ketanserin has been researched along with Ischemia in 17 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of a 2% ointment formulation of ketanserin, an S2-serotoninergic blocking agent, was investigated in a randomized double-blind clinical trial for its effect on the healing of wounds of patients with decubitus, venous, and ischemic skin ulcers." | 9.06 | Use of topical ketanserin in the treatment of skin ulcers: a double-blind study. ( Cauwenbergh, G; De Beule, K; De Doncker, P; Janssen, H; Janssen, PA; Lapière, CM; Lewi, P; Tytgat, HF, 1989) |
| "Biliary fibrosis is a major complication after donation after cardiac death (DCD) liver transplantation." | 5.40 | Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. ( Chen, G; Chen, L; Fan, W; Guo, Y; Liu, L; Qian, Y; Shi, B; Xiao, L, 2014) |
| "The use of a 2% ointment formulation of ketanserin, an S2-serotoninergic blocking agent, was investigated in a randomized double-blind clinical trial for its effect on the healing of wounds of patients with decubitus, venous, and ischemic skin ulcers." | 5.06 | Use of topical ketanserin in the treatment of skin ulcers: a double-blind study. ( Cauwenbergh, G; De Beule, K; De Doncker, P; Janssen, H; Janssen, PA; Lapière, CM; Lewi, P; Tytgat, HF, 1989) |
| "The influence of ketanserin, a S2-serotonergic receptor blocker, on the impaired renal hemodynamics in a clamp model of renal ischemia in rats was investigated in this study." | 3.69 | Beneficial influence of ketanserin on autoregulation of blood flow in post-ischemic kidneys. ( de Ridder, L; Lameire, N; Smöllich, B; van de Voorde, J; Verbeke, M, 1996) |
| "Biliary fibrosis is a major complication after donation after cardiac death (DCD) liver transplantation." | 1.40 | Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. ( Chen, G; Chen, L; Fan, W; Guo, Y; Liu, L; Qian, Y; Shi, B; Xiao, L, 2014) |
| "Ketanserin treatment started 30 min after flap surgery also significantly (P less than 0." | 1.28 | Augmentation of acute random pattern skin flap viability in the pig. ( Forrest, CR; Morris, SF; Pang, CY; Sheffield, WD; Zhong, A, 1992) |
| "Ketanserin was administered as a bolus of 10 mg intravenously, followed by an infusion over 72 h and then oral therapy." | 1.28 | Ketanserin: an effective treatment regimen for digital ischaemia in systemic sclerosis. ( Gould, S; Gush, R; Jayson, MI; Kay, EA; Klimiuk, PS; Mitchell, WS; Taylor, L, 1989) |
| "Ketanserin, given orally has been shown to improve blood filterability in patients with myocardial infarction and intermittent claudication." | 1.27 | Serotonin and haemorrheology. ( Dormandy, JA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishijima, CM | 1 |
| Ganev, EG | 1 |
| Mazzardo-Martins, L | 1 |
| Martins, DF | 1 |
| Rocha, LR | 1 |
| Santos, AR | 1 |
| Hiruma-Lima, CA | 1 |
| Chen, L | 1 |
| Chen, G | 1 |
| Guo, Y | 1 |
| Liu, L | 1 |
| Xiao, L | 1 |
| Fan, W | 1 |
| Shi, B | 1 |
| Qian, Y | 1 |
| Toppin, VA | 1 |
| Harris, MB | 1 |
| Kober, AM | 1 |
| Leiter, JC | 1 |
| St-John, WM | 1 |
| Pang, CY | 2 |
| Chiu, C | 1 |
| Zhong, A | 2 |
| Xu, N | 1 |
| Quero Jiménez, MC | 1 |
| Burgueros Valero, M | 1 |
| González Dieguez, C | 1 |
| Domínguez Pérez, F | 1 |
| Pinto Corraliza, J | 1 |
| Rodríguez Fernández, M | 1 |
| Verbeke, M | 1 |
| Smöllich, B | 1 |
| van de Voorde, J | 1 |
| de Ridder, L | 1 |
| Lameire, N | 1 |
| Sachithanandan, A | 1 |
| Cuthbert, RJ | 1 |
| Barros d'Sa, AA | 1 |
| Sheffield, WD | 1 |
| Morris, SF | 1 |
| Forrest, CR | 1 |
| Walker, RT | 1 |
| Matrai, A | 1 |
| Bogar, L | 1 |
| Dormandy, JA | 2 |
| Janssen, PA | 1 |
| Janssen, H | 1 |
| Cauwenbergh, G | 1 |
| De Doncker, P | 1 |
| De Beule, K | 1 |
| Lewi, P | 1 |
| Tytgat, HF | 1 |
| Lapière, CM | 1 |
| Regenthal, R | 1 |
| Voigt, H | 1 |
| Klimiuk, PS | 1 |
| Kay, EA | 1 |
| Mitchell, WS | 1 |
| Taylor, L | 1 |
| Gush, R | 1 |
| Gould, S | 1 |
| Jayson, MI | 1 |
| Boas, RA | 1 |
| Haugan, A | 1 |
| Kirkebø, A | 1 |
| Gerová, Z | 1 |
| Brimichová, E | 1 |
| Dzúrik, R | 1 |
| Broulíková, A | 1 |
| Linhart, J | 1 |
2 reviews available for ketanserin and Ischemia
| Article | Year |
|---|---|
[Management of pulmonary circulation alterations].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Ca | 1993 |
[The clinical significance of serotonin antagonists].
Topics: Arteriosclerosis Obliterans; Humans; Hypertension; Ischemia; Ketanserin; Leg; Serotonin Antagonists | 1989 |
4 trials available for ketanserin and Ischemia
| Article | Year |
|---|---|
Serotonin and the flow properties of blood.
Topics: Blood Flow Velocity; Blood Viscosity; Hemoglobins; Humans; Ischemia; Ketanserin; Leg; Piperidines; R | 1985 |
Use of topical ketanserin in the treatment of skin ulcers: a double-blind study.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Isch | 1989 |
Intra arterial ketanserin in peripheral vascular disease.
Topics: Aged; Clinical Trials as Topic; Female; Humans; Injections, Intra-Arterial; Ischemia; Ketanserin; Le | 1986 |
[Ketanserin in ischemic disease of the lower extremities. Results of a double-blind cross-over study].
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ischemia; Ketanserin; Leg | 1987 |
11 other studies available for ketanserin and Ischemia
| Article | Year |
|---|---|
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Aci | 2014 |
Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats.
Topics: Animals; Biliary Tract Diseases; Cells, Cultured; Drug Evaluation, Preclinical; Fibroblasts; Fibrosi | 2014 |
Persistence of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Decerebrate State; Disease Models, Animal; Dose-Res | 2007 |
Pharmacologic intervention of skin vasospasm and ischemic necrosis in pigs.
Topics: Adrenergic alpha-Antagonists; Animals; Arginine; Dose-Response Relationship, Drug; Ergolines; In Vit | 1993 |
Beneficial influence of ketanserin on autoregulation of blood flow in post-ischemic kidneys.
Topics: Animals; Glomerular Filtration Rate; Homeostasis; Ischemia; Ketanserin; Kidney; Male; Muscle, Smooth | 1996 |
Interferon induced severe digital ischaemia in chronic myeloid leukaemia--successful treatment using ketanserin.
Topics: Adult; Antineoplastic Agents; Female; Fingers; Humans; Interferons; Ischemia; Ketanserin; Leukemia, | 2001 |
Augmentation of acute random pattern skin flap viability in the pig.
Topics: Animals; Dose-Response Relationship, Drug; Ergolines; Graft Survival; Ischemia; Ketanserin; Regional | 1992 |
Ketanserin: an effective treatment regimen for digital ischaemia in systemic sclerosis.
Topics: Administration, Oral; Adult; Aged; Female; Fingers; Humans; Infusions, Intravenous; Ischemia; Ketans | 1989 |
Local renal ischemia during burn shock in rat effected by thromboxane A2 and serotonin.
Topics: Animals; Blood Pressure; Burns; Indomethacin; Ischemia; Ketanserin; Kidney Cortex; Male; Phentolamin | 1986 |
[Ketanserin in the treatment of ischemic disease of the lower extremities].
Topics: Female; Humans; Ischemia; Ketanserin; Leg; Male; Middle Aged; Piperidines; Regional Blood Flow; Sero | 1985 |
Serotonin and haemorrheology.
Topics: Blood Viscosity; Capillary Permeability; Erythrocyte Deformability; Humans; Ischemia; Ketanserin; Le | 1987 |