Page last updated: 2024-10-25

diazepam and Ischemia

diazepam has been researched along with Ischemia in 16 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
" Additionally, different factors such as temperature, diazepam and ischemia affecting perception thresholds were evaluated."9.08Influence of sympathetic activity, temperature, ischemia and diazepam on thermal and vibration thresholds. ( Denislic, M; Meh, D, 1996)
"The progressive course of hepatic encephalopathy developing in rats after massive hepatic ischemia due to hepatic artery ligation within 48 hr of a portacaval shunt was not altered by the injection of a benzodiazepine antagonist, CGS 8216, in a dose that was sufficient to reverse diazepam-induced coma quickly."7.67A benzodiazepine antagonist does not alter the course of hepatic encephalopathy or neural gamma-aminobutyric acid (GABA) binding. ( Ebner, J; Ferenci, P; Rzepczynski, D; Zieve, L; Zimmermann, C, 1987)
"The progressive course of hepatic encephalopathy developing in rats after massive hepatic ischemia due to hepatic artery ligation within 48 hr of a portacaval shunt was not altered by the injection of a benzodiazepine antagonist, CGS 8216, in a dose that was sufficient to reverse diazepam-induced coma quickly."3.67A benzodiazepine antagonist does not alter the course of hepatic encephalopathy or neural gamma-aminobutyric acid (GABA) binding. ( Ebner, J; Ferenci, P; Rzepczynski, D; Zieve, L; Zimmermann, C, 1987)
"Mannitol flux was greater in ischemic tissues than in reperfused tissues."1.37In vitro and in vivo responses of mucosa from the large colon of horses to ischemia and reperfusion. ( Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Polyak, MM, 2011)
"Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49 degrees C water, after the release of the tourniquet."1.29Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines. ( Cartmell, SM; Mitchell, D, 1993)
"Pressure sore are caused by multiple mechanisms."1.26Pressure ulcerations. ( Elliott, TM, 1982)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19909 (56.25)18.7374
1990's4 (25.00)18.2507
2000's0 (0.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cappelli, A1
Anzini, M1
Castriconi, F1
Grisci, G1
Paolino, M1
Braile, C1
Valenti, S1
Giuliani, G1
Vomero, S1
Di Capua, A1
Betti, L1
Giannaccini, G1
Lucacchini, A1
Ghelardini, C1
Di Cesare Mannelli, L1
Frosini, M1
Ricci, L1
Giorgi, G1
Mascia, MP1
Biggio, G1
Hohenstein, C1
Herdtle, S1
Hoyme, M1
Lauten, A1
Chaudhary, T1
Graham, AS1
Grosche, A1
Morton, AJ1
Polyak, MM1
Freeman, DE1
Elliott, TM1
Rees, M1
Dormandy, J1
Cartmell, SM2
Mitchell, D2
Meh, D1
Denislic, M1
Evans, BM1
De Gasperis, A1
Cosimati, F1
Lorenzetti, A1
Rossini, P1
Zieve, L1
Ferenci, P1
Rzepczynski, D1
Ebner, J1
Zimmermann, C1
Maxwell, DR2
Read, MA2
Sumpter, EA1
Djindjin, R1
Mamo, H1
Saimot, G1
Houdart, R1
Webster, GV1
VĂ­tovec, J1

Trials

1 trial available for diazepam and Ischemia

ArticleYear
Influence of sympathetic activity, temperature, ischemia and diazepam on thermal and vibration thresholds.
    Pflugers Archiv : European journal of physiology, 1996, Volume: 431, Issue:6 Suppl 2

    Topics: Auditory Threshold; Diazepam; GABA Modulators; Humans; Ischemia; Pain Measurement; Pain Threshold; S

1996

Other Studies

15 other studies available for diazepam and Ischemia

ArticleYear
Design, Synthesis, and Biological Evaluation of Imidazo[1,5-a]quinoline as Highly Potent Ligands of Central Benzodiazepine Receptors.
    Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

    Topics: Amnesia; Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Catt

2016
Rescue of the limb after accidental injection of diazepam into femoral artery.
    The American journal of emergency medicine, 2014, Volume: 32, Issue:9

    Topics: Adult; Diazepam; Femoral Artery; Humans; Hypnotics and Sedatives; Injections, Intra-Arterial; Ischem

2014
In vitro and in vivo responses of mucosa from the large colon of horses to ischemia and reperfusion.
    American journal of veterinary research, 2011, Volume: 72, Issue:7

    Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Colon; Diazepam; Electric Impedance; Horse

2011
Pressure ulcerations.
    American family physician, 1982, Volume: 25, Issue:2

    Topics: Blood Proteins; Contracture; Debridement; Diazepam; Humans; Hygiene; Ischemia; Patient Care Team; Pa

1982
Accidental intra-arterial injection of diazepam.
    British medical journal, 1980, Jul-26, Volume: 281, Issue:6235

    Topics: Aged; Diazepam; Female; Gangrene; Humans; Injections, Intra-Arterial; Ischemia; Male; Middle Aged; T

1980
Diazepam attenuates hyperexcitability and mechanical hypersensitivity of dorsal horn convergent neurones during reperfusion of the rat's tail following ischaemia.
    Brain research, 1994, Oct-03, Volume: 659, Issue:1-2

    Topics: Animals; Diazepam; Electrophysiology; Flumazenil; Ischemia; Male; Naloxone; Neurons; Physical Stimul

1994
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-R

1993
Cyclic EEG changes in subacute spongiform and anoxic encephalopathy.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:6

    Topics: Acoustic Stimulation; Aged; Arousal; Brain; Brain Diseases; Cerebellum; Cerebral Cortex; Corpus Stri

1975
[Stellate ganglion block in the treatment of ischemic syndrome in an upper limb due to accidental intra-arterial injection of pharmacologic substances or narcotics].
    Minerva anestesiologica, 1990, Volume: 56, Issue:12

    Topics: Arm; Autonomic Nerve Block; Diazepam; Heroin; Humans; Injections, Intra-Arterial; Ischemia; Regional

1990
A benzodiazepine antagonist does not alter the course of hepatic encephalopathy or neural gamma-aminobutyric acid (GABA) binding.
    Metabolic brain disease, 1987, Volume: 2, Issue:3

    Topics: Animals; Benzodiazepines; Brain; Diazepam; gamma-Aminobutyric Acid; Hepatic Artery; Hepatic Encephal

1987
Pharmacology of M & B 18,706, a drug which selectively reduces decerebrate rigidity.
    British journal of pharmacology, 1974, Volume: 50, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Cats; Cerebellar Ataxia; Cerebellum; Chlorpromaz

1974
[Paroxysmal tetaniform contractures during selective arteriography of the Adamkiewicz's artery].
    La Presse medicale, 1969, Sep-20, Volume: 77, Issue:38

    Topics: Abdominal Muscles; Angiography; Aortography; Contracture; Diazepam; Hemangioma; Humans; Interneurons

1969
The ischemic face-lift.
    Plastic and reconstructive surgery, 1972, Volume: 50, Issue:6

    Topics: Anesthesia, Local; Diazepam; Eyelids; Face; Female; Hemorrhage; Humans; Ischemia; Methods; Postopera

1972
The effects of some drugs on the rigidity of the cat due to ischaemic or intercollicular decerebration.
    Neuropharmacology, 1972, Volume: 11, Issue:6

    Topics: Acepromazine; Animals; Carisoprodol; Cats; Cerebrovascular Circulation; Chlorpromazine; Decerebrate

1972
[Premedication by diazepam during angiographic examinations (author's transl)].
    Ceskoslovenska radiologie, 1974, Volume: 28, Issue:3

    Topics: Adult; Aged; Angiography; Diazepam; Humans; Injections, Intravenous; Ischemia; Leg; Male; Middle Age

1974