hexamethonium has been researched along with Ischemia in 5 studies
Hexamethonium: A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In contrast to selective anoxia (Po2 < 5 mmHg) or glucose withdrawal, respectively, anoxia in combination with glucose withdrawal (5-40 min) markedly potentiated nicotine-induced NE release both in guinea-pig heart and human atrium." | 1.29 | Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: modulation by single components of ischaemia. ( Gerber, S; Haass, M; Haunstetter, A; Kaufmann, A; Krüger, C; Kübler, W; Serf, C, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, W | 1 |
| Kirkup, AJ | 1 |
| Grundy, D | 1 |
| McLAUGHLIN, CR | 1 |
| WATSON, J | 1 |
| Krüger, C | 1 |
| Haunstetter, A | 1 |
| Gerber, S | 1 |
| Serf, C | 1 |
| Kaufmann, A | 1 |
| Kübler, W | 1 |
| Haass, M | 1 |
| Gho, BC | 1 |
| Schoemaker, RG | 1 |
| van den Doel, MA | 1 |
| Duncker, DJ | 2 |
| Verdouw, PD | 2 |
| Liem, DA | 1 |
| Ploeg, H | 1 |
| Kazim, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cardiopulmonary Protection of Modified Remote Ischaemic Preconditioning in Mitral Valve Replacement Surgery[NCT03010839] | 86 participants (Actual) | Interventional | 2016-11-05 | Completed | |||
| Effect of Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery[NCT03016182] | 60 participants (Anticipated) | Interventional | 2017-02-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for hexamethonium and Ischemia
| Article | Year |
|---|---|
Mast cells drive mesenteric afferent signalling during acute intestinal ischaemia.
Topics: Animals; Calcium Channels, L-Type; Gastrointestinal Motility; Hexamethonium; Intestines; Ischemia; M | 2011 |
Operative aspects of postural ischaemia with hexamethonium bromide.
Topics: Bis-Trimethylammonium Compounds; Hexamethonium; Ischemia; Plastic Surgery Procedures; Surgery, Plast | 1951 |
Nicotine-induced exocytotic norepinephrine release in guinea-pig heart, human atrium and bovine adrenal chromaffin cells: modulation by single components of ischaemia.
Topics: Adrenal Medulla; Animals; Calcium; Cattle; Cyanides; Dose-Response Relationship, Drug; Exocytosis; F | 1995 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Myocardial protection by brief ischemia in noncardiac tissue.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Vessels; Ganglia, Autonomic; Heart; H | 1996 |
Sites of action of adenosine in interorgan preconditioning of the heart.
Topics: Adenosine; Animals; Blood Pressure; Coronary Vessels; Ganglionic Blockers; Heart Rate; Hexamethonium | 2002 |