Page last updated: 2024-10-25

deferoxamine and Ischemia

deferoxamine has been researched along with Ischemia in 67 studies

Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

Research Excerpts

ExcerptRelevanceReference
"Twenty-three patients with limb ischemia and referred for below the knee amputations were randomized for treatment: group 1, 7 patients received only a saline injection; group 2, 9 received intramuscular injection of fibrin and group 3, 7 received the fibrin composition with deferoxamine and added VEGF(165)."9.10Therapeutic angiogenesis for patients with limb ischemia by utilization of fibrin meshwork. Pilot randomized controlled study. ( Beridze, N; Kipiani, K; Kipshidze, N; Kipshidze, NN; Moses, J; Roubin, G; Shehzad, MZ; Tsapenko, M, 2003)
"We have previously shown that deferoxamine (DFO) infusion protected myocardium against reperfusion injury in patients undergoing open heart surgery, and reduced brain edema, intracranial pressure, and lung injury in pigs with acute hepatic ischemia (AHI)."7.78Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers renoprotection after acute hepatic ischemia in pigs. ( Arkadopoulos, N; Degiannis, D; Demonakou, M; Kaklamanis, L; Kostopanagiotou, G; Siasiakou, S; Smyrniotis, V; Vlahakos, D, 2012)
"We evaluated the activities of mitochondrial respiratory chain complexes in the brain of rats after renal ischemia and the effect of administration of the antioxidants N-acetylcysteine (NAC) and deferoxamine (DFX)."7.76Inhibition of mitochondrial respiratory chain in the brain of rats after renal ischemia is prevented by N-acetylcysteine and deferoxamine. ( Barbosa, PR; Cardoso, MR; Dal-Pizzol, F; Daufenbach, JF; Gonçalves, CL; Machado, RA; Rezin, GT; Roza, CA; Scaini, G; Schuck, PF; Streck, EL, 2010)
" Considering that creatine kinase (CK) is important for brain energy homeostasis and is inhibited by free radicals, and that oxidative stress is probably involved in the pathogenesis of uremic encephalopathy, we measured CK activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats submitted to renal ischemia and the effect of administration of antioxidants (N-acetylcysteine, NAC and deferoxamine, DFX) on this enzyme."7.74Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration. ( Burigo, M; Constantino, L; Dal-Pizzol, F; Di-Pietro, PB; Dias, ML; Machado, RA; Scaini, G; Streck, EL, 2008)
") injection of a modified fibrin meshwork plus deferoxamine was tested in a rabbit model of acute hind-limb ischemia."7.72Deferoxamine-fibrin accelerates angiogenesis in a rabbit model of peripheral ischemia. ( Akhtar, M; Baibekov, I; Bajwa, T; Chekanov, VS; Hare, J; Karakozov, P; Nikolaychik, V; Tchekanov, G; Zargarian, M, 2003)
"Pretreatment with gadolinium chloride, an inhibitor of Kupffer cell function, significantly decreased LDH and PNP efflux during reperfusion by approximately 60% and 50%, respectively."5.31Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers. ( Bailey, SM; Reinke, LA, 2000)
"Twenty-three patients with limb ischemia and referred for below the knee amputations were randomized for treatment: group 1, 7 patients received only a saline injection; group 2, 9 received intramuscular injection of fibrin and group 3, 7 received the fibrin composition with deferoxamine and added VEGF(165)."5.10Therapeutic angiogenesis for patients with limb ischemia by utilization of fibrin meshwork. Pilot randomized controlled study. ( Beridze, N; Kipiani, K; Kipshidze, N; Kipshidze, NN; Moses, J; Roubin, G; Shehzad, MZ; Tsapenko, M, 2003)
"Although the systemic administration of deferoxamine (DFO) is protective in experimental models of normal ischemic flap and diabetic wound, its effect on diabetic flap ischemia using a local injection remains unknown."3.80Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression. ( Cai, Y; Cui, L; Li, G; Wang, C; Xiong, Z; Zhang, Y, 2014)
"We have previously shown that deferoxamine (DFO) infusion protected myocardium against reperfusion injury in patients undergoing open heart surgery, and reduced brain edema, intracranial pressure, and lung injury in pigs with acute hepatic ischemia (AHI)."3.78Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers renoprotection after acute hepatic ischemia in pigs. ( Arkadopoulos, N; Degiannis, D; Demonakou, M; Kaklamanis, L; Kostopanagiotou, G; Siasiakou, S; Smyrniotis, V; Vlahakos, D, 2012)
"We evaluated the activities of mitochondrial respiratory chain complexes in the brain of rats after renal ischemia and the effect of administration of the antioxidants N-acetylcysteine (NAC) and deferoxamine (DFX)."3.76Inhibition of mitochondrial respiratory chain in the brain of rats after renal ischemia is prevented by N-acetylcysteine and deferoxamine. ( Barbosa, PR; Cardoso, MR; Dal-Pizzol, F; Daufenbach, JF; Gonçalves, CL; Machado, RA; Rezin, GT; Roza, CA; Scaini, G; Schuck, PF; Streck, EL, 2010)
" Considering that creatine kinase (CK) is important for brain energy homeostasis and is inhibited by free radicals, and that oxidative stress is probably involved in the pathogenesis of uremic encephalopathy, we measured CK activity (hippocampus, striatum, cerebellum, cerebral cortex and prefrontal cortex) in brain if rats submitted to renal ischemia and the effect of administration of antioxidants (N-acetylcysteine, NAC and deferoxamine, DFX) on this enzyme."3.74Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration. ( Burigo, M; Constantino, L; Dal-Pizzol, F; Di-Pietro, PB; Dias, ML; Machado, RA; Scaini, G; Streck, EL, 2008)
" The objective of this study was to investigate the efficacy of the iron chelator deferoxamine mesylate in preventing skeletal muscle ischemia."3.72Deferoxamine enhances neovascularization and recovery of ischemic skeletal muscle in an experimental sheep model. ( Adamian, M; Akhtar, M; Chekanov, VS; Dangas, G; Kipshidze, N; Leon, MB; Maternowski, MA; Mehran, R; Moses, J; Nikolaychik, V, 2003)
") injection of a modified fibrin meshwork plus deferoxamine was tested in a rabbit model of acute hind-limb ischemia."3.72Deferoxamine-fibrin accelerates angiogenesis in a rabbit model of peripheral ischemia. ( Akhtar, M; Baibekov, I; Bajwa, T; Chekanov, VS; Hare, J; Karakozov, P; Nikolaychik, V; Tchekanov, G; Zargarian, M, 2003)
"A previous study indicated that hydroxyl radicals are generated in the cat retina during the early reperfusion phase after 90 minutes of ischemia."3.69Protection of the transiently ischemic cat retina by zinc-desferrioxamine. ( Averbukh, E; Berenshtein, E; Kitrossky, N; Ophir, A, 1994)
" To evaluate whether iron chelation with deferoxamine interrupts this process in postischemic skeletal muscle, high-grade partial hindlimb ischemia was created in Sprague-Dawley rats by clamping the infrarenal aorta for 90 min, after which period the clamp was removed and flow was reestablished for 60 min."3.68Deferoxamine prevents lipid peroxidation and attenuates reoxygenation injury in postischemic skeletal muscle. ( Fantini, GA; Yoshioka, T, 1993)
"A series of experiments was performed to characterize the effects of tissue trauma, extracellular calcium concentration, and prior ischemia on oxidative stress, measured by the accumulation of malondialdehyde-like materials (MDA-LM) in slices of rat liver."3.68Traumatic versus postischemic induction of oxidative stress in rat liver. ( Babbs, CF; Pham, J; Salaris, SC, 1993)
" To assess the role of iron-catalyzed oxidant production in ischemia-reperfusion injury, we examined the influence of deferoxamine (an iron chelator) and apotransferrin (iron transporting protein) on the increased intestinal vascular permeability produced by 1 h of ischemia and reperfusion."3.67A role for iron in oxidant-mediated ischemic injury to intestinal microvasculature. ( Granger, DN; Grisham, MB; Hernandez, LA, 1987)
"Ischemia/reperfusion injury is a leading cause of acute renal failure triggering an inflammatory response associated with infiltrating macrophages, which determine disease outcome."1.38Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. ( Hotter, G; Hughes, J; Jung, M; Kluth, DC; Pérez-Ladaga, A; Sola, A; Viñas, JL; Vinuesa, E, 2012)
"Deferoxamine treatment prevented these effects, while the usefulness of L-arginine remained doubtful."1.31Effect of deferoxamine and L-arginine treatment on lipid peroxidation in an intestinal ischaemia-reperfusion model in rats. ( Balogh, N; Gaál, T; Krausz, F; Lévai, P; Ribiczeyné, PS; Vajdovich, P, 2002)
"Pretreatment with gadolinium chloride, an inhibitor of Kupffer cell function, significantly decreased LDH and PNP efflux during reperfusion by approximately 60% and 50%, respectively."1.31Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers. ( Bailey, SM; Reinke, LA, 2000)
" These findings were correlated with the dosage of vitamin E since the vitamin E content was greatly reduced by 46."1.29Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator. ( Defraigne, JO; Detry, O; Franssen, C; Limet, R; Meurisse, M; Pincemail, J, 1994)
"Treatment with gadolinium chloride (GdCl3) selectively reduced the capacity of Kupffer cells to generate superoxide by 65% and attenuated liver injury by 73% at 4 h and 58-69% at 24 h."1.29Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. ( Farhood, A; Fisher, MA; Jaeschke, H; Liu, P; McGuire, GM; Smith, CW, 1995)
"Free radical-mediated reperfusion injury has been demonstrated in ischemic neonatal bowel necrosis, but the mechanism of injury remains elusive."1.29Prevention of postischemic injury in immature intestine by deferoxamine. ( Cobb, LM; Lelli, JL; Pradhan, S, 1993)

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-199013 (19.40)18.7374
1990's29 (43.28)18.2507
2000's11 (16.42)29.6817
2010's11 (16.42)24.3611
2020's3 (4.48)2.80

Authors

AuthorsStudies
Xu, D1
Gan, K1
Wang, Y3
Wu, Z1
Zhang, S1
Peng, Y1
Fang, X1
Wei, H1
Zhang, Y2
Ma, W1
Chen, J1
Yu, X1
Ma, X1
Lyu, J1
Jiang, N1
Lu, Y1
Liao, Y1
Wang, K1
Yu, W1
Huang, Y1
He, N1
Kang, Q1
Shen, D1
Wang, X1
Chen, L1
Tang, LJ1
Luo, XJ1
Tu, H1
Chen, H1
Xiong, XM1
Li, NS1
Peng, J1
Jiang, X1
Malkovskiy, AV1
Tian, W1
Sung, YK1
Sun, W1
Hsu, JL1
Manickam, S1
Wagh, D1
Joubert, LM1
Semenza, GL1
Rajadas, J1
Nicolls, MR1
Saito, T1
Tabata, Y1
Wang, C1
Cai, Y1
Xiong, Z1
Li, G1
Cui, L1
Du, Z1
Zan, T1
Huang, X1
Sheng, L2
Li, H3
Li, Q2
Zhu, Y1
Zhang, L1
Gidday, JM1
Weng, R1
Yang, M1
Barbosa, PR1
Cardoso, MR1
Daufenbach, JF1
Gonçalves, CL1
Machado, RA2
Roza, CA1
Scaini, G2
Rezin, GT1
Schuck, PF1
Dal-Pizzol, F2
Streck, EL2
Ikeda, Y1
Tajima, S1
Yoshida, S1
Yamano, N1
Kihira, Y1
Ishizawa, K1
Aihara, K1
Tomita, S1
Tsuchiya, K1
Tamaki, T1
Vlahakos, D1
Arkadopoulos, N1
Kostopanagiotou, G1
Siasiakou, S1
Kaklamanis, L1
Degiannis, D1
Demonakou, M1
Smyrniotis, V1
Jung, M1
Sola, A1
Hughes, J1
Kluth, DC1
Vinuesa, E1
Viñas, JL1
Pérez-Ladaga, A1
Hotter, G1
Hastings, CL1
Kelly, HM1
Murphy, MJ1
Barry, FP1
O'Brien, FJ1
Duffy, GP1
Balogh, N1
Krausz, F1
Lévai, P1
Ribiczeyné, PS1
Vajdovich, P1
Gaál, T1
Chekanov, VS3
Nikolaychik, V3
Maternowski, MA1
Mehran, R1
Leon, MB1
Adamian, M1
Moses, J2
Dangas, G1
Kipshidze, N2
Akhtar, M2
Huang, H1
He, Z1
Roberts, LJ1
Salahudeen, AK1
Zargarian, M1
Baibekov, I1
Karakozov, P1
Tchekanov, G1
Hare, J1
Bajwa, T1
Kipiani, K1
Beridze, N1
Roubin, G1
Tsapenko, M1
Shehzad, MZ1
Kipshidze, NN1
Di-Pietro, PB1
Dias, ML1
Burigo, M1
Constantino, L1
Franssen, C4
Defraigne, JO4
Detry, O4
Pincemail, J4
Deby, C1
Lamy, M2
Lindnér, P1
Naredi, P1
Peterson, A1
Hafström, L1
Cameron, NE1
Cotter, MA1
Gonzalez-Fajardo, JA1
Fernandez, L1
Alvarez, T1
Vaquero, C1
Ozaki, M2
Fuchinoue, S2
Teraoka, S2
Ota, K2
Reuter, DG1
Tacker, WA1
Babbs, CF3
Badylak, SF1
Voorhees, WD1
Konrad, PE1
Meurisse, M3
Limet, R3
Liu, P1
McGuire, GM1
Fisher, MA1
Farhood, A1
Smith, CW1
Jaeschke, H1
Ophir, A1
Berenshtein, E1
Kitrossky, N1
Averbukh, E1
Gower, JD3
Ambrose, IJ1
Manek, S1
Bright, J1
Dobbin, PS1
Hider, RC1
Goddard, JG1
Thorniley, MS1
Green, CJ7
Fantini, GA1
Yoshioka, T1
Egri, L1
Stahl, GL2
Pan, HL1
Longhurst, JC2
Lelli, JL1
Pradhan, S1
Cobb, LM1
Salaris, SC1
Pham, J1
Ayene, IS1
al-Mehdi, AB1
Fisher, AB1
Messent, M1
Griffiths, MJ1
Quinlan, GJ1
Gutteridge, JM1
Evans, TW1
McAnulty, JF1
Huang, XQ1
Bailey, SM1
Reinke, LA1
Hung, TH1
Skepper, JN1
Burton, GJ1
Andrews, FJ1
Malcontenti, C1
O'Brien, PE1
Halliwell, B1
Kunz, R1
Schoenberg, MH1
Büchler, M1
Jost, K1
Beger, HG1
Drugas, GT1
Paidas, CN1
Yahanda, AM1
Ferguson, D1
Clemens, MG1
Baron, P1
Gomez-Marin, O1
Casas, C1
Heil, J1
Will, N1
Condie, R1
Burke, B1
Najarian, JS1
Sutherland, DE1
Lutz, J1
Augustin, A1
Friedrich, E1
Zimmerman, BJ1
Grisham, MB3
Granger, DN3
Healing, G7
Fuller, BJ5
Perler, BA1
Tohmeh, AG1
Bulkley, GB1
Simpkin, S4
Gower, J2
Green, C2
Omar, R1
Nomikos, I1
Piccorelli, G1
Savino, J1
Agarwal, N1
Dhami, L1
Prasad, S1
Shurey, C1
Hernandez, LA1
Lunec, J3
Paller, MS1
Hedlund, BE1
Fuller, B1
Smith, SM1
Manci, EA1
Kvietys, PR1
White, BC1
Krause, GS1
Aust, SD1
Eyster, GE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes[NCT03085771]Phase 230 participants (Anticipated)Interventional2017-01-01Recruiting
Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations[NCT04333550]Phase 1/Phase 250 participants (Anticipated)Interventional2020-04-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for deferoxamine and Ischemia

ArticleYear
Therapeutic angiogenesis for patients with limb ischemia by utilization of fibrin meshwork. Pilot randomized controlled study.
    International angiology : a journal of the International Union of Angiology, 2003, Volume: 22, Issue:4

    Topics: Adult; Deferoxamine; Drug Therapy, Combination; Feasibility Studies; Fibrin; Fibrinogen; Humans; Inj

2003

Other Studies

66 other studies available for deferoxamine and Ischemia

ArticleYear
A Composite Deferoxamine/Black Phosphorus Nanosheet/Gelatin Hydrogel Scaffold for Ischemic Tibial Bone Repair.
    International journal of nanomedicine, 2022, Volume: 17

    Topics: Animals; Bone Regeneration; Deferoxamine; Fracture Healing; Gelatin; Hydrogels; Ischemia; Nanostruct

2022
Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation.
    Neuroreport, 2022, 11-02, Volume: 33, Issue:16

    Topics: Animals; Brain Injuries; Child; Deferoxamine; Ferroptosis; Humans; Iron; Ischemia; Liver; Liver Tran

2022
A carbon dot-based fluorescent nanoprobe for the associated detection of iron ions and the determination of the fluctuation of ascorbic acid induced by hypoxia in cells and in vivo.
    The Analyst, 2019, Nov-21, Volume: 144, Issue:22

    Topics: Animals; Ascorbic Acid; Carbon; Cell Hypoxia; Deferoxamine; Fluorescent Dyes; Hep G2 Cells; Humans;

2019
Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:2

    Topics: Animals; Biomarkers; Coenzyme A Ligases; Creatine Kinase; Deferoxamine; Ferroptosis; Iron; Ischemia;

2021
Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles.
    Biomaterials, 2014, Volume: 35, Issue:2

    Topics: Angiogenesis Inducing Agents; Animals; Apoptosis; Chemokine CXCL12; Deferoxamine; Endothelial Cells;

2014
Hypoxia-induced angiogenesis is increased by the controlled release of deferoxiamine from gelatin hydrogels.
    Acta biomaterialia, 2014, Volume: 10, Issue:8

    Topics: Animals; Cell Hypoxia; Cells, Cultured; Deferoxamine; Delayed-Action Preparations; Endothelial Cells

2014
Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Animals; Cell Movement; Cell Survival; Deferoxamine; Diabetes Mellitus, Experimental; Dose-Response

2014
DFO enhances the targeting of CD34-positive cells and improves neovascularization.
    Cell transplantation, 2015, Volume: 24, Issue:11

    Topics: Animals; Antigens, CD34; Bone Marrow Cells; Cell Movement; Chemokine CXCL12; Chromones; Deferoxamine

2015
Deferroxamine preconditioning promotes long-lasting retinal ischemic tolerance.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2008, Volume: 24, Issue:6

    Topics: Adrenomedullin; Animals; Deferoxamine; Dose-Response Relationship, Drug; Hypoxia-Inducible Factor 1,

2008
Mimic hypoxia improves angiogenesis in ischaemic random flaps.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2010, Volume: 63, Issue:12

    Topics: Animals; Cell Survival; Cells, Cultured; Deferoxamine; Endothelial Cells; Fibroblasts; Ischemia; Mal

2010
Inhibition of mitochondrial respiratory chain in the brain of rats after renal ischemia is prevented by N-acetylcysteine and deferoxamine.
    Metabolic brain disease, 2010, Volume: 25, Issue:2

    Topics: Acetylcysteine; Animals; Cell Respiration; Deferoxamine; Disease Models, Animal; Drug Combinations;

2010
Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function.
    Atherosclerosis, 2011, Volume: 215, Issue:2

    Topics: Animals; Apoptosis; Cell Proliferation; Deferoxamine; Endothelial Cells; Endothelium, Vascular; Hind

2011
Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers renoprotection after acute hepatic ischemia in pigs.
    Artificial organs, 2012, Volume: 36, Issue:4

    Topics: Acute Disease; Acute Kidney Injury; Animals; Apoptosis; Deferoxamine; Female; Interleukin-6; Ischemi

2012
Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2.
    Kidney international, 2012, Volume: 81, Issue:10

    Topics: Acute Kidney Injury; Adoptive Transfer; Animals; Blood Urea Nitrogen; Cell Survival; Deferoxamine; D

2012
Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia.
    Journal of controlled release : official journal of the Controlled Release Society, 2012, Jul-10, Volume: 161, Issue:1

    Topics: Angiogenesis Inducing Agents; Cell Movement; Cell Proliferation; Cells, Cultured; Chitosan; Deferoxa

2012
Effect of deferoxamine and L-arginine treatment on lipid peroxidation in an intestinal ischaemia-reperfusion model in rats.
    Acta veterinaria Hungarica, 2002, Volume: 50, Issue:3

    Topics: Animals; Arginine; Deferoxamine; Disease Models, Animal; Enzyme Inhibitors; Erythrocytes; Female; Gl

2002
Deferoxamine enhances neovascularization and recovery of ischemic skeletal muscle in an experimental sheep model.
    The Annals of thoracic surgery, 2003, Volume: 75, Issue:1

    Topics: Animals; Deferoxamine; Fibrin Tissue Adhesive; Iron Chelating Agents; Ischemia; Muscle, Skeletal; Ne

2003
Deferoxamine reduces cold-ischemic renal injury in a syngeneic kidney transplant model.
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2003, Volume: 3, Issue:12

    Topics: Animals; Cold Temperature; Deferoxamine; Dose-Response Relationship, Drug; Iron Chelating Agents; Is

2003
Deferoxamine-fibrin accelerates angiogenesis in a rabbit model of peripheral ischemia.
    Vascular medicine (London, England), 2003, Volume: 8, Issue:3

    Topics: Animals; Blood Pressure; Collateral Circulation; Deferoxamine; Disease Models, Animal; Drug Therapy,

2003
Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration.
    Neuroscience letters, 2008, Mar-21, Volume: 434, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Brain; Brain Diseases, Metabolic; Creatine Kinase; Deferoxami

2008
Antioxidant defense and free radical production in a rabbit model of kidney ischemia-reperfusion.
    Transplantation proceedings, 1995, Volume: 27, Issue:5

    Topics: Animals; Antioxidants; Catalase; Deferoxamine; Electron Spin Resonance Spectroscopy; Free Radicals;

1995
Influence of hepatic artery occlusion and desferrioxamine on liver-tumour growth.
    International journal of cancer, 1995, Nov-15, Volume: 63, Issue:4

    Topics: Adenocarcinoma; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Cell Divisi

1995
Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents.
    The Journal of clinical investigation, 1995, Volume: 96, Issue:2

    Topics: Animals; Cell Hypoxia; Chelating Agents; Chelation Therapy; Deferoxamine; Diabetes Mellitus, Experim

1995
Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator.
    Annals of vascular surgery, 1995, Volume: 9, Issue:2

    Topics: Animals; Deferoxamine; Ischemia; Kidney Cortex; Microcirculation; Rabbits; Renal Circulation; Reperf

1995
The in vivo cytoprotection of ascorbic acid against ischemia/reoxygenation injury of rat liver.
    Archives of biochemistry and biophysics, 1995, Apr-20, Volume: 318, Issue:2

    Topics: Adenosine Triphosphate; Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; D

1995
Preliminary results of deferoxamine and L1 treatment of spinal cord ischemia.
    The Journal of thoracic and cardiovascular surgery, 1995, Volume: 109, Issue:5

    Topics: Animals; Deferiprone; Deferoxamine; Dogs; Iron Chelating Agents; Ischemia; Pyridones; Reperfusion In

1995
Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator.
    Annals of vascular surgery, 1994, Volume: 8, Issue:5

    Topics: Animals; Constriction; Deferoxamine; Ischemia; Kidney Cortex; Laser-Doppler Flowmetry; Microcirculat

1994
Direct evidence of free radical production after ischaemia and reperfusion and protective effect of desferrioxamine: ESR and vitamin E studies.
    European journal of vascular surgery, 1994, Volume: 8, Issue:5

    Topics: Animals; Deferoxamine; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free

1994
Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia.
    Shock (Augusta, Ga.), 1995, Volume: 3, Issue:1

    Topics: Animals; Antibodies, Monoclonal; CD11 Antigens; Chromans; Deferoxamine; Gadolinium; Ischemia; Kupffe

1995
Protection of the transiently ischemic cat retina by zinc-desferrioxamine.
    Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:3

    Topics: Animals; Cats; Deferoxamine; Electroretinography; Fundus Oculi; Hydroxybenzoates; Hydroxyl Radical;

1994
The effect of a synthetic hexadentate iron chelator (CP130) and desferrioxamine on rabbit kidneys exposed to cold and warm ischaemia.
    Agents and actions, 1993, Volume: 40, Issue:1-2

    Topics: Animals; Deferoxamine; Iron Chelating Agents; Ischemia; Kidney; Lipid Peroxidation; Male; Pyridones;

1993
Mobilization of low-molecular-weight iron and peroxidative damage during ischemia and reoxygenation of the rat liver.
    Transplantation proceedings, 1994, Volume: 26, Issue:2

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Deferoxamine; Iron

1994
Deferoxamine prevents lipid peroxidation and attenuates reoxygenation injury in postischemic skeletal muscle.
    The American journal of physiology, 1993, Volume: 264, Issue:6 Pt 2

    Topics: Animals; Deferoxamine; Electrophysiology; Hindlimb; Ischemia; Lipid Peroxides; Male; Muscles; Rats;

1993
[Examination of the reperfusion damage to a striated muscle: possible pathomechanism and prevention].
    Magyar traumatologia, ortopedia, kezsebeszet, plasztikai sebeszet, 1993, Volume: 36, Issue:2

    Topics: Animals; Catalase; Deferoxamine; Drug Evaluation, Preclinical; Ischemia; Methylprednisolone; Muscles

1993
Activation of ischemia- and reperfusion-sensitive abdominal visceral C fiber afferents. Role of hydrogen peroxide and hydroxyl radicals.
    Circulation research, 1993, Volume: 72, Issue:6

    Topics: Abdomen; Action Potentials; Animals; Cats; Deferoxamine; Free Radicals; Hydrogen Peroxide; Hydroxide

1993
Prevention of postischemic injury in immature intestine by deferoxamine.
    The Journal of surgical research, 1993, Volume: 54, Issue:1

    Topics: Animals; Constriction; Deferoxamine; Intestines; Ischemia; Male; Mesenteric Arteries; Rats; Rats, Sp

1993
Traumatic versus postischemic induction of oxidative stress in rat liver.
    The Journal of trauma, 1993, Volume: 34, Issue:2

    Topics: Animals; Calcimycin; Deferoxamine; Ischemia; Liver; Male; Malondialdehyde; Organ Culture Techniques;

1993
Inhibition of lung tissue oxidation during ischemia/reperfusion by 2-mercaptopropionylglycine.
    Archives of biochemistry and biophysics, 1993, Volume: 303, Issue:2

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Deferoxamine; Ischemia; Lipid Peroxidation; Lung; Male; Ox

1993
Ischaemia--reperfusion injury in the rat is modulated by superoxide generation and leads to an augmentation of the hypoxic pulmonary vascular response.
    Clinical science (London, England : 1979), 1996, Volume: 90, Issue:1

    Topics: Animals; Arginine; Catalase; Deferoxamine; Ischemia; Linolenic Acids; Lung; Male; NG-Nitroarginine M

1996
The efficacy of antioxidants administered during low temperature storage of warm ischemic kidney tissue slices.
    Cryobiology, 1997, Volume: 34, Issue:4

    Topics: Animals; Antioxidants; Ascorbic Acid; Chromans; Cryopreservation; Deferoxamine; Ischemia; Kidney Cor

1997
Ischemia-reperfusion injury of rabbit kidney: comparative effects of desferrioxamine and N-acetylcysteine as antioxidants.
    Transplantation proceedings, 2000, Volume: 32, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Aspartate Aminotransferases; Deferoxamine; Glutathione; Ische

2000
Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers.
    Free radical research, 2000, Volume: 32, Issue:6

    Topics: Animals; Antioxidants; Blood Flow Velocity; Catalase; Deferoxamine; Endothelium, Vascular; Gadoliniu

2000
In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies.
    The American journal of pathology, 2001, Volume: 159, Issue:3

    Topics: Aldehydes; Cyclic N-Oxides; Deferoxamine; Female; Fluorescent Antibody Technique; Heat-Shock Protein

2001
Iron contributes to endothelial dysfunction in acute ischemic syndromes.
    Circulation, 2002, Jan-29, Volume: 105, Issue:4

    Topics: Acute Disease; Coronary Circulation; Coronary Disease; Deferoxamine; Endothelial Growth Factors; End

2002
Sequence of gastric mucosal injury following ischemia and reperfusion. Role of reactive oxygen metabolites.
    Digestive diseases and sciences, 1992, Volume: 37, Issue:9

    Topics: Allopurinol; Animals; Catalase; Deferoxamine; Free Radicals; Gastric Mucosa; Ischemia; Male; Oxygen;

1992
Hydrogen peroxide-induced cardiovascular reflexes. Role of hydroxyl radicals.
    Circulation research, 1992, Volume: 71, Issue:2

    Topics: Animals; Aspirin; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Cat

1992
Oxygen radicals in liver ischemia and reperfusion--experimental data.
    Klinische Wochenschrift, 1991, Dec-15, Volume: 69, Issue:21-23

    Topics: Allopurinol; Animals; Deferoxamine; Electron Spin Resonance Spectroscopy; Fatty Acids, Nonesterified

1991
Conjugated desferoxamine attenuates hepatic microvascular injury following ischemia/reperfusion.
    Circulatory shock, 1991, Volume: 34, Issue:2

    Topics: Animals; Blood Vessels; Deferoxamine; Ischemia; Liver Circulation; Male; Microcirculation; Rats; Rat

1991
Renal preservation after warm ischemia using oxygen free radical scavengers to prevent reperfusion injury.
    The Journal of surgical research, 1991, Volume: 51, Issue:1

    Topics: Animals; Ceruloplasmin; Creatinine; Deferoxamine; Dogs; Free Radical Scavengers; Hot Temperature; Is

1991
Severity of oxygen free radical effects after ischemia and reperfusion in intestinal tissue and the influence of different drugs.
    Advances in experimental medicine and biology, 1990, Volume: 277

    Topics: Allopurinol; Animals; Catalase; Deferoxamine; Free Radicals; Hemoglobins; Intestinal Mucosa; Intesti

1990
Role of oxidants in ischemia/reperfusion-induced granulocyte infiltration.
    The American journal of physiology, 1990, Volume: 258, Issue:2 Pt 1

    Topics: Animals; Catalase; Cats; Chemotaxis, Leukocyte; Deferoxamine; Dimethyl Sulfoxide; Granulocytes; Hydr

1990
Iron redistribution and lipid peroxidation in the cold ischaemic kidney.
    Advances in experimental medicine and biology, 1990, Volume: 264

    Topics: Animals; Cold Temperature; Deferoxamine; In Vitro Techniques; Iron; Ischemia; Kidney; Kidney Cortex;

1990
Inhibition of the compartment syndrome by the ablation of free radical-mediated reperfusion injury.
    Surgery, 1990, Volume: 108, Issue:1

    Topics: Allopurinol; Animals; Blood Pressure; Compartment Syndromes; Deferoxamine; Free Radicals; Ischemia;

1990
Protection against oxidative damage in cold-stored rabbit kidneys by desferrioxamine and indomethacin.
    Cryobiology, 1989, Volume: 26, Issue:4

    Topics: Animals; Cold Temperature; Deferoxamine; In Vitro Techniques; Indomethacin; Ischemia; Kidney; Kidney

1989
Measurement by HPLC of desferrioxamine-available iron in rabbit kidneys to assess the effect of ischaemia on the distribution of iron within the total pool.
    Free radical research communications, 1989, Volume: 5, Issue:4-5

    Topics: Animals; Chromatography, High Pressure Liquid; Cytosol; Deferoxamine; Iron; Ischemia; Kidney; Kidney

1989
Prevention of postischaemic lipid peroxidation and liver cell injury by iron chelation.
    Gut, 1989, Volume: 30, Issue:4

    Topics: Animals; Deferoxamine; Ischemia; Lipid Peroxidation; Liver; Male; Rats; Rats, Inbred Strains; Reperf

1989
The effect of desferrioxamine on lipid peroxidation and survival of ischaemic island skin flaps in rats.
    British journal of plastic surgery, 1989, Volume: 42, Issue:5

    Topics: Animals; Deferoxamine; Female; Graft Survival; Ischemia; Lipid Peroxidation; Necrosis; Rats; Rats, I

1989
A role for iron in oxidant-mediated ischemic injury to intestinal microvasculature.
    The American journal of physiology, 1987, Volume: 253, Issue:1 Pt 1

    Topics: Animals; Apoproteins; Capillaries; Capillary Permeability; Cats; Deferoxamine; Free Radicals; Hydrox

1987
Reduced susceptibility to lipid peroxidation in cold ischemic rabbit kidneys after addition of desferrioxamine, mannitol, or uric acid to the flush solution.
    Cryobiology, 1986, Volume: 23, Issue:4

    Topics: Animals; Deferoxamine; Freezing; Glutathione; Glutathione Disulfide; Ischemia; Kidney; Lipid Peroxid

1986
Role of iron in postischemic renal injury in the rat.
    Kidney international, 1988, Volume: 34, Issue:4

    Topics: Animals; Deferoxamine; Edetic Acid; Free Radicals; Glomerular Filtration Rate; Iron; Ischemia; Kidne

1988
The post treatment experiment: an operational definition of reperfusion injury.
    Basic life sciences, 1988, Volume: 49

    Topics: Allopurinol; Animals; Creatine Kinase; Deferoxamine; Disease Models, Animal; Heart Arrest; Ischemia;

1988
Lipid peroxidation in the cortex and medulla of rabbit kidneys subjected to cold ischaemia and the value of protective agents.
    Free radical research communications, 1987, Volume: 3, Issue:1-5

    Topics: Animals; Cold Temperature; Deferoxamine; Imidazoles; In Vitro Techniques; Indomethacin; Ischemia; Ki

1987
Reduction of susceptibility to lipid peroxidation by desferrioxamine in rabbit kidneys subjected to 24-hour cold ischemia and reperfusion.
    Transplantation, 1987, Volume: 43, Issue:4

    Topics: Animals; Cold Temperature; Deferoxamine; Free Radicals; Ischemia; Kidney Transplantation; Lipid Pero

1987
Gastric mucosal injury in the rat. Role of iron and xanthine oxidase.
    Gastroenterology, 1987, Volume: 92, Issue:4

    Topics: Animals; Chromium Radioisotopes; Deferoxamine; Erythrocytes; Free Radicals; Gastric Mucosa; Iron; Is

1987
Desferrioxamine reduces susceptibility to lipid peroxidation in rabbit kidneys subjected to warm ischaemia and reperfusion.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1986, Volume: 85, Issue:1

    Topics: Animals; Deferoxamine; Ischemia; Kidney; Kinetics; Lipid Peroxides; Perfusion; Rabbits; Renal Circul

1986
Postischemic tissue injury by iron-mediated free radical lipid peroxidation.
    Annals of emergency medicine, 1985, Volume: 14, Issue:8

    Topics: Calcium; Cell Membrane; Deferoxamine; Free Radicals; Humans; Iron; Ischemia; Lipid Peroxides; Mitoch

1985