4-phenylbutyric acid has been researched along with Ischemia in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In vivo, the induction of ER stress by ischemia-reperfusion and the impact of ER stress amelioration by a small molecule chaperon 4-phenylbutyric acid on liver immune response were studied in a murine partial liver warm ischemia model." | 3.78 | Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. ( Bai, L; Busuttil, RW; Cheng, Q; Gao, F; Kupiec-Weglinski, JW; Liu, J; Ren, F; Shen, X; Zhai, Y, 2012) |
| "Retinal ischemia is a common cause of visual impairment for humans and animals." | 1.34 | Retinal ischemic injury rescued by sodium 4-phenylbutyrate in a rat model. ( Chang, PH; Huang, YP; Jeng, YY; Lin, CT; Lin, NT; Liu, CH; Pang, VF, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Ren, F | 1 |
| Cheng, Q | 1 |
| Bai, L | 1 |
| Shen, X | 1 |
| Gao, F | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Zhai, Y | 1 |
| Jeng, YY | 1 |
| Lin, NT | 1 |
| Chang, PH | 1 |
| Huang, YP | 1 |
| Pang, VF | 1 |
| Liu, CH | 1 |
| Lin, CT | 1 |
2 other studies available for 4-phenylbutyric acid and Ischemia
| Article | Year |
|---|---|
Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury.
Topics: Animals; Endoplasmic Reticulum; Gene Expression Regulation; Hepatocytes; Immune System; Inflammation | 2012 |
Retinal ischemic injury rescued by sodium 4-phenylbutyrate in a rat model.
Topics: Animals; Cell Count; Cell Death; Dose-Response Relationship, Drug; Glaucoma; Ischemia; Male; Microsc | 2007 |