An ectonucleoside triphosphate diphosphohydrolase 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49961]
NTPDase 1;
EC 3.6.1.5;
Ecto-ATP diphosphohydrolase 1;
Ecto-ATPDase 1;
Ecto-ATPase 1;
Ecto-apyrase;
Lymphoid cell activation antigen
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| arl-67156 | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
This protein enables 14 target(s):
| Target | Category | Definition |
|---|---|---|
| GTPase activity | molecular function | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. [PMID:26832457, PMID:27218782] |
| apyrase activity | molecular function | Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs). [EC:3.6.1.5] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| ATP hydrolysis activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065] |
| nucleoside diphosphate phosphatase activity | molecular function | Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. [EC:3.6.1.6] |
| ribonucleoside triphosphate phosphatase activity | molecular function | Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. [RHEA:23680] |
| CDP phosphatase activity | molecular function | Catalysis of the reaction: CDP + H2O = CMP + phosphate. [GOC:al, RHEA:64880] |
| ADP phosphatase activity | molecular function | Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+. [PMID:1470606, RHEA:61436] |
| CTPase activity | molecular function | Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction. [RHEA:29387] |
| ITPase activity | molecular function | Catalysis of the reaction: ITP + H2O = IDP + H+ + phosphate. [GOC:pz, PMID:16216582, RHEA:28330] |
| IDP phosphatase activity | molecular function | Catalysis of the reaction: IDP + H2O = IMP + H+ + phosphate. [PMID:20385596, PMID:22849572, RHEA:35207] |
| UDP phosphatase activity | molecular function | Catalysis of the reaction: UDP + H2O = UMP + phosphate. [RHEA:64876] |
| GDP phosphatase activity | molecular function | Catalysis of the reaction: GDP + H2O = GMP + phosphate. [PMID:2989286, RHEA:22156] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| caveola | cellular component | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. [GOC:mah, ISBN:0721662544, PMID:16645198] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
| blood coagulation | biological process | The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128] |
| platelet aggregation | biological process | The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk] |
| nucleoside diphosphate catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. [GOC:go_curators, ISBN:0198506732] |