HMGB1 Protein; Ischemia; Male; Myeloid Differentiation Factor 88; Myocardial Infarction; NF-kappa B; Rats; Rats, Wistar; Reperfusion Injury; Toll-Like Receptor 4

2021
Dexmedetomidine preconditioning plays a neuroprotective role and suppresses TLR4/NF-κB pathways model of cerebral ischemia reperfusion.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 93

    Topics: Animals; Brain Ischemia; Dexmedetomidine; Infarction, Middle Cerebral Artery; Interferon-beta; Ischemia; Male; Neuroprotection; NF-kappa B; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2017
The protective effect of dexmedetomidine in a rat ex vivo lung model of ischemia-reperfusion injury.
    Acta cirurgica brasileira, 2018, Volume: 33, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Dexmedetomidine; Disease Models, Animal; Heat-Shock Proteins; Ischemia; Lung; Male; Malondialdehyde; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reference Values; Reperfusion Injury; Reproducibility of Results; Superoxide Dismutase; Time Factors; Treatment Outcome

2018
Dexmedetomidine protects liver cell line L-02 from oxygen-glucose deprivation-induced injury by down-regulation of microRNA-711.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:19

    Topics: Apoptosis; Cell Hypoxia; Cell Line; Cytokines; Cytoprotection; Dexmedetomidine; Down-Regulation; Glucose; Humans; Ischemia; Janus Kinase 1; Liver; Liver Diseases; MicroRNAs; Oxygen; p38 Mitogen-Activated Protein Kinases; Signal Transduction; STAT3 Transcription Factor

2018
Irisin Contributes to the Hepatoprotection of Dexmedetomidine during Intestinal Ischemia/Reperfusion.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Alanine Transaminase; Animals; Antibodies, Neutralizing; Aspartate Aminotransferases; Dexmedetomidine; Fibronectins; Intestines; Ischemia; Liver; Male; Malondialdehyde; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha

2019
The protective effects of dexmedetomidine on hepatic ischemia reperfusion injury.
    Bratislavske lekarske listy, 2014, Volume: 115, Issue:11

    Topics: Animals; Dexmedetomidine; Ischemia; Ischemic Preconditioning; Liver; Liver Diseases; Protective Agents; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury

2014
Dexmedetomidine alleviates rat post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia.
    Autonomic neuroscience : basic & clinical, 2015, Volume: 187

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Forelimb; Functional Laterality; G-Protein-Coupled Receptor Kinase 2; Gene Expression Regulation; Hyperalgesia; Hypnotics and Sedatives; Ischemia; Neurons; Pain Threshold; Rats; Reperfusion Injury; Statistics, Nonparametric; Superior Cervical Ganglion; Time Factors

2015
Acute hyperglycemia prevents dexmedetomidine-induced preconditioning against renal ischemia-reperfusion injury.
    Acta cirurgica brasileira, 2014, Volume: 29, Issue:12

    Topics: Acute Disease; Animals; Apoptosis; Blood Glucose; Creatinine; Dexmedetomidine; Hyperglycemia; Ischemia; Ischemic Preconditioning; Kidney; Kidney Tubules; Male; Models, Animal; Nephrectomy; Proto-Oncogene Proteins c-akt; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Urea

2014
The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury.
    Acta cirurgica brasileira, 2015, Volume: 30, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antioxidants; Dexmedetomidine; Immunohistochemistry; Ischemia; Male; Oxidative Stress; Prospective Studies; Random Allocation; Rats, Wistar; Reference Values; Reperfusion Injury; Severity of Illness Index; Spermatic Cord Torsion; Testis; Time Factors

2015
Dexmedetomidine protects against lung ischemia-reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway.
    Journal of anesthesia, 2016, Volume: 30, Issue:5

    Topics: Animals; Chromones; Dexmedetomidine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypnotics and Sedatives; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Lung Injury; Male; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Signal Transduction

2016
The influence of dexmedetomidine on ischemic rat hippocampus.
    Brain research, 2008, Jul-07, Volume: 1218

    Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Catalase; Cytokines; Dexmedetomidine; Disease Models, Animal; Hippocampus; In Situ Nick-End Labeling; Ischemia; Male; Malondialdehyde; Neurons; Nitric Oxide; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Superoxide Dismutase; Tumor Necrosis Factor-alpha

2008
Effect of dexmedetomidine on testicular torsion/detorsion damage in rats.
    Urologia internationalis, 2010, Volume: 84, Issue:1

    Topics: Animals; Antioxidants; Apoptosis; Apoptotic Protease-Activating Factor 1; Dexmedetomidine; Germ Cells; Ischemia; Male; Malondialdehyde; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Testis

2010
An investigation about the inhibition of acute ischemia/reperfusion damage by dexmedetomidine in rat ovarian tissue.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2013, Volume: 29, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Biomarkers; Dexmedetomidine; DNA Damage; Female; Glutathione; Guanine; Ischemia; Lipid Peroxidation; Malondialdehyde; Ovary; Protective Agents; Rats; Rats, Wistar; Reperfusion Injury; Yohimbine

2013