Page last updated: 2024-10-28

ibuprofen and Ischemia

ibuprofen has been researched along with Ischemia in 22 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"Intravenous ibuprofen or lornoxicam administrations during ischemia reperfusion period in rats have no negative effect on erythrocyte deformability."7.83Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury. ( Alkan, M; Arpaci, H; Arslan, M; Aydin, ME; Comu, FM; Kartal, S; Koc, DS; Kosem, B; Kucuk, A; Ozer, A; Sivgin, V; Turgut, HC, 2016)
"This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning."7.71Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs. ( Chen, H; Lin, Z; Ma, W; Ning, G; Tan, Q; Wang, L; Zhou, X, 2002)
" The aim of this study was to determine the effects of cyclosporin A (CsA) and ibuprofen (IBU) on ischemia-reperfusion injury."7.70Effects of cyclosporin A and ibuprofen on liver ischemia-reperfusion injury in the rat. ( Cetinkale, O; Konukoglu, D; Taşci, I, 1998)
"This study evaluates the effects of Indomethacin (IND), Prostaglandin E1 (PGE1), and Ibuprofen (IBP) in a bowel ischemia model."7.66Comparative effects of indomethacin, prostaglandin E1, and ibuprofen on bowel ischemia. ( Cikrit, D; Grosfeld, JL; Gross, K; Kamman, K; Katz, S; Ross, D; Weber, TR; Wolfe, M, 1983)
"Ischemia was induced by 4-h occlusion of the left iliac artery followed by 4-h reperfusion."5.28Effect of cloricromene during ischemia and reperfusion of rabbit hindlimb: evidence for an involvement of leukocytes in reperfusion-mediated tissue and vascular injury. ( Aliev, G; Cirillo, R; Prosdocimi, M; Salvatico, E, 1992)
"1 Twenty-four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo."5.05Response of pathological ischaemic muscle pain to analgesics. ( Battistini, C; Lampugnani, R; Mandelli, V; Sacchetti, G, 1980)
"Intravenous ibuprofen or lornoxicam administrations during ischemia reperfusion period in rats have no negative effect on erythrocyte deformability."3.83Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury. ( Alkan, M; Arpaci, H; Arslan, M; Aydin, ME; Comu, FM; Kartal, S; Koc, DS; Kosem, B; Kucuk, A; Ozer, A; Sivgin, V; Turgut, HC, 2016)
"This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning."3.71Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs. ( Chen, H; Lin, Z; Ma, W; Ning, G; Tan, Q; Wang, L; Zhou, X, 2002)
" The aim of this study was to determine the effects of cyclosporin A (CsA) and ibuprofen (IBU) on ischemia-reperfusion injury."3.70Effects of cyclosporin A and ibuprofen on liver ischemia-reperfusion injury in the rat. ( Cetinkale, O; Konukoglu, D; Taşci, I, 1998)
"The nonsteroidal antiinflammatory drug ibuprofen was tested as a potential agent in the pharmacological management of ischemia and reperfusion injury of swine flaps."3.69Ibuprofen treatment of ischemic musculocutaneous flaps. ( Kerrigan, CL; Lee, C, 1994)
"The present study evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 minutes of warm ischemia."3.67Pharmacologic modulation of experimental postischemic hepatic function. ( Makowka, L; Mazzaferro, V; Ontell, SJ; Ove, P; Starzl, TE; Trager, J, 1989)
"Pretreatment with the thromboxane synthase inhibitor OKY-046 but not the cyclo-oxygenase inhibitor ibuprofen protects against ischemia-induced acute tubular necrosis."3.67A high plasma prostaglandin to thromboxane ratio protects against renal ischemia. ( Anner, H; Hechtman, HB; Kaufman, RP; Kobzik, L; Shepro, D; Valeri, CR, 1987)
"Pharmacologic alteration of the no-reflow phenomenon was determined based on increased tolerance to ischemia in ibuprofen-treated free flaps."3.67Beneficial effects of ibuprofen on experimental microvascular free flaps: pharmacologic alteration of the no-reflow phenomenon. ( Douglas, B; Silverman, DG; Song, Y; Weinberg, H, 1987)
"This study evaluates the effects of Indomethacin (IND), Prostaglandin E1 (PGE1), and Ibuprofen (IBP) in a bowel ischemia model."3.66Comparative effects of indomethacin, prostaglandin E1, and ibuprofen on bowel ischemia. ( Cikrit, D; Grosfeld, JL; Gross, K; Kamman, K; Katz, S; Ross, D; Weber, TR; Wolfe, M, 1983)
"Ischemia was induced by 4-h occlusion of the left iliac artery followed by 4-h reperfusion."1.28Effect of cloricromene during ischemia and reperfusion of rabbit hindlimb: evidence for an involvement of leukocytes in reperfusion-mediated tissue and vascular injury. ( Aliev, G; Cirillo, R; Prosdocimi, M; Salvatico, E, 1992)
"Pretreatment with ibuprofen (n = 10) (12 mg/kg) or OKY 046 and ibuprofen (n = 9) inhibited TxB2 and 6-keto-PGF1 alpha synthesis, but creatinine levels and renal weight rose (p less than 0."1.27Prostacyclin and thromboxane A2 moderate postischemic renal failure. ( Alexander, F; Hechtman, HB; Kobzik, L; Lelcuk, S; Shepro, D; Valeri, CR, 1985)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199012 (54.55)18.7374
1990's6 (27.27)18.2507
2000's1 (4.55)29.6817
2010's3 (13.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sivgin, V1
Kucuk, A1
Comu, FM1
Kosem, B1
Kartal, S1
Turgut, HC1
Arpaci, H1
Aydin, ME1
Koc, DS1
Ozer, A1
Arslan, M1
Alkan, M1
Mitchell, D1
Gelgor, L1
Weber, J1
Kamerman, PR1
Faisal, A1
Dyson, KS1
Hughson, RL2
Tan, Q1
Lin, Z1
Ma, W1
Chen, H1
Wang, L1
Ning, G1
Zhou, X1
Ehrlich, HP2
Grosfeld, JL1
Kamman, K1
Gross, K1
Cikrit, D1
Ross, D1
Wolfe, M1
Katz, S1
Weber, TR1
Sacchetti, G1
Lampugnani, R1
Battistini, C1
Mandelli, V1
Romson, JL1
Bush, LR1
Haack, DW1
Lucchesi, BR1
Lee, C1
Kerrigan, CL1
Engelke, KA1
Halliwill, JR1
Proctor, DN1
Dietz, NM1
Joyner, MJ1
Konukoglu, D1
Taşci, I1
Cetinkale, O1
Naylor, HL1
Shoemaker, JK1
Brock, RW1
Cirillo, R1
Salvatico, E1
Aliev, G1
Prosdocimi, M1
Regas, FC1
Klausner, JM2
Paterson, IS2
Kobzik, L5
Rodzen, C1
Valeri, CR5
Shepro, D5
Hechtman, HB5
Goldman, G1
Ontell, SJ1
Makowka, L1
Trager, J1
Mazzaferro, V1
Ove, P1
Starzl, TE1
Hall, ED1
Wolf, DL1
Kaufman, RP2
Anner, H2
Douglas, B1
Weinberg, H1
Song, Y1
Silverman, DG1
Lelcuk, S1
Alexander, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Anti-oxidants on Clinical Outcomes and Radiological Features of Chronic Spinal Cord Injury: A Pilot Study[NCT01904591]4 participants (Actual)Interventional2013-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for ibuprofen and Ischemia

ArticleYear
Response of pathological ischaemic muscle pain to analgesics.
    British journal of clinical pharmacology, 1980, Volume: 9, Issue:2

    Topics: Aged; Analgesics; Female; Humans; Ibuprofen; Indoprofen; Ischemia; Male; Middle Aged; Muscles; Muscu

1980
Contribution of nitric oxide and prostaglandins to reactive hyperemia in human forearm.
    Journal of applied physiology (Bethesda, Md. : 1985), 1996, Volume: 81, Issue:4

    Topics: Adolescent; Adult; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Female; Fore

1996
Prostaglandin inhibition causes an increase in reactive hyperaemia after ischaemic exercise in human forearm.
    Clinical physiology (Oxford, England), 1999, Volume: 19, Issue:3

    Topics: Adult; Cyclooxygenase Inhibitors; Forearm; Humans; Hyperemia; Ibuprofen; Indomethacin; Ischemia; Mal

1999

Other Studies

19 other studies available for ibuprofen and Ischemia

ArticleYear
Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury.
    Bratislavske lekarske listy, 2016, Volume: 117, Issue:12

    Topics: Administration, Intravenous; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Erythrocyt

2016
Antihypernociceptive synergy between ibuprofen, paracetamol and codeine in rats.
    European journal of pharmacology, 2010, Sep-10, Volume: 642, Issue:1-3

    Topics: Acetaminophen; Analgesics; Animals; Codeine; Drug Combinations; Drug Synergism; Ibuprofen; Ischemia;

2010
Prolonged ischaemia impairs muscle blood flow and oxygen uptake dynamics during subsequent heavy exercise.
    The Journal of physiology, 2010, Oct-01, Volume: 588, Issue:Pt 19

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Blood Pressure; Brachial Artery; Carbon D

2010
Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs.
    Burns : journal of the International Society for Burn Injuries, 2002, Volume: 28, Issue:5

    Topics: Animals; Burns; Cyclooxygenase Inhibitors; Dermis; Disease Models, Animal; Guinea Pigs; Ibuprofen; I

2002
Anti-inflammatory drugs in the vascular response to burn injury.
    The Journal of trauma, 1984, Volume: 24, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Burns; Epoprostenol; Hydrocortisone; Ibuprofen

1984
Comparative effects of indomethacin, prostaglandin E1, and ibuprofen on bowel ischemia.
    Journal of pediatric surgery, 1983, Volume: 18, Issue:6

    Topics: Alprostadil; Animals; Ductus Arteriosus, Patent; Enterocolitis, Pseudomembranous; Ibuprofen; Indomet

1983
The beneficial effects of oral ibuprofen on coronary artery thrombosis and myocardial ischemia in the conscious dog.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:1

    Topics: Administration, Oral; Animals; Arteries; Coronary Disease; Coronary Vessels; Dogs; Drug Evaluation;

1980
Ibuprofen treatment of ischemic musculocutaneous flaps.
    Annals of plastic surgery, 1994, Volume: 32, Issue:3

    Topics: Animals; Graft Survival; Ibuprofen; Ischemia; Muscles; Reperfusion Injury; Skin; Skin Transplantatio

1994
Effects of cyclosporin A and ibuprofen on liver ischemia-reperfusion injury in the rat.
    Clinica chimica acta; international journal of clinical chemistry, 1998, Jul-06, Volume: 275, Issue:1

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases;

1998
Effect of cloricromene during ischemia and reperfusion of rabbit hindlimb: evidence for an involvement of leukocytes in reperfusion-mediated tissue and vascular injury.
    Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6

    Topics: Animals; Blood Pressure; Chromonar; Creatine Kinase; Heart Rate; Hindlimb; Ibuprofen; Ischemia; L-La

1992
Elucidating the vascular response to burns with a new rat model.
    The Journal of trauma, 1992, Volume: 32, Issue:5

    Topics: Animals; Blood Vessels; Burns; Ibuprofen; Ischemia; Male; Rats; Rats, Inbred Strains; Regional Blood

1992
Vasodilating prostaglandins attenuate ischemic renal injury only if thromboxane is inhibited.
    Annals of surgery, 1989, Volume: 209, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Kidney Injury; Animals; Creatinine; Disease Models, Animal; Drug

1989
Thromboxane A2 mediates increased pulmonary microvascular permeability following limb ischemia.
    Circulation research, 1989, Volume: 64, Issue:6

    Topics: Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Capillary Permeability; Drug Combi

1989
Pharmacologic modulation of experimental postischemic hepatic function.
    Annals of surgery, 1989, Volume: 209, Issue:2

    Topics: Animals; Bile; Disease Models, Animal; Drug Evaluation, Preclinical; Hot Temperature; Ibuprofen; Isc

1989
A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia.
    Journal of neurosurgery, 1986, Volume: 64, Issue:6

    Topics: Animals; Benzofurans; Calcium Channel Blockers; Cats; Cyclooxygenase Inhibitors; Diltiazem; Dinopros

1986
A high plasma prostaglandin to thromboxane ratio protects against renal ischemia.
    Surgery, gynecology & obstetrics, 1987, Volume: 165, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Benzofurans; Creatinine; Evaluation Studies as Topic; Ibuprof

1987
Vasodilator prostaglandins (PG) prevent renal damage after ischemia.
    Annals of surgery, 1987, Volume: 205, Issue:2

    Topics: Acute Kidney Injury; Animals; Dopamine; Ibuprofen; Ischemia; Kidney; Kidney Tubular Necrosis, Acute;

1987
Beneficial effects of ibuprofen on experimental microvascular free flaps: pharmacologic alteration of the no-reflow phenomenon.
    Plastic and reconstructive surgery, 1987, Volume: 79, Issue:3

    Topics: Animals; Female; Fluorescein; Fluoresceins; Half-Life; Hemodynamics; Ibuprofen; Ischemia; Microcircu

1987
Prostacyclin and thromboxane A2 moderate postischemic renal failure.
    Surgery, 1985, Volume: 98, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Kidney Injury; Animals; Epoprostenol; Ibuprofen; Ischemia; Male;

1985