trandolapril and Ischemia

The paper describes a case of suicidal poisoning with a combined hypotensive drug.. A 46-year old man ingested, with a suicidal intent, a 0.5 l of vodka and around 20 tabl. of Tarka contains 180 mg of verapamil and 2 mg of trandolapril in 1 tablet. Despite intensive supportive treatment no reperfusion was achieved, and it was necessary to amputate both legs below knees.. Acute overdoses of Tarka may be severe in spite of relatively small amounts of drug ingested by patients (from 5 to 20 tablets). In light of reports of severe ischemic complications, which seem to have thrombotic etiology, it seems advisable to employ prophylaxis with anticoagulants, especially in patients with resistant hypotension. Ischemic complications, which may result in amputation, may present long time after hemodynamic stabilization is achieved.

Topics: Amputation, Surgical; Drug Combinations; Drug Overdose; Ethanol; Humans; Indoles; Ischemia; Leg; Male; Middle Aged; Suicide, Attempted; Verapamil