oxalates and Ischemia

Topics: Aged; Beverages; Female; Fingers; Humans; Ischemia; Necrosis; Oxalates; Plant Extracts; Plant Preparations; Taraxacum

To examine the possible effects of hyperoxalaemia on anaerobic metabolism and erythrocyte pyruvate kinase activity, we induced a rise in plasma oxalate in 11 dialysis patients by the oral administration of ascorbic acid, 500 mg day-1 for 3 weeks. Blood samples were taken from the same antecubital vein before and after the supplementation period, without venous stasis, after an overnight fast. This protocol allowed patients to be used as their own controls. Five healthy subjects underwent an identical protocol to exclude any effect of ascorbate per se. Mean (SEM) plasma oxalate (mumol l-1) rose from 30.3 (3.5) to 48.4 (6.1) in patients and from 1.4 (0.2) to 6.8 (0.9) in healthy subjects. Whole blood ascorbate (mg l-1) rose from 7.0 (0.7) to 26.6 (2.5) in patients and from 9.3 (1.2) to 17.8 (1.8) in healthy subjects (reference range 7.5-20.0 mg l-1). No changes were observed in either group in plasma creatinine, bicarbonate, haemoglobin, or erythrocyte 2,3,diphosphoglycerate (2,3 DPG) after the 3 week supplementation period. Before supplementation lactate generation (area under curve, mmol min l-1) in the 5 min following a 60 s period of standardized ischaemic forearm exercise was significantly (P = 0.026) greater in patients [69.1 (4.7)] than in healthy subjects [46.9 (6.7)]; no significant change in lactate generation occurred in either group after ascorbate-induced hyperoxalaemia. We conclude that changes in plasma oxalate of the order of 20 mumol l-1 have no significant effect on lactate generation or 2,3,DPG levels in uraemic subjects.

Topics: 2,3-Diphosphoglycerate; Adult; Ascorbic Acid; Diphosphoglyceric Acids; Erythrocytes; Forearm; Humans; Ischemia; Lactates; Lactic Acid; Male; Middle Aged; Oxalates; Oxalic Acid; Peritoneal Dialysis, Continuous Ambulatory; Physical Exertion; Renal Dialysis; Uremia

The present status of regular dialysis and renal transplantation in patients with end-stage renal disease secondary to primary hyperoxaluria is reported. Clinical studies include one personal case with an 18-month period of follow-up and data concerning thirteen patients treated in 10 centres in Europe which have been collected through a cooperative survey carried out with the assistance of Registry of the EDTA. On January 1 st, 1974, mean survival of patients with oxalosis treated by RDT was 30.4 months (range 6 to 102 months). Five cadaveric renal transplants have been performed in four patients; two patients are surviving with grafts functioning for 18 and 45 months. Dialysis and/or transplantation should be performed in patients with oxalosis early enough to prevent ischaemic, cardiac and neuromusclar complications which occur at the end-stage of the disease. Evidence for blood coagulation disorders, particularly chronic consumption coagulopathy, should be investigated for with adequate laboratory methods and long-term heparin therapy instituted if necessary. No convincing reports concerning the efficiency of the various drugs which have been tried out to reduce the biosynthesis of oxalic acid in patients with oxalosis have been issued to this date.

Topics: Acute Kidney Injury; Adolescent; Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Disseminated Intravascular Coagulation; Extremities; Female; Humans; Ischemia; Kidney Calculi; Kidney Transplantation; Male; Metabolic Diseases; Middle Aged; Neuromuscular Diseases; Oxalates; Renal Dialysis

Topics: Adult; Bloodletting; Calcium; Creatinine; Female; Humans; Hypothermia, Induced; Ischemia; Kidney; Kidney Calculi; Kidney Pelvis; Male; Methods; Middle Aged; Oxalates; Perfusion; Phosphates; Quaternary Ammonium Compounds; Radiography; Renal Artery; Renal Veins; Suture Techniques; Temperature; Urea; Urine

Topics: Arm; Arteries; Autopsy; Calcinosis; Child; Female; Gangrene; Humans; Ischemia; Kidney; Kidney Tubules; Leg; Metabolic Diseases; Microscopy, Polarization; Oxalates; Radiography; Uremia

Topics: Amides; Animals; Diet; Female; Ischemia; Kidney; Kidney Calculi; Ligation; Male; Microscopy, Electron, Scanning; Nephrocalcinosis; Oxalates; Rabbits; Renal Artery; Renal Veins

Topics: Amides; Animals; Diet; Female; Humans; Ischemia; Kidney; Kidney Diseases; Magnesium; Male; Oxalates; Rabbits; Time Factors; Urinary Calculi

Topics: Acute Kidney Injury; Albumins; Animals; Carbon Monoxide; Cattle; Chromates; Hemoglobins; Hemoglobinuria; Humans; Ischemia; Mercury; Organomercury Compounds; Oxalates; Potassium; Rabbits; Renal Artery Obstruction; Tartrates