robenacoxib and Ischemia

robenacoxib has been researched along with Ischemia* in 1 studies

Other Studies

1 other study(ies) available for robenacoxib and Ischemia

ArticleYear
Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses.
    American journal of veterinary research, 2011, Volume: 72, Issue:2

    To determine the cyclooxygenase (COX) selectivity of robenacoxib and its effect on recovery of jejunal mucosa following ischemic injury in horses.. 12 healthy horses.. Half the maximal inhibition (EC₅₀) of robenacoxib for COX-1 and COX-2 activity was established in bloods samples from 6 horses via measurement of thromboxane B₂ (TXB₂) and prostaglandin E₂ concentrations, respectively; COX selectivity was subsequently calculated. Six other horses were anesthetized, and ischemia was induced in the jejunum for 2 hours. Control and ischemia-injured mucosa were collected and incubated with Ringer's solution (control treatment), flunixin meglumine (2.7 × 10⁻⁵M), or robenacoxib (2.7 × 10⁻⁵M). Transepithelial electrical resistance and mannitol flux were measured over a 4-hour recovery period. Bathing solution TXB₂ and prostaglandin E metabolite concentrations were measured to assess COX-1 and COX-2 function, respectively.. The mean ± SD EC₅₀ value of robenacoxib for COX-1 and COX-2 was 11.46 ± 4.46 μM and 0.19 ± 0.07 μM, respectively, resulting in a COX selectivity ratio of 61.01. The transepithelial electrical resistance of ischemia-injured jejunum treated with flunixin meglumine was significantly lower than that of control and robenacoxib-treated tissues. A significant increase in concentrations of prostaglandin E metabolites and TXB₂ was detected in control and robenacoxib-treated tissues but not flunixin meglumine-treated tissues.. Robenacoxib selectively inhibited COX-2 and allowed recovery of barrier function in ischemia-injured equine jejunal tissue in vitro.

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diphenylamine; Female; Horse Diseases; Horses; Intestinal Diseases; Ischemia; Jejunum; Phenylacetates

2011