metformin has been researched along with Ischemia in 17 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (Met) has a protective effect against cardiac ischemia and reperfusion (I/R) injury." | 8.31 | Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα. ( Bai, Y; Chang, C; Guo, Z; Jiao, Y; Qi, Y; Wu, Z, 2023) |
| "One thousand sixty-four limbs in 1204 patients were identified (147 metformin, 196 other hypoglycemics [OH], 216 insulin, and 645 nondiabetics (nondiabetes mellitus [DM])." | 7.91 | Metformin Is Associated with Improved Survival and Decreased Cardiac Events with No Impact on Patency and Limb Salvage after Revascularization for Peripheral Arterial Disease. ( Cherr, GS; Dosluoglu, HH; Dryjski, ML; Harris, LM; Khan, SZ; Nader, ND; Rivero, M, 2019) |
| "Metformin promoted revascularization in the presence of tissue ischemia through an AMPK/eNOS-related mechanism." | 7.81 | Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model. ( Komori, K; Murohara, T; Ouchi, N; Shibata, R; Sugimoto, M; Takahashi, N, 2015) |
| "Metformin-associated lactic acidosis is a diagnosis by exclusion; however, a high degree of clinical suspicion supplemented by prompt multisystem organ support can significantly influence the outcome in critically ill patients." | 7.80 | Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report. ( Ncomanzi, D; Sicat, RM; Sundararajan, K, 2014) |
| "Lactic acidosis is a rare side effect of metformin." | 5.34 | [Metformin-related lactic acidosis in an 85-year-old woman]. ( Jansen, PA; Knol, W; van der Linden, CM; van Marum, RJ, 2007) |
| "In type 2 diabetic patients, the vasodilating response to forearm ischemia was the same whether patients were treated with diet treatment alone or with glibenclamide or glimepiride at blood glucose-lowering equipotent closes." | 5.09 | Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia. ( Brunelli, C; Cordera, R; Cordone, S; Olivotti, L; Rossettin, P; Schiavo, M; Spallarossa, P, 2001) |
| "Metformin (Met) has a protective effect against cardiac ischemia and reperfusion (I/R) injury." | 4.31 | Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα. ( Bai, Y; Chang, C; Guo, Z; Jiao, Y; Qi, Y; Wu, Z, 2023) |
| "One thousand sixty-four limbs in 1204 patients were identified (147 metformin, 196 other hypoglycemics [OH], 216 insulin, and 645 nondiabetics (nondiabetes mellitus [DM])." | 3.91 | Metformin Is Associated with Improved Survival and Decreased Cardiac Events with No Impact on Patency and Limb Salvage after Revascularization for Peripheral Arterial Disease. ( Cherr, GS; Dosluoglu, HH; Dryjski, ML; Harris, LM; Khan, SZ; Nader, ND; Rivero, M, 2019) |
| "Diabetic mice underwent surgical intervention to induce hind limb ischemia and were treated with simvastatin, metformin, or a combination orally for 28 days and compared to diabetic and nondiabetic mice." | 3.91 | Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia. ( Bhakoo, KK; Boominathan, R; Chan, K; Cheng, P; Goggi, JL; Haslop, A; Robins, EG; Soh, V, 2019) |
| "Metformin promoted revascularization in the presence of tissue ischemia through an AMPK/eNOS-related mechanism." | 3.81 | Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model. ( Komori, K; Murohara, T; Ouchi, N; Shibata, R; Sugimoto, M; Takahashi, N, 2015) |
| "Metformin-associated lactic acidosis is a diagnosis by exclusion; however, a high degree of clinical suspicion supplemented by prompt multisystem organ support can significantly influence the outcome in critically ill patients." | 3.80 | Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report. ( Ncomanzi, D; Sicat, RM; Sundararajan, K, 2014) |
| "Lactic acidosis is a rare side effect of metformin." | 1.34 | [Metformin-related lactic acidosis in an 85-year-old woman]. ( Jansen, PA; Knol, W; van der Linden, CM; van Marum, RJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Z | 3 |
| Wang, H | 3 |
| Zoungrana, LI | 1 |
| James, A | 1 |
| Slotabec, L | 1 |
| Didik, S | 1 |
| Fatmi, MK | 1 |
| Krause-Hauch, M | 1 |
| Lesnefsky, EJ | 1 |
| Li, J | 8 |
| Wu, Z | 1 |
| Bai, Y | 2 |
| Qi, Y | 2 |
| Chang, C | 1 |
| Jiao, Y | 1 |
| Guo, Z | 1 |
| Park, SH | 1 |
| Kang, MA | 1 |
| Moon, YJ | 1 |
| Jang, KY | 1 |
| Kim, JR | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 5 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
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| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
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| Iranzo, A | 1 |
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| Mainwaring, RD | 1 |
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| Li, X | 10 |
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2 reviews available for metformin and Ischemia
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
[Role of AMP-activated protein kinase in renal ischemic preconditioning].
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Energy Metabolism; Enzyme Activa | 2014 |
2 trials available for metformin and Ischemia
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia.
Topics: Aged; Aged, 80 and over; Blood Pressure; Brachial Artery; Diabetes Mellitus, Type 2; Diet, Diabetic; | 2001 |
14 other studies available for metformin and Ischemia
| Article | Year |
|---|---|
Administration of metformin rescues age-related vulnerability to ischemic insults through mitochondrial energy metabolism.
Topics: Animals; Calcium; Energy Metabolism; Female; Ischemia; Male; Metformin; Mice; Mice, Inbred C57BL; Mi | 2023 |
Metformin ameliorates ferroptosis in cardiac ischemia and reperfusion by reducing NOX4 expression via promoting AMPKα.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Line; Ferroptosis; Iron; Ischemia; Metformin | 2023 |
Metformin coordinates osteoblast/osteoclast differentiation associated with ischemic osteonecrosis.
Topics: Angiogenesis Inducing Agents; Angiopoietin-1; Animals; Cell Differentiation; Cell Line, Tumor; Femur | 2020 |
A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.
Topics: Animals; Hindlimb; Hyperglycemia; Hypoglycemic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Im | 2021 |
Metformin Is Associated with Improved Survival and Decreased Cardiac Events with No Impact on Patency and Limb Salvage after Revascularization for Peripheral Arterial Disease.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Chronic Disease; Comorbidity; Diabetes Mellitus; Endo | 2019 |
Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia.
Topics: Animals; Cardiovascular Agents; Diabetes Mellitus, Experimental; Hindlimb; Immunohistochemistry; Isc | 2019 |
Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Heart Arrest; Humans; Hypoglycemic Agents | 2014 |
Metformin stimulates ischemia-induced revascularization through an eNOS dependent pathway in the ischemic hindlimb mice model.
Topics: Adenylate Kinase; Angiogenesis Inducing Agents; Animals; Blood Flow Velocity; Capillaries; Disease M | 2015 |
Selective inhibition of deactivated mitochondrial complex I by biguanides.
Topics: Animals; Electron Spin Resonance Spectroscopy; Electron Transport Complex I; Enzyme Inhibitors; Hear | 2015 |
Diabetes mellitus type 2 through oncology lens.
Topics: Diabetes Complications; Diabetes Mellitus, Type 2; Disease Progression; Female; Humans; Insulin; Isc | 2011 |
Metformin-associated lactic acidosis masquerading as ischemic bowel.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus; Humans; Hypoglycemic Agents; Intestine, Large; Ischemia; | 2012 |
Acid base: back to the basics of Henderson-Hasselbalch.
Topics: Acidosis, Lactic; Humans; Hypoglycemic Agents; Intestine, Large; Ischemia; Male; Metformin | 2012 |
[Metformin-related lactic acidosis in an 85-year-old woman].
Topics: Acidosis, Lactic; Aged, 80 and over; Contraindications; Creatinine; Diabetes Mellitus, Type 2; Fatal | 2007 |
Effects of metformin on insulin resistance after injury in the rat.
Topics: Animals; Blood Glucose; Burns; Glucose; Insulin; Insulin Resistance; Ischemia; Lactates; Liver Glyco | 1976 |