Page last updated: 2024-12-11

11-dehydro-2,3-dinor-thromboxane b2

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

**11-dehydro-2,3-dinor-thromboxane B2 (11-dehydro-2,3-dinor-TXB2)** is a metabolite of thromboxane A2 (TXA2), a potent vasoconstrictor and platelet aggregator.

**Structure and Formation:**

* 11-dehydro-2,3-dinor-TXB2 is formed by the enzymatic breakdown of TXA2 through a series of steps.
* It differs from TXB2, the primary metabolite of TXA2, by the removal of two carbon atoms from the carboxyl end of the molecule (dinor) and the presence of a double bond at position 11 (dehydro).

**Importance for Research:**

11-dehydro-2,3-dinor-TXB2 is an important marker for the production of TXA2 in various research settings, including:

* **Cardiovascular Disease:** Elevated levels of 11-dehydro-2,3-dinor-TXB2 in blood or urine have been associated with an increased risk of cardiovascular events, such as heart attack and stroke.
* **Thrombosis:** TXA2 plays a crucial role in platelet aggregation and thrombus formation. Measuring 11-dehydro-2,3-dinor-TXB2 can provide insights into the activity of the TXA2 pathway and its involvement in thrombosis.
* **Inflammation:** TXA2 is also involved in inflammatory processes. 11-dehydro-2,3-dinor-TXB2 can serve as a marker for inflammation in various tissues and conditions.
* **Drug Development:** The measurement of 11-dehydro-2,3-dinor-TXB2 is used to assess the effectiveness of drugs that target the TXA2 pathway, such as antiplatelet agents.

**Advantages over TXB2:**

* 11-dehydro-2,3-dinor-TXB2 has a longer half-life than TXB2, making it a more stable and reliable marker of TXA2 production.
* It is less likely to be affected by other metabolites or factors that can interfere with TXB2 measurements.

**Measurement Methods:**

11-dehydro-2,3-dinor-TXB2 can be measured using various techniques, including:

* Gas chromatography-mass spectrometry (GC-MS)
* Liquid chromatography-mass spectrometry (LC-MS)
* Enzyme-linked immunosorbent assay (ELISA)

**Conclusion:**

11-dehydro-2,3-dinor-TXB2 is a valuable biomarker for research related to cardiovascular disease, thrombosis, inflammation, and drug development. Its stable nature and accurate measurement make it a reliable indicator of TXA2 production in various biological samples.

Cross-References

ID SourceID
PubMed CID6443676
MeSH IDM0218519

Synonyms (3)

Synonym
148682-73-9
3-pentenoic acid, 5-(tetrahydro-4-hydroxy-2-(3-hydroxy-1-octenyl)-2h-pyran-3-yl)-, (2r-(2alpha(1e,3s*),3beta(z),4beta))-
11-dehydro-2,3-dinor-thromboxane b2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (20.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]