gramicidin-a has been researched along with Ischemia* in 2 studies
2 other study(ies) available for gramicidin-a and Ischemia
| Article | Year |
|---|---|
AntihypoxamiR functionalized gramicidin lipid nanoparticles rescue against ischemic memory improving cutaneous wound healing.
Peripheral vasculopathies cause severe wound hypoxia inducing the hypoxamiR miR-210. High level of miR-210, persisting in wound-edge tissue as ischemic memory, suppresses oxidative metabolism and inhibits cell proliferation necessary for healing. In wound-edge tissue of chronic wound patients, elevated miR-210 was tightly associated with inhibition of epidermal cell proliferation as evident by lowered Ki67 immunoreactivity. To inhibit miR-210 in murine ischemic wound-edge tissue, we report the formulation of antihypoxamiR functionalized gramicidin lipid nanoparticles (AFGLN). A single intradermal delivery of AFGLN encapsulating LNA-conjugated anti-hypoximiR-210 (AFGLN Topics: Animals; Anti-Bacterial Agents; Gramicidin; Humans; Ischemia; Keratinocytes; Lipids; Mice; MicroRNAs; Nanoparticles; Wound Healing | 2016 |
Design of liposome-based pH sensitive nanoSPIN probes: nano-sized particles with incorporated nitroxides.
Liposome-based nanoSized Particles with Incorporated Nitroxides, or nanoSPINs, were designed for EPR applications as pH probes in biological systems. Phospholipid membrane of the liposomes with incorporated gramicidin A showed selective permeability to a small analyte, H(+), while protecting entrapped sensing nitroxide from biological reductants. An application of the pH-sensitive nanoSPIN in an ischemia model in rat heart homogenate allows for monitoring ischemia-induced acidosis while protecting encapsulated nitroxide against bioreduction. Topics: Acidosis; Animals; Electrochemical Techniques; Electron Spin Resonance Spectroscopy; Gramicidin; Hydrogen-Ion Concentration; Ischemia; Liposomes; Molecular Structure; Myocardium; Nanoparticles; Nitrogen Oxides; Oxygen Consumption; Rats; Rats, Sprague-Dawley | 2009 |